메뉴 건너뛰기




Volumn 24, Issue , 2015, Pages 3-16

DAMPs, ageing, and cancer: The 'DAMP Hypothesis'

Author keywords

Ageing; Biomarker; Cancer; Damage associated molecular pattern (DAMP) molecules; Longevity; Receptor

Indexed keywords

CELL PROTEIN; DAMAGE ASSOCIATED MOLECULAR PATTERN MOLECULE; DNA; DOUBLE STRANDED DNA; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE; NUCLEOTIDE; PROTEIN S 100; RNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; PATTERN RECOGNITION RECEPTOR;

EID: 84946845377     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2014.10.004     Document Type: Review
Times cited : (104)

References (294)
  • 1
    • 33947387075 scopus 로고    scopus 로고
    • On the evolutionary origin of aging
    • Ackermann M., et al. On the evolutionary origin of aging. Aging Cell 2007, 6(2):235-244.
    • (2007) Aging Cell , vol.6 , Issue.2 , pp. 235-244
    • Ackermann, M.1
  • 2
    • 33745056414 scopus 로고    scopus 로고
    • Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    • Agrelo R., et al. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc. Natl. Acad. Sci. U.S.A. 2006, 103(23):8822-8827.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , Issue.23 , pp. 8822-8827
    • Agrelo, R.1
  • 3
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: a mechanistic view of its causes and consequences
    • Aguilera A., Gomez-Gonzalez B. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 2008, 9(3):204-217.
    • (2008) Nat. Rev. Genet. , vol.9 , Issue.3 , pp. 204-217
    • Aguilera, A.1    Gomez-Gonzalez, B.2
  • 4
    • 84896844884 scopus 로고    scopus 로고
    • Histones trigger sterile inflammation by activating the NLRP3 inflammasome
    • Allam R., et al. Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur. J. Immunol. 2013, 43(12):3336-3342.
    • (2013) Eur. J. Immunol. , vol.43 , Issue.12 , pp. 3336-3342
    • Allam, R.1
  • 5
    • 84899965398 scopus 로고    scopus 로고
    • Extracellular histones in tissue injury and inflammation
    • Allam R., et al. Extracellular histones in tissue injury and inflammation. J. Mol. Med. 2014, 92(5):465-472.
    • (2014) J. Mol. Med. , vol.92 , Issue.5 , pp. 465-472
    • Allam, R.1
  • 6
    • 79959463520 scopus 로고    scopus 로고
    • Regulation of HSF1 function in the heat stress response: implications in aging and disease
    • Anckar J., Sistonen L. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu. Rev. Biochem. 2011, 80:1089-1115.
    • (2011) Annu. Rev. Biochem. , vol.80 , pp. 1089-1115
    • Anckar, J.1    Sistonen, L.2
  • 8
    • 84867815944 scopus 로고    scopus 로고
    • Editorial: heat shock proteins in cancer
    • Arrigo A.P. Editorial: heat shock proteins in cancer. Curr. Mol. Med. 2012, 12(9):1099-1101.
    • (2012) Curr. Mol. Med. , vol.12 , Issue.9 , pp. 1099-1101
    • Arrigo, A.P.1
  • 9
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406(6796):641-645.
    • (2000) Nature , vol.406 , Issue.6796 , pp. 641-645
    • Artandi, S.E.1
  • 10
    • 0034113617 scopus 로고    scopus 로고
    • HSP70 stimulates cytokine production through a CD14-dependant pathway: demonstrating its dual role as a chaperone and cytokine
    • Asea A., et al. HSP70 stimulates cytokine production through a CD14-dependant pathway: demonstrating its dual role as a chaperone and cytokine. Nat. Med. 2000, 6(4):435-442.
    • (2000) Nat. Med. , vol.6 , Issue.4 , pp. 435-442
    • Asea, A.1
  • 11
    • 39349083915 scopus 로고    scopus 로고
    • Adapting proteostasis for disease intervention
    • Balch W.E., et al. Adapting proteostasis for disease intervention. Science 2008, 319(5865):916-919.
    • (2008) Science , vol.319 , Issue.5865 , pp. 916-919
    • Balch, W.E.1
  • 12
    • 84895871023 scopus 로고    scopus 로고
    • Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
    • Bald T., et al. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 2014, 507(7490):109-113.
    • (2014) Nature , vol.507 , Issue.7490 , pp. 109-113
    • Bald, T.1
  • 13
    • 84879120185 scopus 로고    scopus 로고
    • NF-kappaB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
    • Balistreri C.R., et al. NF-kappaB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies. Immun. Ageing 2013, 10(1):24.
    • (2013) Immun. Ageing , vol.10 , Issue.1 , pp. 24
    • Balistreri, C.R.1
  • 14
    • 84870533099 scopus 로고    scopus 로고
    • The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence
    • Bao L., et al. The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence. FEBS J. 2012, 279(24):4576-4588.
    • (2012) FEBS J. , vol.279 , Issue.24 , pp. 4576-4588
    • Bao, L.1
  • 15
    • 79551510805 scopus 로고    scopus 로고
    • Obesity and cancer risk: recent review and evidence
    • Basen-Engquist K., Chang M. Obesity and cancer risk: recent review and evidence. Curr. Oncol. Rep. 2011, 13(1):71-76.
    • (2011) Curr. Oncol. Rep. , vol.13 , Issue.1 , pp. 71-76
    • Basen-Engquist, K.1    Chang, M.2
  • 16
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor T.H. The DNA methyltransferases of mammals. Hum. Mol. Genet. 2000, 9(16):2395-2402.
    • (2000) Hum. Mol. Genet. , vol.9 , Issue.16 , pp. 2395-2402
    • Bestor, T.H.1
  • 17
    • 31544463026 scopus 로고    scopus 로고
    • P53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia
    • Bianchi G., et al. p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology 2006, 52(1):17-23.
    • (2006) Gerontology , vol.52 , Issue.1 , pp. 17-23
    • Bianchi, G.1
  • 18
    • 79953214581 scopus 로고    scopus 로고
    • S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release
    • Bianchi R., et al. S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release. J. Biol. Chem. 2011, 286(9):7214-7226.
    • (2011) J. Biol. Chem. , vol.286 , Issue.9 , pp. 7214-7226
    • Bianchi, R.1
  • 19
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: all we need to know about danger
    • Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 2007, 81(1):1-5.
    • (2007) J. Leukoc. Biol. , vol.81 , Issue.1 , pp. 1-5
    • Bianchi, M.E.1
  • 20
    • 58849156936 scopus 로고    scopus 로고
    • Hsp receptors: the cases of identity and mistaken identity
    • Binder R.J. Hsp receptors: the cases of identity and mistaken identity. Curr. Opin. Mol. Ther. 2009, 11(1):62-71.
    • (2009) Curr. Opin. Mol. Ther. , vol.11 , Issue.1 , pp. 62-71
    • Binder, R.J.1
  • 21
    • 33846517601 scopus 로고    scopus 로고
    • Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis
    • Blanco R., et al. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 2007, 21(2):206-220.
    • (2007) Genes Dev. , vol.21 , Issue.2 , pp. 206-220
    • Blanco, R.1
  • 22
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: ageing, cancer and beyond
    • Blasco M.A. Telomeres and human disease: ageing, cancer and beyond. Nat. Rev. Genet. 2005, 6(8):611-622.
    • (2005) Nat. Rev. Genet. , vol.6 , Issue.8 , pp. 611-622
    • Blasco, M.A.1
  • 23
    • 33947317206 scopus 로고    scopus 로고
    • The epigenetic regulation of mammalian telomeres
    • Blasco M.A. The epigenetic regulation of mammalian telomeres. Nat. Rev. Genet. 2007, 8(4):299-309.
    • (2007) Nat. Rev. Genet. , vol.8 , Issue.4 , pp. 299-309
    • Blasco, M.A.1
  • 24
    • 60849100524 scopus 로고    scopus 로고
    • Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    • Bollati V., et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech. Ageing Dev. 2009, 130(4):234-239.
    • (2009) Mech. Ageing Dev. , vol.130 , Issue.4 , pp. 234-239
    • Bollati, V.1
  • 25
    • 4243824006 scopus 로고    scopus 로고
    • The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding
    • Bonaldi T., et al. The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding. EMBO J. 2002, 21(24):6865-6873.
    • (2002) EMBO J. , vol.21 , Issue.24 , pp. 6865-6873
    • Bonaldi, T.1
  • 27
    • 33745915850 scopus 로고    scopus 로고
    • Nuclear lamins: laminopathies and their role in premature ageing
    • Broers J.L., et al. Nuclear lamins: laminopathies and their role in premature ageing. Physiol. Rev. 2006, 86(3):967-1008.
    • (2006) Physiol. Rev. , vol.86 , Issue.3 , pp. 967-1008
    • Broers, J.L.1
  • 28
    • 38049090214 scopus 로고    scopus 로고
    • DNA replication stress, genome instability and aging
    • Burhans W.C., Weinberger M. DNA replication stress, genome instability and aging. Nucleic Acids Res. 2007, 35(22):7545-7556.
    • (2007) Nucleic Acids Res. , vol.35 , Issue.22 , pp. 7545-7556
    • Burhans, W.C.1    Weinberger, M.2
  • 29
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke S.N., Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 2006, 7(1):30-40.
    • (2006) Nat. Rev. Neurosci. , vol.7 , Issue.1 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 30
    • 84871501642 scopus 로고    scopus 로고
    • The nuclear lamins: flexibility in function
    • Burke B., Stewart C.L. The nuclear lamins: flexibility in function. Nat. Rev. Mol. Cell Biol. 2013, 14(1):13-24.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , Issue.1 , pp. 13-24
    • Burke, B.1    Stewart, C.L.2
  • 31
    • 34447550254 scopus 로고    scopus 로고
    • Extracellular heat shock proteins in cell signaling
    • Calderwood S.K., et al. Extracellular heat shock proteins in cell signaling. FEBS Lett. 2007, 581(19):3689-3694.
    • (2007) FEBS Lett. , vol.581 , Issue.19 , pp. 3689-3694
    • Calderwood, S.K.1
  • 32
    • 0033052037 scopus 로고    scopus 로고
    • The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
    • Calogero S., et al. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat. Genet. 1999, 22(3):276-280.
    • (1999) Nat. Genet. , vol.22 , Issue.3 , pp. 276-280
    • Calogero, S.1
  • 33
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 2013, 75:685-705.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 685-705
    • Campisi, J.1
  • 34
  • 35
    • 69849107217 scopus 로고    scopus 로고
    • Caloric restriction, SIRT1 and longevity
    • Canto C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol. Metab. 2009, 20(7):325-331.
