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Volumn 51, Issue , 2000, Pages 245-270

Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty

Author keywords

Cachexia; Cytokines; Dementia; Immune dysregulation; Immunodeficiency; Osteoporosis; Sarcopenia

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; ESTROGEN; INTERLEUKIN 6; SERUM ALBUMIN; SERUM AMYLOID A; TESTOSTERONE;

EID: 0034051068     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.51.1.245     Document Type: Review
Times cited : (1004)

References (197)
  • 1
    • 0027503291 scopus 로고
    • Interleukin-6: A cytokine for gerontologists
    • 1. Ershler WB. 1993. Interleukin-6: a cytokine for gerontologists. J. Am. Geriatr. Soc. 41(2):176-81
    • (1993) J. Am. Geriatr. Soc. , vol.41 , Issue.2 , pp. 176-181
    • Ershler, W.B.1
  • 2
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • 2. Van Snick J. 1990. Interleukin-6: an overview. Annu. Rev. Immunol. 8:253-78
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 253-278
    • Van Snick, J.1
  • 3
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • 3. Akira S, Taga T, Kishimoto T. 1993. Interleukin-6 in biology and medicine. Adv. Immunol. 54:1-78
    • (1993) Adv. Immunol. , vol.54 , pp. 1-78
    • Akira, S.1    Taga, T.2    Kishimoto, T.3
  • 4
    • 0019128380 scopus 로고
    • Two interferon mRNA in human fibroblasts: In vitro translation and Escherichia coli cloning studies
    • 4. Weissenbach J, Chernajovsky Y, Zeevi M, et al. 1980. Two interferon mRNA in human fibroblasts: in vitro translation and Escherichia coli cloning studies. Proc. Natl. Acad. Sci. USA 77:7152-56
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 7152-7156
    • Weissenbach, J.1    Chernajovsky, Y.2    Zeevi, M.3
  • 6
    • 0021256525 scopus 로고
    • Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor acting on Staphylococcus aureus Cowen I-stimulated B cells
    • 6. Hirano T, Teranishi T, Lin BH, Onoue K. 1984. Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor acting on Staphylococcus aureus Cowen I-stimulated B cells. J. Immunol. 133:798-802
    • (1984) J. Immunol. , vol.133 , pp. 798-802
    • Hirano, T.1    Teranishi, T.2    Lin, B.H.3    Onoue, K.4
  • 7
    • 0023851809 scopus 로고
    • The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
    • 7. Muraguchi A, Hirano T, Tang B, et al. 1988. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 67:332-44
    • (1988) J. Exp. Med. , vol.67 , pp. 332-344
    • Muraguchi, A.1    Hirano, T.2    Tang, B.3
  • 8
    • 0023575852 scopus 로고
    • Receptors for B cell stimulatory factor 2
    • 8. Taga T, Kawanishi Y, Hardy TT, et al. 1987. Receptors for B cell stimulatory factor 2. J. Exp. Med. 166:967-81
    • (1987) J. Exp. Med. , vol.166 , pp. 967-981
    • Taga, T.1    Kawanishi, Y.2    Hardy, T.T.3
  • 9
    • 0025176999 scopus 로고
    • Human polysaccharide-specific B cells are responsive to pokeweed mitogen and IL-6
    • 9. Ambrosino DM, Delaney NR, Shamberger RC. 1990. Human polysaccharide-specific B cells are responsive to pokeweed mitogen and IL-6. J. Immunol. 144:1221-26
    • (1990) J. Immunol. , vol.144 , pp. 1221-1226
    • Ambrosino, D.M.1    Delaney, N.R.2    Shamberger, R.C.3
  • 10
    • 0023732978 scopus 로고
    • Human recombinant IL-6/B cell-stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo
    • 10. Takatsuki F, Okano A, Suzuki C, et al. 1988. Human recombinant IL-6/B cell-stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo. J. Immunol. 141:3072-77
    • (1988) J. Immunol. , vol.141 , pp. 3072-3077
    • Takatsuki, F.1    Okano, A.2    Suzuki, C.3
  • 11
    • 0023944384 scopus 로고
    • T cell growth and differentiation induced by interleukin HP1/IL-6, the murine hybridoma/plasmacytoma growth factor
    • 11. Uyttenhove C, Coulie PG, Van Snick J. 1988. T cell growth and differentiation induced by interleukin HP1/IL-6, the murine hybridoma/plasmacytoma growth factor. J. Exp. Med. 167:1414-27
    • (1988) J. Exp. Med. , vol.167 , pp. 1414-1427
    • Uyttenhove, C.1    Coulie, P.G.2    Van Snick, J.3
  • 12
    • 0023920214 scopus 로고
    • B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes
    • 12. Lotz M, Jirik F, Kabouridis R, et al. 1988. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J. Exp. Med. 167:1253-58
    • (1988) J. Exp. Med. , vol.167 , pp. 1253-1258
    • Lotz, M.1    Jirik, F.2    Kabouridis, R.3
  • 14
    • 0023803252 scopus 로고
    • IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells
    • 14. Okada M, Kitahara N, Kishimoto S, et al. 1988. IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J. Immunol. 141:1543-49
    • (1988) J. Immunol. , vol.141 , pp. 1543-1549
    • Okada, M.1    Kitahara, N.2    Kishimoto, S.3
  • 15
    • 0024456071 scopus 로고
    • IL1 and IL6 in CTL induction-accessory signals in murine cytolytic T cell responses: Dual requirement for IL1 and IL6
    • 15. Renauld JC, Vink A, Van Snick J. 1989. IL1 and IL6 in CTL induction-accessory signals in murine cytolytic T cell responses: dual requirement for IL1 and IL6. J. Immunol. 143:1894-98
    • (1989) J. Immunol. , vol.143 , pp. 1894-1898
    • Renauld, J.C.1    Vink, A.2    Van Snick, J.3
  • 16
    • 0024314766 scopus 로고
    • IFNβ/IL-6 augments the activity of human natural killer cells
    • 16. Luger TA, Krutman J, Kirnbauer T, et al. 1989. IFNβ/IL-6 augments the activity of human natural killer cells. J. Immunol. 143:1206-9
    • (1989) J. Immunol. , vol.143 , pp. 1206-1209
    • Luger, T.A.1    Krutman, J.2    Kirnbauer, T.3
  • 17
    • 0025313227 scopus 로고
    • IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release
    • 17. Kurihara N, Bertolini D, Suda T, et al. 1990. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J. Immunol. 144:4226-30
    • (1990) J. Immunol. , vol.144 , pp. 4226-4230
    • Kurihara, N.1    Bertolini, D.2    Suda, T.3
  • 18
    • 0027136189 scopus 로고
    • Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6
    • 18. Tamura T, Udagawa N, Takahashi N, et al. 1993. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc. Natl. Acad. Sci. USA 90:11924-28
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11924-11928
    • Tamura, T.1    Udagawa, N.2    Takahashi, N.3
  • 19
    • 0000726129 scopus 로고
    • 17B-estradiol regulates IL-6 production and osteoclast development in murine calvaria cell cultures
    • 19. Passeri G, Girasole G, Markus T, et al. 1991. 17B-estradiol regulates IL-6 production and osteoclast development in murine calvaria cell cultures. J. Bone Miner. Res. 6:S263 (Suppl. 1)
    • (1991) J. Bone Miner. Res. , vol.6 , Issue.SUPPL. 1
    • Passeri, G.1    Girasole, G.2    Markus, T.3
  • 20
    • 0026516415 scopus 로고
    • 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens
    • 20. Girasole G, Jilka RL, Passeri G, et al. 1992. 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J. Clin. Invest. 89(3): 883-91
    • (1992) J. Clin. Invest. , vol.89 , Issue.3 , pp. 883-891
    • Girasole, G.1    Jilka, R.L.2    Passeri, G.3
  • 21
    • 0026777433 scopus 로고
    • Increased osteoclast development after estrogen loss: Mediation by interleukin-6
    • 21. Jilka RL, Hangoc C, Girasole G, et al. 1992. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-91
    • (1992) Science , vol.257 , pp. 88-91
    • Jilka, R.L.1    Hangoc, C.2    Girasole, G.3
  • 22
    • 0029088925 scopus 로고
    • Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6
    • 22. Miyaura C, Kusano K, Masuzawa T, et al. 1995. Endogenous bone-resorbing factors in estrogen deficiency: cooperative effects of IL-1 and IL-6. J. Bone Miner. Res. 10:1365-73
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 1365-1373
    • Miyaura, C.1    Kusano, K.2    Masuzawa, T.3
  • 23
    • 0028266906 scopus 로고
    • Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
    • 23. Poli V, Balena R, Fattori E, et al. 1994. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 13:1189-96
    • (1994) EMBO J. , vol.13 , pp. 1189-1196
    • Poli, V.1    Balena, R.2    Fattori, E.3
  • 24
    • 0028843930 scopus 로고
    • Progressive rise in the expression of interleukin-6 in human endometrium during menstrual cycle is initiated during the implantation window
    • 24. Tabibzadeh S, Kong QF, Babaknia A, May LT. 1995. Progressive rise in the expression of interleukin-6 in human endometrium during menstrual cycle is initiated during the implantation window. Mol. Hum. Reprod. 1:2793-99
    • (1995) Mol. Hum. Reprod. , vol.1 , pp. 2793-2799
    • Tabibzadeh, S.1    Kong, Q.F.2    Babaknia, A.3    May, L.T.4
  • 25
    • 0024557271 scopus 로고
    • Cytokine-induced production of IFN-β2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17β
    • 25. Tabibzadeh SS, Santhanam U, Sehgal PB, May LT. 1989. Cytokine-induced production of IFN-β2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17β. J. Immunol. 142(9):3134-39
    • (1989) J. Immunol. , vol.142 , Issue.9 , pp. 3134-3139
    • Tabibzadeh, S.S.1    Santhanam, U.2    Sehgal, P.B.3    May, L.T.4
  • 26
    • 0028918585 scopus 로고
    • Function of interleukin-6 as an inhibitor of meiotic DNA synthesis in the rat seminiferous epithelium
    • 26. Hakovirta H, Syed V, Jegou B, Parvinen M. 1995. Function of interleukin-6 as an inhibitor of meiotic DNA synthesis in the rat seminiferous epithelium. Mol. Cell. Endocrinol. 108:193-98
    • (1995) Mol. Cell. Endocrinol. , vol.108 , pp. 193-198
    • Hakovirta, H.1    Syed, V.2    Jegou, B.3    Parvinen, M.4
  • 27
    • 0025337639 scopus 로고
    • Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis
    • 27. Krueger JG, Krane JF, Carter DM, Gottlieb AB. 1990. Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis. J. Invest. Dermatol. 94:135-140 (Suppl.)
