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Volumn 75, Issue , 2013, Pages 645-668

Genome instability and aging

Author keywords

Age related disease; DNA damage; Epimutations; Gene regulation; Genetic variation; Longevity; Mutations

Indexed keywords

MITOCHONDRIAL DNA;

EID: 84873635293     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-030212-183715     Document Type: Review
Times cited : (288)

References (131)
  • 1
    • 34248966321 scopus 로고
    • Biological mechanisms underlying the aging process
    • Curtis H. 1963. Biological mechanisms underlying the aging process. Science 141:686-94
    • (1963) Science , vol.141 , pp. 686-694
    • Curtis, H.1
  • 3
    • 0000572335 scopus 로고
    • The aging process and carcinogenesis
    • Failla G. 1958. The aging process and carcinogenesis. Ann. N. Y. Acad. Sci. 71:1124-35
    • (1958) Ann. N. Y. Acad. Sci. , vol.71 , pp. 1124-1135
    • Failla, G.1
  • 4
    • 0002235236 scopus 로고
    • On the nature of the aging process
    • Szilard L. 1959. On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45:30-45
    • (1959) Proc. Natl. Acad. Sci. USA , vol.45 , pp. 30-45
    • Szilard, L.1
  • 5
    • 33747830026 scopus 로고
    • Artificial transmutation of the gene
    • Muller HJ. 1927. Artificial transmutation of the gene. Science 66:84-87
    • (1927) Science , vol.66 , pp. 84-87
    • Muller, H.J.1
  • 6
  • 7
    • 14144250844 scopus 로고    scopus 로고
    • The onset of selection
    • de Duve C. 2005. The onset of selection. Nature 433:581-82
    • (2005) Nature , vol.433 , pp. 581-582
    • De Duve, C.1
  • 8
    • 0023496247 scopus 로고
    • The molecular basis of the evolution of sex
    • Bernstein H, Hopf FA, Michod RE. 1987. The molecular basis of the evolution of sex. Adv. Genet. 24:323-70
    • (1987) Adv. Genet. , vol.24 , pp. 323-370
    • Bernstein, H.1    Hopf, F.A.2    Michod, R.E.3
  • 9
    • 79961096926 scopus 로고    scopus 로고
    • Getting past the RNA world: The initial Darwinian ancestor
    • Yarus M. 2010. Getting past the RNA world: the initial Darwinian ancestor. Cold Spring Harb. Perspect. Biol. 3:a003590
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.3
    • Yarus, M.1
  • 11
    • 24644497236 scopus 로고    scopus 로고
    • Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
    • Erusalimsky JD, Kurz DJ. 2005. Cellular senescence in vivo: its relevance in ageing and cardiovascular disease. Exp. Gerontol. 40:634-42
    • (2005) Exp. Gerontol. , vol.40 , pp. 634-642
    • Erusalimsky, J.D.1    Kurz, D.J.2
  • 13
    • 0038049143 scopus 로고    scopus 로고
    • Cancer and ageing: Rival demons?
    • Campisi J. 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3:339-49
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 339-349
    • Campisi, J.1
  • 14
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366-74
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 15
    • 34247115941 scopus 로고    scopus 로고
    • Genome dynamics and transcriptional deregulation in aging
    • Busuttil R, Bahar R, Vijg J. 2007. Genome dynamics and transcriptional deregulation in aging. Neuroscience 145:1341-47
    • (2007) Neuroscience , vol.145 , pp. 1341-1347
    • Busuttil, R.1    Bahar, R.2    Vijg, J.3
  • 16
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • Lindahl T. 1993. Instability and decay of the primary structure of DNA. Nature 362:709-15
    • (1993) Nature , vol.362 , pp. 709-715
    • Lindahl, T.1
  • 18
    • 84870312272 scopus 로고    scopus 로고
    • Chromosome-specific accumulation of aneuploidy in the aging mouse brain
    • In press
    • Faggioli F, Wang T, Vijg J, Montagna C. 2012. Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Hum. Mol. Genet. In press
    • (2012) Hum. Mol. Genet
    • Faggioli, F.1    Wang, T.2    Vijg, J.3    Montagna, C.4
  • 19
    • 66749169417 scopus 로고    scopus 로고
    • Chromosome instability is common in human cleavage-stage embryos
    • Vanneste E, Voet T, Le Caignec C, Ampe M, Konings P, et al. 2009. Chromosome instability is common in human cleavage-stage embryos. Nat. Med. 15:577-83
    • (2009) Nat. Med. , vol.15 , pp. 577-583
    • Vanneste, E.1    Voet, T.2    Le Caignec, C.3    Ampe, M.4    Konings, P.5
  • 20
