-
1
-
-
33750293584
-
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
-
Baba M, Hong S-B, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF 3rd, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR Jr, Linehan WM, Schmidt LS, Zbar B (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl Acad. Sci. USA 103, 15552-15557.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 15552-15557
-
-
Baba, M.1
Hong, S.-B.2
Sharma, N.3
Warren, M.B.4
Nickerson, M.L.5
Iwamatsu, A.6
Esposito, D.7
Gillette, W.K.8
Hopkins 3rd, R.F.9
Hartley, J.L.10
Furihata, M.11
Oishi, S.12
Zhen, W.13
Burke Jr., T.R.14
Linehan, W.M.15
Schmidt, L.S.16
Zbar, B.17
-
2
-
-
38449122032
-
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys
-
Baba M, Furihata M, Hong S-B, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, Zbar B, Linehan WM, Schmidt LS (2008) Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J. Natl Cancer Inst. 100, 140-154.
-
(2008)
J. Natl Cancer Inst.
, vol.100
, pp. 140-154
-
-
Baba, M.1
Furihata, M.2
Hong, S.-B.3
Tessarollo, L.4
Haines, D.C.5
Southon, E.6
Patel, V.7
Igarashi, P.8
Alvord, W.G.9
Leighty, R.10
Yao, M.11
Bernardo, M.12
Ileva, L.13
Choyke, P.14
Warren, M.B.15
Zbar, B.16
Linehan, W.M.17
Schmidt, L.S.18
-
3
-
-
84880507563
-
-
BHD Foundation What is BHD? Available at: [accessed on 21 February 2012]
-
BHD Foundation (2012) What is BHD? Available at: http://www.bhdsyndrome.org/wp-content/uploads/2011/03/What-is-BHD.pdf [accessed on 21 February 2012]
-
(2012)
-
-
-
4
-
-
0017760671
-
Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons
-
Birt AR, Hogg GR, Dubé WJ (1977) Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch. Dermatol. 113, 1674-1677.
-
(1977)
Arch. Dermatol.
, vol.113
, pp. 1674-1677
-
-
Birt, A.R.1
Hogg, G.R.2
Dubé, W.J.3
-
5
-
-
8844284460
-
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans
-
Bishop T, Lau KW, Epstein ACR, Kim SK, Jiang M, O'Rourke D, Pugh CW, Gleadle JM, Taylor MS, Hodgkin J, Ratcliffe PJ (2004) Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol. 2, e289.
-
(2004)
PLoS Biol.
, vol.2
-
-
Bishop, T.1
Lau, K.W.2
Epstein, A.C.R.3
Kim, S.K.4
Jiang, M.5
O'Rourke, D.6
Pugh, C.W.7
Gleadle, J.M.8
Taylor, M.S.9
Hodgkin, J.10
Ratcliffe, P.J.11
-
6
-
-
79953231709
-
A longer and healthier life with TOR down-regulation: genetics and drugs
-
Bjedov I, Partridge L (2011) A longer and healthier life with TOR down-regulation: genetics and drugs. Biochem. Soc. Trans. 39, 460-465.
-
(2011)
Biochem. Soc. Trans.
, vol.39
, pp. 460-465
-
-
Bjedov, I.1
Partridge, L.2
-
7
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
8
-
-
64949182754
-
How does proliferative homeostasis change with age? What causes it and how does it contribute to aging?
-
Campisi J, Sedivy J (2009) How does proliferative homeostasis change with age? What causes it and how does it contribute to aging? J. Gerontol. A Biol. Sci. Med. Sci. 64, 164-166.
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.64
, pp. 164-166
-
-
Campisi, J.1
Sedivy, J.2
-
9
-
-
66149173551
-
Aging and cancer cell biology, 2009
-
Campisi J, Yaswen P (2009) Aging and cancer cell biology, 2009. Aging Cell 8, 221-225.
-
(2009)
Aging Cell
, vol.8
, pp. 221-225
-
-
Campisi, J.1
Yaswen, P.2
-
10
-
-
79957887216
-
Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription
-
Cash TP, Gruber JJ, Hartman TR, Henske EP, Simon MC (2011) Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription. Oncogene 30, 2534-2546.
