DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

PLoS Genetics

Volumn 10, Issue 2, 2014, Pages

  Tullet, Jennifer M A ^a   Araiz, Caroline ^a   Sanders, Matthew J ^a   Au, Catherine ^a   Benedetto, Alexandre ^a   Papatheodorou, Irene ^b   Clark, Emily ^a   Schmeisser, Kathrin ^a   Jones, Daniel ^a   Schuster, Eugene F ^a   Thornton, Janet M ^b   Gems, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MESSENGER RNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; INSULIN RECEPTOR; ISOPROTEIN; TRANSCRIPTION FACTOR;

AAKG 1 GENE; AAKG 2 GENE; AAKG 3 GENE; AAKG 4 GENE; AAKG 5 GENE; AGING; ALPHA CHAIN; ARTICLE; BETA CHAIN; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEEDBACK SYSTEM; GAMMA SUBUNIT; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; REGULATORY MECHANISM; RESIDUE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; GENE REGULATORY NETWORK; GENETICS; LONGEVITY; METABOLISM; TRANSCRIPTION INITIATION;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; PROTEIN ISOFORMS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84901741224     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004109     Document Type: Article

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