    • 0002029190 scopus 로고
    • Chromosomally abnormal gametes as a cause of developmental and congenital anomalies in humans
    • Kamiguchi Y, Tateno H, Mikamo K. 1994. Chromosomally abnormal gametes as a cause of developmental and congenital anomalies in humans. Congenit. Anom. 34:1-12
    • (1994) Congenit. Anom. , vol.34 , pp. 1-12
    • Kamiguchi, Y.1    Tateno, H.2    Mikamo, K.3
  • 21
    • 0023279221 scopus 로고
    • From oocyte to embryo: A model, deduced from in vitro fertilization, for natural selection against chromosome abnormalities
    • Plachot M, de Grouchy J, Junca AM, Mandelbaum J, Turleau C, et al. 1987. From oocyte to embryo: a model, deduced from in vitro fertilization, for natural selection against chromosome abnormalities. Ann. Genet. 30:22-32
    • (1987) Ann. Genet. , vol.30 , pp. 22-32
    • Plachot, M.1    De Grouchy, J.2    Junca, A.M.3    Mandelbaum, J.4    Turleau, C.5
  • 22
    • 4043128880 scopus 로고    scopus 로고
    • Features of chromosomal abnormalitiesinspontaneous abortion cell culture failures detectedbyinterphaseFISH analysis
    • Lebedev IN, Ostroverkhova NV, Nikitina TV, Sukhanova NN, Nazarenko SA. 2004. Features of chromosomal abnormalitiesinspontaneous abortion cell culture failures detectedbyinterphaseFISH analysis. Eur. J. Hum. Genet. 12:513-20
    • (2004) Eur. J. Hum. Genet. , vol.12 , pp. 513-520
    • Lebedev, I.N.1    Ostroverkhova, N.V.2    Nikitina, T.V.3    Sukhanova, N.N.4    Nazarenko, S.A.5
  • 23
    • 0034303523 scopus 로고    scopus 로고
    • The origins, patterns and implications of human spontaneous mutation
    • Crow JF. 2000. The origins, patterns and implications of human spontaneous mutation. Nat. Rev. Genet. 1:40-47
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 40-47
    • Crow, J.F.1
  • 24
    • 1042278890 scopus 로고    scopus 로고
    • Are we sure we know how to measure 8-oxo-7, 8-dihydroguanine in DNA from human cells?
    • Collins AR, Cadet J, Moller L, Poulsen HE, Vina J. 2004. Are we sure we know how to measure 8-oxo-7, 8-dihydroguanine in DNA from human cells? Arch. Biochem. Biophys. 423:57-65
    • (2004) Arch. Biochem. Biophys. , vol.423 , pp. 57-65
    • Collins, A.R.1    Cadet, J.2    Moller, L.3    Poulsen, H.E.4    Vina, J.5
  • 25
    • 0037139232 scopus 로고    scopus 로고
    • Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice
    • Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR. 2002. Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat. Res. 500:135-45
    • (2002) Mutat. Res. , vol.500 , pp. 135-145
    • Cabelof, D.C.1    Raffoul, J.J.2    Yanamadala, S.3    Ganir, C.4    Guo, Z.5    Heydari, A.R.6
  • 26
    • 28444474288 scopus 로고    scopus 로고
    • DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons
    • Vyjayanti VN, Rao KS. 2006. DNA double strand break repair in brain: reduced NHEJ activity in aging rat neurons. Neurosci. Lett. 393:18-22
    • (2006) Neurosci. Lett. , vol.393 , pp. 18-22
    • Vyjayanti, V.N.1    Rao, K.S.2
  • 27
    • 0029829265 scopus 로고    scopus 로고
    • The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
    • Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T. 1996. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc. Natl. Acad. Sci. USA 93:8919-23
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8919-8923
    • Xanthoudakis, S.1    Smeyne, R.J.2    Wallace, J.D.3    Curran, T.4
  • 28
    • 0001279015 scopus 로고
    • Distribution of human chromosome counts in relation to age
    • Jacobs PA, Court Brown WM, Doll R. 1961. Distribution of human chromosome counts in relation to age. Nature 191:1178-80
    • (1961) Nature , vol.191 , pp. 1178-1180
    • Jacobs, P.A.1    Court Brown, W.M.2    Doll, R.3
  • 29
    • 0000999226 scopus 로고
    • The development of somatic mutations in mice with age
    • Crowley C, Curtis HJ. 1963. The development of somatic mutations in mice with age. Proc. Natl. Acad. Sci. USA 49:626-28
    • (1963) Proc. Natl. Acad. Sci. USA , vol.49 , pp. 626-628
    • Crowley, C.1    Curtis, H.J.2
  • 30
    • 0029166930 scopus 로고
    • The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting
    • Ramsey MJ, Moore DH 2nd, Briner JF, Lee DA, Olsen L, et al. 1995. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res. 338:95-106
