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Volumn 9, Issue 11, 2013, Pages 693-700

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(21)  Schmeisser, Kathrin a   Mansfeld, Johannes a,b,c   Kuhlow, Doreen a,d   Weimer, Sandra b,d   Priebe, Steffen e   Heiland, Ines a,k   Birringer, Marc f   Groth, Marco g   Segref, Alexandra h   Kanfi, Yariv i   Price, Nathan L j   Schmeisser, Sebastian a,g   Schuster, Stefan a   Pfeiffer, Andreas F H d   Guthke, Reinhard e   Platzer, Matthias g   Hoppe, Thorsten h   Cohen, Haim Y i   Zarse, Kim a,b   Sinclair, David A j   more..


Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLNICOTINAMIDE; HYDROGEN PEROXIDE; METHYLTRANSFERASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE METHYLTRANSFERASE; SIRTUIN; TRANSCRIPTION FACTOR NRF2;

EID: 84886476382     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1352     Document Type: Article
Times cited : (201)

References (56)
  • 1
    • 84864062918 scopus 로고    scopus 로고
    • Sirtuins: Physiological modulators of metabolism
    • Nogueiras, R. et al. Sirtuins: Physiological modulators of metabolism. Physiol. Rev. 92, 1479-1514 (2012).
    • (2012) Physiol. Rev. , vol.92 , pp. 1479-1514
    • Nogueiras, R.1
  • 2
    • 0030820491 scopus 로고    scopus 로고
    • Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
    • Sinclair, D.A., Mills, K. & Guarente, L. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277, 1313-1316 (1997).
    • (1997) Science , vol.277 , pp. 1313-1316
    • Sinclair, D.A.1    Mills, K.2    Guarente, L.3
  • 3
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 4
    • 0037130175 scopus 로고    scopus 로고
    • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    • Lin, S.J. et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-348 (2002).
    • (2002) Nature , vol.418 , pp. 344-348
    • Lin, S.J.1
  • 5
    • 0038329323 scopus 로고    scopus 로고
    • Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
    • Anderson, R.M., Bitterman, K.J., Wood, J.G., Medvedik, O. & Sinclair, D.A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423, 181-185 (2003).
    • (2003) Nature , vol.423 , pp. 181-185
    • Anderson, R.M.1    Bitterman, K.J.2    Wood, J.G.3    Medvedik, O.4    Sinclair, D.A.5
  • 6
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • Kaeberlein, M., Kirkland, K.T., Fields, S. & Kennedy, B.K. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2, E296 (2004).
    • (2004) PLoS Biol. , vol.2
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 7
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz, T.J. et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280-293 (2007).
    • (2007) Cell Metab. , vol.6 , pp. 280-293
    • Schulz, T.J.1
  • 8
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum, H.A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230 (2001).
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 9
    • 80053134340 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
    • Viswanathan, M. & Guarente, L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477, E1-E2 (2011).
    • (2011) Nature , vol.477
    • Viswanathan, M.1    Guarente, L.2
  • 10
    • 80053460544 scopus 로고    scopus 로고
    • The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
    • Rizki,, G. et al. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet 7, e1002235 (2011).
    • (2011) PLoS Genet , vol.7
    • Rizki, G.1
  • 11
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina, B. & Helfand, S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998-16003 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 12
    • 84871695502 scopus 로고    scopus 로고
    • DSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner
    • Banerjee, K.K. et al. dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner. Cell Rep 2, 1485-1491 (2012).
    • (2012) Cell Rep , vol.2 , pp. 1485-1491
    • Banerjee, K.K.1
  • 13
    • 80053168829 scopus 로고    scopus 로고
    • Absence of effects of Sir2 overexpression on lifespan in C. Elegans and Drosophila
    • Burnett, C. et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485 (2011).
    • (2011) Nature , vol.477 , pp. 482-485
    • Burnett, C.1
  • 14
    • 45549098657 scopus 로고    scopus 로고
    • SirT1 regulates energy metabolism and response to caloric restriction in mice
    • Boily, G. et al. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One 3, e1759 (2008).
    • (2008) PLoS One , vol.3
    • Boily, G.1
  • 15
    • 84858000209 scopus 로고    scopus 로고
    • The sirtuin SIRT6 regulates lifespan in male mice
    • Kanfi, Y. et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221 (2012).
    • (2012) Nature , vol.483 , pp. 218-221
    • Kanfi, Y.1
  • 16
    • 84865963028 scopus 로고    scopus 로고
    • NAD+ biosynthesis and salvage-A phylogenetic perspective
    • Gossmann, T.I. et al. NAD+ biosynthesis and salvage-A phylogenetic perspective. FEBS J. 279, 3355-3363 (2012).
    • (2012) FEBS J , vol.279 , pp. 3355-3363
    • Gossmann, T.I.1
  • 17
    • 0008912941 scopus 로고
    • Methylation of nicotinamide with soluble enzyme system from rat liver
    • Cantoni, G.L. Methylation of nicotinamide with soluble enzyme system from rat liver. J. Biol. Chem. 189, 203-216 (1951).
    • (1951) J. Biol. Chem. , vol.189 , pp. 203-216
    • Cantoni, G.L.1
  • 18
    • 0028807607 scopus 로고
    • Radical formation site of cerebral complex I and Parkinson's disease
    • Fukushima, T. et al. Radical formation site of cerebral complex I and Parkinson's disease. J. Neurosci. Res. 42, 385-390 (1995).
    • (1995) J. Neurosci. Res. , vol.42 , pp. 385-390
    • Fukushima, T.1
  • 19
    • 77952548782 scopus 로고    scopus 로고
    • How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
    • Ristow, M. & Zarse, K. How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp. Gerontol. 45, 410-418 (2010).
    • (2010) Exp. Gerontol. , vol.45 , pp. 410-418
    • Ristow, M.1    Zarse, K.2
  • 21
    • 73449114300 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16
    • Hashimoto, T., Horikawa, M., Nomura, T. & Sakamoto, K. Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. Biogerontology 11, 31-43 (2010).
    • (2010) Biogerontology , vol.11 , pp. 31-43
    • Hashimoto, T.1    Horikawa, M.2    Nomura, T.3    Sakamoto, K.4
  • 22
    • 84877681309 scopus 로고    scopus 로고
    • Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
    • Schmeisser, S. et al. Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol. Metab. 2, 92-102 (2013).
    • (2013) Mol. Metab. , vol.2 , pp. 92-102
    • Schmeisser, S.1
  • 23
    • 33947723940 scopus 로고    scopus 로고
    • Characterization of superoxide production from aldehyde oxidase: An important source of oxidants in biological tissues
    • Kundu, T.K., Hille, R., Velayutham, M. & Zweier, J.L. Characterization of superoxide production from aldehyde oxidase: An important source of oxidants in biological tissues. Arch. Biochem. Biophys. 460, 113-121 (2007).
    • (2007) Arch. Biochem. Biophys. , vol.460 , pp. 113-121
    • Kundu, T.K.1    Hille, R.2    Velayutham, M.3    Zweier, J.L.4
  • 24
    • 79960130059 scopus 로고    scopus 로고
    • Overcoming redundancy: An RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans
    • Sawyer, J.M. et al. Overcoming redundancy: An RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics 188, 549-564 (2011).
    • (2011) Genetics , vol.188 , pp. 549-564
    • Sawyer, J.M.1
  • 25
    • 10644265439 scopus 로고    scopus 로고
    • Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: Inhibition by isovanillin
    • Panoutsopoulos, G.I. & Beedham, C. Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: Inhibition by isovanillin. Acta Biochim. Pol. 51, 943-951 (2004).
    • (2004) Acta Biochim. Pol. , vol.51 , pp. 943-951
    • Panoutsopoulos, G.I.1    Beedham, C.2
  • 27
    • 84859475161 scopus 로고    scopus 로고
    • Impaired insulin/IGF1-signaling extends life span by promoting mitochondrial l-proline catabolism to induce a transient ROS signal
    • Zarse, K. et al. Impaired insulin/IGF1-signaling extends life span by promoting mitochondrial l-proline catabolism to induce a transient ROS signal. Cell Metab. 15, 451-465 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 451-465
    • Zarse, K.1
  • 28
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C elegans
    • Bishop, N.A. & Guarente, L. Two neurons mediate diet-restriction- induced longevity in C. elegans. Nature 447, 545-549 (2007).
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 29
    • 84864117744 scopus 로고    scopus 로고
    • Aldehyde oxidase 1 gene is regulated by Nrf2 pathway
    • Maeda, K. et al. Aldehyde oxidase 1 gene is regulated by Nrf2 pathway. Gene 505, 374-378 (2012).
