메뉴 건너뛰기




Volumn 9, Issue 3, 2010, Pages 433-447

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

Author keywords

Aging; C. elegans; Electron transport; Isp 1; Mitochondria; Nuo 6

Indexed keywords

HEAT SHOCK PROTEIN; PARAQUAT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; CAENORHABDITIS ELEGANS PROTEIN; ISP 1 PROTEIN, CAENORHABDITIS ELEGANS; ISP-1 PROTEIN, CAENORHABDITIS ELEGANS; UBIQUINOL CYTOCHROME C REDUCTASE;

EID: 77956241785     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00571.x     Document Type: Article
Times cited : (202)

References (61)
  • 1
    • 34848911606 scopus 로고    scopus 로고
    • Genetics of aging in Caenorhabditis elegans
    • Antebi A (2007) Genetics of aging in Caenorhabditis elegans. PLoS Genet. 3, 1565-1571.
    • (2007) PLoS Genet , vol.3 , pp. 1565-1571
    • Antebi, A.1
  • 2
    • 34547956260 scopus 로고    scopus 로고
    • Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans
    • Brys K, Vanfleteren JR, Braeckman BP (2007) Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans. Exp. Gerontol. 42, 845-851.
    • (2007) Exp. Gerontol. , vol.42 , pp. 845-851
    • Brys, K.1    Vanfleteren, J.R.2    Braeckman, B.P.3
  • 3
    • 67651004289 scopus 로고    scopus 로고
    • A conserved ubiquitination pathway determines longevity in response to diet restriction
    • Carrano AC, Liu Z, Dillin A, Hunter T (2009) A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460, 396-399.
    • (2009) Nature , vol.460 , pp. 396-399
    • Carrano, A.C.1    Liu, Z.2    Dillin, A.3    Hunter, T.4
  • 4
    • 67149107430 scopus 로고    scopus 로고
    • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    • Chen D, Thomas EL, Kapahi P (2009) HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet. 5, e1000486.
    • (2009) PLoS Genet , vol.5
    • Chen, D.1    Thomas, E.L.2    Kapahi, P.3
  • 5
    • 34548645020 scopus 로고    scopus 로고
    • Caenorhabditis elegans integrates food and reproductive signals in lifespan determination
    • Crawford D, Libina N, Kenyon C (2007) Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell 6, 715-721.
    • (2007) Aging Cell , vol.6 , pp. 715-721
    • Crawford, D.1    Libina, N.2    Kenyon, C.3
  • 6
    • 66149087761 scopus 로고    scopus 로고
    • A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    • Cristina D, Cary M, Lunceford A, Clarke C, Kenyon C (2009) A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet. 5, e1000450.
    • (2009) PLoS Genet , vol.5
    • Cristina, D.1    Cary, M.2    Lunceford, A.3    Clarke, C.4    Kenyon, C.5
  • 7
    • 34247569105 scopus 로고    scopus 로고
    • Lifespan regulation by evolutionarily conserved genes essential for viability
    • Curran SP, Ruvkun G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 3, e56.
    • (2007) PLoS Genet , vol.3
    • Curran, S.P.1    Ruvkun, G.2
  • 9
    • 57749095081 scopus 로고    scopus 로고
    • Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    • Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, Matscheski A, Vanfleteren JR, Gems D (2008) Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev. 22, 3236-3241.
    • (2008) Genes Dev , vol.22 , pp. 3236-3241
    • Doonan, R.1    McElwee, J.J.2    Matthijssens, F.3    Walker, G.A.4    Houthoofd, K.5    Back, P.6    Matscheski, A.7    Vanfleteren, J.R.8    Gems, D.9
  • 10
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
    • Dorman JB, Albinder B, Shroyer T, Kenyon C (1995) The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-1406.
    • (1995) Genetics , vol.141 , pp. 1399-1406
    • Dorman, J.B.1    Albinder, B.2    Shroyer, T.3    Kenyon, C.4
  • 13
    • 33747174906 scopus 로고    scopus 로고
    • Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans
    • Falk MJ, Kayser EB, Morgan PG, Sedensky MM (2006) Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans. Curr. Biol. 16, 1641-1645.
    • (2006) Curr. Biol. , vol.16 , pp. 1641-1645