    • (1990) J. Invest. Dermatol. , vol.94 , Issue.SUPPL. , pp. 135-140
    • Krueger, J.G.1    Krane, J.F.2    Carter, D.M.3    Gottlieb, A.B.4
  • 28
    • 0343019918 scopus 로고
    • Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
    • 28. Grossman RM, Kreuger J, Yourish D, et al. 1989. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl. Acad. Sci. USA 86:6367-71
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6367-6371
    • Grossman, R.M.1    Kreuger, J.2    Yourish, D.3
  • 29
    • 0025494032 scopus 로고
    • Interleukin-6 and expression of its receptor on epidermal keratinocytes
    • 29. Yoshizaki K, Nishimoto N, Matsumoto K, et al. 1990. Interleukin-6 and expression of its receptor on epidermal keratinocytes. Cytokines 2:381-87
    • (1990) Cytokines , vol.2 , pp. 381-387
    • Yoshizaki, K.1    Nishimoto, N.2    Matsumoto, K.3
  • 30
    • 0025971594 scopus 로고
    • Interleukin-6 and its receptor are expressed by human megakaryocytes: In vitro effects on proliferation and endo-replication
    • 30. Navarro S, Devili N, LeCouedic JP, et al. 1991. Interleukin-6 and its receptor are expressed by human megakaryocytes: in vitro effects on proliferation and endo-replication. Blood 77:461-71
    • (1991) Blood , vol.77 , pp. 461-471
    • Navarro, S.1    Devili, N.2    LeCouedic, J.P.3
  • 31
    • 0027787510 scopus 로고
    • The influence of recombinant human interleukin-6 on blood and immune parameters in middle-aged and old rhesus monkeys
    • 31. Sun WH, Binkley N, Bidwell DW, Ershler WB. 1993. The influence of recombinant human interleukin-6 on blood and immune parameters in middle-aged and old rhesus monkeys. Lymphokine Cytokine Res. 12(6):449-55
    • (1993) Lymphokine Cytokine Res. , vol.12 , Issue.6 , pp. 449-455
    • Sun, W.H.1    Binkley, N.2    Bidwell, D.W.3    Ershler, W.B.4
  • 32
    • 0025326192 scopus 로고
    • Stimulation of thrombopoiesis in mice by human recombinant interleukin-6
    • 32. Hill RJ, Warren MK, Levin J. 1990. Stimulation of thrombopoiesis in mice by human recombinant interleukin-6. J. Clin. Invest. 85:1242-47
    • (1990) J. Clin. Invest. , vol.85 , pp. 1242-1247
    • Hill, R.J.1    Warren, M.K.2    Levin, J.3
  • 33
    • 0024466595 scopus 로고
    • Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats
    • 33. Hama T, Miyamoto M, Tsukui H, et al. 1989. Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci. Lett. 104:340-44
    • (1989) Neurosci. Lett. , vol.104 , pp. 340-344
    • Hama, T.1    Miyamoto, M.2    Tsukui, H.3
  • 34
    • 0023691651 scopus 로고
    • Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6
    • 34. Satoh T, Nakamura S, Taga T, et al. 1988. Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 8:3546-49
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3546-3549
    • Satoh, T.1    Nakamura, S.2    Taga, T.3
  • 36
    • 0022801346 scopus 로고
    • Structure and expression of cDNA and genes for human interferon b-2, a distinct species inducible by growth-stimulatory cytokines
    • 36. Zilberstein A, Ruggieri R, Korn JH, Revel M. 1986. Structure and expression of cDNA and genes for human interferon b-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J. 5:2529-37
    • (1986) EMBO J. , vol.5 , pp. 2529-2537
    • Zilberstein, A.1    Ruggieri, R.2    Korn, J.H.3    Revel, M.4
  • 37
    • 0023425699 scopus 로고
    • Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene
    • 37. Yasukawa K, Hirano T, Watanabe Y, et al. 1987. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J. 6(10):2939-45
    • (1987) EMBO J. , vol.6 , Issue.10 , pp. 2939-2945
    • Yasukawa, K.1    Hirano, T.2    Watanabe, Y.3
  • 38
    • 0023676132 scopus 로고
    • Murine hybridoma/plasmacytoma growth factor: Complete amino acid sequence and relation to human interleukin-6
    • 38. Simpson RJ, Moritz RL, Rubira MR, Van Snick J. 1988. Murine hybridoma/ plasmacytoma growth factor: complete amino acid sequence and relation to human interleukin-6. Eur. J. Biochem. 176:187-97
    • (1988) Eur. J. Biochem. , vol.176 , pp. 187-197
    • Simpson, R.J.1    Moritz, R.L.2    Rubira, M.R.3    Van Snick, J.4
  • 39
    • 0023191793 scopus 로고
    • Rapid enhancement of β2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187
    • 39. Sehgal PB, Walther Z, Tamm I. 1987. Rapid enhancement of β2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Proc. Natl. Acad. Sci. USA 84:3633-35
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3633-3635
    • Sehgal, P.B.1    Walther, Z.2    Tamm, I.3
  • 40
    • 0023951336 scopus 로고
    • Synthesis of interleukin-6 (interferon-β2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP
    • 40. Zhang Y, Lin J-X, Vilcek J. 1988. Synthesis of interleukin-6 (interferon-β2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. J. Biol. Chem. 263:6177-82
    • (1988) J. Biol. Chem. , vol.263 , pp. 6177-6182
    • Zhang, Y.1    Lin, J.-X.2    Vilcek, J.3
  • 41
    • 0141929200 scopus 로고
    • Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin-1 in human fibroblasts: Role in the induction of interleukin-6
    • 41. Zhang Y, Lin J-X, Yip YK, Vilcek J. 1988. Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin-1 in human fibroblasts: role in the induction of interleukin-6. Proc. Natl. Acad. Sci. USA 85:6802-6
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6802-6806
    • Zhang, Y.1    Lin, J.-X.2    Yip, Y.K.3    Vilcek, J.4
  • 42
    • 0028211011 scopus 로고
    • Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B
    • 42. Zhang Y, Broser M, Rom WN. 1994. Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B. Proc. Natl. Acad. Sci USA 91(6):2225-29
    • (1994) Proc. Natl. Acad. Sci USA , vol.91 , Issue.6 , pp. 2225-2229
    • Zhang, Y.1    Broser, M.2    Rom, W.N.3
  • 43
    • 0027363297 scopus 로고
    • Transcriptonal activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-κB-like binding site
    • 43. Muraoka O, Kaisho T, Tanabe M, Hirano T. 1993. Transcriptonal activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-κB-like binding site. Itnmunol. Lett. 37:159-65
    • (1993) Itnmunol. Lett. , vol.37 , pp. 159-165
    • Muraoka, O.1    Kaisho, T.2    Tanabe, M.3    Hirano, T.4
  • 44
    • 0027936021 scopus 로고