    • (1995) Mutat. Res. , vol.338 , pp. 95-106
    • Ramsey, M.J.1    Moore II, D.H.2    Briner, J.F.3    Lee, D.A.4    Olsen, L.5
  • 33
    • 0035319804 scopus 로고    scopus 로고
    • To err (meiotically) is human: The genesis of human aneuploidy
    • Hassold T, Hunt P. 2001. To err (meiotically) is human: the genesis of human aneuploidy. Nat. Rev. Genet. 2:280-91
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 280-291
    • Hassold, T.1    Hunt, P.2
  • 34
  • 35
    • 0034769358 scopus 로고    scopus 로고
    • HPRT mutations in humans: Biomarkers for mechanistic studies
    • Albertini RJ. 2001. HPRT mutations in humans: biomarkers for mechanistic studies. Mutat. Res. 489:1-16
    • (2001) Mutat. Res. , vol.489 , pp. 1-16
    • Albertini, R.J.1
  • 36
    • 0029144265 scopus 로고
    • Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans
    • Jones IM, Thomas CB, Tucker B, Thompson CL, Pleshanov P, et al. 1995. Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans. Mutat. Res. 338:129-39
    • (1995) Mutat. Res. , vol.338 , pp. 129-139
    • Jones, I.M.1    Thomas, C.B.2    Tucker, B.3    Thompson, C.L.4    Pleshanov, P.5
  • 37
    • 0027400411 scopus 로고
    • Effect of dietary restriction on in vivo somatic mutation in mice
    • Dempsey JL, Pfeiffer M, Morley AA. 1993. Effect of dietary restriction on in vivo somatic mutation in mice. Mutat. Res. 291:141-45
    • (1993) Mutat. Res. , vol.291 , pp. 141-145
    • Dempsey, J.L.1    Pfeiffer, M.2    Morley, A.A.3
  • 40
    • 0024374202 scopus 로고
    • Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
    • Gossen JA, de Leeuw WJ, Tan CH, Zwarthoff EC, Berends F, et al. 1989. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86:7971-75
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7971-7975
    • Gossen, J.A.1    De Leeuw, W.J.2    Tan, C.H.3    Zwarthoff, E.C.4    Berends, F.5
  • 41
    • 0027461464 scopus 로고
    • - phage using a galactose-sensitive E. coli host
    • - phage using a galactose-sensitive E. coli host. Biotechniques 14:326, 330
    • (1993) Biotechniques , vol.14 , Issue.326 , pp. 330
    • Gossen, J.A.1    Vijg, J.2
  • 42
  • 45
    • 0034682523 scopus 로고    scopus 로고
    • Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
    • Dollé ME, Snyder WK, Gossen JA, Lohman PH, Vijg J. 2000. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc. Natl. Acad. Sci. USA 97:8403-8
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8403-8408
    • Dollé, M.E.1    Snyder, W.K.2    Gossen, J.A.3    Lohman, P.H.4    Vijg, J.5
  • 46
    • 0037082948 scopus 로고    scopus 로고
    • Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice
    • Giese H, Snyder WK, van Oostrom C, van Steeg H, Dollé ME, Vijg J. 2002. Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Mutat. Res. 514:153-63
    • (2002) Mutat. Res. , vol.514 , pp. 153-163
    • Giese, H.1    Snyder, W.K.2    Van Oostrom, C.3    Van Steeg, H.4    Dollé, M.E.5    Vijg, J.6
  • 51
    • 0037342752 scopus 로고    scopus 로고
    • Somatic gene mutation and human disease other than cancer
    • Erickson R. 2003. Somatic gene mutation and human disease other than cancer. Mutat. Res. Rev. Mutat. Res. 543:125-36
    • (2003) Mutat. Res. Rev. Mutat. Res. , vol.543 , pp. 125-136
    • Erickson, R.1
  • 52
    • 77956161900 scopus 로고    scopus 로고
    • Somatic gene mutation and human disease other than cancer: An update
    • Erickson RP. 2010. Somatic gene mutation and human disease other than cancer: an update. Mutat. Res. 705:96-106
    • (2010) Mutat. Res. , vol.705 , pp. 96-106
    • Erickson, R.P.1
  • 53
    • 3242808027 scopus 로고    scopus 로고
    • Large-scale copy number polymorphism in the human genome
    • Sebat J, Lakshmi B, Troge J, Alexander J, Young J, et al. 2004. Large-scale copy number polymorphism in the human genome. Science 305:525-28
    • (2004) Science , vol.305 , pp. 525-528
    • Sebat, J.1    Lakshmi, B.2    Troge, J.3    Alexander, J.4    Young, J.5
  • 56
    • 84859646140 scopus 로고    scopus 로고
    • Somatic activation of AKT3 causes hemispheric developmental brain malformations
