Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones

Molecular Biology of the Cell

Volumn 15, Issue 2, 2004, Pages 657-664

  Morley, James F ^a   Morimoto, Richard I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK FACTOR 1; HEAT SHOCK PROTEIN; UNCLASSIFIED DRUG;

ADAPTATION; AGING; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE SWITCHING; HOMEOSTASIS; INSULIN LIKE ACTIVITY; LARVA; LIFESPAN; LONGEVITY; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STRESS; TEMPERATURE DEPENDENCE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; HEAT-SHOCK PROTEINS; LONGEVITY; MOLECULAR CHAPERONES; MUTATION; NERVOUS SYSTEM; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 0742323000     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-07-0532     Document Type: Article

References (53)

1. Ailion, M., and Thomas, J.H. (2000). Dauer formation induced by high temperatures in Caenorhabditis elegans. Genetics 156, 1047-1067.
2. Altun-Gultekin, Z., Andachi, Y., Tsalik, E. L., Pilgrim, D., Kohara, Y., and Hobert, O. (2001). A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. Development 128, 1951-1969.
3. Apfeld, J., and Kenyon, C. (1998). Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95, 199-210.
4. Beere, H.M., Wolf, B.B., Cain, K., Mosser, D.D., Mahboubi, A., Kuwana, T., Tailor, P., Morimoto, R.I., Cohen, G.M., and Green, D.R. (2000). Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat. Cell Biol. 2, 469-475.
5. Birnby, D.A., Link, E.M., Vowels, J.J., Tian, H., Colacurcio, P.L., and Thomas, J.H. (2000). A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans. Genetics 155, 85-104.
6. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
7. Clancy, D.J., Gems, D., Harshman, L.G., Oldham, S., Stocker, H., Hafen, E., Leevers, S.J., and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106.
8. Cypser, J.R., and Johnson, T.E. (2002). Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 57, B109-B114.
9. Dillin, A., Crawford, D.K., and Kenyon, C. (2002). Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298, 830-834.
10. Dorman, J.B., Albinder, B., Shroyer, T., and Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-1406.
11. Fargnoli, J., Kunisada, T., Fornace, A.J., Jr., Schneider, E.L., and Holbrook, N.J. (1990). Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc. Natl. Acad. Sci. USA 87, 846-850.
12. Fawcett, T.W., Sylvester, S.L., Sarge, K.D., Morimoto, R.I., and Holbrook, N.J. (1994). Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J. Biol. Chem. 269, 32272-32278.
13. Finkel, T., and Holbrook, N.J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247.
14. Garigan, D., Hsu, A.L., Fraser, A.G., Kamath, R.S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112.
15. Gottlieb, S., and Ruvkun, G. (1994). daf-2, daf-16 and daf-23, genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics 137, 107-120.
16. Guarente, L., and Kenyon, C. (2000). Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262
17. Herndon, LA., Schmeissner, P.J., Dudaronek, J.M., Brown, P.A., Listner, K.M., Sakano, Y., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814.
18. Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Gâeloèen, A., Even, P.C., Cervera, P., and Le Bouc, Y. (2003). IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187.
19. Hsu, A.L., Murphy, C.T., and Kenyon, C. (2003). Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145.
20. Jedlicka, P., Mortin, M.A., and Wu, C. (1997). Multiple functions of Drosophila heat shock transcription factor in vivo. EMBO J. 16, 2452-2462.
21. Kelly, W.G., Xu, S., Montgomery, M.K., and Fire, A. (1997). Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene. Genetics 146, 227-238.
22. Kimura, K.D., Tissenbaum, H.A., Liu, Y., and Ruvkun, G. (1997). daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
23. Larsen, P.L. (1993). Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 90, 8905-8909.
24. Lin, K., Dorman, J.B., Rodan, A., and Kenyon, C. (1997). daf-16, An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322.