-
(2011)
Oncogene
, vol.30
, pp. 2534-2546
-
-
Cash, T.P.1
Gruber, J.J.2
Hartman, T.R.3
Henske, E.P.4
Simon, M.C.5
-
11
-
-
67149107430
-
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
-
Chen D, Thomas EL, Kapahi P (2009) HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet. 5, e1000486.
-
(2009)
PLoS Genet.
, vol.5
-
-
Chen, D.1
Thomas, E.L.2
Kapahi, P.3
-
12
-
-
36749081539
-
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P (2007) mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450, 736-740.
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
13
-
-
77956299355
-
An antibiotic selection marker for nematode transgenesis
-
Giordano-Santini R, Milstein S, Svrzikapa N, Tu D, Johnsen R, Baillie D, Vidal M, Dupuy D (2010) An antibiotic selection marker for nematode transgenesis. Nat. Methods 7, 721-723.
-
(2010)
Nat. Methods
, vol.7
, pp. 721-723
-
-
Giordano-Santini, R.1
Milstein, S.2
Svrzikapa, N.3
Tu, D.4
Johnsen, R.5
Baillie, D.6
Vidal, M.7
Dupuy, D.8
-
14
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh F-M, Lubensky I, Duan DR, Florence C, Pozzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaacs WB, Lerman MI, Zbar B, Linehan WM (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet. 7, 85-90.
-
(1994)
Nat. Genet.
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
Schmidt, L.4
Wei, M.H.5
Li, H.6
Latif, F.7
Liu, S.8
Chen, F.9
Duh, F.-M.10
Lubensky, I.11
Duan, D.R.12
Florence, C.13
Pozzatti, R.14
Walther, M.M.15
Bander, N.H.16
Grossman, H.B.17
Brauch, H.18
Pomer, S.19
Brooks, J.D.20
Isaacs, W.B.21
Lerman, M.I.22
Zbar, B.23
Linehan, W.M.24
more..
-
15
-
-
64049090204
-
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis
-
Hartman TR, Nicolas E, Klein-Szanto A, Al-Saleem T, Cash TP, Simon MC, Henske EP (2009) The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene 28, 1594-1604.
-
(2009)
Oncogene
, vol.28
, pp. 1594-1604
-
-
Hartman, T.R.1
Nicolas, E.2
Klein-Szanto, A.3
Al-Saleem, T.4
Cash, T.P.5
Simon, M.C.6
Henske, E.P.7
-
16
-
-
42649092576
-
Identification and characterization of a novel folliculin-interacting protein FNIP2
-
Hasumi H, Baba M, Hong S-B, Hasumi Y, Huang Y, Yao M, Valera VA, Linehan WM, Schmidt LS (2008) Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene 415, 60-67.
-
(2008)
Gene
, vol.415
, pp. 60-67
-
-
Hasumi, H.1
Baba, M.2
Hong, S.-B.3
Hasumi, Y.4
Huang, Y.5
Yao, M.6
Valera, V.A.7
Linehan, W.M.8
Schmidt, L.S.9
-
17
-
-
73249138930
-
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
-
Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong S-B, Yamaguchi TP, Schmidt LS, Linehan WM (2009) Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc. Natl Acad. Sci. USA 106, 18722-18727.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 18722-18727
-
-
Hasumi, Y.1
Baba, M.2
Ajima, R.3
Hasumi, H.4
Valera, V.A.5
Klein, M.E.6
Haines, D.C.7
Merino, M.J.8
Hong, S.-B.9
Yamaguchi, T.P.10
Schmidt, L.S.11
Linehan, W.M.12
-
18
-
-
77953719290
-
Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling
-
Hong S-B, Oh H, Valera VA, Stull J, Ngo D-T, Baba M, Merino MJ, Linehan WM, Schmidt LS (2010) Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol. Cancer 9, 160.
-
(2010)
Mol. Cancer
, vol.9
, pp. 160
-
-
Hong, S.-B.1
Oh, H.2
Valera, V.A.3
Stull, J.4
Ngo, D.-T.5
Baba, M.6
Merino, M.J.7
Linehan, W.M.8
Schmidt, L.S.9
-
19
-
-
77949681085
-
Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin
-
Hudon V, Sabourin S, Dydensborg AB, Kottis V, Ghazi A, Paquet M, Crosby K, Pomerleau V, Uetani N, Pause A (2010) Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. J. Med. Genet. 47, 182-189.