    • (2009) Trends Endocrinol. Metab. , vol.20 , Issue.7 , pp. 325-331
    • Canto, C.1    Auwerx, J.2
  • 36
    • 78650727963 scopus 로고    scopus 로고
    • Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity
    • Carranco R., et al. Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(50):21908-21913.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.50 , pp. 21908-21913
    • Carranco, R.1
  • 37
    • 70149123249 scopus 로고    scopus 로고
    • DAMPs and inflammatory processes: the role of redox in the different outcomes
    • Carta S., et al. DAMPs and inflammatory processes: the role of redox in the different outcomes. J. Leukoc. Biol. 2009, 86(3):549-555.
    • (2009) J. Leukoc. Biol. , vol.86 , Issue.3 , pp. 549-555
    • Carta, S.1
  • 38
    • 0037012845 scopus 로고    scopus 로고
    • Genomic instability in mice lacking histone H2AX
    • Celeste A., et al. Genomic instability in mice lacking histone H2AX. Science 2002, 296(5569):922-927.
    • (2002) Science , vol.296 , Issue.5569 , pp. 922-927
    • Celeste, A.1
  • 39
    • 79959811626 scopus 로고    scopus 로고
    • Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output
    • Celona B., et al. Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output. PLoS Biol. 2011, 9(6):e1001086.
    • (2011) PLoS Biol. , vol.9 , Issue.6 , pp. e1001086
    • Celona, B.1
  • 40
    • 22144476221 scopus 로고    scopus 로고
    • Modeling aging and cancer in the telomerase knockout mouse
    • Chang S. Modeling aging and cancer in the telomerase knockout mouse. Mutat. Res. 2005, 576(1-2):39-53.
    • (2005) Mutat. Res. , vol.576 , Issue.1-2 , pp. 39-53
    • Chang, S.1
  • 41
    • 84906859591 scopus 로고    scopus 로고
    • Release and activity of histone in diseases
    • Chen R., et al. Release and activity of histone in diseases. Cell Death Dis. 2014, 5:pe1370.
    • (2014) Cell Death Dis. , vol.5 , pp. pe1370
    • Chen, R.1
  • 42
    • 84901596684 scopus 로고    scopus 로고
    • S100 protein family in human cancer
    • Chen H., et al. S100 protein family in human cancer. Am. J. Cancer Res. 2014, 4(2):89-115.
    • (2014) Am. J. Cancer Res. , vol.4 , Issue.2 , pp. 89-115
    • Chen, H.1
  • 43
    • 0024975155 scopus 로고
    • A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
    • Chiang H.L., et al. A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 1989, 246(4928):382-385.
    • (1989) Science , vol.246 , Issue.4928 , pp. 382-385
    • Chiang, H.L.1
  • 44
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi A.M., Ryter S.W., Levine B. Autophagy in human health and disease. N. Engl. J. Med. 2013, 368(7):651-662.
    • (2013) N. Engl. J. Med. , vol.368 , Issue.7 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 45
    • 70149099610 scopus 로고    scopus 로고
    • Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    • Christensen B.C., et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 2009, 5(8):e1000602.
    • (2009) PLoS Genet. , vol.5 , Issue.8 , pp. e1000602
    • Christensen, B.C.1
  • 46
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in rhesus monkeys
    • Colman R.J., et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009, 325(5937):201-204.
    • (2009) Science , vol.325 , Issue.5937 , pp. 201-204
    • Colman, R.J.1
  • 47
    • 84903629564 scopus 로고    scopus 로고
    • ATM signalling and cancer
    • Cremona C.A., Behrens A. ATM signalling and cancer. Oncogene 2014, 33(26):3351-3360.
    • (2014) Oncogene , vol.33 , Issue.26 , pp. 3351-3360
    • Cremona, C.A.1    Behrens, A.2
  • 48
    • 0035394668 scopus 로고    scopus 로고
    • Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
    • Cummings C.J., et al. Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum. Mol. Genet. 2001, 10(14):1511-1518.
    • (2001) Hum. Mol. Genet. , vol.10 , Issue.14 , pp. 1511-1518
    • Cummings, C.J.1
  • 49
    • 34548658230 scopus 로고    scopus 로고
    • Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    • Dai C., et al. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007, 130(6):1005-1018.
    • (2007) Cell , vol.130 , Issue.6 , pp. 1005-1018
    • Dai, C.1
  • 50
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang E.V., et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 2011, 146(5):772-784.
    • (2011) Cell , vol.146 , Issue.5 , pp. 772-784
    • Dang, E.V.1
  • 51
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang C.V. Links between metabolism and cancer. Genes Dev. 2012, 26(9):877-890.
    • (2012) Genes Dev. , vol.26 , Issue.9 , pp. 877-890
    • Dang, C.V.1
  • 52
    • 84878619211 scopus 로고    scopus 로고
    • P53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
    • Davalos A.R., et al. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J. Cell Biol. 2013, 201(4):613-629.
    • (2013) J. Cell Biol. , vol.201 , Issue.4 , pp. 613-629
    • Davalos, A.R.1
  • 53
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: the protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19(18):2100-2110.
    • (2005) Genes Dev. , vol.19 , Issue.18 , pp. 2100-2110
    • de Lange, T.1
  • 54
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: what do metabolic outliers teach us?
    • DeBerardinis R.J., Thompson C.B. Cellular metabolism and disease: what do metabolic outliers teach us?. Cell 2012, 148(6):1132-1144.
    • (2012) Cell , vol.148 , Issue.6 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 55
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis: inflammation, and tumorigenesis
    • Degenhardt K., et al. Autophagy promotes tumor cell survival and restricts necrosis: inflammation, and tumorigenesis. Cancer Cell 2006, 10(1):51-64.
    • (2006) Cancer Cell , vol.10 , Issue.1 , pp. 51-64
    • Degenhardt, K.1
  • 56
    • 33645003172 scopus 로고    scopus 로고
    • BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
    • Deng C.X. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 2006, 34(5):1416-1426.
    • (2006) Nucleic Acids Res. , vol.34 , Issue.5 , pp. 1416-1426
    • Deng, C.X.1
  • 57
    • 77953944814 scopus 로고    scopus 로고
    • Chromatin modifications: the driving force of senescence and aging?
    • Dimauro T., David G. Chromatin modifications: the driving force of senescence and aging?. Aging (Albany NY) 2009, 1(2):182-190.
    • (2009) Aging (Albany NY) , vol.1 , Issue.2 , pp. 182-190
    • Dimauro, T.1    David, G.2
  • 58
    • 84864026012 scopus 로고    scopus 로고
    • Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats
    • Ding Q., et al. Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats. J. Nutr. Biochem. 2012, 23(8):867-874.
    • (2012) J. Nutr. Biochem. , vol.23 , Issue.8 , pp. 867-874
    • Ding, Q.1
  • 60
    • 84876030376 scopus 로고    scopus 로고
    • Functions of S100 proteins
    • Donato R., et al. Functions of S100 proteins. Curr. Mol. Med. 2013, 13(1):24-57.
    • (2013) Curr. Mol. Med. , vol.13 , Issue.1 , pp. 24-57
    • Donato, R.1
  • 61
    • 38349138516 scopus 로고    scopus 로고
    • RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins
    • Donato R. RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins. Curr. Mol. Med. 2007, 7(8):711-724.
    • (2007) Curr. Mol. Med. , vol.7 , Issue.8 , pp. 711-724
    • Donato, R.1
  • 62
    • 58149100407 scopus 로고    scopus 로고
    • The ageing immune system: is it ever too old to become young again?
    • Dorshkind K., Montecino-Rodriguez E., Signer R.A. The ageing immune system: is it ever too old to become young again?. Nat. Rev. Immunol. 2009, 9(1):57-62.
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.1 , pp. 57-62
    • Dorshkind, K.1    Montecino-Rodriguez, E.2    Signer, R.A.3
  • 63
    • 4444257692 scopus 로고    scopus 로고
    • The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae
    • Dror V., Winston F. The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae. Mol. Cell. Biol. 2004, 24(18):8227-8235.
    • (2004) Mol. Cell. Biol. , vol.24 , Issue.18 , pp. 8227-8235
    • Dror, V.1    Winston, F.2
  • 64
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G., et al. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429(6990):457-463.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1
  • 65
    • 84902183747 scopus 로고    scopus 로고
    • S100A4 and Uric Acid Promote Mesenchymal Stromal Cell Induction of IL-10+/IDO+ Lymphocytes
    • Eisenbacher J.L., et al. S100A4 and Uric Acid Promote Mesenchymal Stromal Cell Induction of IL-10+/IDO+ Lymphocytes. J. Immunol. 2014, 192(12):6102-6110.
    • (2014) J. Immunol. , vol.192 , Issue.12 , pp. 6102-6110
    • Eisenbacher, J.L.1
  • 66
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: targeting chromatin modifications
    • Ellis L., Atadja P.W., Johnstone R.W. Epigenetics in cancer: targeting chromatin modifications. Mol. Cancer Ther. 2009, 8(6):1409-1420.
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.6 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 67
    • 0027203055 scopus 로고
    • Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E
    • Engelkamp D., et al. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Proc. Natl. Acad. Sci. U.S.A. 1993, 90(14):6547-6551.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , Issue.14 , pp. 6547-6551
    • Engelkamp, D.1
  • 68
    • 52349109175 scopus 로고    scopus 로고
    • Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain
    • Enokido Y., et al. Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain. Biochem. Biophys. Res. Commun. 2008, 376(1):128-133.
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , Issue.1 , pp. 128-133
    • Enokido, Y.1
  • 69
    • 34948846000 scopus 로고    scopus 로고
    • Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p
    • Erjavec N., et al. Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev. 2007, 21(19):2410-2421.
    • (2007) Genes Dev. , vol.21 , Issue.19 , pp. 2410-2421
    • Erjavec, N.1
  • 70
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    • Ershler W.B., Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 2000, 51:245-270.
    • (2000) Annu. Rev. Med. , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 71
    • 84856100695 scopus 로고    scopus 로고
    • Is cancer a metabolic rebellion against host aging? In the quest for immortality: tumor cells try to save themselves by boosting mitochondrial metabolism
    • Ertel A., et al. Is cancer a metabolic rebellion against host aging? In the quest for immortality: tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle 2012, 11(2):253-263.
    • (2012) Cell Cycle , vol.11 , Issue.2 , pp. 253-263
    • Ertel, A.1
  • 72
    • 0033057848 scopus 로고    scopus 로고
    • Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
    • Feder M.E., Hofmann G.E. Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu. Rev. Physiol. 1999, 61:243-282.
    • (1999) Annu. Rev. Physiol. , vol.61 , pp. 243-282
    • Feder, M.E.1    Hofmann, G.E.2
  • 73
    • 3242880238 scopus 로고    scopus 로고
    • H2AX: the histone guardian of the genome
    • Fernandez-Capetillo O., et al. H2AX: the histone guardian of the genome. DNA Repair (Amst.) 2004, 3(8-9):959-967.
