Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

Aging Cell

Volumn 13, Issue 6, 2014, Pages 1075-1085

  Moroz, Natalie ^a,b   Carmona, Juan J ^a,b   Anderson, Edward ^c   Hart, Anne C ^c   Sinclair, David A ^b,d   Blackwell, T Keith ^b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROWN UNIVERSITY   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Aging; C. elegans; Dietary restriction; NAD+; Sirtuins; Stress response

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXA; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR NRF3; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; SIRTUIN;

ADULT; AEROBIC METABOLISM; AGING; AMPK GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CAENORHABDITIS ELEGANS; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; FOXA GENE; FOXO GENE; GENETIC ANALYSIS; INTRACELLULAR SIGNALING; LIFE EXTENSION; MITOCHONDRIAL RESPIRATION; NONHUMAN; NRF1 GENE; NRF2 GENE; NRF3 GENE; NUCLEOTIDE METABOLISM; OXYGEN CONSUMPTION; PNC 1 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIRT1 GENE; ANIMAL; CALORIC RESTRICTION; DIET; LONGEVITY; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CAENORHABDITIS ELEGANS;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALORIC RESTRICTION; DIET; LONGEVITY; NAD; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SIRTUINS; TRANSCRIPTION FACTORS;

EID: 84911447491     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12273     Document Type: Article

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