    • Poduri A, Evrony GD, Cai X, Elhosary PC, Beroukhim R, et al. 2012. Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron 74:41-48
    • (2012) Neuron , vol.74 , pp. 41-48
    • Poduri, A.1    Evrony, G.D.2    Cai, X.3    Elhosary, P.C.4    Beroukhim, R.5
  • 58
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, et al. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-52
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3    Holt, S.E.4    Chiu, C.P.5
  • 59
    • 0032171293 scopus 로고    scopus 로고
    • Comparison of chromosome telomere integrity in multiple tissues from subjects at different ages
    • Butler MG, Tilburt J, DeVries A, Muralidhar B, Aue G, et al. 1998. Comparison of chromosome telomere integrity in multiple tissues from subjects at different ages. Cancer Genet. Cytogenet. 105:138-44
    • (1998) Cancer Genet. Cytogenet. , vol.105 , pp. 138-144
    • Butler, M.G.1    Tilburt, J.2    Devries, A.3    Muralidhar, B.4    Aue, G.5
  • 60
    • 20544466648 scopus 로고    scopus 로고
    • Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
    • Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. 2005. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435:903-10
    • (2005) Nature , vol.435 , pp. 903-910
    • Muotri, A.R.1    Chu, V.T.2    Marchetto, M.C.3    Deng, W.4    Moran, J.V.5    Gage, F.H.6
  • 61
    • 81855178276 scopus 로고    scopus 로고
    • Somatic retrotransposition alters the genetic landscape of the human brain
    • Baillie JK, Barnett MW, Upton KR, Gerhardt DJ, Richmond TA, et al. 2011. Somatic retrotransposition alters the genetic landscape of the human brain. Nature 479:534-37
    • (2011) Nature , vol.479 , pp. 534-537
    • Baillie, J.K.1    Barnett, M.W.2    Upton, K.R.3    Gerhardt, D.J.4    Richmond, T.A.5
  • 63
    • 17144407279 scopus 로고    scopus 로고
    • Genomic rearrangements on VCAM1, SELE, APEG1 and AIF1 loci in atherosclerosis
    • Arvanitis DA, Flouris GA, Spandidos DA. 2005. Genomic rearrangements on VCAM1, SELE, APEG1 and AIF1 loci in atherosclerosis. J. Cell. Mol. Med. 9:153-59
    • (2005) J. Cell. Mol. Med. , vol.9 , pp. 153-159
    • Arvanitis, D.A.1    Flouris, G.A.2    Spandidos, D.A.3
  • 64
    • 84859516414 scopus 로고    scopus 로고
    • Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues
    • Shibata Y, Kumar P, Layer R, Willcox S, Gagan JR, et al. 2012. Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues. Science 336:82-86
    • (2012) Science , vol.336 , pp. 82-86
    • Shibata, Y.1    Kumar, P.2    Layer, R.3    Willcox, S.4    Gagan, J.R.5
  • 65
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles-a cause of aging in yeast
    • Sinclair DA, Guarente L. 1997. Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91:1033-42
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 66
    • 75749100093 scopus 로고    scopus 로고
    • Mutational heterogeneity in human cancers: Origin and consequences
    • Salk JJ, Fox EJ, Loeb LA. 2010. Mutational heterogeneity in human cancers: origin and consequences. Annu. Rev. Pathol. Mech. Dis. 5:51-75
    • (2010) Annu. Rev. Pathol. Mech. Dis. , vol.5 , pp. 51-75
    • Salk, J.J.1    Fox, E.J.2    Loeb, L.A.3
  • 68
    • 84863338168 scopus 로고    scopus 로고
    • Direct, genome-wide assessment of DNA mutations in single cells
    • Gundry M, Li W, Maqbool SB, Vijg J. 2012. Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res. 40:2032-40
    • (2012) Nucleic Acids Res. , vol.40 , pp. 2032-2040
    • Gundry, M.1    Li, W.2    Maqbool, S.B.3    Vijg, J.4
  • 69
    • 33847076248 scopus 로고    scopus 로고
    • Chromatin challenges during DNA replication and repair
    • Groth A, Rocha W, Verreault A, Almouzni G. 2007. Chromatin challenges during DNA replication and repair. Cell 128:721-33
    • (2007) Cell , vol.128 , pp. 721-733
    • Groth, A.1    Rocha, W.2    Verreault, A.3    Almouzni, G.4
  • 70
  • 71
    • 73749085370 scopus 로고    scopus 로고
    • Epigenetic factors in aging and longevity
    • Gravina S, Vijg J. 2010. Epigenetic factors in aging and longevity. Pflüg. Arch. 459:247-58
    • (2010) Pflüg. Arch. , vol.459 , pp. 247-258
    • Gravina, S.1    Vijg, J.2
  • 72
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • Day JJ, Sweatt JD. 2010. DNA methylation and memory formation. Nat. Neurosci. 13:1319-23
