Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages E4458-E4467

  Hwang, Ara B ^a   Ryu, Eun A ^a   Artan, Murat ^a   Chang, Hsin Wen ^b   Kabir, Mohammad Humayun ^c   Nam, Hyun Jun ^a   Lee, Dongyeop ^a   Yang, Jae Seong ^a,f   Kim, Sanguk ^a   Mair, William B ^d   Lee, Cheolju ^c,e   Lee, Siu Sylvia ^b   Lee, Seung Jae ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Department of Obstetrics Gynecology   (United States)

^c Korea Institute of Science and Technology   (South Korea)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e University of Science and Technology (UST)   (South Korea)

^f CENTRE FOR GENOMIC REGULATION CRG   (Spain)

Author keywords

Aging; C. Elegans; Immunity; Mitochondria; Reactive oxygen species

Indexed keywords

ADENYLATE KINASE; FERRITIN; HYPOXIA INDUCIBLE FACTOR 1; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PARAQUAT; REACTIVE OXYGEN METABOLITE; TUBULIN; CAENORHABDITIS ELEGANS PROTEIN; HIF-1 PROTEIN, C ELEGANS; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; TRANSCRIPTION FACTOR;

ARTICLE; CAENORHABDITIS ELEGANS; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEEDBACK SYSTEM; IMMUNITY; LONGEVITY; LOSS OF FUNCTION MUTATION; MICROBACTERIUM; MITOCHONDRION; NONHUMAN; PSEUDOMONAS AERUGINOSA; SERRATIA; UNFOLDED PROTEIN RESPONSE; AGING; ANIMAL; CELL RESPIRATION; CHEMISTRY; HOMEOSTASIS; IMMUNOLOGY; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL RESPIRATION; FEEDBACK, PHYSIOLOGICAL; HOMEOSTASIS; IRON; LONGEVITY; MITOCHONDRIA; MUTATION; PARAQUAT; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS;

EID: 84908068704     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411199111     Document Type: Article

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