    • Transactivation of the human interleukin-6 gene by human T-lymphotropic virus type 1 Tax protein
    • 44. Yamashita I, Katamine S, Moriuchi R, et al. 1994. Transactivation of the human interleukin-6 gene by human T-lymphotropic virus type 1 Tax protein. Blood 84(5):1573-78
    • (1994) Blood , vol.84 , Issue.5 , pp. 1573-1578
    • Yamashita, I.1    Katamine, S.2    Moriuchi, R.3
  • 45
    • 0029052335 scopus 로고
    • Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6
    • 45. Yan SF, Tritto I, Pinsky D, et al. 1995. Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. J. Biol. Chem. 270(19): 11463-71
    • (1995) J. Biol. Chem. , vol.270 , Issue.19 , pp. 11463-11471
    • Yan, S.F.1    Tritto, I.2    Pinsky, D.3
  • 46
    • 0028362019 scopus 로고
    • Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide
    • 46. Dendorfer U, Oettgen P, Libermann TA. 1994. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol. Cell. Biol. 14(7): 4443-54
    • (1994) Mol. Cell. Biol. , vol.14 , Issue.7 , pp. 4443-4454
    • Dendorfer, U.1    Oettgen, P.2    Libermann, T.A.3
  • 47
    • 0027955428 scopus 로고
    • The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein
    • 47. Scala G, Ruocco MR, Ambrosino C, et al. 1994. The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein. J. Exp. Med. 179(3):961-71
    • (1994) J. Exp. Med. , vol.179 , Issue.3 , pp. 961-971
    • Scala, G.1    Ruocco, M.R.2    Ambrosino, C.3
  • 48
    • 0027401660 scopus 로고
    • Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B
    • 48. Brach MA, Gruss HJ, Kaisho T, et al. 1993. Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B. J. Biol. Chem. 268(12): 8466-72
    • (1993) J. Biol. Chem. , vol.268 , Issue.12 , pp. 8466-8472
    • Brach, M.A.1    Gruss, H.J.2    Kaisho, T.3
  • 49
    • 0027244682 scopus 로고
    • Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBPβ (NF-IL6) activity by p534 species
    • 49. Margulies L, Sehgal PB. 1993. Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBPβ (NF-IL6) activity by p534 species. J. Biol. Chem. 268:15096-100
    • (1993) J. Biol. Chem. , vol.268 , pp. 15096-15100
    • Margulies, L.1    Sehgal, P.B.2
  • 50
    • 0026459649 scopus 로고
    • Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins
    • 50. Janaswami PM, Kalvakolanu DV, Zhang Y, Sen GC. 1992. Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins. J. Biol. Chem. 267(34):24886-91
    • (1992) J. Biol. Chem. , vol.267 , Issue.34 , pp. 24886-24891
    • Janaswami, P.M.1    Kalvakolanu, D.V.2    Zhang, Y.3    Sen, G.C.4
  • 51
    • 0026612229 scopus 로고
    • Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6
    • 51. Brach MA, de Vos S, Arnold C, et al. 1992. Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6. Eur. J. Immunol. 22(10):2705-11
    • (1992) Eur. J. Immunol. , vol.22 , Issue.10 , pp. 2705-2711
    • Brach, M.A.1    De Vos, S.2    Arnold, C.3
  • 52
    • 0026457215 scopus 로고
    • Involvement of nuclear factor-kappa B in induction of the interleukin-6 gene by leukemia inhibitory factor
    • 52. Gruss HJ, Brach MA, Herrmann F. 1992. Involvement of nuclear factor-kappa B in induction of the interleukin-6 gene by leukemia inhibitory factor. Blood 80(10):2563-70
    • (1992) Blood , vol.80 , Issue.10 , pp. 2563-2570
    • Gruss, H.J.1    Brach, M.A.2    Herrmann, F.3
  • 53
    • 0025936536 scopus 로고
    • Regulation of interleukin-6 expression in the lymphoma cell line OCI-LY3
    • 53. Yee CS, Messner HA, Minden MD. 1991. Regulation of interleukin-6 expression in the lymphoma cell line OCI-LY3. J. Cell. Physiol. 148:426-29
    • (1991) J. Cell. Physiol. , vol.148 , pp. 426-429
    • Yee, C.S.1    Messner, H.A.2    Minden, M.D.3
  • 54
    • 0025280023 scopus 로고
    • Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa b-like sequence
    • 54. Zhang Y, Lin J-X, Vilcek J. 1990. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol. Cell. Biol. 10:3818-23
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3818-3823
    • Zhang, Y.1    Lin, J.-X.2    Vilcek, J.3
  • 55
    • 0025138248 scopus 로고
    • Involvement of a NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
    • 55. Shimizu H, Mitomo K, Watanabe T, et al. 1990. Involvement of a NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol. Cell. Biol. 10:561-68
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 561-568
    • Shimizu, H.1    Mitomo, K.2    Watanabe, T.3
  • 56
    • 0024157116 scopus 로고
    • Genomic structure of the murine IL-6 gene: High degree of conservation of potential regulatory sequences between mouse and human
    • 56. Tanabe O, Akira S, Kamiya T, et al. 1988. Genomic structure of the murine IL-6 gene: high degree of conservation of potential regulatory sequences between mouse and human. J. Immunol. 141:3875-81
    • (1988) J. Immunol. , vol.141 , pp. 3875-3881
    • Tanabe, O.1    Akira, S.2    Kamiya, T.3
  • 57
    • 0022375426 scopus 로고
    • Corticotropin-releasing activity in monokines
    • 57. Woloski BMRNJ, Smith EM, Meyer WJ III, et al. 1985. Corticotropin-releasing activity in monokines. Science 230: 1035-37
    • (1985) Science , vol.230 , pp. 1035-1037
    • Woloski, B.M.R.N.J.1    Smith, E.M.2    Meyer W.J. III3
  • 58
    • 0023252343 scopus 로고
    • Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin-1 and epidermal growth factor in human fibroblasts
    • 58. Kohase M, Henriksen-DiStefano D, May LT, Vilcek J. 1987. Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin-1 and epidermal growth factor in human fibroblasts. J. Cell. Physiol. 132:271-78
    • (1987) J. Cell. Physiol. , vol.132 , pp. 271-278
    • Kohase, M.1    Henriksen-DiStefano, D.2    May, L.T.3    Vilcek, J.4
  • 60
    • 0025047444 scopus 로고
    • On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: Enhancer, TATA box, and RNA start site (Inr motif) occlusion
    • 60. Ray A, LaForge KS, Sehgal PB. 1990. On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Mol. Cell. Biol. 10:5736-16
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5736-5746
    • Ray, A.1    LaForge, K.S.2    Sehgal, P.B.3
  • 61
    • 0025770260 scopus 로고
    • Represser to activator switch by mutations in the glucocorticoid receptor: Is direct DNA binding necessary?