-
(2010)
J. Med. Genet.
, vol.47
, pp. 182-189
-
-
Hudon, V.1
Sabourin, S.2
Dydensborg, A.B.3
Kottis, V.4
Ghazi, A.5
Paquet, M.6
Crosby, K.7
Pomerleau, V.8
Uetani, N.9
Pause, A.10
-
20
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
Inoki K, Corradetti MN, Guan K-L (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet. 37, 19-24.
-
(2005)
Nat. Genet.
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
21
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian Y-M, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.-M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
22
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL (1996) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem. 271, 17771-17778.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
23
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin WG (2002) Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2, 673-682.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin, W.G.1
-
24
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
-
Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-237.
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
Fraser, A.G.2
Dong, Y.3
Poulin, G.4
Durbin, R.5
Gotta, M.6
Kanapin, A.7
Le Bot, N.8
Moreno, S.9
Sohrmann, M.10
Welchman, D.P.11
Zipperlen, P.12
Ahringer, J.13
-
25
-
-
78650118680
-
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression
-
Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, MacKeigan JP, Teh BT, Furge KA (2010) Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. BMC Med. Genomics 3, 59.
-
(2010)
BMC Med. Genomics
, vol.3
, pp. 59
-
-
Klomp, J.A.1
Petillo, D.2
Niemi, N.M.3
Dykema, K.J.4
Chen, J.5
Yang, X.J.6
Sääf, A.7
Zickert, P.8
Aly, M.9
Bergerheim, U.10
Nordenskjöld, M.11
Gad, S.12
Giraud, S.13
Denoux, Y.14
Yonneau, L.15
Méjean, A.16
Vasiliu, V.17
Richard, S.18
MacKeigan, J.P.19
Teh, B.T.20
Furge, K.A.21
more..
-
26
-
-
70349576333
-
Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation
-
Landau D, Eshet R, Troib A, Gurman Y, Chen Y, Rabkin R, Segev Y (2009) Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation. Endocrine 36, 126-134.
-
(2009)
Endocrine
, vol.36
, pp. 126-134
-
-
Landau, D.1
Eshet, R.2
Troib, A.3
Gurman, Y.4
Chen, Y.5
Rabkin, R.6
Segev, Y.7
-
27
-
-
78650177082
-
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity
-
Lee S-J, Hwang AB, Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr. Biol. 20, 2131-2136.
-
(2010)
Curr. Biol.
, vol.20
, pp. 2131-2136
-
-
Lee, S.-J.1
Hwang, A.B.2
Kenyon, C.3
-
28
-
-
78049380218
-
The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging
-
Leiser SF, Kaeberlein M (2010) The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol. Chem. 391, 1131-1137.
-
(2010)
Biol. Chem.
, vol.391
, pp. 1131-1137
-
-
Leiser, S.F.1
Kaeberlein, M.2
-
29
-
-
79952582588
-
HIF-1 modulates longevity and healthspan in a temperature-dependent manner
-
Leiser SF, Begun A, Kaeberlein M (2011) HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10, 318-326.
-
(2011)
Aging Cell
, vol.10
, pp. 318-326
-
-
Leiser, S.F.1
Begun, A.2
Kaeberlein, M.3
-
30
-
-
74049133329
-
A new locus-specific database (LSDB) for mutations in the folliculin (FLCN) gene
-
Lim DHK, Rehal PK, Nahorski MS, Macdonald F, Claessens T, Van Geel M, Gijezen L, Gille JJP, Giraud S, Richard S, Van Steensel M, Menko FH, Maher ER (2010) A new locus-specific database (LSDB) for mutations in the folliculin (FLCN) gene. Hum. Mutat. 31, E1043-E1051.
-
(2010)
Hum. Mutat.
, vol.31
-
-
Lim, D.H.K.1
Rehal, P.K.2
Nahorski, M.S.3
Macdonald, F.4
Claessens, T.5
Van Geel, M.6
Gijezen, L.7
Gille, J.J.P.8
Giraud, S.9
Richard, S.10
Van Steensel, M.11
Menko, F.H.12
Maher, E.R.13
-
32
-
-
84864591065
-
EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways
-
Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE (2012) EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways. PLoS Pathog. 8, e1002798.
-
(2012)
PLoS Pathog.
, vol.8
-
-
Luhachack, L.G.1
Visvikis, O.2
Wollenberg, A.C.3
Lacy-Hulbert, A.4
Stuart, L.M.5
Irazoqui, J.E.6
-
33
-
-
66349098677
-
Proteasomal regulation of the hypoxic response modulates aging in C. elegans
-
Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M (2009) Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324, 1196-1198.
-
(2009)
Science
, vol.324
, pp. 1196-1198
-
-
Mehta, R.1
Steinkraus, K.A.2
Sutphin, G.L.3
Ramos, F.J.4
Shamieh, L.S.5
Huh, A.6
Davis, C.7
Chandler-Brown, D.8
Kaeberlein, M.9
-
34
-
-
72049106682
-
The von Hippel Lindau tumor suppressor limits longevity
-
Müller R-U, Fabretti F, Zank S, Burst V, Benzing T, Schermer B (2009) The von Hippel Lindau tumor suppressor limits longevity. J. Am. Soc. Nephrol. 20, 2513-2517.
-
(2009)
J. Am. Soc. Nephrol.
, vol.20
, pp. 2513-2517
-
-
Müller, R.-U.1
Fabretti, F.2
Zank, S.3
Burst, V.4
Benzing, T.5
Schermer, B.6
-
35
-
-
53549131261
-
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans
-
Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M (2008) SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. Genes Dev. 22, 2721-2735.
-
(2008)
Genes Dev.
, vol.22
, pp. 2721-2735
-
-
Neumann-Haefelin, E.1
Qi, W.2
Finkbeiner, E.3
Walz, G.4
Baumeister, R.5
Hertweck, M.6
-
36
-
-
0000939691
-
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome
-
Nickerson ML, Warren MB, Toro JR, Matrosova V, Glenn G, Turner ML, Duray P, Merino M, Choyke P, Pavlovich CP, Sharma N, Walther M, Munroe D, Hill R, Maher E, Greenberg C, Lerman MI, Linehan WM, Zbar B, Schmidt LS (2002) Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. Cancer Cell 2, 157-164.
-
(2002)
Cancer Cell
, vol.2
, pp. 157-164
-
-
Nickerson, M.L.1
Warren, M.B.2
Toro, J.R.3
Matrosova, V.4
Glenn, G.5
Turner, M.L.6
Duray, P.7
Merino, M.8
Choyke, P.9
Pavlovich, C.P.10
Sharma, N.11
Walther, M.12
Munroe, D.13
Hill, R.14
Maher, E.15
Greenberg, C.16
Lerman, M.I.17
Linehan, W.M.18
Zbar, B.19
Schmidt, L.S.20
more..
-
37
-
-
84870859143
-
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer
-
Available at: [accessed on 15 December 2012].
-
Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL (2012) Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol. 2. Available at: http://rsob.royalsocietypublishing.org/content/2/8/120071 [accessed on 15 December 2012].
-
(2012)
Open Biol.
, vol.2
-
-
Nookala, R.K.1
Langemeyer, L.2
Pacitto, A.3
Ochoa-Montaño, B.4
Donaldson, J.C.5
Blaszczyk, B.K.6
Chirgadze, D.Y.7
Barr, F.A.8
Bazan, J.F.9
Blundell, T.L.10
-
38
-
-
77956919284
-
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans
-
Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, Hisamoto N, Matsumoto K, Nishida E (2010) The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J. Biol. Chem. 285, 30274-30281.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 30274-30281
-
-
Okuyama, T.1
Inoue, H.2
Ookuma, S.3
Satoh, T.4
Kano, K.5
Honjoh, S.6
Hisamoto, N.7
Matsumoto, K.8
Nishida, E.9
-
39
-
-
0035099902
-
Creation of low-copy integrated transgenic lines in Caenorhabditis elegans
-
Praitis V, Casey E, Collar D, Austin J (2001) Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157, 1217-1226.
