Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

Genes and Development

Volumn 15, Issue 6, 2001, Pages 672-686

  Pierce, Sarah B ^a,b   Costa, Michael ^c   Wisotzkey, Robert ^d,e   Devadhar, Sharmila ^c   Homburger, Sheila A ^c   Buchman, Andrew R ^c   Ferguson, Kimberly C ^c   Heller, Jonathan ^c   Platt, Darren M ^c   Pasquinelli, Amy A ^a,b   Liu, Leo X ^d,f   Doberstein, Stephen K ^c   Ruvkun, Gary ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EXELIXIS INC   (United States)

^d Axys Pharmaceuticals Inc   (United States)

^e Deltagen Inc   (United States)

^f Cambria Pharmaceuticals Inc   (United States)

Author keywords

C peptide; Caenorhabditis elegans; DAF 2; Dauer; Insulin signaling; Life span

Indexed keywords

C PEPTIDE; DAF 2 RECEPTOR; HUMAN INSULIN; INSULIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; GENE DELETION; GENITAL SYSTEM; LIFESPAN; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CLONING, MOLECULAR; ENHANCER ELEMENTS (GENETICS); GENE DELETION; HELMINTH PROTEINS; HUMANS; INSULIN; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TEMPERATURE; TIME FACTORS;

CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA; NEMATODA;

EID: 0035868890     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.867301     Document Type: Article

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