    • Falk, M.J.1    Kayser, E.B.2    Morgan, P.G.3    Sedensky, M.M.4
  • 14
    • 0033118981 scopus 로고    scopus 로고
    • CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
    • Felkai S, Ewbank JJ, Lemieux J, Labbe JC, Brown GG, Hekimi S (1999) CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18, 1783-1792.
    • (1999) EMBO J , vol.18 , pp. 1783-1792
    • Felkai, S.1    Ewbank, J.J.2    Lemieux, J.3    Labbe, J.C.4    Brown, G.G.5    Hekimi, S.6
  • 15
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng J, Bussiere F, Hekimi S (2001) Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell. 1, 633-644.
    • (2001) Dev. Cell. , vol.1 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 17
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8, 113-127.
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 19
    • 33645472504 scopus 로고    scopus 로고
    • New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
    • Hansen M, Hsu AL, Dillin A, Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1, 119-128.
    • (2005) PLoS Genet , vol.1 , pp. 119-128
    • Hansen, M.1    Hsu, A.L.2    Dillin, A.3    Kenyon, C.4
  • 20
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4, e24.
    • (2008) PLoS Genet , vol.4
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 22
    • 0028786075 scopus 로고
    • Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans
    • Hekimi S, Boutis P, Lakowski B (1995) Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Genetics 141, 1351-1364.
    • (1995) Genetics , vol.141 , pp. 1351-1364
    • Hekimi, S.1    Boutis, P.2    Lakowski, B.3
  • 25
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu AL, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (New York, NY) 300, 1142-1145.
    • (2003) Science (New York, NY) , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 26
    • 41349103857 scopus 로고    scopus 로고
    • An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans
    • Ichishita R, Tanaka K, Sugiura Y, Sayano T, Mihara K, Oka T (2008) An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans. J. Biochem. 143, 449-454.
    • (2008) J. Biochem. , vol.143 , pp. 449-454
    • Ichishita, R.1    Tanaka, K.2    Sugiura, Y.3    Sayano, T.4    Mihara, K.5    Oka, T.6
  • 28
    • 35848937781 scopus 로고    scopus 로고
    • Autophagy is required for dietary restrictionmediated life span extension in C. elegans
    • Jia K, Levine B (2007) Autophagy is required for dietary restrictionmediated life span extension in C. elegans. Autophagy 3, 597-599.
    • (2007) Autophagy , vol.3 , pp. 597-599
    • Jia, K.1    Levine, B.2
  • 29
    • 0035229245 scopus 로고    scopus 로고
    • Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    • RESEARCH0002
    • Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol. 2, RESEARCH0002.
    • (2001) Genome Biol , vol.2
    • Kamath, R.S.1    Martinez-Campos, M.2    Zipperlen, P.3    Fraser, A.G.4    Ahringer, J.5
  • 30
    • 0035827706 scopus 로고    scopus 로고
    • Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans
    • Kayser EB, Morgan PG, Hoppel CL, Sedensky MM (2001) Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans. J. Biol. Chem. 276, 20551-20558.
    • (2001) J. Biol. Chem. , vol.276 , pp. 20551-20558
    • Kayser, E.B.1    Morgan, P.G.2    Hoppel, C.L.3    Sedensky, M.M.4
  • 31
    • 34247171756 scopus 로고    scopus 로고
    • Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans
    • Kimura K, Tanaka N, Nakamura N, Takano S, Ohkuma S (2007) Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans. J. Biol. Chem. 282, 5910-5918.
    • (2007) J. Biol. Chem. , vol.282 , pp. 5910-5918
    • Kimura, K.1    Tanaka, N.2    Nakamura, N.3    Takano, S.4    Ohkuma, S.5
  • 32
    • 0032947552 scopus 로고    scopus 로고
    • Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