    • (2004) DNA Repair (Amst.) , vol.3 , Issue.8-9 , pp. 959-967
    • Fernandez-Capetillo, O.1
  • 74
    • 77956520661 scopus 로고    scopus 로고
    • Elevated histone expression promotes life span extension
    • Feser J., et al. Elevated histone expression promotes life span extension. Mol. Cell 2010, 39(5):724-735.
    • (2010) Mol. Cell , vol.39 , Issue.5 , pp. 724-735
    • Feser, J.1
  • 75
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408(6809):239-247.
    • (2000) Nature , vol.408 , Issue.6809 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 76
    • 34547941973 scopus 로고    scopus 로고
    • The common biology of cancer and ageing
    • Finkel T., Serrano M., Blasco M.A. The common biology of cancer and ageing. Nature 2007, 448(7155):767-774.
    • (2007) Nature , vol.448 , Issue.7155 , pp. 767-774
    • Finkel, T.1    Serrano, M.2    Blasco, M.A.3
  • 78
    • 33845868493 scopus 로고    scopus 로고
    • S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    • Foell D., et al. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J. Leukoc. Biol. 2007, 81(1):28-37.
    • (2007) J. Leukoc. Biol. , vol.81 , Issue.1 , pp. 28-37
    • Foell, D.1
  • 79
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: the targets and the marks
    • Fraga M.F., Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet. 2007, 23(8):413-418.
    • (2007) Trends Genet. , vol.23 , Issue.8 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 80
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(30):10604-10609.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.30 , pp. 10604-10609
    • Fraga, M.F.1
  • 81
    • 84882846112 scopus 로고    scopus 로고
    • The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy
    • Fullgrabe J., et al. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature 2013, 500(7463):468-471.
    • (2013) Nature , vol.500 , Issue.7463 , pp. 468-471
    • Fullgrabe, J.1
  • 82
    • 80054807562 scopus 로고    scopus 로고
    • Aging: immunity, and cancer
    • Fulop T., et al. Aging: immunity, and cancer. Discov. Med. 2011, 11(61):537-550.
    • (2011) Discov. Med. , vol.11 , Issue.61 , pp. 537-550
    • Fulop, T.1
  • 83
    • 84857169594 scopus 로고    scopus 로고
    • Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    • Gabai V.L., et al. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol. Cell. Biol. 2012, 32(5):929-940.
    • (2012) Mol. Cell. Biol. , vol.32 , Issue.5 , pp. 929-940
    • Gabai, V.L.1
  • 84
    • 78751502344 scopus 로고    scopus 로고
    • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
    • Gao H.M., et al. HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J. Neurosci. 2011, 31(3):1081-1092.
    • (2011) J. Neurosci. , vol.31 , Issue.3 , pp. 1081-1092
    • Gao, H.M.1
  • 85
    • 84856696459 scopus 로고    scopus 로고
    • Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin
    • Garg A.D., et al. Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin. Cancer Immunol. Immunother. 2012, 61(2):215-221.
    • (2012) Cancer Immunol. Immunother. , vol.61 , Issue.2 , pp. 215-221
    • Garg, A.D.1
  • 86
    • 0037683347 scopus 로고    scopus 로고
    • Pediatric concentrations of S100B protein in blood: age- and sex-related changes
    • Gazzolo D., et al. Pediatric concentrations of S100B protein in blood: age- and sex-related changes. Clin. Chem. 2003, 49(6 Pt 1):967-970.
    • (2003) Clin. Chem. , vol.49 , Issue.6 , pp. 967-970
    • Gazzolo, D.1
  • 87
    • 39549098128 scopus 로고    scopus 로고
    • RAGE signaling sustains inflammation and promotes tumor development
    • Gebhardt C., et al. RAGE signaling sustains inflammation and promotes tumor development. J. Exp. Med. 2008, 205(2):275-285.
    • (2008) J. Exp. Med. , vol.205 , Issue.2 , pp. 275-285
    • Gebhardt, C.1
  • 88
    • 11844262653 scopus 로고    scopus 로고
    • Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability
    • Giavara S., et al. Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability. Curr. Biol. 2005, 15(1):68-72.
    • (2005) Curr. Biol. , vol.15 , Issue.1 , pp. 68-72
    • Giavara, S.1
  • 89
    • 34648843213 scopus 로고    scopus 로고
    • How telomeres are replicated
    • Gilson E., Geli V. How telomeres are replicated. Nat. Rev. Mol. Cell Biol. 2007, 8(10):825-838.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , Issue.10 , pp. 825-838
    • Gilson, E.1    Geli, V.2
  • 90
    • 84879002067 scopus 로고    scopus 로고
    • Redox regulation of the immune response
    • Gostner J.M., et al. Redox regulation of the immune response. Redox Rep. 2013, 18(3):88-94.
    • (2013) Redox Rep. , vol.18 , Issue.3 , pp. 88-94
    • Gostner, J.M.1
  • 91
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in tetrahymena extracts
    • Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 1985, 43(2 Pt 1):405-413.
    • (1985) Cell , vol.43 , Issue.2 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 92
    • 0034193776 scopus 로고    scopus 로고
    • Sir2 links chromatin silencing: metabolism, and aging
    • Guarente L. Sir2 links chromatin silencing: metabolism, and aging. Genes Dev. 2000, 14(9):1021-1026.
    • (2000) Genes Dev. , vol.14 , Issue.9 , pp. 1021-1026
    • Guarente, L.1
  • 93
    • 84855321183 scopus 로고    scopus 로고
    • Histone methylation makes its mark on longevity
    • Han S., Brunet A. Histone methylation makes its mark on longevity. Trends Cell Biol. 2012, 22(1):42-49.
    • (2012) Trends Cell Biol. , vol.22 , Issue.1 , pp. 42-49
    • Han, S.1    Brunet, A.2
  • 94
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 95
    • 0026047662 scopus 로고
    • The aging process: major risk factor for disease and death
    • Harman D. The aging process: major risk factor for disease and death. Proc. Natl. Acad. Sci. U.S.A. 1991, 88(12):5360-5363.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , Issue.12 , pp. 5360-5363
    • Harman, D.1
  • 96
    • 0026775958 scopus 로고
    • Free radical theory of aging
    • Harman D. Free radical theory of aging. Mutat. Res. 1992, 275(3-6):257-266.
    • (1992) Mutat. Res. , vol.275 , Issue.3-6 , pp. 257-266
    • Harman, D.1
  • 97
    • 3042685214 scopus 로고    scopus 로고
    • S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma
    • Harpio R., Einarsson R. S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma. Clin. Biochem. 2004, 37(7):512-518.
    • (2004) Clin. Biochem. , vol.37 , Issue.7 , pp. 512-518
    • Harpio, R.1    Einarsson, R.2
  • 98
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison D.E., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460(7253):392-395.
    • (2009) Nature , vol.460 , Issue.7253 , pp. 392-395
    • Harrison, D.E.1
  • 99
    • 84859105367 scopus 로고    scopus 로고
    • Alternate day calorie restriction improves systemic inflammation in a mouse model of sepsis induced by cecal ligation and puncture
    • Hasegawa A., et al. Alternate day calorie restriction improves systemic inflammation in a mouse model of sepsis induced by cecal ligation and puncture. J. Surg. Res. 2012, 174(1):136-141.
    • (2012) J. Surg. Res. , vol.174 , Issue.1 , pp. 136-141
    • Hasegawa, A.1
  • 100
    • 84872530748 scopus 로고    scopus 로고
    • Tissue damage-associated 'danger signals' influence T cell responses that promote the progression of pre-neoplasia to cancer
    • He Y., et al. Tissue damage-associated 'danger signals' influence T cell responses that promote the progression of pre-neoplasia to cancer. Cancer Res. 2013, 73(2):629-639.
    • (2013) Cancer Res. , vol.73 , Issue.2 , pp. 629-639
    • He, Y.1
  • 101
    • 0036580943 scopus 로고    scopus 로고
    • S100 proteins: structure, functions and pathology
    • Heizmann C.W., Fritz G., Schafer B.W. S100 proteins: structure, functions and pathology. Front. Biosci. 2002, 7:d1356-d1368.
    • (2002) Front. Biosci. , vol.7 , pp. d1356-d1368
    • Heizmann, C.W.1    Fritz, G.2    Schafer, B.W.3
  • 103
    • 55549128598 scopus 로고    scopus 로고
    • The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    • Hiratsuka S., et al. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 2008, 10(11):1349-1355.
    • (2008) Nat. Cell Biol. , vol.10 , Issue.11 , pp. 1349-1355
    • Hiratsuka, S.1
  • 104
    • 0033603241 scopus 로고    scopus 로고
    • RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    • Hofmann M.A., et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999, 97(7):889-901.
    • (1999) Cell , vol.97 , Issue.7 , pp. 889-901
    • Hofmann, M.A.1
  • 105
    • 52249118563 scopus 로고    scopus 로고
    • Clinical relevance of circulating nucleosomes in cancer
    • Holdenrieder S., et al. Clinical relevance of circulating nucleosomes in cancer. Ann. N.Y. Acad. Sci. 2008, 1137:180-189.
    • (2008) Ann. N.Y. Acad. Sci. , vol.1137 , pp. 180-189
    • Holdenrieder, S.1
  • 106
    • 84891754287 scopus 로고    scopus 로고
    • Strange attractors: DAMPs and autophagy link tumor cell death and immunity
    • Hou W., et al. Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis. 2013, 4:e966.
    • (2013) Cell Death Dis. , vol.4 , pp. e966
    • Hou, W.1
  • 107
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu P.P., Sabatini D.M. Cancer cell metabolism: Warburg and beyond. Cell 2008, 134(5):703-707.
    • (2008) Cell , vol.134 , Issue.5 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 108
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu A.L., Murphy C.T., Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 2003, 300(5622):1142-1145.
    • (2003) Science , vol.300 , Issue.5622 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 109
    • 84893931097 scopus 로고    scopus 로고
    • Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
    • Hu Z., et al. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. Genes Dev. 2014, 28(4):396-408.
    • (2014) Genes Dev. , vol.28 , Issue.4 , pp. 396-408
    • Hu, Z.1
  • 110
    • 80051969149 scopus 로고    scopus 로고
    • Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice
    • Huang H., et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology 2011, 54(3):999-1008.
    • (2011) Hepatology , vol.54 , Issue.3 , pp. 999-1008
    • Huang, H.1
  • 111
    • 84855406005 scopus 로고    scopus 로고
    • HMGB1 promotes drug resistance in osteosarcoma
    • Huang J., et al. HMGB1 promotes drug resistance in osteosarcoma. Cancer Res. 2012, 72(1):230-238.
    • (2012) Cancer Res. , vol.72 , Issue.1 , pp. 230-238
    • Huang, J.1
  • 112
    • 84883367417 scopus 로고    scopus 로고
    • Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
    • Huang H., et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J. Immunol. 2013, 191(5):2665-2679.
