The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity

Aging Cell

Volumn 10, Issue 4, 2011, Pages 724-728

  Yang, Christine C ^a   Chen, Diana ^a   Lee, Siu Sylvia ^a   Walter, Ludivine ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITÉ DE LYON   (France)

Author keywords

Aging; Caenorhabditis elegans; Fission protein DRP 1; Insulin signaling; Mitochondria

Indexed keywords

DYNAMIN I; INSULIN;

ARTICLE; CAENORHABDITIS ELEGANS; CELL AGING; CELL STRUCTURE; CELL SURVIVAL; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DYNAMINS; INSULIN; LONGEVITY; PHENOTYPE; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 79960339919     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00711.x     Document Type: Article

References (29)

1. Artal-Sanz M, Tavernarakis N (2009) Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature 461, 793-797.
2. Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D (2008) Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol. Cell 31, 586-597.
3. Dorman JB, Albinder B, Shroyer T, Kenyon C (1995) The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-1406.
4. Felkai S, Ewbank JJ, Lemieux J, Labbe JC, Brown GG, Hekimi S (1999) CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18, 1783-1792.
5. Feng J, Bussiere F, Hekimi S (2001) Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell. 1, 633-644.
6. Friedman DB, Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86.
7. Hekimi S, Burgess J, Bussiere F, Meng Y, Benard C (2001) Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity. Trends Genet. 17, 712-718.
8. Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-366.
9. Johnson TE, de Castro E, Hegi de Castro S, Cypser J, Henderson S, Tedesco P (2001) Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans. Exp. Gerontol. 36, 1609-1617.
10. Kaeberlein TL, Smith ED, Tsuchiya M, Welton KL, Thomas JH, Fields S, Kennedy BK, Kaeberlein M (2006) Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell. 5, 487-494.
11. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
12. Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM (1999) C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell 4, 815-826.
13. Lee RY, Hench J, Ruvkun G (2001) Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11, 1950-1957.
14. Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, Youle RJ, Cho H (2007) Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J. Biol. Chem. 282, 22977-22983.
15. Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS (2008) Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol. 6, e233.
16. Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536-539.
17. Okamoto K, Shaw JM (2005) Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu. Rev. Genet. 39, 503-536.
18. Padmanabhan S, Mukhopadhyay A, Narasimhan SD, Tesz G, Czech MP, Tissenbaum HA (2009) A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell 136, 939-951.
19. Palermo V, Falcone C, Calvani M, Mazzoni C (2010) Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. Aging Cell. 9, 570-579.
20. Pinkston JM, Garigan D, Hansen M, Kenyon C (2006) Mutations that increase the life span of C. elegans inhibit tumor growth. Science 313, 971-975.
21. Rockenfeller P, Madeo F (2008) Apoptotic death of ageing yeast. Exp. Gerontol. 43, 876-881.
22. Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz HD (2007) Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat. Cell Biol. 9, 99-105.
23. Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C (2010) New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J. Cell Sci. 123, 2533-2542.
24. Sohal RD (1975) Mitochondrial changes in flight muscles of normal and flightless Drosophila melanogaster with age. J. Morphol. 145, 337-353.
25. Spanier B, Rubio-Aliaga I, Hu H, Daniel H (2010) Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity. Aging Cell. 9, 636-646.
26. Westermann B (2010) Mitochondrial dynamics in model organisms: what yeasts, worms and flies have taught us about fusion and fission of mitochondria. Semin. Cell Dev. Biol. 21, 542-549.
27. Yasuda K, Ishii T, Suda H, Akatsuka A, Hartman PS, Goto S, Miyazawa M, Ishii N (2006) Age-related changes of mitochondrial structure and function in Caenorhabditis elegans. Mech. Ageing Dev. 127, 763-770.
28. Yoon Y, Galloway CA, Jhun BS, Yu T (2011) Mitochondrial dynamics in diabetes. Antioxid. Redox Signal. 14, 439-457.
29. Zorzano A, Liesa M, Palacin M (2009) Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance. Arch. Physiol. Biochem. 115, 1-12.