p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

Journal of Cell Biology

Volumn 201, Issue 4, 2013, Pages 613-629

  Davalos, Albert R ^a,b   Kawahara, Misako ^a   Malhotra, Gautam K ^a   Schaum, Nicholas ^b   Huang, Jiahao ^a   Ved, Urvi ^a   Beausejour, Christian M ^c   Coppe, Jean Philippe ^a   Rodoer, Francis ^a,b   Campisi, Judith ^a,b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; PROTEIN P53; STROMELYSIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL LOSS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; EXTRACELLULAR SPACE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL AGING; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOKINES; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HMGB1 PROTEIN; HUMANS; INFLAMMATION; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84878619211     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201206006     Document Type: Article

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