    • (2012) Gene , vol.505 , pp. 374-378
    • Maeda, K.1
  • 30
    • 0036279460 scopus 로고    scopus 로고
    • Reporter transgenes for study of oxidant stress in Caenorhabditis elegans
    • Link, C.D. & Johnson, C.J. Reporter transgenes for study of oxidant stress in Caenorhabditis elegans. Methods Enzymol. 353, 497-505 (2002).
    • (2002) Methods Enzymol. , vol.353 , pp. 497-505
    • Link, C.D.1    Johnson, C.J.2
  • 31
    • 84859575436 scopus 로고    scopus 로고
    • Superoxide dismutase is dispensable for normal animal lifespan
    • Van Raamsdonk, J.M. & Hekimi, S. Superoxide dismutase is dispensable for normal animal lifespan. Proc. Natl. Acad. Sci. USA 109, 5785-5790 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 5785-5790
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 32
    • 0037147103 scopus 로고    scopus 로고
    • Rates of behavior and aging specified by mitochondrial function during development
    • Dillin, A. et al. Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-2401 (2002).
    • (2002) Science , vol.298 , pp. 2398-2401
    • Dillin, A.1
  • 33
    • 77956241785 scopus 로고    scopus 로고
    • Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans
    • Yang, W. & Hekimi, S. Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell 9, 433-447 (2010).
    • (2010) Aging Cell , vol.9 , pp. 433-447
    • Yang, W.1    Hekimi, S.2
  • 34
    • 66649109663 scopus 로고    scopus 로고
    • Antioxidants prevent health-promoting effects of physical exercise in humans
    • Ristow, M. et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc. Natl. Acad. Sci. USA 106, 8665-8670 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 8665-8670
    • Ristow, M.1
  • 35
    • 79958068191 scopus 로고    scopus 로고
    • Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling
    • Pan, Y., Schroeder, E.A., Ocampo, A., Barrientos, A. & Shadel, G.S. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab. 13, 668-678 (2011).
    • (2011) Cell Metab. , vol.13 , pp. 668-678
    • Pan, Y.1    Schroeder, E.A.2    Ocampo, A.3    Barrientos, A.4    Shadel, G.S.5
  • 37
    • 84877642187 scopus 로고    scopus 로고
    • The sirtuins, oxidative stress and aging: An emerging link
    • Merksamer, P.I. et al. The sirtuins, oxidative stress and aging: An emerging link. Aging (Albany NY) 5, 144-150 (2013).
    • (2013) Aging (Albany NY) , vol.5 , pp. 144-150
    • Merksamer, P.I.1
  • 38
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet, A. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1
  • 39
    • 84886587391 scopus 로고    scopus 로고
    • Method for treating hypertriglyceridemia, dyslipidemia and hyperchlosterolemia with a 1-methylnicotinamide salt
    • Gebicki, J. & Chlopicki, S. Method for treating hypertriglyceridemia, dyslipidemia and hyperchlosterolemia with a 1-methylnicotinamide salt. US Patent 7,935,717 B2 10 (2011).
    • (2011) US Patent 7,935,717 B2 , vol.10
    • Gebicki, J.1    Chlopicki, S.2
  • 40
    • 34447511196 scopus 로고    scopus 로고
    • Triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • Nordestgaard, B.G., Benn, M., Schnohr, P. & Tybjaerg-Hansen, A. Triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. J. Am. Med. Assoc. 298, 299-308 (2007).
    • (2007) J. Am. Med. Assoc. , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 41
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown, B.G. et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N. Engl. J. Med. 345, 1583-1592 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1583-1592
    • Brown, B.G.1
  • 42
    • 0023001772 scopus 로고
    • Fifteen year mortality in coronary drug project patients: Long-Term benefit with niacin
    • Canner, P.L. et al. Fifteen year mortality in Coronary Drug Project patients: Long-Term benefit with niacin. J. Am. Coll. Cardiol. 8, 1245-1255 (1986).
    • (1986) J. Am. Coll. Cardiol. , vol.8 , pp. 1245-1255
    • Canner, P.L.1
  • 43
    • 33645236199 scopus 로고    scopus 로고
    • Health benefits of physical activity: The evidence
    • Warburton, D.E., Nicol, C.W. & Bredin, S.S. Health benefits of physical activity: The evidence. CMAJ 174, 801-809 (2006).