    • 61. Ray A, LaForge KS, Sehgal PB. 1991. Represser to activator switch by mutations in the glucocorticoid receptor: Is direct DNA binding necessary? Proc. Natl. Acad. Sci. USA 88(16):7086-90
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , Issue.16 , pp. 7086-7090
    • Ray, A.1    LaForge, K.S.2    Sehgal, P.B.3
  • 62
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    • 62. Ray A, Prefontaine KE. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91(2):752-56
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.2 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 63
    • 0013655501 scopus 로고    scopus 로고
    • Deleted in proof
    • 63. Deleted in proof
  • 64
    • 0028879819 scopus 로고
    • Role of transcriptional activation of iκbα in mediation of immunosuppression by glucocorticoids
    • 64. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283-86
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin A.S., Jr.4
  • 65
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
    • 65. Auphan N, DiDonato A, Rosette C, 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286-290
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, A.2    Rosette, C.3
  • 66
    • 0026081754 scopus 로고
    • Interleukm-1 and -6 stimulate the release of corticotropin-releasing hormone from rat hypothalamus in vitro via eicosanoid cyclooxygenase pathway
    • 66. Navarra P, Tsagarakis S, Fana M, et al. 1990. Interleukm-1 and -6 stimulate the release of corticotropin-releasing hormone from rat hypothalamus in vitro via eicosanoid cyclooxygenase pathway. Endocrinology 128:37-44
    • (1990) Endocrinology , vol.128 , pp. 37-44
    • Navarra, P.1    Tsagarakis, S.2    Fana, M.3
  • 67
    • 0013635001 scopus 로고
    • The stimulatory effect of interleukin-6 on corticotropin-releasing factor and thyrotropin-releasing hormone secretion in vitro
    • 67. Lyson K, Milenkovic K, McCann SM. 1991. The stimulatory effect of interleukin-6 on corticotropin-releasing factor and thyrotropin-releasing hormone secretion in vitro. Prog. Neuroendocrinol. Immunol. 4:161-65
    • (1991) Prog. Neuroendocrinol. Immunol. , vol.4 , pp. 161-165
    • Lyson, K.1    Milenkovic, K.2    McCann, S.M.3
  • 69
    • 0028903358 scopus 로고
    • Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density
    • 69. Kania DM, Binkley N, Checovich M, et al. 1995. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J. Am. Geriatr. Soc. 43(3):236-39
    • (1995) J. Am. Geriatr. Soc. , vol.43 , Issue.3 , pp. 236-239
    • Kania, D.M.1    Binkley, N.2    Checovich, M.3
  • 70
    • 0028245512 scopus 로고
    • Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis
    • 70. Ralston SH. 1994. Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis. J. Bone Miner. Res. 9:883-90
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 883-890
    • Ralston, S.H.1
  • 71
    • 0027162602 scopus 로고
    • A dysregulation in the production of interleukin-6 with normal aging: Probable linkage to the age associated depression in dehydroepiandrosterone (DHEA) and its sulfated derivative
    • 71. Daynes RA, Araneo BA, Ershler WB, et al. 1993. A dysregulation in the production of interleukin-6 with normal aging: probable linkage to the age associated depression in dehydroepiandrosterone (DHEA) and its sulfated derivative. J. Immunol. 150:5219-30
    • (1993) J. Immunol. , vol.150 , pp. 5219-5230
    • Daynes, R.A.1    Araneo, B.A.2    Ershler, W.B.3
  • 72
    • 0025955604 scopus 로고
    • Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells
    • 72. Pacifici R, Brown C, Puscheck E, et al. 1991. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc. Natl. Acad. Sci. USA 88:5134-38
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5134-5138
    • Pacifici, R.1    Brown, C.2    Puscheck, E.3
  • 73
    • 0026705210 scopus 로고
    • Spontaneous release of interleukin-1 and interleukin-6 by peripheral blood mononuclear cells after oophorectomy
    • 73. Pioli G, Basini G, Pedtazzoni M, et al. 1992. Spontaneous release of interleukin-1 and interleukin-6 by peripheral blood mononuclear cells after oophorectomy. Clin. Sci. 83:503-7
    • (1992) Clin. Sci. , vol.83 , pp. 503-507
    • Pioli, G.1    Basini, G.2    Pedtazzoni, M.3
  • 74
    • 0030020568 scopus 로고    scopus 로고
    • Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptor
    • 74. Kassem M, Harris SA, Spelsberg TC, Riggs BL. 1996. Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptor. J. Bone Miner. Res. 11:193-99
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 193-199
    • Kassem, M.1    Harris, S.A.2    Spelsberg, T.C.3    Riggs, B.L.4
  • 75
    • 0026770902 scopus 로고
    • Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1β and tumor necrosis factor-α: Lack of regulation by 17β-estradiol
    • 75. Chaudhary LR, Spelsberg TC, Riggs BL. 1992. Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1β and tumor necrosis factor-α: lack of regulation by 17β-estradiol. Endocrinology 130:2528-34
    • (1992) Endocrinology , vol.130 , pp. 2528-2534
    • Chaudhary, L.R.1    Spelsberg, T.C.2    Riggs, B.L.3
  • 76
    • 0028151432 scopus 로고
    • Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice
    • 76. Kitazawa R, Kimble RB, Vannice JL, et al. 1994. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J. Clin. Invest. 94:2397-406
    • (1994) J. Clin. Invest. , vol.94 , pp. 2397-2406
    • Kitazawa, R.1    Kimble, R.B.2    Vannice, J.L.3
  • 77
    • 0026545499 scopus 로고
    • Oestradiol inhibits the release of tumor necrosis factor but not interleukin-6 from adult human osteoblasts in vitro
    • 77. Rickard D, Russel G, Gowen M. 1992. Oestradiol inhibits the release of tumor necrosis factor but not interleukin-6 from adult human osteoblasts in vitro. Osteoporosis Int. 2:94-102
    • (1992) Osteoporosis Int. , vol.2 , pp. 94-102
    • Rickard, D.1    Russel, G.2    Gowen, M.3
  • 78
    • 0029088462 scopus 로고
    • Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: Evidence that induction by interleukin-1 and tumor necrosis factor-a is not regulated by ovarian steroids
    • 78. Rifas L, Kenney JS, Marcelli M, et al. 1995. Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-a is not regulated by ovarian steroids. Endocrinology 136:4056-67
    • (1995) Endocrinology , vol.136 , pp. 4056-4067
    • Rifas, L.1    Kenney, J.S.2    Marcelli, M.3
  • 79
    • 0028180435 scopus 로고
    • 17β-estradiol inhibits expression of human promoter-reporter constructs by a receptor-dependent mechanism
    • 79. Pottratz ST, Bellido T, Mocharla H, et al. 1994. 17β-Estradiol inhibits expression of human promoter-reporter constructs by a receptor-dependent mechanism. J. Clin. Invest. 93(3):944-50
    • (1994) J. Clin. Invest. , vol.93 , Issue.3 , pp. 944-950
    • Pottratz, S.T.1    Bellido, T.2    Mocharla, H.3
  • 80
    • 0028222533 scopus 로고
    • Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor
    • 80. Ray A, Prefontaine KE, Ray P. 1994. Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. Biol. Chem. 269(17):12940-46
    • (1994) J. Biol. Chem. , vol.269 , Issue.17 , pp. 12940-12946
    • Ray, A.1    Prefontaine, K.E.2    Ray, P.3
  • 81
    • 0013634823 scopus 로고    scopus 로고
    • Deleted in proof
    • 81. Deleted in proof
  • 82
    • 0029147741 scopus 로고
    • Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ
    • 82. Stein B, Yang MX. 1995. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/ EBPβ. Mol. Cell. Biol. 15(9):4971-79
    • (1995) Mol. Cell. Biol. , vol.15 , Issue.9 , pp. 4971-4979
    • Stein, B.1    Yang, M.X.2
  • 83
    • 0032571073 scopus 로고    scopus 로고
    • Estrogen inhibits phorbol ester-induced IκBα transcription and protein degradation
    • 83. Sun WH, Keller ET, Stabler BS, Ershler WB. 1998. Estrogen inhibits phorbol ester-induced IκBα transcription and protein degradation. Biochem. Biophys. Res. Commun. 244:691-95
    • (1998) Biochem. Biophys. Res. Commun. , vol.244 , pp. 691-695
    • Sun, W.H.1    Keller, E.T.2    Stabler, B.S.3    Ershler, W.B.4
  • 84
    • 0029889675 scopus 로고    scopus 로고
    • Involvement of CCAAT/enhancer binding protein and nuclear factor-κb binding sites in interleukin-6 promoter inhibition by estrogens
    • 84. Galien R, Evans HF, Garcia T. 1996. Involvement of CCAAT/enhancer binding protein and nuclear factor-κB binding sites in interleukin-6 promoter inhibition by estrogens. Mol. Endocrinol. 10:713-22
    • (1996) Mol. Endocrinol. , vol.10 , pp. 713-722
    • Galien, R.1    Evans, H.F.2    Garcia, T.3
  • 85
    • 0029051331 scopus 로고
    • Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor
    • 85. Bellido T, Jilka RL, Boyce BF, et al. 1995. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J. Clin. Inv. 95(6):2886-95
    • (1995) J. Clin. Inv. , vol.95 , Issue.6 , pp. 2886-2895
    • Bellido, T.1    Jilka, R.L.2    Boyce, B.F.3
  • 86
    • 0029662224 scopus 로고    scopus 로고
    • Inhibition of NFκB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
    • 86. Keller ET, Chang C, Ershler WB. 1996. Inhibition of NFκB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. J. Biol. Chem. 271:26267-75
    • (1996) J. Biol. Chem. , vol.271 , pp. 26267-26275
    • Keller, E.T.1    Chang, C.2    Ershler, W.B.3
  • 87
    • 0031882145 scopus 로고    scopus 로고