    • (2010) Nat. Neurosci. , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 73
    • 80054718602 scopus 로고    scopus 로고
    • Spontaneous epigenetic variation in the Arabidopsis thaliana methylome
    • Becker C, Hagmann J, Muller J, Koenig D, Stegle O, et al. 2011. Spontaneous epigenetic variation in the Arabidopsis thaliana methylome. Nature 480:245-49
    • (2011) Nature , vol.480 , pp. 245-249
    • Becker, C.1    Hagmann, J.2    Muller, J.3    Koenig, D.4    Stegle, O.5
  • 74
    • 80054837794 scopus 로고    scopus 로고
    • Transgenerational epige-netic instability is a source of novel methylation variants
    • Schmitz RJ, Schultz MD, Lewsey MG, O'Malley RC, Urich MA, et al. 2011. Transgenerational epige-netic instability is a source of novel methylation variants. Science 334:369-73
    • (2011) Science , vol.334 , pp. 369-373
    • Schmitz, R.J.1    Schultz, M.D.2    Lewsey, M.G.3    O'Malley, R.C.4    Urich, M.A.5
  • 75
    • 9144228185 scopus 로고    scopus 로고
    • Hairpin-bisulfite PCR: Assessing epigenetic methylation patterns on complementary strands of individual DNA molecules
    • Laird CD, Pleasant ND, Clark AD, Sneeden JL, Hassan KM, et al. 2004. Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proc. Natl. Acad. Sci. USA 101:204-9
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 204-209
    • Laird, C.D.1    Pleasant, N.D.2    Clark, A.D.3    Sneeden, J.L.4    Hassan, K.M.5
  • 76
    • 59349086549 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and aging: Devils in the details?
    • Khrapko K, Vijg J. 2009. Mitochondrial DNA mutations and aging: devils in the details? Trends Genet. 25:91-98
    • (2009) Trends Genet. , vol.25 , pp. 91-98
    • Khrapko, K.1    Vijg, J.2
  • 77
    • 77953348161 scopus 로고    scopus 로고
    • Mitochondrial DNA repair and association with aging-an update
    • Gredilla R, Bohr VA, Stevnsner T. 2010. Mitochondrial DNA repair and association with aging-an update. Exp. Gerontol. 45:478-88
    • (2010) Exp. Gerontol. , vol.45 , pp. 478-488
    • Gredilla, R.1    Bohr, V.A.2    Stevnsner, T.3
  • 79
    • 0016669094 scopus 로고
    • Evolution at two levels in humans and chimpanzees
    • King MC, Wilson AC. 1975. Evolution at two levels in humans and chimpanzees. Science 188:107-16
    • (1975) Science , vol.188 , pp. 107-116
    • King, M.C.1    Wilson, A.C.2
  • 80
    • 0015253454 scopus 로고
    • Simplicity of mammalian regulatory systems
    • Ohno S. 1972. Simplicity of mammalian regulatory systems. Dev. Biol. 27:131-36
    • (1972) Dev. Biol. , vol.27 , pp. 131-136
    • Ohno, S.1
  • 81
    • 33644855479 scopus 로고    scopus 로고
    • Expression profiling in primates reveals a rapid evolution of human transcription factors
    • Gilad Y, Oshlack A, Smyth GK, Speed TP, White KP. 2006. Expression profiling in primates reveals a rapid evolution of human transcription factors. Nature 440:242-45
    • (2006) Nature , vol.440 , pp. 242-245
    • Gilad, Y.1    Oshlack, A.2    Smyth, G.K.3    Speed, T.P.4    White, K.P.5
  • 82
    • 84859462157 scopus 로고    scopus 로고
    • The genomic basis of adaptive evolution in threespine sticklebacks
    • Jones FC, Grabherr MG, Chan YF, Russell P, Mauceli E, et al. 2012. The genomic basis of adaptive evolution in threespine sticklebacks. Nature 484:55-61
    • (2012) Nature , vol.484 , pp. 55-61
    • Jones, F.C.1    Grabherr, M.G.2    Chan, Y.F.3    Russell, P.4    Mauceli, E.5
  • 83
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabasi AL, Gulbahce N, Loscalzo J. 2011. Network medicine: a network-based approach to human disease. Nat. Rev. Genet. 12:56-68
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 84
    • 0011555560 scopus 로고
    • Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
    • Hart RW, Setlow RB. 1974. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc. Natl. Acad. Sci. USA 71:2169-73
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 2169-2173
    • Hart, R.W.1    Setlow, R.B.2
  • 85
    • 0027081044 scopus 로고
    • Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
    • Grube K, Burkle A. 1992. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc. Natl. Acad. Sci. USA 89:11759-63
