A Hormonal Signaling Pathway Influencing C. elegans Metabolism, Reproductive Development, and Life Span

Developmental Cell

Volumn 1, Issue 6, 2001, Pages 841-851

  Gerisch, Birgit ^a   Weitzel, Cindy ^a   Kober Eisermann, Corinna ^a   Rottiers, Veerle ^a   Antebi, Adam ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; HYPODERRIS; VERTEBRATA;

CAENORHABDITIS ELEGANS PROTEIN; CELL RECEPTOR; CHOLESTEROL; CYTOCHROME P 450 ENZYME SYSTEM; CYTOCHROME P450; DAF 12 PROTEIN; DAF-12 PROTEIN; HYBRID PROTEIN; INSULIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CAENORHABDITIS ELEGANS; CLASSIFICATION; GENETIC EPISTASIS; GENETICS; HISTOLOGY; LARVA; LONGEVITY; METABOLISM; PHENOTYPE; PHYLOGENY; PHYSIOLOGY; REPORTER GENE; REPRODUCTION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ANIMAL; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; EPISTASIS, GENETIC; GENES, REPORTER; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LARVA; LONGEVITY; MODELS, BIOLOGICAL; PHENOTYPE; PHYLOGENY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; REPRODUCTION; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035656274     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(01)00085-5     Document Type: Article

References (61)