    • (2013) J. Immunol. , vol.191 , Issue.5 , pp. 2665-2679
    • Huang, H.1
  • 113
    • 84899472038 scopus 로고    scopus 로고
    • Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection
    • Huang H., et al. Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection. Hepatology 2014, 59(5):1984-1997.
    • (2014) Hepatology , vol.59 , Issue.5 , pp. 1984-1997
    • Huang, H.1
  • 114
    • 84895754369 scopus 로고    scopus 로고
    • High-mobility group box 1 is dispensable for autophagy: mitochondrial quality control, and organ function in vivo
    • Huebener P., et al. High-mobility group box 1 is dispensable for autophagy: mitochondrial quality control, and organ function in vivo. Cell Metab. 2014, 19(3):539-547.
    • (2014) Cell Metab. , vol.19 , Issue.3 , pp. 539-547
    • Huebener, P.1
  • 115
    • 0037102393 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis
    • Huttunen H.J., et al. Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res. 2002, 62(16):4805-4811.
    • (2002) Cancer Res. , vol.62 , Issue.16 , pp. 4805-4811
    • Huttunen, H.J.1
  • 116
    • 78650990326 scopus 로고    scopus 로고
    • Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
    • Jaskelioff M., et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011, 469(7328):102-106.
    • (2011) Nature , vol.469 , Issue.7328 , pp. 102-106
    • Jaskelioff, M.1
  • 117
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., Allis C.D. Translating the histone code. Science 2001, 293(5532):1074-1080.
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 118
    • 36649001174 scopus 로고    scopus 로고
    • Growth suppression and radiosensitivity increase by HMGB1 in breast cancer
    • Jiao Y., Wang H.C., Fan S.J. Growth suppression and radiosensitivity increase by HMGB1 in breast cancer. Acta Pharmacol. Sin. 2007, 28(12):1957-1967.
    • (2007) Acta Pharmacol. Sin. , vol.28 , Issue.12 , pp. 1957-1967
    • Jiao, Y.1    Wang, H.C.2    Fan, S.J.3
  • 119
    • 84861322460 scopus 로고    scopus 로고
    • Modern Biological Theories of Aging
    • Jin K. Modern Biological Theories of Aging. Aging Dis. 2010, 1(2):72-74.
    • (2010) Aging Dis. , vol.1 , Issue.2 , pp. 72-74
    • Jin, K.1
  • 120
    • 84859044056 scopus 로고    scopus 로고
    • S100A9 interaction with TLR4 promotes tumor growth
    • Kallberg E., et al. S100A9 interaction with TLR4 promotes tumor growth. PLoS One 2012, 7(3):e34207.
    • (2012) PLoS One , vol.7 , Issue.3 , pp. e34207
    • Kallberg, E.1
  • 121
    • 64549097439 scopus 로고    scopus 로고
    • Guidelines for the nomenclature of the human heat shock proteins
    • Kampinga H.H., et al. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones 2009, 14(1):105-111.
    • (2009) Cell Stress Chaperones , vol.14 , Issue.1 , pp. 105-111
    • Kampinga, H.H.1
  • 122
    • 84858000209 scopus 로고    scopus 로고
    • The sirtuin SIRT6 regulates lifespan in male mice
    • Kanfi Y., et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012, 483(7388):218-221.
    • (2012) Nature , vol.483 , Issue.7388 , pp. 218-221
    • Kanfi, Y.1
  • 123
    • 84860813449 scopus 로고    scopus 로고
    • The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
    • Kang R., et al. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. Proc. Natl. Acad. Sci. U.S.A. 2012, 109(18):7031-7036.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , Issue.18 , pp. 7031-7036
    • Kang, R.1
  • 124
    • 84881231803 scopus 로고    scopus 로고
    • HMGB1 in cancer: good, bad, or both?
    • Kang R., et al. HMGB1 in cancer: good, bad, or both?. Clin. Cancer Res. 2013, 19(15):4046-4057.
    • (2013) Clin. Cancer Res. , vol.19 , Issue.15 , pp. 4046-4057
    • Kang, R.1
  • 125
    • 84896478042 scopus 로고    scopus 로고
    • Intracellular hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
    • Kang R., et al. Intracellular hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology 2014, 146(4):1097-1107.
    • (2014) Gastroenterology , vol.146 , Issue.4 , pp. 1097-1107
    • Kang, R.1
  • 126
    • 84893245205 scopus 로고    scopus 로고
    • The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics
    • Kang R., et al. The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene 2014, 33(5):567-577.
    • (2014) Oncogene , vol.33 , Issue.5 , pp. 567-577
    • Kang, R.1
  • 127
    • 84908448181 scopus 로고    scopus 로고
    • HMGB1 in health and disease
    • Epub ahead of print
    • Kang R., et al. HMGB1 in health and disease. Mol. Aspects Med. 2014, pii: S0098-2997(14)00037-5. [Epub ahead of print]. 10.1016/j.mam.2014.05.001.
    • (2014) Mol. Aspects Med.
    • Kang, R.1
  • 128
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006, 441(7092):431-436.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 431-436
    • Karin, M.1
  • 129
    • 77649246145 scopus 로고    scopus 로고
    • Histone modification levels are predictive for gene expression
    • Karlic R., et al. Histone modification levels are predictive for gene expression. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(7):2926-2931.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.7 , pp. 2926-2931
    • Karlic, R.1
  • 130
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics, microRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
    • Kasinski A.L., Slack F.J. Epigenetics and genetics, microRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat. Rev. Cancer 2011, 11(12):849-864.
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.12 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 131
    • 58149090925 scopus 로고    scopus 로고
    • SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
    • Kawahara T.L., et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009, 136(1):62-74.
    • (2009) Cell , vol.136 , Issue.1 , pp. 62-74
    • Kawahara, T.L.1
  • 132
    • 78649892452 scopus 로고    scopus 로고
    • SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells
    • Kim Y.S., et al. SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells. J. Cell Biochem. 2010, 111(5):1310-1320.
    • (2010) J. Cell Biochem. , vol.111 , Issue.5 , pp. 1310-1320
    • Kim, Y.S.1
  • 133
    • 84871940714 scopus 로고    scopus 로고
    • Chloroquine in cancer therapy: a double-edged sword of autophagy
    • Kimura T., et al. Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res. 2013, 73(1):3-7.
    • (2013) Cancer Res. , vol.73 , Issue.1 , pp. 3-7
    • Kimura, T.1
  • 134
  • 135
    • 77950487987 scopus 로고    scopus 로고
    • Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems
    • Korolchuk V.I., Menzies F.M., Rubinsztein D.C. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett. 2010, 584(7):1393-1398.
    • (2010) FEBS Lett. , vol.584 , Issue.7 , pp. 1393-1398
    • Korolchuk, V.I.1    Menzies, F.M.2    Rubinsztein, D.C.3
  • 136
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 2007, 128(4):693-705.
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 137
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk C.M., et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 2010, 115(23):4742-4749.
    • (2010) Blood , vol.115 , Issue.23 , pp. 4742-4749
    • Krawczyk, C.M.1
  • 138
    • 84870239310 scopus 로고    scopus 로고
    • Immunogenic cell death and DAMPs in cancer therapy
    • Krysko D.V., et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 2012, 12(12):860-875.
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.12 , pp. 860-875
    • Krysko, D.V.1
  • 139
    • 84879395771 scopus 로고    scopus 로고
    • Many faces of DAMPs in cancer therapy
    • Krysko O., et al. Many faces of DAMPs in cancer therapy. Cell Death Dis. 2013, 4:e631.
    • (2013) Cell Death Dis. , vol.4 , pp. e631
    • Krysko, O.1
  • 140
    • 82755161786 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNAs in cancer: an integrated review of literature
    • Kunej T., et al. Epigenetic regulation of microRNAs in cancer: an integrated review of literature. Mutat. Res. 2011, 717(1-2):77-84.
    • (2011) Mutat. Res. , vol.717 , Issue.1-2 , pp. 77-84
    • Kunej, T.1
  • 141
    • 0036156244 scopus 로고    scopus 로고
    • Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer
    • Kuniyasu H., et al. Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer. J. Pathol. 2002, 196(2):163-170.
    • (2002) J. Pathol. , vol.196 , Issue.2 , pp. 163-170
    • Kuniyasu, H.1
  • 142
    • 67651091574 scopus 로고    scopus 로고
    • Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer
    • Kusume A., et al. Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer. Pathobiology 2009, 76(4):155-162.
    • (2009) Pathobiology , vol.76 , Issue.4 , pp. 155-162
    • Kusume, A.1
  • 143
    • 77249170184 scopus 로고    scopus 로고
    • Establishing, maintaining and modifying DNA methylation patterns in plants and animals
    • Law J.A., Jacobsen S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat. Rev. Genet. 2010, 11(3):204-220.
    • (2010) Nat. Rev. Genet. , vol.11 , Issue.3 , pp. 204-220
    • Law, J.A.1    Jacobsen, S.E.2
  • 144
    • 24644445998 scopus 로고    scopus 로고
    • Rapamycin: an anti-cancer immunosuppressant?
    • Law B.K. Rapamycin: an anti-cancer immunosuppressant?. Crit. Rev. Oncol. Hematol. 2005, 56(1):47-60.
    • (2005) Crit. Rev. Oncol. Hematol. , vol.56 , Issue.1 , pp. 47-60
    • Law, B.K.1
  • 145
    • 33745816760 scopus 로고    scopus 로고
    • Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
    • Lecker S.H., Goldberg A.L., Mitch W.E. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J. Am. Soc. Nephrol. 2006, 17(7):1807-1819.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , Issue.7 , pp. 1807-1819
    • Lecker, S.H.1    Goldberg, A.L.2    Mitch, W.E.3
  • 146
    • 67349265963 scopus 로고    scopus 로고
    • Binding of S100 proteins to RAGE: an update
    • Leclerc E., et al. Binding of S100 proteins to RAGE: an update. Biochim. Biophys. Acta 2009, 1793(6):993-1007.
    • (2009) Biochim. Biophys. Acta , vol.1793 , Issue.6 , pp. 993-1007
    • Leclerc, E.1
  • 147
    • 42649094198 scopus 로고    scopus 로고
    • A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1
    • Li W.et al. A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One 2007, 2(11):e1153.
    • (2007) PLoS One , vol.2 , Issue.11 , pp. e1153
    • Li, W.A.1
  • 148
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang X.H., et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402(6762):672-676.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 672-676
    • Liang, X.H.1
  • 149
    • 39649083371 scopus 로고    scopus 로고
    • Inflammatory mechanisms: the molecular basis of inflammation and disease
    • Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr. Rev. 2007, 65(12 Pt 2):S140-S146.
    • (2007) Nutr. Rev. , vol.65 , Issue.12 , pp. S140-S146
    • Libby, P.1
  • 150
    • 0028074815 scopus 로고
    • Regional changes in expression of NCAM, GFAP, and S100 in aging rat brain
    • Linnemann D., Skarsfelt T. Regional changes in expression of NCAM, GFAP, and S100 in aging rat brain. Neurobiol. Aging 1994, 15(5):651-655.