    • Orchiectomy increases bone marrow interleukin-6 expression in mice
    • 87. Zhang J, Keller ET, Pugh TD, et al. 1998. Orchiectomy increases bone marrow interleukin-6 expression in mice. Calcif. Tissue Int. 62:219-26
    • (1998) Calcif. Tissue Int. , vol.62 , pp. 219-226
    • Zhang, J.1    Keller, E.T.2    Pugh, T.D.3
  • 88
    • 0028143234 scopus 로고
    • Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man
    • 88. Smith EP, Boyd J, Frank GR, et al. 1994. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N. Engl. J. Med. 331:1056-61
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1056-1061
    • Smith, E.P.1    Boyd, J.2    Frank, G.R.3
  • 89
    • 0023685762 scopus 로고
    • Cloning and expression of the human interleukin-6 (BSF-2/IFNβ 2) receptor
    • 89. Yamasaki K, Taga T, Hirata Y, et al. 1988. Cloning and expression of the human interleukin-6 (BSF-2/IFNβ 2) receptor. Science 241:825-28
    • (1988) Science , vol.241 , pp. 825-828
    • Yamasaki, K.1    Taga, T.2    Hirata, Y.3
  • 90
    • 0025881291 scopus 로고
    • Structural and functional studies on the human hepatic interleukin-6 receptor
    • 90. Schooltink H, Stoyan T, Lenz D, et al. 1991. Structural and functional studies on the human hepatic interleukin-6 receptor. Biochem. J. 277:659-64
    • (1991) Biochem. J. , vol.277 , pp. 659-664
    • Schooltink, H.1    Stoyan, T.2    Lenz, D.3
  • 91
    • 0027536408 scopus 로고
    • The human interleukin-6 receptor a chain gene is localized on chromosome 1 band q21
    • 91. Kluck PMC, Wiegant J, Hansen RPM, et al. 1993. The human interleukin-6 receptor a chain gene is localized on chromosome 1 band q21. Hum. Genet. 90:542-44
    • (1993) Hum. Genet. , vol.90 , pp. 542-544
    • Kluck, P.M.C.1    Wiegant, J.2    Hansen, R.P.M.3
  • 92
    • 0024469936 scopus 로고
    • A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain
    • 92. Bazan JF. 1989. A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain. Biochem. Biophys. Res. Commun. 164:788-95
    • (1989) Biochem. Biophys. Res. Commun. , vol.164 , pp. 788-795
    • Bazan, J.F.1
  • 94
    • 0026526873 scopus 로고
    • Interleukin-6 receptor and signals
    • 1992
    • 94. Taga T, Hibi M, Murakami M, et al. 1992. Interleukin-6 receptor and signals. Chem. Immunol. 1992; 51:181-204
    • (1992) Chem. Immunol. , vol.51 , pp. 181-204
    • Taga, T.1    Hibi, M.2    Murakami, M.3
  • 95
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130
    • 95. Taga T, Hibi M, Hirata Y, et al. 1989. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130. Cell 58:573-81
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3
  • 96
    • 0027199126 scopus 로고
    • IL-6-induced homodimerization of gp 130 and associated activation of a tyrosine kinase
    • 96. Murakami M, Hibi M, Nakagawa N, et al. 1993. IL-6-induced homodimerization of gp 130 and associated activation of a tyrosine kinase. Science 260:1808-10
    • (1993) Science , vol.260 , pp. 1808-1810
    • Murakami, M.1    Hibi, M.2    Nakagawa, N.3
  • 97
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a hexameric consisting of two molecules each of interleukin-6, receptor, and gp-130
    • 97. Ward LD, Howlett GJ, Discolo G, et al. 1994. High affinity interleukin-6 receptor is a hexameric consisting of two molecules each of interleukin-6, receptor, and gp-130. J. Biol. Chem. 269:23286-89
    • (1994) J. Biol. Chem. , vol.269 , pp. 23286-23289
    • Ward, L.D.1    Howlett, G.J.2    Discolo, G.3
  • 98
    • 0024458160 scopus 로고
    • Soluble cytokine receptors are present in normal human urine
    • 98. Novick D, Engelmann H, Wallach D, Rubinstein M. 1989. Soluble cytokine receptors are present in normal human urine. J. Exp. Med. 170:1409-14
    • (1989) J. Exp. Med. , vol.170 , pp. 1409-1414
    • Novick, D.1    Engelmann, H.2    Wallach, D.3    Rubinstein, M.4
  • 99
    • 0028035051 scopus 로고
    • Sequence, expression and function of an mrna encoding of the human interleukin-6 receptor (sIL-6R)
    • 99. Lust JA, Jelinek DF, Donovan KA, et al. 1994. Sequence, expression and function of an mRNA encoding of the human interleukin-6 receptor (sIL-6R). Curr. Top. Microbiol. Immunol. 194:199-205
    • (1994) Curr. Top. Microbiol. Immunol. , vol.194 , pp. 199-205
    • Lust, J.A.1    Jelinek, D.F.2    Donovan, K.A.3
  • 100
    • 0027398766 scopus 로고
    • The soluble interleukin-6 receptor is generated by shedding
    • 100. Mullberg J, Schooltink J, Stoyan T, et al. 1993. The soluble interleukin-6 receptor is generated by shedding. Eur. J. Immunol. 23:473-80
    • (1993) Eur. J. Immunol. , vol.23 , pp. 473-480
    • Mullberg, J.1    Schooltink, J.2    Stoyan, T.3
  • 101
    • 0026522985 scopus 로고
    • Soluble interleukin-6 receptor is released from receptor-bearing cell line in vitro
    • 101. Nakajima T, Yamamoto S, Cheng M, et al. 1992. Soluble interleukin-6 receptor is released from receptor-bearing cell line in vitro. Jpn. J. Cancer Res. 83:373-78
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 373-378
    • Nakajima, T.1    Yamamoto, S.2    Cheng, M.3
  • 102
    • 0024361118 scopus 로고
    • Modulation of interleukin-6 receptors in human cells
    • 102. Snyers L, Fontaine V, Content J. 1989. Modulation of interleukin-6 receptors in human cells. Ann. NY Acad. Sci. 557:388-93
    • (1989) Ann. NY Acad. Sci. , vol.557 , pp. 388-393
    • Snyers, L.1    Fontaine, V.2    Content, J.3
  • 103
    • 0030770949 scopus 로고    scopus 로고
    • Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow
    • 103. Lin SC, Yamate T, Taguchi Y, et al. 1997. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. J. Clin. Invest. 100:1980-90
    • (1997) J. Clin. Invest. , vol.100 , pp. 1980-1990
    • Lin, S.C.1    Yamate, T.2    Taguchi, Y.3
  • 104
    • 0025854604 scopus 로고
    • Age-associated increase in interleukin 6 in MRL/lpr mice
    • 104. Tang B, Matsuda T, Akira S, et al. 1991. Age-associated increase in interleukin 6 in MRL/lpr mice. Int. Immunol. 3(3): 273-78
    • (1991) Int. Immunol. , vol.3 , Issue.3 , pp. 273-278
    • Tang, B.1    Matsuda, T.2    Akira, S.3
  • 105
    • 0027480306 scopus 로고
    • Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal
    • 105. Suzuki H, Yasukawa K, Saito T, et al. 1993. Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur. J. Immunol. 23(5):1078-82
    • (1993) Eur. J. Immunol. , vol.23 , Issue.5 , pp. 1078-1082
    • Suzuki, H.1    Yasukawa, K.2    Saito, T.3
  • 106
    • 0025827542 scopus 로고
    • Influence of age and caloric restriction on macrophage IL-6 and TNF production
    • 106. Effros RB, Svoboda K, Walford RL. 1993. Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res. 10(5):347-51
    • (1993) Lymphokine Cytokine Res. , vol.10 , Issue.5 , pp. 347-351
    • Effros, R.B.1    Svoboda, K.2    Walford, R.L.3
  • 107
    • 0027230586 scopus 로고
    • Increased production of TGF-beta and IL-6 by aged spleen cells
    • 107. Zhou D, Chrest FJ, Adler W, et al. 1993. Increased production of TGF-beta and IL-6 by aged spleen cells. Immunol. Lett. 36(1):7-11
    • (1993) Immunol. Lett. , vol.36 , Issue.1 , pp. 7-11
    • Zhou, D.1    Chrest, F.J.2    Adler, W.3
  • 108
    • 0026550820 scopus 로고
    • Fever, tumor necrosis factor, and interleukin-6 in young, mature, and aged Fischer 344 rats
    • 108. Foster KD, Conn CA, Kluger MJ. 1992. Fever, tumor necrosis factor, and interleukin-6 in young, mature, and aged Fischer 344 rats. Am. J. Physiol. 262: R211-15
    • (1992) Am. J. Physiol. , vol.262
    • Foster, K.D.1    Conn, C.A.2    Kluger, M.J.3
  • 109
    • 0026497223 scopus 로고
    • Increase of plasma IL-6 concentrations with age in healthy subjects
    • 109. Wei J, Xu H, Davies JL, Hemmings GP. 1992. Increase of plasma IL-6 concentrations with age in healthy subjects. Life Sci. 51:1953-56
    • (1992) Life Sci. , vol.51 , pp. 1953-1956
    • Wei, J.1    Xu, H.2    Davies, J.L.3    Hemmings, G.P.4
  • 110
    • 0027074489 scopus 로고
    • In vivo effects of growth hormone on thymus function in aging mice
    • 110. Goya RG, Gagnerault MC, De Moraes, et al. 1992. In vivo effects of growth hormone on thymus function in aging mice. Brain Behav. Immunol. 6:341-54
    • (1992) Brain Behav. Immunol. , vol.6 , pp. 341-354
    • Goya, R.G.1    Gagnerault, M.C.2    De Moraes3
  • 111
    • 0027161033 scopus 로고
    • Interleukin-6 and aging: Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction
    • 111. Ershler WB, Sun WH, Binkley N, et al. 1993. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res. 12(4):225-30
    • (1993) Lymphokine Cytokine Res. , vol.12 , Issue.4 , pp. 225-230
    • Ershler, W.B.1    Sun, W.H.2    Binkley, N.3
  • 112
    • 0027205238 scopus 로고
    • Investigations of the lymphokine system in elderly individuals
    • 112. Sindermann J, Kruse A, Frercks HJ, et al. 1993. Investigations of the lymphokine system in elderly individuals. Mech. Ageing Dev. 70(1-2):149-59
    • (1993) Mech. Ageing Dev. , vol.70 , Issue.1-2 , pp. 149-159
    • Sindermann, J.1    Kruse, A.2    Frercks, H.J.3
  • 113
    • 0000172868 scopus 로고
    • Effect of age and menopause on serum interleukin-6 levels in women
    • 113. McKane R, Khosla S, Peterson J. 1993. Effect of age and menopause on serum interleukin-6 levels in women. J. Bone Miner. Res. 8:S157 (Suppl.)