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11759-11763
    • Grube, K.1    Burkle, A.2
  • 86
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith GC, Jackson SP. 1999. The DNA-dependent protein kinase. Genes Dev. 13:916-34
    • (1999) Genes Dev. , vol.13 , pp. 916-934
    • Smith, G.C.1    Jackson, S.P.2
  • 87
    • 0022534918 scopus 로고
    • Rates of DNA sequence evolution differ between taxonomic groups
    • Britten RJ. 1986. Rates of DNA sequence evolution differ between taxonomic groups. Science 231:1393-98
    • (1986) Science , vol.231 , pp. 1393-1398
    • Britten, R.J.1
  • 88
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi J. 2001. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11:S27-31
    • (2001) Trends Cell Biol. , vol.11
    • Campisi, J.1
  • 89
    • 0035163025 scopus 로고    scopus 로고
    • Revisiting the rodent repairadox
    • Hanawalt PC. 2001. Revisiting the rodent repairadox. Environ. Mol. Mutagen. 38:89-96
    • (2001) Environ. Mol. Mutagen. , vol.38 , pp. 89-96
    • Hanawalt, P.C.1
  • 90
    • 13944280713 scopus 로고    scopus 로고
    • Genetic modulation of senescent phenotypes in Homo sapiens
    • Martin GM. 2005. Genetic modulation of senescent phenotypes in Homo sapiens. Cell 120:523-32
    • (2005) Cell , vol.120 , pp. 523-532
    • Martin, G.M.1
  • 91
    • 0017840139 scopus 로고
    • Genetic syndromes in man with potential relevance to the pathobiology of aging
    • Martin GM. 1978. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects 14:5-39
    • (1978) Birth Defects , vol.14 , pp. 5-39
    • Martin, G.M.1
  • 92
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
    • Goto M. 1997. Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech. Ageing Dev. 98:239-54
    • (1997) Mech. Ageing Dev. , vol.98 , pp. 239-254
    • Goto, M.1
  • 93
    • 15844409553 scopus 로고    scopus 로고
    • Positional cloning of the Werner's syndrome gene
    • Yu C, Oshima J, Fu YH, Wijsman EM, Hisama F, et al. 1996. Positional cloning of the Werner's syndrome gene. Science 272:258-62
    • (1996) Science , vol.272 , pp. 258-262
    • Yu, C.1    Oshima, J.2    Fu, Y.H.3    Wijsman, E.M.4    Hisama, F.5
  • 94
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterized by extensive deletions
    • Fukuchi K, Martin GM, Monnat RJ Jr. 1989. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86:5893-97
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat Jr., R.J.3
  • 95
    • 33845998966 scopus 로고    scopus 로고
    • Prelamin A farnesylation and progeroid syndromes
    • Young SG, Meta M, Yang SH, Fong LG. 2006. Prelamin A farnesylation and progeroid syndromes. J. Biol. Chem. 281:39741-45
    • (2006) J. Biol. Chem. , vol.281 , pp. 39741-39745
    • Young, S.G.1    Meta, M.2    Yang, S.H.3    Fong, L.G.4
  • 96
    • 80053165077 scopus 로고    scopus 로고
    • A-type lamins and Hutchinson-Gilford progeria syndrome: Pathogenesis and therapy
    • Gonzalez JM, Pla D, Perez-Sala D, Andres V. 2011. A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy. Front. Biosci. 3:1133-46
    • (2011) Front. Biosci. , vol.3 , pp. 1133-1146
    • Gonzalez, J.M.1    Pla, D.2    Perez-Sala, D.3    Andres, V.4
  • 97
    • 22544466685 scopus 로고    scopus 로고
    • Genomic instability in laminopathy-based premature aging
    • Liu B, Wang J, Chan KM, Tjia WM, Deng W, et al. 2005. Genomic instability in laminopathy-based premature aging. Nat. Med. 11:780-85
    • (2005) Nat. Med. , vol.11 , pp. 780-785
    • Liu, B.1    Wang, J.2    Chan, K.M.3    Tjia, W.M.4    Deng, W.5
  • 98
    • 0037123638 scopus 로고    scopus 로고
    • Premature aging in mice deficient in DNA repair and transcription
    • de Boer J, Andressoo JO, de Wit J, Huijmans J, Beems RB, et al. 2002. Premature aging in mice deficient in DNA repair and transcription. Science 296:1276-79
    • (2002) Science , vol.296 , pp. 1276-1279
    • De Boer, J.1    Andressoo, J.O.2    De Wit, J.3    Huijmans, J.4    Beems, R.B.5
  • 99
    • 0942268166 scopus 로고    scopus 로고
    • DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    • Lehmann AR. 2003. DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85:1101-11
    • (2003) Biochimie , vol.85 , pp. 1101-1111
    • Lehmann, A.R.1