    • (1994) Neurobiol. Aging , vol.15 , Issue.5 , pp. 651-655
    • Linnemann, D.1    Skarsfelt, T.2
  • 151
    • 78650831662 scopus 로고    scopus 로고
    • DAMP-mediated autophagy contributes to drug resistance
    • Liu L., et al. DAMP-mediated autophagy contributes to drug resistance. Autophagy 2011, 7(1):112-114.
    • (2011) Autophagy , vol.7 , Issue.1 , pp. 112-114
    • Liu, L.1
  • 152
    • 78651286142 scopus 로고    scopus 로고
    • HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells
    • Liu L., et al. HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells. Leukemia 2011, 25(1):23-31.
    • (2011) Leukemia , vol.25 , Issue.1 , pp. 23-31
    • Liu, L.1
  • 153
    • 79960387864 scopus 로고    scopus 로고
    • Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8T cell-dependent antitumor immunity
    • Liu Z., Falo L.D., You Z. Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8T cell-dependent antitumor immunity. J. Immunol. 2011, 187(1):118-125.
    • (2011) J. Immunol. , vol.187 , Issue.1 , pp. 118-125
    • Liu, Z.1    Falo, L.D.2    You, Z.3
  • 154
    • 84907218485 scopus 로고    scopus 로고
    • HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE
    • Liu L., et al. HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE. Biochem. Biophys. Res. Commun. 2014, 450(1):851-856.
    • (2014) Biochem. Biophys. Res. Commun. , vol.450 , Issue.1 , pp. 851-856
    • Liu, L.1
  • 155
    • 84860163119 scopus 로고    scopus 로고
    • P53/HMGB1 complexes regulate autophagy and apoptosis
    • Livesey K.M., et al. p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer Res. 2012, 72(8):1996-2005.
    • (2012) Cancer Res. , vol.72 , Issue.8 , pp. 1996-2005
    • Livesey, K.M.1
  • 156
    • 79952219736 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers
    • Lo J.F., et al. The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers. Cancer Res. 2011, 71(5):1912-1923.
    • (2011) Cancer Res. , vol.71 , Issue.5 , pp. 1912-1923
    • Lo, J.F.1
  • 157
    • 13944249618 scopus 로고    scopus 로고
    • DNA repair: genome stability, and aging
    • Lombard D.B., et al. DNA repair: genome stability, and aging. Cell 2005, 120(4):497-512.
    • (2005) Cell , vol.120 , Issue.4 , pp. 497-512
    • Lombard, D.B.1
  • 158
    • 84878864199 scopus 로고    scopus 로고
    • The hallmarks of aging
    • Lopez-Otin C., et al. The hallmarks of aging. Cell 2013, 153(6):1194-1217.
    • (2013) Cell , vol.153 , Issue.6 , pp. 1194-1217
    • Lopez-Otin, C.1
  • 159
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est1- senescence
    • Lundblad V., Blackburn E.H. An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell 1993, 73(2):347-360.
    • (1993) Cell , vol.73 , Issue.2 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.H.2
  • 160
    • 48049110892 scopus 로고    scopus 로고
    • Epigenetic regulation of stem cell fate
    • Lunyak V.V., Rosenfeld M.G. Epigenetic regulation of stem cell fate. Hum. Mol. Genet. 2008, 17(R1):R28-R36.
    • (2008) Hum. Mol. Genet. , vol.17 , Issue.R1 , pp. R28-R36
    • Lunyak, V.V.1    Rosenfeld, M.G.2
  • 161
    • 84867140008 scopus 로고    scopus 로고
    • Emerging roles of PKM2 in cell metabolism and cancer progression
    • Luo W., Semenza G.L. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol. Metab. 2012, 23(11):560-566.
    • (2012) Trends Endocrinol. Metab. , vol.23 , Issue.11 , pp. 560-566
    • Luo, W.1    Semenza, G.L.2
  • 163
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: crosstalk between autophagy and apoptosis
    • Maiuri M.C., et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2007, 8(9):741-752.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1
  • 164
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • Martinez P., Blasco M.A. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat. Rev. Cancer 2011, 11(3):161-176.
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.3 , pp. 161-176
    • Martinez, P.1    Blasco, M.A.2
  • 165
    • 34249863298 scopus 로고    scopus 로고
    • Autophagy suppresses tumor progression by limiting chromosomal instability
    • Mathew R., et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 2007, 21(11):1367-1381.
    • (2007) Genes Dev. , vol.21 , Issue.11 , pp. 1367-1381
    • Mathew, R.1
  • 166
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 1994, 12:991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 167
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science 2002, 296(5566):301-305.
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 168
    • 33846990935 scopus 로고    scopus 로고
    • Friendly and dangerous signals: is the tissue in control?
    • Matzinger P. Friendly and dangerous signals: is the tissue in control?. Nat. Immunol. 2007, 8(1):11-13.
    • (2007) Nat. Immunol. , vol.8 , Issue.1 , pp. 11-13
    • Matzinger, P.1
  • 169
    • 0024424288 scopus 로고
    • DNA methylation in aging and cancer
    • Mays-Hoopes L.L. DNA methylation in aging and cancer. J. Gerontol. 1989, 44(6):35-36.
    • (1989) J. Gerontol. , vol.44 , Issue.6 , pp. 35-36
    • Mays-Hoopes, L.L.1
  • 170
    • 0031836938 scopus 로고    scopus 로고
    • Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
    • Melcher A., et al. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat. Med. 1998, 4(5):581-587.
    • (1998) Nat. Med. , vol.4 , Issue.5 , pp. 581-587
    • Melcher, A.1
  • 171
    • 77956929098 scopus 로고    scopus 로고
    • Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    • Meng L., Gabai V.L., Sherman M.Y. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene 2010, 29(37):5204-5213.
    • (2010) Oncogene , vol.29 , Issue.37 , pp. 5204-5213
    • Meng, L.1    Gabai, V.L.2    Sherman, M.Y.3
  • 172
    • 79959670292 scopus 로고    scopus 로고
    • Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    • Meng L., et al. Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene 2011, 30(25):2836-2845.
    • (2011) Oncogene , vol.30 , Issue.25 , pp. 2836-2845
    • Meng, L.1
  • 173
    • 84878917282 scopus 로고    scopus 로고
    • Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis
    • Minina E.A., et al. Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis. Aging Cell 2013, 12(2):327-329.
    • (2013) Aging Cell , vol.12 , Issue.2 , pp. 327-329
    • Minina, E.A.1
  • 174
    • 77954951851 scopus 로고    scopus 로고
    • TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
    • Mittal D., et al. TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J. 2010, 29(13):2242-2252.
    • (2010) EMBO J. , vol.29 , Issue.13 , pp. 2242-2252
    • Mittal, D.1
  • 176
    • 0013844612 scopus 로고
    • A soluble protein characteristic of the nervous system
    • Moore B.W. A soluble protein characteristic of the nervous system. Biochem. Biophys. Res. Commun. 1965, 19(6):739-744.
    • (1965) Biochem. Biophys. Res. Commun. , vol.19 , Issue.6 , pp. 739-744
    • Moore, B.W.1
  • 177
    • 84866488172 scopus 로고    scopus 로고
    • The heat shock response: systems biology of proteotoxic stress in aging and disease
    • Morimoto R.I. The heat shock response: systems biology of proteotoxic stress in aging and disease. Cold Spring Harb. Symp. Quant. Biol. 2011, 76:91-99.
    • (2011) Cold Spring Harb. Symp. Quant. Biol. , vol.76 , pp. 91-99
    • Morimoto, R.I.1
  • 178
    • 0742323000 scopus 로고    scopus 로고
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    • Morley J.F., Morimoto R.I. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol. Biol. Cell 2004, 15(2):657-664.
    • (2004) Mol. Biol. Cell , vol.15 , Issue.2 , pp. 657-664
    • Morley, J.F.1    Morimoto, R.I.2
  • 179
    • 2442649342 scopus 로고    scopus 로고
    • Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
    • Morrow G., et al. Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress. FASEB J. 2004, 18(3):598-599.
    • (2004) FASEB J. , vol.18 , Issue.3 , pp. 598-599
    • Morrow, G.1
  • 180
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky R., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124(2):315-329.
    • (2006) Cell , vol.124 , Issue.2 , pp. 315-329
    • Mostoslavsky, R.1
  • 181
    • 78651276219 scopus 로고    scopus 로고
    • Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans
    • Mouchiroud L., et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell 2011, 10(1):39-54.
    • (2011) Aging Cell , vol.10 , Issue.1 , pp. 39-54
    • Mouchiroud, L.1
  • 182
    • 0013462065 scopus 로고
    • A highly conserved repetitive DNA sequence: (TTAGGG)n, present at the telomeres of human chromosomes
    • Moyzis R.K., et al. A highly conserved repetitive DNA sequence: (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. U.S.A. 1988, 85(18):6622-6626.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , Issue.18 , pp. 6622-6626
    • Moyzis, R.K.1
  • 183
    • 0035882102 scopus 로고    scopus 로고
    • New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal
    • Muller S., et al. New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal. EMBO J. 2001, 20(16):4337-4340.
    • (2001) EMBO J. , vol.20 , Issue.16 , pp. 4337-4340
    • Muller, S.1
  • 184
    • 0028953056 scopus 로고
    • A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells: but not on normal cells
    • Multhoff G., et al. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells: but not on normal cells. Int. J. Cancer 1995, 61(2):272-279.
    • (1995) Int. J. Cancer , vol.61 , Issue.2 , pp. 272-279
    • Multhoff, G.1
  • 186
    • 84875892111 scopus 로고    scopus 로고
    • Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease
    • Murrow L., Debnath J. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu. Rev. Pathol. 2013, 8:105-137.
    • (2013) Annu. Rev. Pathol. , vol.8 , pp. 105-137
    • Murrow, L.1    Debnath, J.2
  • 187
    • 78650806593 scopus 로고    scopus 로고
    • Suppression of inflammation by a synthetic histone mimic
    • Nicodeme E., et al. Suppression of inflammation by a synthetic histone mimic. Nature 2010, 468(7327):1119-1123.
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1119-1123
    • Nicodeme, E.1
  • 188
    • 33845914051 scopus 로고    scopus 로고
    • A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
    • Niedernhofer L.J., et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006, 444(7122):1038-1043.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1038-1043
    • Niedernhofer, L.J.1
  • 189
    • 0025332602 scopus 로고
    • Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster
    • Niedzwiecki A., Fleming J.E. Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster. Mech. Ageing Dev. 1990, 52(2-3):295-304.