    • (2006) CMAJ , vol.174 , pp. 801-809
    • Warburton, D.E.1    Nicol, C.W.2    Bredin, S.S.3
  • 44
    • 84862224732 scopus 로고    scopus 로고
    • Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma
    • Chlopicki, S. et al. Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma. Pharmacol. Rep. 64, 369-376 (2012).
    • (2012) Pharmacol. Rep. , vol.64 , pp. 369-376
    • Chlopicki, S.1
  • 45
    • 84879083630 scopus 로고    scopus 로고
    • NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
    • Ulanovskaya, O.A., Zuhl, A.M. & Cravatt, B.F. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat. Chem. Biol. 9, 300-306 (2013).
    • (2013) Nat. Chem. Biol. , vol.9 , pp. 300-306
    • Ulanovskaya, O.A.1    Zuhl, A.M.2    Cravatt, B.F.3
  • 46
    • 79955526612 scopus 로고    scopus 로고
    • The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
    • Parsons, R.B. et al. The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors. Biochem. J. 436, 145-155 (2011).
    • (2011) Biochem. J. , vol.436 , pp. 145-155
    • Parsons, R.B.1
  • 47
    • 84880517634 scopus 로고    scopus 로고
    • The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
    • Mouchiroud, L. et al. The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154, 430-441 (2013).
    • (2013) Cell , vol.154 , pp. 430-441
    • Mouchiroud, L.1
  • 48
    • 84858274558 scopus 로고    scopus 로고
    • Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans
    • Segref, A. & Hoppe, T. Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans. Methods Mol. Biol. 832, 531-544 (2012).
    • (2012) Methods Mol. Biol. , vol.832 , pp. 531-544
    • Segref, A.1    Hoppe, T.2
  • 49
    • 34147196228 scopus 로고    scopus 로고
    • Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts
    • Janssen, A.J. et al. Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin. Chem. 53, 729-734 (2007).
    • (2007) Clin. Chem. , vol.53 , pp. 729-734
    • Janssen, A.J.1
  • 50
    • 0035152802 scopus 로고    scopus 로고
    • Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow
    • Musfeld, C., Biollaz, J., Belaz, N., Kesselring, U.W. & Decosterd, L.A. Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow. J. Pharm. Biomed. Anal. 24, 391-404 (2001).
    • (2001) J. Pharm. Biomed. Anal. , vol.24 , pp. 391-404
    • Musfeld, C.1    Biollaz, J.2    Belaz, N.3    Kesselring, U.W.4    Decosterd, L.A.5
  • 51
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • Trapnell, C., Pachter, L. & Salzberg, S.L. TopHat: Discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105-1111 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 52
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).
    • (2010) Genome Biol. , vol.11
    • Anders, S.1    Huber, W.2
  • 53
    • 75249087100 scopus 로고    scopus 로고
    • EdgeR: A Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson, M.D., McCarthy, D.J. & Smyth, G.K. edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139-140 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 54
    • 79952039532 scopus 로고    scopus 로고
    • FungiFun: A web-based application for functional categorization of fungal genes and proteins
    • Priebe, S., Linde, J., Albrecht, D., Guthke, R. & Brakhage, A.A. FungiFun: A web-based application for functional categorization of fungal genes and proteins. Fungal Genet. Biol. 48, 353-358 (2011).
    • (2011) Fungal Genet. Biol. , vol.48 , pp. 353-358
    • Priebe, S.1    Linde, J.2    Albrecht, D.3    Guthke, R.4    Brakhage, A.A.5
  • 55
    • 46049087782 scopus 로고    scopus 로고
    • The transfac project as an example of framework technology that supports the analysis of genomic regulation
    • Wingender, E. The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation. Brief. Bioinform. 9, 326-332 (2008).
    • (2008) Brief. Bioinform. , vol.9 , pp. 326-332
    • Wingender, E.1
  • 56
    • 0028104274 scopus 로고
    • Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements
    • Blackwell, T.K., Bowerman, B., Priess, J.R. & Weintraub, H. Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements. Science 266, 621-628 (1994).
    • (1994) Science , vol.266 , pp. 621-628
    • Blackwell, T.K.1    Bowerman, B.2    Priess, J.R.3    Weintraub, H.4


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