The DNA methyltransferases of mammals

Human Molecular Genetics

Volumn 9, Issue 16 REV. ISS., 2000, Pages 2395-2402

  Bestor, T H ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; CYTOSINE; DNA METHYLTRANSFERASE; MESSENGER RNA;

ANIMAL TISSUE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DNA METHYLATION; EMBRYO DEVELOPMENT; EXON; FEMALE; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE SILENCING; GENE STRUCTURE; GENETIC STABILITY; GENETIC TRANSCRIPTION; GENOME IMPRINTING; HUMAN; MALE; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; REVIEW; TRANSPOSON; X CHROMOSOME INACTIVATION;

ANIMALIA; MAMMALIA;

EID: 0033753779     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.16.2395     Document Type: Review

References (52)

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3. Modulation of DNA binding protein affinity directly affects target site demethylation
4. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster
5. Multipoint analysis of human chromosome 11p15/ mouse distal chromosome 7: Inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting
6. Sex brings transposons and genomes into conflict
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8. Interspersed repeats and other momentos of transposable elements in mammalian genomes
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10. Creation of genomic methylation patterns
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12. Epigenetic gene silencing in cancer
13. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
14. Direct identification of the active site nucleophile in a DNA (cytosine-5)-methyltransferase
15. On the mechanism of inhibition of DNA-cytosine methyltransferase by cytosine analogs
16. Enzymatic DNA methylation through a locally unpaired intermediate
17. HhaI methyltransferase flips its target base out of the DNA helix
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21. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzyme is related to bacterial restriction methyltransferases
22. DNA methyltransferases in mouse tissues and cells. Studies with a mechanism-based probe
23. Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases
24. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
25. DNA methylation, genomic imprinting, and mammalian development
26. Role for DNA methylation in genomic imprinting
27. Loss of methylation activates Xist in somatic but not in embryonic cells
28. DNA hypomethylation leads to elevated mutation rates
29. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
30. Sex-specific exons control DNA methyltransferase in mammalian germ cells
31. Localization and properties of DNA methyltransferase in preimplantation mouse embryos: Implications for genomic imprinting
32. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
33. Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation
34. Mechanisms for the involvement of DNA methylation in colon carcinogenesis
35. Cytosine methylation and human neoplasia
36. Transcriptional regulation of the human DNA methyltransferase (dnmt1) gene
37. Regulation of the DNA methyltransferase by the RAS-AP1 signaling pathway
38. The mouse DNA methyltransferase 5' region. A unique housekeeping gene promoter
39. New 5' regions of the murine and human genes for DNA (cytosine-5) methyltransferase
40. DNA methyltransferase is developmentally expressed in replicating and non-replicating male germ cells
41. A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast
42. The fission yeast gene pmt1+ encodes a DNA methyltransferase homologue
43. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
44. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
45. Localization of the ICF syndrome to chromosome 20 by homozygosity mapping
46. An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome
47. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
48. Whole-genome methylation scan in ICF syndrome: Hypomethylation of non-satellite DNA repeats D4Z4 and NBL2
49. Abnormal methylation does not prevent X inactivation in ICF patients
50. Activation of mammalian DNA methyltransferase by cleavage of a Zn-binding regulatory domain
51. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family
52. Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation