Physiology: A developmental timing microRNA and its target regulate life span in C. elegans

Science

Volumn 310, Issue 5756, 2005, Pages 1954-1957

  Boehm, Michelle ^a   Slack, Frank ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PHYSIOLOGY; TISSUE;

CAENORHABDITIS ELEGANS; LIFE-SPAN; MICRORNA;

RNA;

INSULIN; MICRORNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR HSF 1; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DAF 16 PROTEIN, C ELEGANS; DAF 2 PROTEIN, C ELEGANS; DAF-16 PROTEIN, C ELEGANS; DAF-2 PROTEIN, C ELEGANS; HELMINTH RNA; INSULIN RECEPTOR; LIN 14 PROTEIN, C ELEGANS; LIN 4 PROTEIN, C ELEGANS; LIN-14 PROTEIN, C ELEGANS; LIN-4 PROTEIN, C ELEGANS; LIPOFUSCIN; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

BIOLOGY;

3' UNTRANSLATED REGION; ARTICLE; CAENORHABDITIS ELEGANS; GENE; GENE MUTATION; LARVAL DEVELOPMENT; LIFESPAN; LIN 14 GENE; LIN 4 GENE; NONHUMAN; PRIORITY JOURNAL; AGING; AMINO ACID SEQUENCE; ANIMAL; DEVELOPMENTAL GENE; GENE EXPRESSION REGULATION; GENETICS; HEAT SHOCK RESPONSE; LONGEVITY; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CAENORHABDITIS ELEGANS;

AGING; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DEVELOPMENTAL; HEAT-SHOCK RESPONSE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIPOFUSCIN; LONGEVITY; MICRORNAS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; RECEPTOR, INSULIN; REPRESSOR PROTEINS; RNA, HELMINTH; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 29344467120     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1115596     Document Type: Article

References (32)

1. C. Kenyon, Cell 120, 449 (2005).
2. S. A. McCarroll et al., Nat. Genet. 36, 197 (2004).
3. C. Kenyon, in C. elegans II: Monograph 33, D. L. Riddle, Ed. (Cold Spring Harbor monograph series, Cold Spring Harbor Laboratory, Plainview, New York, 1997), p. xvii, p. 796.
4. T. Lu et al., Nature 429, 883 (2004).
5. V. Ambros, H. R. Horvitz, Genes Dev. 1, 398 (1987).
6. D. Banerjee, F. Slack, Bioessays 24, 119 (2002).
7. F. Slack, G. Ruvkun, Annu. Rev. Genet 31, 611 (1997).
8. R. C. Lee, R. L. Feinbaum, V. Ambros, Cell 75, 843 (1993).
9. B. Wightman, I. Ha, G. Ruvkun, Cell 75, 855 (1993).
10. P. H. Olsen, V. Ambros, Dev. Biol. 216, 671 (1999).
11. R. Feinbaum, V. Ambros, Dev. Biol. 210, 87 (1999).
12. G. Ruvkun, J. Giusto, Nature 338, 313 (1989).
13. Y. Hong, R. C. Lee, V. Ambros, Mol. Cell. Biol. 20, 2285 (2000).
14. L. P. Lim et al., Genes Dev. 17, 991 (2003).
15. A. Esquela-Kerscher et al., Dev. Dyn. 234, 868 (2005).
16. B. Wightman, T. R. Burglin, J. Gatto, P. Arasu, G. Ruvkun, Genes Dev. 5, 1813 (1991).
17. D. Garigan et al., Genetics 161, 1101 (2002).
18. C. Kenyon, J. Chang, E. Gensch, A. Rudner, R. Tabtiang, Nature 366, 461 (1993).
19. K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997).
20. P. L. Larsen, P. S. Albert, D. L. Riddle, Genetics 139, 1567 (1995).
21. K. D. Kimura, H. A. Tissenbaum, Y. Liu, G. Ruvkun, Science 277, 942 (1997).
22. G. J. Lithgow, T. M. White, S. Melov, T. E. Johnson, Proc. Natl. Acad. Sci. U.S.A. 92, 7540 (1995).
23. S. S. Lee et al., Nat. Genet. 33, 40 (2003).
24. S. Ogg et al., Nature 389, 994 (1997).
25. A. L. Hsu, C. T. Murphy, C. Kenyon, Science 300, 1142 (2003).
26. K. Lin, H. Hsin, N. Libina, C. Kenyon, Nat. Genet. 28, 139 (2001).
27. K. A. Hughes, R. M. Reynolds, Annu. Rev. Entomol. 50, 421 (2005).
28. D. P. Bartel, Cell 116, 281 (2004).
29. J. Brennecke, D. R. Hipfner, A. Stark, R. B. Russell, S. M. Cohen, Cell 113, 25 (2003).
30. M. N. Poy et al., Nature 432, 226 (2004).
31. B. J. Reinhart et al., Nature 403, 901 (2000).
32. We thank A. Esquela-Kerscher, D. Banerjee, and K. Carter for critical reading of this manuscript; K. Carter and L. Bai for providing the zals1 strain; S. S. Lee for technical advice; and R. Lee and V. Ambros, and the C. elegans Genetic Center, for supplying strains. This work was supported by an NIH grant (GM64701) to F.S.