    • (1993) J. Bone Miner. Res. , vol.8 , Issue.SUPPL.
    • McKane, R.1    Khosla, S.2    Peterson, J.3
  • 114
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • 114. Fagiolo U, Cossarizza A, Scala E, et al. 1993. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23(9):2375-78
    • (1993) Eur. J. Immunol. , vol.23 , Issue.9 , pp. 2375-2378
    • Fagiolo, U.1    Cossarizza, A.2    Scala, E.3
  • 116
    • 0023849455 scopus 로고
    • Automne generation and requirement of BSF-2/IL-6 for human multiple myeloma
    • 116. Kawano M, Hirano T, Matsuda T, et al. 1988. Automne generation and requirement of BSF-2/IL-6 for human multiple myeloma. Nature 332:83-85
    • (1988) Nature , vol.332 , pp. 83-85
    • Kawano, M.1    Hirano, T.2    Matsuda, T.3
  • 117
    • 0024503249 scopus 로고
    • Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
    • 117. Klein B, Zhang X, Jourdan M, et al. 1989. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73(2):517-26
    • (1989) Blood , vol.73 , Issue.2 , pp. 517-526
    • Klein, B.1    Zhang, X.2    Jourdan, M.3
  • 118
    • 0023677601 scopus 로고
    • Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma
    • 118. Asaoku H, Kaeano M, Iwato K, et al. 1988. Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma. Blood 72:429-32
    • (1988) Blood , vol.72 , pp. 429-432
    • Asaoku, H.1    Kaeano, M.2    Iwato, K.3
  • 119
    • 0029970464 scopus 로고    scopus 로고
    • Elevated serum interleukin-6 (IL-6) is derived from neoplastic lymphoid cells in patients with B-cell non-Hodgkin's lymphoma: Correlation with extent of IL-6 expression and serum concentration
    • 119. Kato H, Kinoshita T, Suzuki S, et al. 1996. Elevated serum interleukin-6 (IL-6) is derived from neoplastic lymphoid cells in patients with B-cell non-Hodgkin's lymphoma: correlation with extent of IL-6 expression and serum concentration. Er. J. Haematol. 92(4):1014-21
    • (1996) Er. J. Haematol. , vol.92 , Issue.4 , pp. 1014-1021
    • Kato, H.1    Kinoshita, T.2    Suzuki, S.3
  • 120
    • 0027278569 scopus 로고
    • Serum interleukin 6 levels are elevated in lymphoma patients and correlate with survival in advanced Hodgkin's disease and with B symptoms
    • 120. Kurzrock R, Redman J, Cabanillas F, et al. 1993. Serum interleukin 6 levels are elevated in lymphoma patients and correlate with survival in advanced Hodgkin's disease and with B symptoms. Cancer Res. 53:2118-22
    • (1993) Cancer Res. , vol.53 , pp. 2118-2122
    • Kurzrock, R.1    Redman, J.2    Cabanillas, F.3
  • 121
    • 0028883640 scopus 로고
    • Detection of membrane and soluble interleukin-6 receptor, in lymphoid malignancies
    • 121. Lavabre-Bertrand T, Exbrayat C, Liautard J, et al. 1995. Detection of membrane and soluble interleukin-6 receptor, in lymphoid malignancies. Br. J. Haemaol. 91(4):871-77
    • (1995) Br. J. Haemaol. , vol.91 , Issue.4 , pp. 871-877
    • Lavabre-Bertrand, T.1    Exbrayat, C.2    Liautard, J.3
  • 122
    • 0024459013 scopus 로고
    • Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease
    • 122. Yoshizaki K, Matsuda T, Nishimoto N, et al. 1989. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74:1360-67
    • (1989) Blood , vol.74 , pp. 1360-1367
    • Yoshizaki, K.1    Matsuda, T.2    Nishimoto, N.3
  • 123
    • 0025183151 scopus 로고
    • Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice
    • 123. Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW. 1990. Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J. Clin. Invest. 86:592-99
    • (1990) J. Clin. Invest. , vol.86 , pp. 592-599
    • Brandt, S.J.1    Bodine, D.M.2    Dunbar, C.E.3    Nienhuis, A.W.4
  • 124
    • 0026341620 scopus 로고
    • Increased levels of circulating interleukin-6 in patients with Hodgkin's disease
    • 124. Gause A, Scholz R, Klein S, et al. 1991. Increased levels of circulating interleukin-6 in patients with Hodgkin's disease. Hematol. Oncol. 9(6):307-13
    • (1991) Hematol. Oncol. , vol.9 , Issue.6 , pp. 307-313
    • Gause, A.1    Scholz, R.2    Klein, S.3
  • 125
    • 9544230673 scopus 로고    scopus 로고
    • Increased levels of interleukin-6 (IL-6) in serum and spontaneous in vitro production of IL-6 by lymph node mononuclear cells of patients with angioimmunoblastic lymphadenopathy with dyspioteinemia (AILD) and clinical effectiveness of cyclosporin A
    • 125. Yamamura M, Honda M, Yamada Y, et al. 1996. Increased levels of interleukin-6 (IL-6) in serum and spontaneous in vitro production of IL-6 by lymph node mononuclear cells of patients with angioimmunoblastic lymphadenopathy with dyspioteinemia (AILD) and clinical effectiveness of cyclosporin A. Leukemia 10(9):1504-8
    • (1996) Leukemia , vol.10 , Issue.9 , pp. 1504-1508
    • Yamamura, M.1    Honda, M.2    Yamada, Y.3
  • 126
    • 0029385483 scopus 로고
    • Expression of interleukin-6 in polymorphic reticulosis - Immunohistochemical study
    • 126. Kim SS, Chung SM, Choi IP, Byun KH. 1995. Expression of interleukin-6 in polymorphic reticulosis - immunohistochemical study. J. Korean Med. Sci. 10(5):324-28
    • (1995) J. Korean Med. Sci. , vol.10 , Issue.5 , pp. 324-328
    • Kim, S.S.1    Chung, S.M.2    Choi, I.P.3    Byun, K.H.4
  • 127
    • 0028893151 scopus 로고
    • Clinical implications of cytokine and soluble receptor measurements in patients with newly-diagnosed aggressive non-Hodgkin's lymphoma
    • 127. Stasi R, Zinzani L, Galieni P, et al. 1995. Clinical implications of cytokine and soluble receptor measurements in patients with newly-diagnosed aggressive non-Hodgkin's lymphoma. Eur. J. Haematol. 54(1):9-17
    • (1995) Eur. J. Haematol. , vol.54 , Issue.1 , pp. 9-17
    • Stasi, R.1    Zinzani, L.2    Galieni, P.3
  • 128
    • 0028986492 scopus 로고
    • Serum interleukin-6 levels correlate with prognosis in diffuse large-cell lymphoma
    • 128. Seymour JF, Talpaz M, Cabanillas F, et al. 1995. Serum interleukin-6 levels correlate with prognosis in diffuse large-cell lymphoma. J. Clin. Oncol. 13(3):575-82
    • (1995) J. Clin. Oncol. , vol.13 , Issue.3 , pp. 575-582
    • Seymour, J.F.1    Talpaz, M.2    Cabanillas, F.3
  • 129
    • 0029767042 scopus 로고    scopus 로고
    • Interleukin-6 mediated growth enhancement of cell lines derived from pyothorax-associated lymphoma
    • 129. Kanno H, Yasunaga Y, Iuchi K, et al. 1996. Interleukin-6 mediated growth enhancement of cell lines derived from pyothorax-associated lymphoma. Lab. Invest. 75(2):167-73
    • (1996) Lab. Invest. , vol.75 , Issue.2 , pp. 167-173
    • Kanno, H.1    Yasunaga, Y.2    Iuchi, K.3
  • 130
    • 0024598468 scopus 로고
    • Interleukin 6 gene expression in normal and neoplastic B cells
    • 130. Freeman GJ, Freedman AS, Rabinowe SN, et al. 1989. Interleukin 6 gene expression in normal and neoplastic B cells. J. Clin. Invest. 83:1512-18
    • (1989) J. Clin. Invest. , vol.83 , pp. 1512-1518
    • Freeman, G.J.1    Freedman, A.S.2    Rabinowe, S.N.3
  • 131
    • 0024399987 scopus 로고
    • A possible autocrine role for interleukin-6 in two lymphoma cell lines
    • 131. Yee C, Biondi A, Wang XH, et al. 1989. A possible autocrine role for interleukin-6 in two lymphoma cell lines. Blood 74(2):798-804
    • (1989) Blood , vol.74 , Issue.2 , pp. 798-804
    • Yee, C.1    Biondi, A.2    Wang, X.H.3
  • 132
    • 0027457466 scopus 로고
    • Cytokine (interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6)-possessing cells in lymph nodes of malignant lymphoma
    • 132. Takeshita M, Sumiyoshi Y, Masuda, Y, et al. 1993. Cytokine (interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6)-possessing cells in lymph nodes of malignant lymphoma. Pathol. Res. Pract. 189(1):18-25