  • 100
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366-74
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 101
    • 33845914051 scopus 로고    scopus 로고
    • A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
    • Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, et al. 2006. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444:1038-43
    • (2006) Nature , vol.444 , pp. 1038-1043
    • Niedernhofer, L.J.1    Garinis, G.A.2    Raams, A.3    Lalai, A.S.4    Robinson, A.R.5
  • 102
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • Shiloh Y, Kastan MB. 2001. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83:209-54
    • (2001) Adv. Cancer Res. , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 103
    • 76749160296 scopus 로고    scopus 로고
    • Rothmund-Thomson syndrome helicase RECQ4: On the crossroad between DNA replication and repair
    • Liu Y. 2010. Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair. DNA Repair 9:325-30
    • (2010) DNA Repair , vol.9 , pp. 325-330
    • Liu, Y.1
  • 105
    • 0030062815 scopus 로고    scopus 로고
    • The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870-1900
    • Herskind AM, McGue M, Holm NV, Sorensen TI, Harvald B, Vaupel JW. 1996. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 97:319-23
    • (1996) Hum. Genet. , vol.97 , pp. 319-323
    • Herskind, A.M.1    McGue, M.2    Holm, N.V.3    Sorensen, T.I.4    Harvald, B.5    Vaupel, J.W.6
  • 106
    • 0027482067 scopus 로고
    • Longevity is moderately heritable in a sample of Danish twins born 1870-1880
    • McGue M, Vaupel JW, Holm N, Harvald B. 1993. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. J. Gerontol. 48:B237-44
    • (1993) J. Gerontol. , vol.48
    • McGue, M.1    Vaupel, J.W.2    Holm, N.3    Harvald, B.4
  • 108
    • 0036672740 scopus 로고    scopus 로고
    • The genetics of exceptional human longevity
    • Perls T, Kunkel LM, Puca AA. 2002. The genetics of exceptional human longevity. J. Mol. Neurosci. 19:233-38
    • (2002) J. Mol. Neurosci. , vol.19 , pp. 233-238
    • Perls, T.1    Kunkel, L.M.2    Puca, A.A.3
  • 109
    • 14544271073 scopus 로고    scopus 로고
    • Genetics of longevity and aging
    • Vijg J, Suh Y. 2005. Genetics of longevity and aging. Annu. Rev. Med. 56:193-212
    • (2005) Annu. Rev. Med. , vol.56 , pp. 193-212
    • Vijg, J.1    Suh, Y.2
  • 110
    • 35748929967 scopus 로고    scopus 로고
    • Genetic correlates of longevity and selected age-related phenotypes: A genome-wide association study in the Framingham Study
    • Lunetta KL, D'Agostino RB Sr, Karasik D, Benjamin EJ, Guo CY, et al. 2007. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med. Genet. 8(Suppl. 1):13
    • (2007) BMC Med. Genet. , vol.8 , Issue.SUPPL. 1 , pp. 13
    • Lunetta, K.L.1    D'Agostino, R.B.S.R.2    Karasik, D.3    Benjamin, E.J.4    Guo, C.Y.5
  • 114
    • 34250355147 scopus 로고    scopus 로고
    • Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    • Orsted DD, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. 2007. Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population. J. Exp. Med. 204:1295-301
    • (2007) J. Exp. Med. , vol.204 , pp. 1295-1301
    • Orsted, D.D.1    Bojesen, S.E.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 115
    • 76549104441 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashke-nazi centenarians
    • Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, et al. 2010. Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashke-nazi centenarians. Proc. Natl. Acad. Sci. USA 107(Suppl. 1):1710-17
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.SUPPL. 1 , pp. 1710-1717
    • Atzmon, G.1    Cho, M.2    Cawthon, R.M.3    Budagov, T.4    Katz, M.5
  • 116
    • 77954817812 scopus 로고    scopus 로고
    • Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity
    • Polosak J, Roszkowska-Gancarz M, Kurylowicz A, Owczarz M, Dobosz P, et al. 2010. Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. Biogerontology 11:287-97
    • (2010) Biogerontology , vol.11 , pp. 287-297
    • Polosak, J.1    Roszkowska-Gancarz, M.2    Kurylowicz, A.3    Owczarz, M.4    Dobosz, P.5
  • 118
    • 78249280592 scopus 로고    scopus 로고
    • Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
    • Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, et al. 2010. Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 9:1010-17
    • (2010) Aging Cell , vol.9 , pp. 1010-1017
    • Soerensen, M.1    Dato, S.2    Christensen, K.3    McGue, M.4    Stevnsner, T.5
  • 119
    • 79951475133 scopus 로고    scopus 로고
    • A decade's perspective on DNA sequencing technology
    • Mardis ER. 2011. A decade's perspective on DNA sequencing technology. Nature 470:198-203
    • (2011) Nature , vol.470 , pp. 198-203
    • Mardis, E.R.1
  • 120
    • 0032565568 scopus 로고    scopus 로고
    • The influence of DNA glycosylases on spontaneous mutation
    • Glassner BJ, Posnick LM, Samson LD. 1998. The influence of DNA glycosylases on spontaneous mutation. Mutat. Res. 400:33-44
    • (1998) Mutat. Res. , vol.400 , pp. 33-44
    • Glassner, B.J.1    Posnick, L.M.2    Samson, L.D.3
  • 122
    • 0027477075 scopus 로고
    • In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells
    • Xiao W, Samson L. 1993. In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc. Natl. Acad. Sci. USA 90:2117-21
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2117-2121
    • Xiao, W.1    Samson, L.2
  • 123
    • 0036827991 scopus 로고    scopus 로고
    • Induction of a low level of microsatellite instability by overexpression of DNA polymerase β
    • Yamada NA, Farber RA. 2002. Induction of a low level of microsatellite instability by overexpression of DNA polymerase β. Cancer Res. 62:6061-64
    • (2002) Cancer Res. , vol.62 , pp. 6061-6064
    • Yamada, N.A.1    Farber, R.A.2
  • 124
    • 9144271661 scopus 로고    scopus 로고
    • The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
    • Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, et al. 2003. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J. Clin. Investig. 112:1887-94
    • (2003) J. Clin. Investig. , vol.112 , pp. 1887-1894
    • Hofseth, L.J.1    Khan, M.A.2    Ambrose, M.3    Nikolayeva, O.4    Xu-Welliver, M.5
  • 125
    • 54049088551 scopus 로고    scopus 로고
    • Resist or die: FOXO transcription factors determine the cellular response to chemotherapy
    • Gomes AR, Brosens JJ, Lam EW. 2008. Resist or die: FOXO transcription factors determine the cellular response to chemotherapy. Cell Cycle 7:3133-36
    • (2008) Cell Cycle , vol.7 , pp. 3133-3136
    • Gomes, A.R.1    Brosens, J.J.2    Lam, E.W.3
  • 127
    • 34447564992 scopus 로고    scopus 로고
    • Mutation rate variation in multicellular eukaryotes: Causes and consequences
    • Baer CF, Miyamoto MM, Denver DR. 2007. Mutation rate variation in multicellular eukaryotes: causes and consequences. Nat. Rev. Genet. 8:619-31
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 619-631
    • Baer, C.F.1    Miyamoto, M.M.2    Denver, D.R.3
  • 129
    • 56849091295 scopus 로고    scopus 로고
    • Network hubs buffer environmental variation in Saccharomyces cerevisiae
    • Levy SF, Siegal ML. 2008. Network hubs buffer environmental variation in Saccharomyces cerevisiae. PLoS Biol. 6:e264
    • (2008) PLoS Biol. , vol.6
    • Levy, S.F.1    Siegal, M.L.2
  • 130
    • 34548756696 scopus 로고    scopus 로고
    • Detection and analysis of somatic mutations at alacZ reporter locus inhigher organisms: Application to Mus musculus and Drosophila melanogaster
    • Garcia AM, Busuttil RA, Rodriguez A, Cabrera C, Lundell M, et al. 2007. Detection and analysis of somatic mutations at alacZ reporter locus inhigher organisms: application to Mus musculus and Drosophila melanogaster. Methods Mol. Biol. 371:267-87
    • (2007) Methods Mol. Biol. , vol.371 , pp. 267-287
    • Garcia, A.M.1    Busuttil, R.A.2    Rodriguez, A.3    Cabrera, C.4    Lundell, M.5
  • 131
    • 0035913336 scopus 로고    scopus 로고
    • Evolution of digital organisms at high mutation rates leads to survival of the flattest
    • Wilke CO, Wang JL, Ofria C, Lenski RE, Adami C. 2001. Evolution of digital organisms at high mutation rates leads to survival of the flattest. Nature 412:331-33
    • (2001) Nature , vol.412 , pp. 331-333
    • Wilke, C.O.1    Wang, J.L.2    Ofria, C.3    Lenski, R.E.4    Adami, C.5


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