-
(2001)
Genetics
, vol.157
, pp. 1217-1226
-
-
Praitis, V.1
Casey, E.2
Collar, D.3
Austin, J.4
-
40
-
-
79952536485
-
Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility
-
Preston RS, Philp A, Claessens T, Gijezen L, Dydensborg AB, Dunlop EA, Harper KT, Brinkhuizen T, Menko FH, Davies DM, Land SC, Pause A, Baar K, Van Steensel MAM, Tee AR (2011) Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene 30, 1159-1173.
-
(2011)
Oncogene
, vol.30
, pp. 1159-1173
-
-
Preston, R.S.1
Philp, A.2
Claessens, T.3
Gijezen, L.4
Dydensborg, A.B.5
Dunlop, E.A.6
Harper, K.T.7
Brinkhuizen, T.8
Menko, F.H.9
Davies, D.M.10
Land, S.C.11
Pause, A.12
Baar, K.13
Van Steensel, M.A.M.14
Tee, A.R.15
-
41
-
-
70349912096
-
Exploiting synthetic lethal interactions for targeted cancer therapy
-
Reinhardt HC, Jiang H, Hemann MT, Yaffe MB (2009) Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle 8, 3112-3119.
-
(2009)
Cell Cycle
, vol.8
, pp. 3112-3119
-
-
Reinhardt, H.C.1
Jiang, H.2
Hemann, M.T.3
Yaffe, M.B.4
-
42
-
-
7444270371
-
Toward Improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library
-
Rual J-F, Ceron J, Koreth J, Hao T, Nicot A-S, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, Van den Heuvel S, Vidal M (2004) Toward Improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res. 14, 2162-2168.
-
(2004)
Genome Res.
, vol.14
, pp. 2162-2168
-
-
Rual, J.-F.1
Ceron, J.2
Koreth, J.3
Hao, T.4
Nicot, A.-S.5
Hirozane-Kishikawa, T.6
Vandenhaute, J.7
Orkin, S.H.8
Hill, D.E.9
Van den Heuvel, S.10
Vidal, M.11
-
44
-
-
77953184918
-
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
-
Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO (2010) HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 465, 577-583.
-
(2010)
Nature
, vol.465
, pp. 577-583
-
-
Sendoel, A.1
Kohler, I.2
Fellmann, C.3
Lowe, S.W.4
Hengartner, M.O.5
-
45
-
-
77958129103
-
C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1
-
Shao Z, Zhang Y, Ye Q, Saldanha JN, Powell-Coffman JA (2010) C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1. PLoS Pathog. 6, e1001075.
-
(2010)
PLoS Pathog.
, vol.6
-
-
Shao, Z.1
Zhang, Y.2
Ye, Q.3
Saldanha, J.N.4
Powell-Coffman, J.A.5
-
46
-
-
20144362749
-
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans
-
Shen C, Nettleton D, Jiang M, Kim SK, Powell-Coffman JA (2005) Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. J. Biol. Chem. 280, 20580-20588.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20580-20588
-
-
Shen, C.1
Nettleton, D.2
Jiang, M.3
Kim, S.K.4
Powell-Coffman, J.A.5
-
47
-
-
80051699717
-
OASIS: online application for the survival analysis of lifespan assays performed in aging research
-
Yang J-S, Nam H-J, Seo M, Han SK, Choi Y, Nam HG, Lee S-J, Kim S (2011) OASIS: online application for the survival analysis of lifespan assays performed in aging research. PLoS One 6, e23525.
-
(2011)
PLoS One
, vol.6
-
-
Yang, J.-S.1
Nam, H.-J.2
Seo, M.3
Han, S.K.4
Choi, Y.5
Nam, H.G.6
Lee, S.-J.7
Kim, S.8
-
48
-
-
68149149835
-
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
-
Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA (2009) The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One 4, e6348.
-
(2009)
PLoS One
, vol.4
-
-
Zhang, Y.1
Shao, Z.2
Zhai, Z.3
Shen, C.4
Powell-Coffman, J.A.5
|