    • (1990) Mech. Ageing Dev. , vol.52 , Issue.2-3 , pp. 295-304
    • Niedzwiecki, A.1    Fleming, J.E.2
  • 190
    • 0000839280 scopus 로고    scopus 로고
    • Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    • O'Hagan R.C., et al. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2002, 2(2):149-155.
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 149-155
    • O'Hagan, R.C.1
  • 191
    • 77649180958 scopus 로고    scopus 로고
    • Telomeres: protecting chromosomes against genome instability
    • O'Sullivan R.J., Karlseder J. Telomeres: protecting chromosomes against genome instability. Nat. Rev. Mol. Cell Biol. 2010, 11(3):171-181.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , Issue.3 , pp. 171-181
    • O'Sullivan, R.J.1    Karlseder, J.2
  • 192
    • 77957814604 scopus 로고    scopus 로고
    • Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
    • O'Sullivan R.J., et al. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat. Struct. Mol. Biol. 2010, 17(10):1218-1225.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , Issue.10 , pp. 1218-1225
    • O'Sullivan, R.J.1
  • 193
    • 84862616714 scopus 로고    scopus 로고
    • Longevity pathways: HSF1 and FoxO pathways, a new therapeutic target to prevent age-related diseases
    • Perez F.P., et al. Longevity pathways: HSF1 and FoxO pathways, a new therapeutic target to prevent age-related diseases. Curr. Aging Sci. 2012, 5(2):87-95.
    • (2012) Curr. Aging Sci. , vol.5 , Issue.2 , pp. 87-95
    • Perez, F.P.1
  • 194
    • 84864882450 scopus 로고    scopus 로고
    • HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
    • Polanska E., et al. HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. Chromosoma 2012, 121(4):419-431.
    • (2012) Chromosoma , vol.121 , Issue.4 , pp. 419-431
    • Polanska, E.1
  • 195
    • 79952235291 scopus 로고    scopus 로고
    • Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
    • Polo S.E., Jackson S.P. Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev. 2011, 25(5):409-433.
    • (2011) Genes Dev. , vol.25 , Issue.5 , pp. 409-433
    • Polo, S.E.1    Jackson, S.P.2
  • 196
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A., Esteller M. Epigenetic modifications and human disease. Nat. Biotechnol. 2010, 28(10):1057-1068.
    • (2010) Nat. Biotechnol. , vol.28 , Issue.10 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 197
    • 18444375559 scopus 로고    scopus 로고
    • The serum S100B concentration is age dependent
    • Portela L.V., et al. The serum S100B concentration is age dependent. Clin. Chem. 2002, 48(6 Pt 1):950-952.
    • (2002) Clin. Chem. , vol.48 , Issue.6 , pp. 950-952
    • Portela, L.V.1
  • 198
    • 0024154516 scopus 로고
    • In vitro acetylation of the liver HMG non-histone proteins and its modulation by spermine and dexamethasone during aging of rats
    • Prasad S., Thakur M.K. In vitro acetylation of the liver HMG non-histone proteins and its modulation by spermine and dexamethasone during aging of rats. Mol. Biol. Rep. 1988, 13(4):221-224.
    • (1988) Mol. Biol. Rep. , vol.13 , Issue.4 , pp. 221-224
    • Prasad, S.1    Thakur, M.K.2
  • 199
    • 0025278543 scopus 로고
    • Distribution of high mobility group proteins in different tissues of rats during aging
    • Prasad S., Thakur M.K. Distribution of high mobility group proteins in different tissues of rats during aging. Biochem. Int. 1990, 20(4):687-695.
    • (1990) Biochem. Int. , vol.20 , Issue.4 , pp. 687-695
    • Prasad, S.1    Thakur, M.K.2
  • 200
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz J.D., White E. Autophagy and metabolism. Science 2010, 330(6009):1344-1348.
    • (2010) Science , vol.330 , Issue.6009 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 201
    • 26444478269 scopus 로고    scopus 로고
    • Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation
    • Ramasamy R., et al. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 2005, 15(7):16R-28R.
    • (2005) Glycobiology , vol.15 , Issue.7 , pp. 16R-28R
    • Ramasamy, R.1
  • 202
    • 0030898101 scopus 로고    scopus 로고
    • Myeloid-related protein (MRP) 8 and MRP14: calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway
    • Rammes A., et al. Myeloid-related protein (MRP) 8 and MRP14: calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J. Biol. Chem. 1997, 272(14):9496-9502.
    • (1997) J. Biol. Chem. , vol.272 , Issue.14 , pp. 9496-9502
    • Rammes, A.1
  • 203
    • 67650711140 scopus 로고    scopus 로고
    • Genome-wide views of chromatin structure
    • Rando O.J., Chang H.Y. Genome-wide views of chromatin structure. Annu. Rev. Biochem. 2009, 78:245-271.
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 245-271
    • Rando, O.J.1    Chang, H.Y.2
  • 204
    • 84892882660 scopus 로고    scopus 로고
    • A dual role for autophagy in a murine model of lung cancer
    • Rao S., et al. A dual role for autophagy in a murine model of lung cancer. Nat. Commun. 2014, 5:3056.
    • (2014) Nat. Commun. , vol.5 , pp. 3056
    • Rao, S.1
  • 205
    • 0034857281 scopus 로고    scopus 로고
    • Neuroendocrinology of ageing
    • Rehman H.U., Masson E.A. Neuroendocrinology of ageing. Age Ageing 2001, 30(4):279-287.
    • (2001) Age Ageing , vol.30 , Issue.4 , pp. 279-287
    • Rehman, H.U.1    Masson, E.A.2
  • 206
    • 84856905397 scopus 로고    scopus 로고
    • Loss of epidermal hypoxia-inducible factor-1alpha accelerates epidermal aging and affects re-epithelialization in human and mouse
    • Rezvani H.R., et al. Loss of epidermal hypoxia-inducible factor-1alpha accelerates epidermal aging and affects re-epithelialization in human and mouse. J. Cell Sci. 2011, 124(Pt 24):4172-4183.
    • (2011) J. Cell Sci. , vol.124 , pp. 4172-4183
    • Rezvani, H.R.1
  • 207
    • 78649346692 scopus 로고    scopus 로고
    • The heat shock response: life on the verge of death
    • Richter K., Haslbeck M., Buchner J. The heat shock response: life on the verge of death. Mol. Cell 2010, 40(2):253-266.
    • (2010) Mol. Cell , vol.40 , Issue.2 , pp. 253-266
    • Richter, K.1    Haslbeck, M.2    Buchner, J.3
  • 208
    • 84904607895 scopus 로고    scopus 로고
    • Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
    • Rickenbacher A., et al. Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice. J. Hepatol. 2014, 61(2):301-308.
    • (2014) J. Hepatol. , vol.61 , Issue.2 , pp. 301-308
    • Rickenbacher, A.1
  • 209
    • 79951912532 scopus 로고    scopus 로고
    • Four faces of cellular senescence
    • Rodier F., Campisi J. Four faces of cellular senescence. J. Cell Biol. 2011, 192(4):547-556.
    • (2011) J. Cell Biol. , vol.192 , Issue.4 , pp. 547-556
    • Rodier, F.1    Campisi, J.2
  • 210
    • 38048999665 scopus 로고    scopus 로고
    • Two faces of p53: aging and tumor suppression
    • Rodier F., Campisi J., Bhaumik D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 2007, 35(22):7475-7484.
    • (2007) Nucleic Acids Res. , vol.35 , Issue.22 , pp. 7475-7484
    • Rodier, F.1    Campisi, J.2    Bhaumik, D.3
  • 211
    • 0035978090 scopus 로고    scopus 로고
    • S100A8 and S100A9 in inflammatory diseases
    • Roth J., Goebeler M., Sorg C. S100A8 and S100A9 in inflammatory diseases. Lancet 2001, 357(9261):p1041.
    • (2001) Lancet , vol.357 , Issue.9261 , pp. p1041
    • Roth, J.1    Goebeler, M.2    Sorg, C.3
  • 212
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox
    • Rubartelli A., Lotze M.T. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol. 2007, 28(10):429-436.
    • (2007) Trends Immunol. , vol.28 , Issue.10 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 213
    • 25844492027 scopus 로고    scopus 로고
    • Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells
    • Saito K., Dai Y., Ohtsuka K. Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells. Exp. Cell Res. 2005, 310(1):229-236.
    • (2005) Exp. Cell Res. , vol.310 , Issue.1 , pp. 229-236
    • Saito, K.1    Dai, Y.2    Ohtsuka, K.3
  • 214
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A., et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 2004, 73:39-85.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 39-85
    • Sancar, A.1
  • 215
    • 18744382481 scopus 로고    scopus 로고
    • Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas
    • Sasahira T., et al. Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas. Virchows Arch. 2005, 446(4):411-415.
    • (2005) Virchows Arch. , vol.446 , Issue.4 , pp. 411-415
    • Sasahira, T.1
  • 216
    • 33847727064 scopus 로고    scopus 로고
    • The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma
    • Sasahira T., et al. The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma. Virchows Arch. 2007, 450(3):287-295.
    • (2007) Virchows Arch. , vol.450 , Issue.3 , pp. 287-295
    • Sasahira, T.1
  • 217
    • 84883476818 scopus 로고    scopus 로고
    • Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
    • Satoh A., et al. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 2013, 18(3):416-430.
    • (2013) Cell Metab. , vol.18 , Issue.3 , pp. 416-430
    • Satoh, A.1
  • 218
    • 33745203038 scopus 로고    scopus 로고
    • The biochemistry of sirtuins
    • Sauve A.A., et al. The biochemistry of sirtuins. Annu. Rev. Biochem. 2006, 75:435-465.
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 435-465
    • Sauve, A.A.1
  • 219
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418(6894):191-195.
    • (2002) Nature , vol.418 , Issue.6894 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 220
    • 0029669991 scopus 로고    scopus 로고
    • The S100 family of EF-hand calcium-binding proteins: functions and pathology
    • Schafer B.W., Heizmann C.W. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem. Sci. 1996, 21(4):134-140.
    • (1996) Trends Biochem. Sci. , vol.21 , Issue.4 , pp. 134-140
    • Schafer, B.W.1    Heizmann, C.W.2
  • 221
    • 2642575862 scopus 로고    scopus 로고
    • Functional significance of metastasis-inducing S100A4(Mts1) in tumor-stroma interplay
    • Schmidt-Hansen B., et al. Functional significance of metastasis-inducing S100A4(Mts1) in tumor-stroma interplay. J. Biol. Chem. 2004, 279(23):24498-24504.
    • (2004) J. Biol. Chem. , vol.279 , Issue.23 , pp. 24498-24504
    • Schmidt-Hansen, B.1
  • 222
    • 84870874690 scopus 로고    scopus 로고
    • The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
    • Sebastian C., et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012, 151(6):1185-1199.
    • (2012) Cell , vol.151 , Issue.6 , pp. 1185-1199
    • Sebastian, C.1
  • 223
    • 84866601479 scopus 로고    scopus 로고
    • Regulation of metabolism by hypoxia-inducible factor 1
    • Semenza G.L. Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harb. Symp. Quant. Biol. 2011, 76:347-353.