25. Lin, K., Hsin, H., Libina, N., and Kenyon, C. (2001). Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet 28, 139-145.
26. Lithgow, G.J., White, T.M., Melov, S., and Johnson, T.E. (1995). Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl. Acad. Sci. USA 92, 7540-7544.
27. Lund, J., Tedesco, P., Duke, K., Wang, J., Kim, S.K., and Johnson, T.E. (2002). Transcriptional profile of aging in C. elegans. Curr. Biol. 12, 1566-1573.
28. Malone, E.A., Inoue, T., and Thomas, J.H. (1996). Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143, 1193-1205.
29. McElwee, J., Bubb, K., and Thomas, J.H. (2003). Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2, 111-121.
30. Mello, C.C., Kramer, J.M., Stinchcomb, D., and Ambros, V. (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
31. Morimoto, R.I. (1998). Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 12, 3788-3796.
32. Morimoto, R.I. (2002). Dynamic remodeling of transcription complexes by molecular chaperones. Cell 110, 281-284.
33. Morley, J.F., Brignull, H.R., Weyers, J.J., and Morimoto, R.I. (2002). The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 99,10417-10422.
34. Morris, J.Z., Tissenbaum, H.A., and Ruvkun, G. (1996). A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536-539.
35. Muänoz, M.J., and Riddle, D.L. (2003). Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics 163, 171-180.
36. Murakami, S., and Johnson, T.E. (1996). A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143, 1207-1218.
37. Murakami, S., and Johnson, T.E. (2001). The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Curr. Biol. 11, 1517-1523.
38. Murphy, C.T., McCarroll, S.A., Bargmann, C.I., Fraser, A., Kamath, R.S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283.
39. Nollen, E.A., and Morimoto, R.I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J. Cell Sci. 115, 2809-2816.
40. Ogg, S., Paradis, S., Gottlieb, S., Patterson, G.I., Lee, L., Tissenbaum, H.A., and Ruvkun, G. (1997). The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C elegans. Nature 389, 994-999.
41. Ookuma, S., Fukuda, M., and Nishida, E. (2003). Identification of a DAF-16 transcriptional target Gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr. Biol. 13, 427-431.
42. Snutch, T.P., Heschl, M.F., and Baillie, D.L. (1988). The Caenorhabditis elegans hsp70 gene family: a molecular genetic characterization. Gene 64, 241-255.
43. Song, J., Takeda, M., and Morimoto, R.I. (2001). Bagl-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat. Cell Biol. 3, 276-282.
44. Tatar, M., Khazaeli, A.A., and Curtsinger, J.W. (1997). Chaperoning extended life. Nature 390, 30.
45. Timmons, L., Court, D.L., and Fire, A. (2001). Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263, 103-112.
46. Tower, J. (2000). Transgenic methods for increasing Drosophila life span. Mech. Ageing Dev. 118, 1-14.
47. Walker, G.A., and Lithgow, G.J. (2003). Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2, 131.
48. Walker, G.A., Thompson, F.J., Brawley, A., Scanlon, T., and Devaney, E. (2003). Heat shock factor functions at the convergence of the stress response and developmental pathways in Caenorhabditis elegans. FASEB J 17, 1960-1962.
49. Wang, J., Tokarz, R., and Savage-Dunn, C. (2002). The expression of TGFbeta signal transducers in the hypodermis regulates body size in C. elegans. Development 129, 4989-4998.
50. Werner-Washburne, M., Stone, D.E., and Craig, E.A. (1987). Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 7, 2568-2577.
51. Wolkow, C.A., Kimura, K.D., Lee, M.S., and Ruvkun, G. (2000). Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290, 147-150.
52. Wu, C. (1995). Heat shock transcription factors: structure and regulation. Annu. Rev. Cell Dev. Biol. 11, 441-469.
53. Yokoyama, K., Fukumoto, K., Murakami, T., Harada, S., Hosono, R., Wadhwa, R., Mitsui, Y., and Ohkuma, S. (2002). Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2(mortalin)/mthsp70/Grp75. FEBS Lett. 516, 53-57.