Autophagy genes are required for normal lipid levels in C. elegans

Autophagy

Volumn 9, Issue 3, 2013, Pages 278-286

  Lapierre, Louis R ^a   Silvestrini, Melissa J ^b,d   Nuñez, Lizbeth ^b   Ames, Kristina ^b,d   Wong, Sara ^b   Le, Thuc T ^c   Hansen, Malene ^a   Meléndez, Alicia ^b,d  

^a BURNHAM INSTITUTE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c NEVADA CANCER INSTITUTE   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Autophagy; C. Elegans; Cars Microscopy; Fat Storage; Intestine; Lipid Metabolism; Oil Red O Staining

Indexed keywords

BECLIN 1; FAT DROPLET; INSULIN RECEPTOR; LIPID;

ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CONTROLLED STUDY; FAT CONTENT; GENE INACTIVATION; INTESTINE; LIPID BLOOD LEVEL; LIPID STORAGE; MUTANT; NONHUMAN; PROTEIN DEPLETION; RAMAN SPECTROMETRY; SIGNAL TRANSDUCTION; WILD TYPE;

EID: 84877086717     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.22930     Document Type: Article

References (36)

1. Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab 2008; 7:533-44; PMID:18522834; http://dx.doi.org/10.1016/ j.cmet.2008.04.012
2. Czaja MJ. Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: Pathophysiological implications. Am J Physiol Cell Physiol 2010; 298:C973-8; PMID:20089934; http://dx.doi.org/10.1152/ ajpcell.00527.2009
3. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, et al. Autophagy regulates lipid metabolism. Nature 2009; 458:1131-5; PMID:19339967; http://dx.doi.org/10.1038/nature07976
4. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, et al. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009; 119:3329-39; PMID:19855132
5. Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagyrelated gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A 2009; 106:19860-5; PMID:19910529
6. Lapierre LR, Gelino S, Meléndez A, Hansen M. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol 2011; 21:1507-14; PMID:21906946; http://dx.doi.org/10.1016/j.cub.2011.07. 042
7. Dall'Armi C, Hurtado-Lorenzo A, Tian H, Morel E, Nezu A, Chan RB, et al. The phospholipase D1 pathway modulates macroautophagy. Nat Commun 2010; 1:142; PMID:21266992; http://dx.doi.org/10.1038/ncomms1144
8. Czaja MJ, Cuervo AM. Lipases in lysosomes, what for? Autophagy 2009; 5:866-7; PMID:19502773
9. Watts JL, Browse J. Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2002; 99:5854-9; PMID:11972048; http://dx.doi.org/10.1073/pnas.092064799
10. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 2003; 421:268-72; PMID:12529643; http://dx.doi.org/10.1038/nature01279
11. McKay RM, McKay JP, Avery L, Graff JM. C elegans: A model for exploring the genetics of fat storage. Dev Cell 2003; 4:131-42; PMID:12530969; http://dx.doi.org/10.1016/S1534-5807(02)00411-2
12. Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, et al. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY) 2011; 3:125-47; PMID:21386131
13. Narbonne P, Roy R. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature 2009; 457:210-4; PMID:19052547; http://dx.doi.org/10.1038/nature07536
14. Hu PJ. Dauer. WormBook 2007; 1-19; PMID:17988074
15. Meléndez A, Tallóczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301:1387-91; PMID:12958363; http://dx.doi.org/10.1126/science.1087782
16. Tóth ML, Sigmond T, Borsos E, Barna J, Erdélyi P, Takács-Vellai K, et al. Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy 2008; 4:330-8; PMID:18219227
17. Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 2008; 4:e24; PMID:18282106; http://dx.doi.org/10.1371/journal.pgen. 0040024
18. Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, et al. Autophagy regulates ageing in C. elegans. Autophagy 2007; 3:93-5; PMID:17204841
19. Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science 2008; 322:957-60; PMID:18988854; http://dx.doi.org/10.1126/science.1162011
20. O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab 2009; 10:430-5; PMID:19883620; http://dx.doi.org/10.1016/j. cmet.2009.10.002
21. Takacs-Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, et al. Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol 2005; 15:1513-7; PMID:16111945; http://dx.doi.org/10.1016/j. cub.2005.07.035
22. Ruck A, Attonito J, Garces KT, Núnez L, Palmisano NJ, Rubel Z, et al. The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy 2011; 7:386-400; PMID:21183797; http://dx.doi.org/10.4161/auto.7.4.14391
23. Elle IC, Olsen LC, Pultz D, Rødkaer SV, Faergeman NJ. Something worth dyeing for: Molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans. FEBS Lett 2010; 584:2183-93; PMID:20371247; http://dx.doi.org/10.1016/j.febslet.2010.03.046
24. Brooks KK, Liang B, Watts JL. The influence of bacterial diet on fat storage in C. elegans. PLoS One 2009; 4:e7545; PMID:19844570; http://dx.doi.org/10.1371/journal.pone.0007545
25. Yen K, Le TT, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One 2010; 5:5; PMID:20862331; http://dx.doi.org/10.1371/journal. pone.0012810
26. Perez CL, Van Gilst MR. A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab 2008; 8:266-74; PMID:18762027; http://dx.doi.org/10.1016/j. cmet.2008.08.007
27. Meléndez A, Levine B. Autophagy in C. elegans. WormBook 2009; 1-26; PMID:19705512; http://dx.doi.org/10.1895/wormbook.1.147.1
28. Meléndez A, Hall DH, Hansen M. Monitoring the role of autophagy in C. elegans aging. Methods Enzymol 2008; 451:493-520; PMID:19185737; http://dx.doi.org/10.1016/S0076-6879(08)03229-1
29. Zhang D, Isack NR, Glodowski DR, Liu J, Chen CC, Xu XZ, et al. RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway. J Cell Biol 2012; 196:85-101; PMID:22213799; http://dx.doi.org/10.1083/ jcb.201104141
30. Shi A, Sun L, Banerjee R, Tobin M, Zhang Y, Grant BD. Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8. EMBO J 2009; 28:3290-302; PMID:19763082; http://dx.doi.org/10.1038/emboj.2009.272
31. Zhang Y, Grant B, Hirsh D. RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans. Mol Biol Cell 2001; 12:2011-21; PMID:11451999
32. Zhang SO, Box AC, Xu N, Le Men J, Yu J, Guo F, et al. Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2010; 107:4640-5; PMID:20176933; http://dx.doi.org/10.1073/pnas. 0912308107
33. Mukhopadhyay A, Pan X, Lambright DG, Tissenbaum HA. An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep 2007; 8:931-8; PMID:17762880; http://dx.doi.org/10.1038/sj.embor.7401055
34. Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat Genet 2006; 38:363-8; PMID:16462744; http://dx.doi.org/10.1038/ng1739
35. Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 2003; 421:231-7; PMID:12529635; http://dx.doi.org/10.1038/nature01278
36. Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, et al. Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 2004; 14(10B):2162-8; PMID:15489339; http://dx.doi.org/10.1101/gr.2505604