    • (1993) Pathol. Res. Pract. , vol.189 , Issue.1 , pp. 18-25
    • Takeshita, M.1    Sumiyoshi, Y.2    Masuda, Y.3
  • 133
    • 0030447760 scopus 로고    scopus 로고
    • Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors
    • 133. Voorzanger N, Touitou R, Garcia E, et al. 1996. Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors. Cancer Res. 56(23): 5499-505
    • (1996) Cancer Res. , vol.56 , Issue.23 , pp. 5499-5505
    • Voorzanger, N.1    Touitou, R.2    Garcia, E.3
  • 135
    • 0028308494 scopus 로고
    • Dietary restriction from middle age attenuates age-associated lymphoma development and EL-6 dysregulation in C57BL/6 mice
    • 135. Volk MJ, Pugh TD, Kim MJ, et al. 1993. Dietary restriction from middle age attenuates age-associated lymphoma development and EL-6 dysregulation in C57BL/6 mice. Cancer Res. 54:3054-63
    • (1993) Cancer Res. , vol.54 , pp. 3054-3063
    • Volk, M.J.1    Pugh, T.D.2    Kim, M.J.3
  • 137
    • 0029024829 scopus 로고
    • Role of cytokines in termination of the B cell lymphoma dormant state in AKR mice
    • 137. Peled A, Tzehoval E, Haran-Ghera N. 1995. Role of cytokines in termination of the B cell lymphoma dormant state in AKR mice. Leukemia 9(6):1095-101
    • (1995) Leukemia , vol.9 , Issue.6 , pp. 1095-1101
    • Peled, A.1    Tzehoval, E.2    Haran-Ghera, N.3
  • 138
    • 0029069307 scopus 로고
    • Interleukin-6 is essential for in vivo development of B lineage neoplasms
    • 138. Hubert DM, Kopf M, Mock BA, et al. 1995. Interleukin-6 is essential for in vivo development of B lineage neoplasms. J. Exp. Med. 182(1):243-48
    • (1995) J. Exp. Med. , vol.182 , Issue.1 , pp. 243-248
    • Hubert, D.M.1    Kopf, M.2    Mock, B.A.3
  • 139
    • 0024369797 scopus 로고
    • Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma
    • 139. Zhang XG, Klein B, Bataille R. 1989. Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma. Blood 74:11-13
    • (1989) Blood , vol.74 , pp. 11-13
    • Zhang, X.G.1    Klein, B.2    Bataille, R.3
  • 140
    • 0027417547 scopus 로고
    • Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy
    • 140. Gaillard JP, Bataille R, Brailly H, et al. 1993. Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy. Eur. J. Immunol. 23:820-24
    • (1993) Eur. J. Immunol. , vol.23 , pp. 820-824
    • Gaillard, J.P.1    Bataille, R.2    Brailly, H.3
  • 141
    • 0026560724 scopus 로고
    • Radioimmunoassay for the measurement of serum IL-6 and its correlation with tumor cell mass parameters in multiple myeloma
    • 141. Solary E, Guiguet M, Zeller V, et al. 1992. Radioimmunoassay for the measurement of serum IL-6 and its correlation with tumor cell mass parameters in multiple myeloma. Am. J. Hematol. 39:163-71
    • (1992) Am. J. Hematol. , vol.39 , pp. 163-171
    • Solary, E.1    Guiguet, M.2    Zeller, V.3
  • 142
    • 0024832002 scopus 로고
    • Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflection of disease severity in plasma cell dyscrasias
    • 142. Bataille R, Jourdan M, Zhang XG, Klein B. 1989. Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflection of disease severity in plasma cell dyscrasias. J. Clin. Invest. 84:2008-11
    • (1989) J. Clin. Invest. , vol.84 , pp. 2008-2011
    • Bataille, R.1    Jourdan, M.2    Zhang, X.G.3    Klein, B.4
  • 143
    • 0028267592 scopus 로고
    • High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma
    • 143. Ballester OF, Moscinski LC, Lyman GH, et al. 1994. High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood 83:1903-8
    • (1994) Blood , vol.83 , pp. 1903-1908
    • Ballester, O.F.1    Moscinski, L.C.2    Lyman, G.H.3
  • 144
    • 0029907810 scopus 로고    scopus 로고
    • Different CD44 splicing patterns define prognostic subgroups in multiple myeloma
    • 144. Stauder R, Van Driel M, Schwarzler C, et al. 1996. Different CD44 splicing patterns define prognostic subgroups in multiple myeloma. Blood 88(8):3101-8
    • (1996) Blood , vol.88 , Issue.8 , pp. 3101-3108
    • Stauder, R.1    Van Driel, M.2    Schwarzler, C.3
  • 146
    • 0026453572 scopus 로고
    • Clinical applications of IL6 inhibitors
    • 146. Klein B, Lu ZY, Bataille R. 1992. Clinical applications of IL6 inhibitors. Res. Immunol. 143(7):774-76
    • (1992) Res. Immunol. , vol.143 , Issue.7 , pp. 774-776
    • Klein, B.1    Lu, Z.Y.2    Bataille, R.3
  • 147
    • 0025990893 scopus 로고
    • Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia
    • 147. Klein B, Wijdenes J, Zhang XG, et al. 1991. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 5:1198-204
    • (1991) Blood , vol.5 , pp. 1198-1204
    • Klein, B.1    Wijdenes, J.2    Zhang, X.G.3
  • 148
    • 0026527776 scopus 로고
    • Modification of proinflammatory production by the antirheumatic agents Tenidap and Naproxen. A possible correlate with the clinical acute phase response
    • 148. Sipe JD, Bartle LM, Loose LD. 1992. Modification of proinflammatory production by the antirheumatic agents Tenidap and Naproxen. A possible correlate with the clinical acute phase response. J. Immunol. 148:480-84
    • (1992) J. Immunol. , vol.148 , pp. 480-484
    • Sipe, J.D.1    Bartle, L.M.2    Loose, L.D.3
  • 149
    • 0025221030 scopus 로고
    • Glucocorticoids inhibit production of IL-6 from monocytes, endothelial cells and fibroblasts
    • 149. Wagge A, Slupphaug G, Shalaby R. 1990. Glucocorticoids inhibit production of IL-6 from monocytes, endothelial cells and fibroblasts. Eur. J. Immunol. 20:2439-43
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2439-2443
    • Wagge, A.1    Slupphaug, G.2    Shalaby, R.3
  • 150
    • 0028920301 scopus 로고
    • Effect of IL-6 receptor antisense oligodeoxynucleotides on in vitro proliferation of myeloma cells
    • 150. Keller ET, Ershler WB. 1995. Effect of IL-6 receptor antisense oligodeoxynucleotides on in vitro proliferation of myeloma cells. J. Immunol. 154:4091-98
    • (1995) J. Immunol. , vol.154 , pp. 4091-4098
    • Keller, E.T.1    Ershler, W.B.2
  • 151
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • 151. Manolagas SC, Jilka RL. 1995. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N. Engl. J. Med. 332(5):305-11
    • (1995) N. Engl. J. Med. , vol.332 , Issue.5 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 152
    • 0026321453 scopus 로고
    • The role of cytokines in the regulation of local bone resorption
    • 152. Lorenzo JA. 1991. The role of cytokines in the regulation of local bone resorption. Crit. Rev. Immunol. 11:195-213
    • (1991) Crit. Rev. Immunol. , vol.11 , pp. 195-213
    • Lorenzo, J.A.1
  • 153
    • 0013681969 scopus 로고
    • Sex steroids regulate the expression of the gp130 transduction pathway by bone marrow and bone cells
    • 153. Bellido T, Girasole G, Passeri G, et al. 1994. Sex steroids regulate the expression of the gp130 transduction pathway by bone marrow and bone cells. Bone Miner. 25(S1):S39
    • (1994) Bone Miner. , vol.25 , Issue.S1
    • Bellido, T.1    Girasole, G.2    Passeri, G.3
  • 154
    • 0025965312 scopus 로고
    • Effects of interleukin-6 on cellular function in UMR-106-01 osteoblast-like cells
    • 154. Fang MA, Hahn TJ. 1991. Effects of interleukin-6 on cellular function in UMR-106-01 osteoblast-like cells. J. Bone Miner. Res. 6:133-39
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 133-139
    • Fang, M.A.1    Hahn, T.J.2
  • 155
    • 0013659701 scopus 로고    scopus 로고
    • Interleukin-6 induces osteoblast differentiation in uncommitted embryonic fibroblasts (EF)
    • Abstr.