    • Kirchman PA, Kim S, Lai CY, Jazwinski SM (1999) Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152, 179-190.
    • (1999) Genetics , vol.152 , pp. 179-190
    • Kirchman, P.A.1    Kim, S.2    Lai, C.Y.3    Jazwinski, S.M.4
  • 33
    • 0029776793 scopus 로고    scopus 로고
    • Determination of life-span in Caenorhabditis elegans by four clock genes
    • Lakowski B, Hekimi S (1996) Determination of life-span in Caenorhabditis elegans by four clock genes. Science (New York, NY) 272, 1010-1013.
    • (1996) Science (New York, NY) , vol.272 , pp. 1010-1013
    • Lakowski, B.1    Hekimi, S.2
  • 34
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in Caenorhabditis elegans
    • Lakowski B, Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U S A 95, 13091-13096.
    • (1998) Proc. Natl. Acad. Sci. U S A , vol.95 , pp. 13091-13096
    • Lakowski, B.1    Hekimi, S.2
  • 35
    • 54449091329 scopus 로고    scopus 로고
    • Early mitochondrial dysfunction in longlived Mclk1+/- mice
    • Lapointe J, Hekimi S (2008) Early mitochondrial dysfunction in longlived Mclk1+/- mice. J. Biol. Chem. 283, 26217-26227.
    • (2008) J. Biol. Chem. , vol.283 , pp. 26217-26227
    • Lapointe, J.1    Hekimi, S.2
  • 36
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G (2003) A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33, 40-48.
    • (2003) Nat. Genet. , vol.33 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 37
    • 0032873464 scopus 로고    scopus 로고
    • A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function
    • Liu Z, Butow RA (1999) A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function. Mol. Cell. Biol. 19, 6720-6728.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6720-6728
    • Liu, Z.1    Butow, R.A.2
  • 41
    • 0141510019 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry
    • Murray J, Taylor SW, Zhang B, Ghosh SS, Capaldi RA (2003) Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry. J. Biol. Chem. 278, 37223-37230.
    • (2003) J. Biol. Chem. , vol.278 , pp. 37223-37230
    • Murray, J.1    Taylor, S.W.2    Zhang, B.3    Ghosh, S.S.4    Capaldi, R.A.5
  • 43
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A (2007) PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447, 550-555.
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 45
    • 33747588775 scopus 로고    scopus 로고
    • Mutations that increase the life span of C. elegans inhibit tumor growth
    • Pinkston JM, Garigan D, Hansen M, Kenyon C (2006) Mutations that increase the life span of C. elegans inhibit tumor growth. Science (New York, NY) 313, 971-975.
    • (2006) Science (New York, NY) , vol.313 , pp. 971-975
    • Pinkston, J.M.1    Garigan, D.2    Hansen, M.3    Kenyon, C.4
  • 46
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • Rea SL, Ventura N, Johnson TE (2007) Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. 5, e259.
    • (2007) PLoS Biol , vol.5
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 48
    • 0035834789 scopus 로고    scopus 로고
    • A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans
    • Senoo-Matsuda N, Yasuda K, Tsuda M, Ohkubo T, Yoshimura S, Nakazawa H, Hartman PS, Ishii N (2001) A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J. Biol. Chem. 276, 41553-41558.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41553-41558
    • Senoo-Matsuda, N.1    Yasuda, K.2    Tsuda, M.3    Ohkubo, T.4    Yoshimura, S.5    Nakazawa, H.6    Hartman, P.S.7    Ishii, N.8
  • 50
    • 16244381751 scopus 로고    scopus 로고
    • Direct measurement of oxygen consumption rate on the nematode Caenorhabditis elegans by using an optical technique
    • Suda H, Shouyama T, Yasuda K, Ishii N (2005) Direct measurement of oxygen consumption rate on the nematode Caenorhabditis elegans by using an optical technique. Biochem. Biophys. Res. Commun. 330, 839-843.
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 839-843
