A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 12, 2007, Pages 5014-5019

  Gerisch, Birgit ^a   Rottiers, Veerle ^b   Li, Dongling ^b   Motola, Daniel L ^c   Cummins, Carolyn L ^c   Lehrach, Hans ^a   Mangelsdorf, David J ^c   Antebi, Adam ^b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aging; DAF 12; Dafachronic acid; Germ line longevity; Hormone

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; DAFACHRONIC ACID; OXYGENASE; PROTEIN DAF 12; STEROID; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CELL RECEPTOR; DAF 9 PROTEIN, C ELEGANS; DAF-9 PROTEIN, C ELEGANS; HORMONE; HYBRID PROTEIN; LIGAND;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; DIAPAUSE; GERM LINE; LARVAL DEVELOPMENT; LIFESPAN; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRESS; ADAPTATION; ANIMAL; CELL NUCLEUS; DRUG EFFECT; GERM CELL; INTESTINE; LARVA; METABOLISM; PHYSIOLOGY; TEMPERATURE;

ANIMALIA; CAENORHABDITIS ELEGANS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BILE ACIDS AND SALTS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL NUCLEUS; CYTOCHROME P-450 ENZYME SYSTEM; GERM CELLS; INTESTINES; INVERTEBRATE HORMONES; LARVA; LIGANDS; LONGEVITY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TEMPERATURE;

EID: 34247563364     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700847104     Document Type: Article

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