1. Albert P.S., Riddle D.L. Mutants of C. elegans that form dauer-like larvae. Dev. Biol. 126:1988;270-293.
2. Antebi A., Culotti J.G., Hedgecock E.M. daf-12 regulates developmental age and the dauer alternative in C. elegans. Development. 125:1998;1191-1205.
3. Antebi A., Yeh W.H., Tait D., Hedgecock E.M., Riddle D.L. daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev. 14:2000;1512-1527.
4. Apfeld J., Kenyon C. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell. 95:1998;199-210.
5. Bassett M.H., McCarthy J.L., Waterman M.R., Sliter T.J. Sequence and developmental expression of Cyp18, a member of a new cytochrome P450 family from Drosophila. Mol. Cell. Endocrinol. 131:1997;39-49.
6. Birnby D.A., Link E.M., Vowels J.J., Tian H., Colacurcio P.L., Thomas J.H. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in C. elegans. Genetics. 155:2000;85-104.
7. Bruning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., Klein R., Krone W., Muller-Wieland D., Kahn C.R. Role of brain insulin receptor in control of body weight and reproduction. Science. 289:2000;2122-2125.
8. Burks D.J., de Mora J.F., Schubert M., Withers D.J., Myers M.G., Towery H.H., Altamuro S.L., Flint C.L., White M.F. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature. 407:2000;377-382.
9. Genome sequence of the nematode C. elegans. a platform for investigating biology Science. 282:1998;2012-2018.
10. Chitwood D.J. Biochemistry and function of nematode steroids. Crit. Rev. Biochem. Mol. Biol. 34:1999;273-284.
11. Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., Hafen E., Leevers S.J., Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 292:2001;104-106.
12. Coburn C.M., Mori I., Ohshima Y., Bargmann C.I. A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult C. elegans. a distinct pathway for maintenance of sensory axon structure Development. 125:1998;249-258.
13. Estevez M., Attisano L., Wrana J.L., Albert P.S., Massague J., Riddle D.L. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 365:1993;644-649.
14. Finch C.E. Longevity, Senescence and the Genome. 1994;Univ. of Chicago Press, Chicago.
15. Friedman D.B., Johnson T.E. A mutation in the age-1 gene in C. elegans lengthens life and reduces hermaphrodite fertility. Genetics. 118:1988;75-86.
16. Gems D., Partridge L. Insulin/IGF signalling and ageing. seeing the bigger picture Curr. Opin. Genet. Dev. 11:2001;287-292.
17. Gems D., Sutton A.J., Sundermeyer M.L., Albert P.S., King K.V., Edgley M.L., Larsen P.L., Riddle D.L. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in C. elegans. Genetics. 150:1998;129-155.
18. Georgi L.L., Albert P.S., Riddle D.L. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell. 61:1990;635-645.
19. Gotoh O. Divergent structures of C. elegans cytochrome P450 genes suggest the frequent loss and gain of introns during the evolution of nematodes. Mol. Biol. Evol. 15:1998;1447-1459.
20. Graham-Lorence S., Khalil M.W., Lorence M.C., Mendelson C.R., Simpson E.R. Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis. J. Biol. Chem. 266:1991;11939-11946.
21. Greenspan F.S., Baxter J.D. Basic and Clinical Endocrinology. Fourth Edition:1994;Prentice Hall International, London.
22. Hasemann C.A., Kurumbail R.G., Boddupalli S.S., Peterson J.A., Deisenhofer J. Structure and function of cytochromes P450. a comparative analysis of three crystal structures Structure. 3:1995;41-62.
23. Honda Y., Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in C. elegans. FASEB J. 13:1999;1385-1393.
24. Hsin H., Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature. 399:1999;362-366.
25. Inoue T., Thomas J.H. Targets of TGF-beta signaling in C. elegans dauer formation. Dev. Biol. 217:2000;192-204.
26. Jia K., Albert P.S., Riddle D.L. DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development. in press:2001.
27. Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 366:1993;461-464.
28. Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science. 277:1997;942-946.
29. Klass M.R. Aging in the nematode C. elegans. major biological and environmental factors influencing life span Mech. Ageing Dev. 6:1977;413-429.
30. Larsen P.L. Aging and resistance to oxidative damage in C. elegans. Proc. Natl. Acad. Sci. USA. 90:1993;8905-8909.
31. Larsen P.L., Albert P.S., Riddle D.L. Genes that regulate both development and longevity in C. elegans. Genetics. 139:1995;1567-1583.
32. Leighton J.K., DeBrunner-Vossbrinck B.A., Kemper B. Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form. Biochemistry. 23:1984;204-210.
33. Lin K., Dorman J.B., Rodan A., Kenyon C. daf-16. An HNF-3/FORKHEAD family member that can function to double the life-span of C. elegans Science. 278:1997;1319-1322.
34. Lowry R. VassarStats. Web Site for Statistical Computation:2001;Mann-Whitney test, http://faculty.vassar.edu/lowry/vsleft.html.
35. Morris J.Z., Tissenbaum H.A., Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in C. elegans. Nature. 382:1996;536-539.
36. Nelson D.R. Metazoan cytochrome P450 evolution. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 121:1998;15-22.
37. Ogg S., Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell. 2:1998;887-893.
38. Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 389:1997;994-999.
39. Paradis S., Ruvkun G. C. elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12:1998;2488-2498.
40. Paradis S., Ailion M., Toker A., Thomas J.H., Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in C. elegans. Genes Dev. 13:1999;1438-1452.
41. Patterson G.I., Koweek A., Wong A., Liu Y., Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the C. elegans dauer pathway. Genes Dev. 11:1997;2679-2690.
42. Pendurthi U.R., Lamb J.G., Nguyen N., Johnson E.F., Tukey R.H. Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P. 450IIC5.(J. Biol. Chem. 265):1990;14662-14668.
43. Pierce S.B., Costa M., Wisotzkey R., Devadhar S., Homburger S.A., Buchman A.R., Ferguson K.C., Heller J., Platt D.M., Pasquinelli A.A.et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 15:2001;672-686.
44. Puca A.A., Daly M.J., Brewster S.J., Matise T.C., Barrett J., Shea-Drinkwater M., Kang S., Joyce E., Nicoli J., Benson E.et al. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc. Natl. Acad. Sci. USA. 98:2001;10505-10508.
45. Ren P., Lim C.S., Johnsen R., Albert P.S., Pilgrim D., Riddle D.L. Control of C. elegans larval development by neuronal expression of a TGF-beta homolog. Science. 274:1996;1389-1391.
46. Riddle D.L., Albert P.S. Genetic and environmental regulation of dauer larva development. Riddle D.L., Meyer B., Priess J., Blumenthal T. C. elegans II. 1997;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
47. Riddle D.L., Swanson M.M., Albert P.S. Interacting genes in nematode dauer larva formation. Nature. 290:1981;668-671.
48. Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry. 30:1991;3247-3255.
49. Schackwitz W.S., Inoue T., Thomas J.H. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron. 17:1996;719-728.
50. Schwartz M.W., Woods S.C., Porte D. Jr., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature. 404:2000;661-671.
51. Sze J.Y., Victor M., Loer C., Shi Y., Ruvkun G. Food and metabolic signalling defects in a C. elegans serotonin-synthesis mutant. Nature. 403:2000;560-564.
52. Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science. 292:2001;107-110.
53. Taub J., Lau J.F., Ma C., Hahn J.H., Hoque R., Rothblatt J., Chalfie M. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-c and clk-1 mutants. Nature. 399:1999;162-166.
54. Thomas J.H., Birnby D.A., Vowels J.J. Evidence for parallel processing of sensory information controlling dauer formation in C. elegans. Genetics. 134:1993;1105-1117.
55. Tissenbaum H.A., Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in C. elegans. Genetics. 148:1998;703-717.
56. White J.G., Southgate E., Thomson J.N., Brenner S. The structure of the nervous system of the nematode C. elegans. Phil. Trans. R. Soc. Lond. 314:1986;1-340.
57. Williams P.A., Cosme J., Sridhar V., Johnson E.F., McRee D.E. Mammalian microsomal cytochrome P450 monooxygenase. structural adaptations for membrane binding and functional diversity Mol. Cell. 5:2000;121-131.
58. Wolkow C.A., Kimura K.D., Lee M.S., Ruvkun G. Regulation of C. elegans life-span by insulin-like signaling in the nervous system. Science. 290:2000;147-150.
59. Yochem J., Gu T., Han M. A new marker for mosaic analysis in C. elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis. Genetics. 149:1998;1323-1334.
60. Yochem J., Tuck S., Greenwald I., Han M. A gp330/megalin-related protein is required in the major epidermis of C. elegans for completion of molting. Development. 126:1999;597-606.
61. Yoshikawa K., Noguti T., Tsujimura M., Koga H., Yasukochi T., Horiuchi T., Go M. Hydrogen bond network of cytochrome P-450cam. a network connecting the heme group with helix K Biochim Biophys. Acta. 1122:1992;41-44.