    • Suda, H.1    Shouyama, T.2    Yasuda, K.3    Ishii, N.4
  • 51
    • 0000182225 scopus 로고
    • Methods
    • Wood WB, ed. Plainview, New York.: Cold Spring Harbor Laboratory Press
    • Sulston JE, Hodgkin J (1988) Methods. In The Nematode Caenorhabidits Elegans. (Wood WB, ed). Plainview, New York.: Cold Spring Harbor Laboratory Press, pp. 587-606.
    • (1988) The Nematode Caenorhabidits Elegans , pp. 587-606
    • Sulston, J.E.1    Hodgkin, J.2
  • 53
    • 0035943727 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span
    • Tsang WY, Sayles LC, Grad LI, Pilgrim DB, Lemire BD (2001) Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. J. Biol. Chem. 276, 32240-32246.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32240-32246
    • Tsang, W.Y.1    Sayles, L.C.2    Grad, L.I.3    Pilgrim, D.B.4    Lemire, B.D.5
  • 54
    • 61449184625 scopus 로고    scopus 로고
    • Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    • Van Raamsdonk JM, Hekimi S (2009) Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5, e1000361.
    • (2009) PLoS Genet , vol.5
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 55
    • 77955503270 scopus 로고    scopus 로고
    • Decreased energy metabolism extends lifespan in Caenorhabditis elegans without reducing oxidative damage
    • in press
    • Van Raamsdonk J, Meng Y, Camp D, Yang W, Jia X, Benard C, Hekimi S (2010) Decreased energy metabolism extends lifespan in Caenorhabditis elegans without reducing oxidative damage. Genetics, in press.
    • (2010) Genetics
    • Van Raamsdonk, J.1    Meng, Y.2    Camp, D.3    Yang, W.4    Jia, X.5    Benard, C.6    Hekimi, S.7
  • 56
    • 0026487290 scopus 로고
    • Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction
    • Walker JE, Arizmendi JM, Dupuis A, Fearnley IM, Finel M, Medd SM, Pilkington SJ, Runswick MJ, Skehel JM (1992) Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction. J. Mol. Biol. 226, 1051-1072.
    • (1992) J. Mol. Biol. , vol.226 , pp. 1051-1072
    • Walker, J.E.1    Arizmendi, J.M.2    Dupuis, A.3    Fearnley, I.M.4    Finel, M.5    Medd, S.M.6    Pilkington, S.J.7    Runswick, M.J.8    Skehel, J.M.9
  • 57
    • 33644750381 scopus 로고    scopus 로고
    • SMK-1, an essential regulator of DAF-16-mediated longevity
    • Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A (2006) SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124, 1039-1053.
    • (2006) Cell , vol.124 , pp. 1039-1053
    • Wolff, S.1    Ma, H.2    Burch, D.3    Maciel, G.A.4    Hunter, T.5    Dillin, A.6
  • 58
    • 67349272355 scopus 로고    scopus 로고
    • The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation
    • Woo DK, Poyton RO (2009) The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation. Exp. Gerontol. 44, 390-397.
    • (2009) Exp. Gerontol. , vol.44 , pp. 390-397
    • Woo, D.K.1    Poyton, R.O.2
  • 59
    • 37249016870 scopus 로고    scopus 로고
    • A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans
    • Yang W, Li J, Hekimi S (2007) A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genetics 177, 2063-2074.
    • (2007) Genetics , vol.177 , pp. 2063-2074
    • Yang, W.1    Li, J.2    Hekimi, S.3
  • 60
    • 4944234936 scopus 로고    scopus 로고
    • Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
    • Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D (2004) Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J. Cell Sci. 117, 4055-4066.
    • (2004) J. Cell Sci. , vol.117 , pp. 4055-4066
    • Yoneda, T.1    Benedetti, C.2    Urano, F.3    Clark, S.G.4    Harding, H.P.5    Ron, D.6
  • 61
    • 51349095898 scopus 로고    scopus 로고
    • Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
    • Zhang C, Cuervo AM (2008) Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat. Med. 14, 959-965.
    • (2008) Nat. Med. , vol.14 , pp. 959-965
    • Zhang, C.1    Cuervo, A.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.