    • (2011) Cold Spring Harb. Symp. Quant. Biol. , vol.76 , pp. 347-353
    • Semenza, G.L.1
  • 224
    • 84866754237 scopus 로고    scopus 로고
    • An immunosurveillance mechanism controls cancer cell ploidy
    • Senovilla L., et al. An immunosurveillance mechanism controls cancer cell ploidy. Science 2012, 337(6102):1678-1684.
    • (2012) Science , vol.337 , Issue.6102 , pp. 1678-1684
    • Senovilla, L.1
  • 225
    • 84888134171 scopus 로고    scopus 로고
    • Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans
    • Seo K., et al. Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell 2013, 12(6):1073-1081.
    • (2013) Aging Cell , vol.12 , Issue.6 , pp. 1073-1081
    • Seo, K.1
  • 226
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
    • Seong S.Y., Matzinger P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 2004, 4(6):469-478.
    • (2004) Nat. Rev. Immunol. , vol.4 , Issue.6 , pp. 469-478
    • Seong, S.Y.1    Matzinger, P.2
  • 227
    • 84860456242 scopus 로고    scopus 로고
    • Removal of shelterin reveals the telomere end-protection problem
    • Sfeir A., de Lange T. Removal of shelterin reveals the telomere end-protection problem. Science 2012, 336(6081):593-597.
    • (2012) Science , vol.336 , Issue.6081 , pp. 593-597
    • Sfeir, A.1    de Lange, T.2
  • 228
    • 2342620177 scopus 로고    scopus 로고
    • Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome
    • Shapiro L.A., Marks A., Whitaker-Azmitia P.M. Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome. Brain Res. 2004, 1010(1-2):17-21.
    • (2004) Brain Res. , vol.1010 , Issue.1-2 , pp. 17-21
    • Shapiro, L.A.1    Marks, A.2    Whitaker-Azmitia, P.M.3
  • 230
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi L.Z., et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 2011, 208(7):1367-1376.
    • (2011) J. Exp. Med. , vol.208 , Issue.7 , pp. 1367-1376
    • Shi, L.Z.1
  • 231
    • 0037470247 scopus 로고    scopus 로고
    • Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function
    • Shin B.K., et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J. Biol. Chem. 2003, 278(9):7607-7616.
    • (2003) J. Biol. Chem. , vol.278 , Issue.9 , pp. 7607-7616
    • Shin, B.K.1
  • 232
    • 37349051709 scopus 로고    scopus 로고
    • Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase
    • Shinmura K., et al. Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation 2007, 116(24):2809-2817.
    • (2007) Circulation , vol.116 , Issue.24 , pp. 2809-2817
    • Shinmura, K.1
  • 233
    • 84872160110 scopus 로고    scopus 로고
    • Influence of threonine metabolism on S-adenosylmethionine and histone methylation
    • Shyh-Chang N., et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 2013, 339(6116):222-226.
    • (2013) Science , vol.339 , Issue.6116 , pp. 222-226
    • Shyh-Chang, N.1
  • 234
    • 1342286733 scopus 로고    scopus 로고
    • Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunction
    • Simm A., et al. Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunction. Exp. Gerontol. 2004, 39(3):407-413.
    • (2004) Exp. Gerontol. , vol.39 , Issue.3 , pp. 407-413
    • Simm, A.1
  • 235
    • 74949140154 scopus 로고    scopus 로고
    • S100A6 (calcyclin) deficiency induces senescence-like changes in cell cycle, morphology and functional characteristics of mouse NIH 3T3 fibroblasts
    • Slomnicki L.P., Lesniak W. S100A6 (calcyclin) deficiency induces senescence-like changes in cell cycle, morphology and functional characteristics of mouse NIH 3T3 fibroblasts. J. Cell Biochem. 2010, 109(3):576-584.
    • (2010) J. Cell Biochem. , vol.109 , Issue.3 , pp. 576-584
    • Slomnicki, L.P.1    Lesniak, W.2
  • 236
    • 84858142662 scopus 로고    scopus 로고
    • MicroRNAs and their roles in aging
    • Smith-Vikos T., Slack F.J. MicroRNAs and their roles in aging. J. Cell Sci. 2012, 125(Pt 1):7-17.
    • (2012) J. Cell Sci. , vol.125 , pp. 7-17
    • Smith-Vikos, T.1    Slack, F.J.2
  • 237
    • 84868530905 scopus 로고    scopus 로고
    • RAGE in tissue homeostasis: repair and regeneration
    • Sorci G., et al. RAGE in tissue homeostasis: repair and regeneration. Biochim. Biophys. Acta 2013, 1833(1):101-109.
    • (2013) Biochim. Biophys. Acta , vol.1833 , Issue.1 , pp. 101-109
    • Sorci, G.1
  • 238
    • 64749107607 scopus 로고    scopus 로고
    • RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
    • Sparvero L.J., et al. RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation. J. Transl. Med. 2009, 7:17.
    • (2009) J. Transl. Med. , vol.7 , pp. 17
    • Sparvero, L.J.1
  • 239
    • 0036512171 scopus 로고    scopus 로고
    • Roles of heat-shock proteins in innate and adaptive immunity
    • Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2002, 2(3):185-194.
    • (2002) Nat. Rev. Immunol. , vol.2 , Issue.3 , pp. 185-194
    • Srivastava, P.1
  • 240
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403(6765):41-45.
    • (2000) Nature , vol.403 , Issue.6765 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 241
    • 0028979675 scopus 로고
    • A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
    • Suto R., Srivastava P.K. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 1995, 269(5230):1585-1588.
    • (1995) Science , vol.269 , Issue.5230 , pp. 1585-1588
    • Suto, R.1    Srivastava, P.K.2
  • 242
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suva M.L., Riggi N., Bernstein B.E. Epigenetic reprogramming in cancer. Science 2013, 339(6127):1567-1570.
    • (2013) Science , vol.339 , Issue.6127 , pp. 1567-1570
    • Suva, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 243
    • 0034682315 scopus 로고    scopus 로고
    • Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
    • Taguchi A., et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000, 405(6784):354-360.
    • (2000) Nature , vol.405 , Issue.6784 , pp. 354-360
    • Taguchi, A.1
  • 244
    • 84876499607 scopus 로고    scopus 로고
    • Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy
    • Takahashi Y., et al. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Blood 2013.
    • (2013) Blood
    • Takahashi, Y.1
  • 245
    • 33847775295 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1
    • Tang D., et al. Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J. Leukoc. Biol. 2007, 81(3):741-747.
    • (2007) J. Leukoc. Biol. , vol.81 , Issue.3 , pp. 741-747
    • Tang, D.1
  • 246
    • 34249779532 scopus 로고    scopus 로고
    • Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release
    • Tang D., et al. Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. J. Immunol. 2007, 178(11):7376-7384.
    • (2007) J. Immunol. , vol.178 , Issue.11 , pp. 7376-7384
    • Tang, D.1
  • 247
    • 34548760956 scopus 로고    scopus 로고
    • The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages
    • Tang D., et al. The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J. Immunol. 2007, 179(2):1236-1244.
    • (2007) J. Immunol. , vol.179 , Issue.2 , pp. 1236-1244
    • Tang, D.1
  • 248
    • 71049128963 scopus 로고    scopus 로고
    • Quercetin prevents lipopolysaccharide-induced HMGB1 release and proinflammatory function
    • Tang D., et al. Quercetin prevents lipopolysaccharide-induced HMGB1 release and proinflammatory function. Am. J. Respir. Cell. Mol. Biol. 2009, 41(6):651-660.
    • (2009) Am. J. Respir. Cell. Mol. Biol. , vol.41 , Issue.6 , pp. 651-660
    • Tang, D.1
  • 249
    • 74549175673 scopus 로고    scopus 로고
    • High-mobility group box 1 and cancer
    • Tang D., et al. High-mobility group box 1 and cancer. Biochim. Biophys. Acta 2010, 1799(1-2):131-140.
    • (2010) Biochim. Biophys. Acta , vol.1799 , Issue.1-2 , pp. 131-140
    • Tang, D.1
  • 250
    • 77956386515 scopus 로고    scopus 로고
    • Endogenous HMGB1 regulates autophagy
    • Tang D., et al. Endogenous HMGB1 regulates autophagy. J. Cell Biol. 2010, 190(5):881-892.
    • (2010) J. Cell Biol. , vol.190 , Issue.5 , pp. 881-892
    • Tang, D.1
  • 251
    • 77957106729 scopus 로고    scopus 로고
    • HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
    • Tang D., et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 2010, 29(38):5299-5310.
    • (2010) Oncogene , vol.29 , Issue.38 , pp. 5299-5310
    • Tang, D.1
  • 252
    • 79952366675 scopus 로고    scopus 로고
    • High-mobility group box 1: oxidative stress, and disease
    • Tang D., et al. High-mobility group box 1: oxidative stress, and disease. Antioxid. Redox Signal. 2011, 14(7):1315-1335.
    • (2011) Antioxid. Redox Signal. , vol.14 , Issue.7 , pp. 1315-1335
    • Tang, D.1
  • 253
    • 79958050965 scopus 로고    scopus 로고
    • High-mobility group box 1 is essential for mitochondrial quality control
    • Tang D., et al. High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab. 2011, 13(6):701-711.
    • (2011) Cell Metab. , vol.13 , Issue.6 , pp. 701-711
    • Tang, D.1
  • 254
    • 80052589806 scopus 로고    scopus 로고
    • High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    • Tang D., et al. High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress. Antioxid. Redox Signal. 2011, 15(8):2185-2195.
    • (2011) Antioxid. Redox Signal. , vol.15 , Issue.8 , pp. 2185-2195
    • Tang, D.1
  • 255
    • 84865299726 scopus 로고    scopus 로고
    • PAMPs and DAMPs: signal 0s that spur autophagy and immunity
    • Tang D., et al. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol. Rev. 2012, 249(1):158-175.
    • (2012) Immunol. Rev. , vol.249 , Issue.1 , pp. 158-175
    • Tang, D.1
  • 256
    • 84907375442 scopus 로고    scopus 로고
    • HMGB1 phenotypic role revealed with stress
    • Tang D., et al. HMGB1 phenotypic role revealed with stress. Mol. Med. 2014, 20(1):359-362.
    • (2014) Mol. Med. , vol.20 , Issue.1 , pp. 359-362
    • Tang, D.1
  • 258
    • 0026110912 scopus 로고
    • Analysis of age-associated alteration in the synthesis of HMG nonhistone proteins of the rat liver
    • Thakur M.K., Prasad S. Analysis of age-associated alteration in the synthesis of HMG nonhistone proteins of the rat liver. Mol. Biol. Rep. 1991, 15(1):19-24.
    • (1991) Mol. Biol. Rep. , vol.15 , Issue.1 , pp. 19-24
    • Thakur, M.K.1    Prasad, S.2
  • 259
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian J., et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 2007, 8(5):487-496.
    • (2007) Nat. Immunol. , vol.8 , Issue.5 , pp. 487-496
    • Tian, J.1
  • 260
    • 0033982418 scopus 로고    scopus 로고
    • Differential expression of S100B and S100A6(1) in the human fetal and aged cerebral cortex
    • Tiu S.C., et al. Differential expression of S100B and S100A6(1) in the human fetal and aged cerebral cortex. Brain Res. Dev. Brain Res. 2000, 119(2):159-168.
    • (2000) Brain Res. Dev. Brain Res. , vol.119 , Issue.2 , pp. 159-168
    • Tiu, S.C.1
  • 261
    • 38449105997 scopus 로고    scopus 로고
    • The aging process and potential interventions to extend life expectancy
    • Tosato M., et al. The aging process and potential interventions to extend life expectancy. Clin. Interv. Aging 2007, 2(3):401-412.
    • (2007) Clin. Interv. Aging , vol.2 , Issue.3 , pp. 401-412
    • Tosato, M.1
  • 262
    • 38349084667 scopus 로고    scopus 로고
    • RAGE: diabetes, and the nervous system
    • Toth C., Martinez J., Zochodne D.W. RAGE: diabetes, and the nervous system. Curr. Mol. Med. 2007, 7(8):766-776.
    • (2007) Curr. Mol. Med. , vol.7 , Issue.8 , pp. 766-776
    • Toth, C.1    Martinez, J.2    Zochodne, D.W.3
  • 263
  • 264
    • 67149133632 scopus 로고    scopus 로고
    • Heat shock proteins and immune system
    • Tsan M.F., Gao B. Heat shock proteins and immune system. J. Leukoc. Biol. 2009, 85(6):905-910.
    • (2009) J. Leukoc. Biol. , vol.85 , Issue.6 , pp. 905-910
    • Tsan, M.F.1    Gao, B.2
  • 265
    • 36548999695 scopus 로고    scopus 로고
    • HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling
    • Tsung A., et al. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J. Exp. Med. 2007, 204(12):2913-2923.
    • (2007) J. Exp. Med. , vol.204 , Issue.12 , pp. 2913-2923
    • Tsung, A.1
  • 266
    • 80052381608 scopus 로고    scopus 로고
    • Characterization of extracellular circulating microRNA
    • Turchinovich A., et al. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011, 39(16):7223-7233.
    • (2011) Nucleic Acids Res. , vol.39 , Issue.16 , pp. 7223-7233
    • Turchinovich, A.1
  • 267
    • 84872615463 scopus 로고    scopus 로고
    • Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1
    • van Beijnum J.R., et al. Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1. Oncogene 2013, 32(3):363-374.
    • (2013) Oncogene , vol.32 , Issue.3 , pp. 363-374
    • van Beijnum, J.R.1
  • 268
    • 84888198135 scopus 로고    scopus 로고
    • Insulin, IGF-1 and longevity
    • van Heemst D. Insulin, IGF-1 and longevity. Aging Dis. 2010, 1(2):147-157.
    • (2010) Aging Dis. , vol.1 , Issue.2 , pp. 147-157
    • van Heemst, D.1
  • 269
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324(5930):1029-1033.
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 270
    • 58149337527 scopus 로고    scopus 로고
    • Inflammation, ageing and cancer
    • Vasto S., et al. Inflammation, ageing and cancer. Mech. Ageing Dev. 2009, 130(1-2):40-45.
    • (2009) Mech. Ageing Dev. , vol.130 , Issue.1-2 , pp. 40-45
    • Vasto, S.1
  • 271
    • 56649115881 scopus 로고    scopus 로고
    • Epigenetic regulation of telomeres in human cancer
    • Vera E., et al. Epigenetic regulation of telomeres in human cancer. Oncogene 2008, 27(54):6817-6833.
    • (2008) Oncogene , vol.27 , Issue.54 , pp. 6817-6833
    • Vera, E.1
  • 272
    • 84873635293 scopus 로고    scopus 로고
    • Genome instability and aging
    • Vijg J., Suh Y. Genome instability and aging. Annu. Rev. Physiol. 2013, 75:645-668.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 645-668
    • Vijg, J.1    Suh, Y.2
  • 273
    • 34948900275 scopus 로고    scopus 로고
    • Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4: promoting lethal, endotoxin-induced shock
    • Vogl T., et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4: promoting lethal, endotoxin-induced shock. Nat. Med. 2007, 13(9):1042-1049.
    • (2007) Nat. Med. , vol.13 , Issue.9 , pp. 1042-1049
    • Vogl, T.1
  • 274
    • 84877930649 scopus 로고    scopus 로고
    • Targeting histone modifications-epigenetics in cancer
    • Waldmann T., Schneider R. Targeting histone modifications-epigenetics in cancer. Curr. Opin. Cell Biol. 2013, 25(2):184-189.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , Issue.2 , pp. 184-189
    • Waldmann, T.1    Schneider, R.2
  • 275
    • 84899651248 scopus 로고    scopus 로고
    • Good things come in small packages: exosomes, immunity and cancer
    • Wang W., Lotze M.T. Good things come in small packages: exosomes, immunity and cancer. Cancer Gene Ther. 2014, 21(4):139-141.
    • (2014) Cancer Gene Ther. , vol.21 , Issue.4 , pp. 139-141
    • Wang, W.1    Lotze, M.T.2
  • 276
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H., et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999, 285(5425):248-251.
    • (1999) Science , vol.285 , Issue.5425 , pp. 248-251
    • Wang, H.1
  • 277
    • 4344591769 scopus 로고    scopus 로고
    • Multiple-stress analysis for isolation of Drosophila longevity genes
    • Wang H.D., Kazemi-Esfarjani P., Benzer S. Multiple-stress analysis for isolation of Drosophila longevity genes. Proc. Natl. Acad. Sci. U.S.A. 2004, 101(34):12610-12615.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , Issue.34 , pp. 12610-12615
    • Wang, H.D.1    Kazemi-Esfarjani, P.2    Benzer, S.3
  • 278
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 2012, 12(6):401-410.
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.6 , pp. 401-410
    • White, E.1
  • 279
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong K.K., et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003, 421(6923):643-648.
    • (2003) Nature , vol.421 , Issue.6923 , pp. 643-648
    • Wong, K.K.1
  • 280
    • 0037023680 scopus 로고    scopus 로고
    • Apoptotic release of histones from nucleosomes
    • Wu D., et al. Apoptotic release of histones from nucleosomes. J. Biol. Chem. 2002, 277(14):12001-12008.
    • (2002) J. Biol. Chem. , vol.277 , Issue.14 , pp. 12001-12008
    • Wu, D.1
  • 281
    • 70449107044 scopus 로고    scopus 로고
    • Extracellular histones are major mediators of death in sepsis
    • Xu J., et al. Extracellular histones are major mediators of death in sepsis. Nat. Med. 2009, 15(11):1318-1321.
    • (2009) Nat. Med. , vol.15 , Issue.11 , pp. 1318-1321
    • Xu, J.1
  • 282
    • 80051882006 scopus 로고    scopus 로고
    • Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury
    • Xu J., et al. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J. Immunol. 2011, 187(5):2626-2631.
    • (2011) J. Immunol. , vol.187 , Issue.5 , pp. 2626-2631
    • Xu, J.1
  • 283
    • 84875894854 scopus 로고    scopus 로고
    • The role of telomere biology in cancer
    • Xu L., Li S., Stohr B.A. The role of telomere biology in cancer. Annu. Rev. Pathol. 2013, 8:49-78.
    • (2013) Annu. Rev. Pathol. , vol.8 , pp. 49-78
    • Xu, L.1    Li, S.2    Stohr, B.A.3
  • 284
    • 84905053185 scopus 로고    scopus 로고
    • Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis
    • Xu J., et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014, 21(8):1229-1239.
    • (2014) Cell Death Differ. , vol.21 , Issue.8 , pp. 1229-1239
    • Xu, J.1
  • 285
    • 84890839101 scopus 로고    scopus 로고
    • Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection
    • Yanai H., et al. Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(51):20699-20704.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , Issue.51 , pp. 20699-20704
    • Yanai, H.1
  • 286
    • 84904489275 scopus 로고    scopus 로고
    • PKM2 regulates the Warburg effect and promotes HMGB1 release in Sepsis
    • Yang L., et al. PKM2 regulates the Warburg effect and promotes HMGB1 release in Sepsis. Nat. Commun. 2014, 5:4436.
    • (2014) Nat. Commun. , vol.5 , pp. 4436
    • Yang, L.1
  • 287
    • 84901356565 scopus 로고    scopus 로고
    • S100A8 contributes to drug resistance by promoting autophagy in leukemia cells
    • Yang M., et al. S100A8 contributes to drug resistance by promoting autophagy in leukemia cells. PLoS One 2014, 9(5):e97242.
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e97242
    • Yang, M.1
  • 288
    • 0037051942 scopus 로고    scopus 로고
    • Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75
    • Yokoyama K., et al. Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett. 2002, 516(1-3):53-57.
    • (2002) FEBS Lett. , vol.516 , Issue.1-3 , pp. 53-57
    • Yokoyama, K.1
  • 289
    • 84885167222 scopus 로고    scopus 로고
    • Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
    • Youm Y.H., et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013, 18(4):519-532.
    • (2013) Cell Metab. , vol.18 , Issue.4 , pp. 519-532
    • Youm, Y.H.1
  • 290
    • 34547912119 scopus 로고    scopus 로고
    • Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex
    • Yu E.Y., et al. Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex. Mol. Cell. Biol. 2007, 27(16):5639-5649.
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.16 , pp. 5639-5649
    • Yu, E.Y.1
  • 291
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H., Pardoll D., Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 2009, 9(11):798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 292
    • 84877328234 scopus 로고    scopus 로고
    • DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death
    • Zhang Q., et al. DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy 2013, 9(4):451-458.
    • (2013) Autophagy , vol.9 , Issue.4 , pp. 451-458
    • Zhang, Q.1
  • 293
    • 84860918805 scopus 로고    scopus 로고
    • A dual role for UVRAG in maintaining chromosomal stability independent of autophagy
    • Zhao Z., et al. A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell 2012, 22(5):1001-1016.
    • (2012) Dev Cell , vol.22 , Issue.5 , pp. 1001-1016
    • Zhao, Z.1
  • 294
    • 84858643750 scopus 로고    scopus 로고
    • Inflammasomes in carcinogenesis and anticancer immune responses
    • Zitvogel L., et al. Inflammasomes in carcinogenesis and anticancer immune responses. Nat. Immunol. 2012, 13(4):343-351.
    • (2012) Nat. Immunol. , vol.13 , Issue.4 , pp. 343-351
    • Zitvogel, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.