    • 155. Taguchi Y, Yamate T, Mocharia H, et al. 1996. Interleukin-6 induces osteoblast differentiation in uncommitted embryonic fibroblasts (EF). J. Bone Miner. Res. 11:S101 (Suppl.) (Abstr.)
    • (1996) J. Bone Miner. Res. , vol.11 , Issue.SUPPL.
    • Taguchi, Y.1    Yamate, T.2    Mocharia, H.3
  • 156
    • 0025259989 scopus 로고
    • IL-6 is produced by osteoblasts and induces bone resorption
    • 156. Ishimi Y, Miyaura C, Jin CH, et al. 1990. IL-6 is produced by osteoblasts and induces bone resorption. J. Immunol. 145:3297-303
    • (1990) J. Immunol. , vol.145 , pp. 3297-3303
    • Ishimi, Y.1    Miyaura, C.2    Jin, C.H.3
  • 157
    • 0028291884 scopus 로고
    • Interleukin-6 attenuates agonist-mediated calcium mobilization in murine osteoblastic cells
    • 157. Green H, Schotland S, Sella Z, Kleeman CR. 1994. Interleukin-6 attenuates agonist-mediated calcium mobilization in murine osteoblastic cells. J. Clin. Invest. 93:2340-50
    • (1994) J. Clin. Invest. , vol.93 , pp. 2340-2350
    • Green, H.1    Schotland, S.2    Sella, Z.3    Kleeman, C.R.4
  • 158
    • 0026085747 scopus 로고
    • Human osteoblastlike cells do not respond to interleukin-6
    • 158. Littlewood AJ, Aarden LA, Evans DB, et al. 1991. Human osteoblastlike cells do not respond to interleukin-6. J. Bone Miner. Res. 6:141-48
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 141-148
    • Littlewood, A.J.1    Aarden, L.A.2    Evans, D.B.3
  • 159
    • 0029088732 scopus 로고
    • Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption
    • 159. Greenfield EM, Shaw SM, Gornik SA, Banks MA. 1995. Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. J. Clin. Invest. 96:1238-44
    • (1995) J. Clin. Invest. , vol.96 , pp. 1238-1244
    • Greenfield, E.M.1    Shaw, S.M.2    Gornik, S.A.3    Banks, M.A.4
  • 160
    • 0024404268 scopus 로고
    • Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis
    • 160. Löwik CWGM, van der Pluijm G, Bloys H, et al. 1989. Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. Biochem. Biophys. Res. Commun. 162:1546-52
    • (1989) Biochem. Biophys. Res. Commun. , vol.162 , pp. 1546-1552
    • Löwik, C.W.G.M.1    Van Der Pluijm, G.2    Bloys, H.3
  • 161
    • 0026517112 scopus 로고
    • Bradykinin stimulates the production of prostaglandin E2 and interleukin-6 in human osteoblast-like cells
    • 161. Rahman S, Bunning RAD, Dobson PRM, et al. 1992. Bradykinin stimulates the production of prostaglandin E2 and interleukin-6 in human osteoblast-like cells. Biochim. Biophys. Acta 1135:97-102
    • (1992) Biochim. Biophys. Acta , vol.1135 , pp. 97-102
    • Rahman, S.1    Bunning, R.A.D.2    Dobson, P.R.M.3
  • 162
    • 0027993620 scopus 로고
    • Recombinant human bone morphogenetic protein-2 enhances expression of interleukin-6 and transforming growth factor-β1 genes in normal human osteoblast-like cells
    • 162. Zheng MH, Wood DJ, Wysocki S, et al. 1994. Recombinant human bone morphogenetic protein-2 enhances expression of interleukin-6 and transforming growth factor-β1 genes in normal human osteoblast-like cells. J. Cell. Physiol. 159:76-82
    • (1994) J. Cell. Physiol. , vol.159 , pp. 76-82
    • Zheng, M.H.1    Wood, D.J.2    Wysocki, S.3
  • 163
    • 0026012956 scopus 로고
    • Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae
    • 163. Al-Humidan A, Ralston SH, Hughes DE, et al. 1991. Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae. J. Bone Miner. Res. 6:3-8
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 3-8
    • Al-Humidan, A.1    Ralston, S.H.2    Hughes, D.E.3
  • 164
    • 0029144320 scopus 로고
    • The effect of interleukin-6 and soluble interleukin-6 receptor protein on the bone resorptive activity of human osteoclasts generated in vitro
    • 164. Flanagan AM, Stow MD, Williams R. 1995. The effect of interleukin-6 and soluble interleukin-6 receptor protein on the bone resorptive activity of human osteoclasts generated in vitro. J. Pathol. 176:289-97
    • (1995) J. Pathol. , vol.176 , pp. 289-297
    • Flanagan, A.M.1    Stow, M.D.2    Williams, R.3
  • 165
    • 0026530892 scopus 로고
    • Interleukin-6: A potential autocrine/paracrine factor in Paget's disease of bone
    • 165. Roodman GD, Kurihara N, Ohsaki Y, et al. 1992. Interleukin-6: a potential autocrine/paracrine factor in Paget's disease of bone. J. Clin. Invest. 89:46-52
    • (1992) J. Clin. Invest. , vol.89 , pp. 46-52
    • Roodman, G.D.1    Kurihara, N.2    Ohsaki, Y.3
  • 166
    • 0010388158 scopus 로고
    • Interleukin-6 causes hypercalcemia in vivo, and enhances the bone resorbing potency of interleukin-1 and tumor necrosis factor by two orders of magnitude in vitro
    • 166. Black KS, Mundy GR, Garrett IR. 1991. Interleukin-6 causes hypercalcemia in vivo, and enhances the bone resorbing potency of interleukin-1 and tumor necrosis factor by two orders of magnitude in vitro. J. Bone Miner. Res. 6:S271 (Suppl.)
    • (1991) J. Bone Miner. Res. , vol.6 , Issue.SUPPL.
    • Black, K.S.1    Mundy, G.R.2    Garrett, I.R.3
  • 167
    • 0026437455 scopus 로고
    • Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone
    • 167. Ohsaki Y, Takahashi S, Scarcez T, et al. 1992. Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology 131: 2229-34
    • (1992) Endocrinology , vol.131 , pp. 2229-2234
    • Ohsaki, Y.1    Takahashi, S.2    Scarcez, T.3
  • 168
    • 0029161781 scopus 로고
    • Glial cytokines in Alzheimer's disease review and pathogenic implications
    • 168. Mrak RE, Sheng JG, Griffin WS. 1995. Glial cytokines in Alzheimer's disease review and pathogenic implications. Hum. Pathol. 26:816-23
    • (1995) Hum. Pathol. , vol.26 , pp. 816-823
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.3
  • 169
    • 0026744420 scopus 로고
    • The participation of interleukin-6 in the pathogenesis of Alzheimer's disease
    • 169. Bauer J, Ganter U, Strauss S, et al. 1992. The participation of interleukin-6 in the pathogenesis of Alzheimer's disease. Res. Immunol. 143(6):650-57
    • (1992) Res. Immunol. , vol.143 , Issue.6 , pp. 650-657
    • Bauer, J.1    Ganter, U.2    Strauss, S.3
  • 170
    • 0025801468 scopus 로고
    • Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated "acute phase response" in the brain?
    • 170. Vandenabelle P, Fiers W. 1991. Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated "acute phase response" in the brain? Immunol. Today 12:217-19
    • (1991) Immunol. Today , vol.12 , pp. 217-219
    • Vandenabelle, P.1    Fiers, W.2
  • 171
    • 0025881467 scopus 로고
    • Alpha-2 macroglobulin synthesis in interleukin-6 stimulated human neuronal (SH-SY5Y neuroblastoma) cells
    • 171. Ganter U, Strauss S, Jonas V, et al. 1991. Alpha-2 macroglobulin synthesis in interleukin-6 stimulated human neuronal (SH-SY5Y neuroblastoma) cells. FEBS Lett. 282:127-31
    • (1991) FEBS Lett. , vol.282 , pp. 127-131
    • Ganter, U.1    Strauss, S.2    Jonas, V.3
  • 172
    • 0026553710 scopus 로고
    • Detection of interleukin-6 and a2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients
    • 172. Strauss S, Bauer J, Ganter U, et al. 1992. Detection of interleukin-6 and a2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab. Invest. 66:223-30
    • (1992) Lab. Invest. , vol.66 , pp. 223-230
    • Strauss, S.1    Bauer, J.2    Ganter, U.3
  • 173
    • 0025763298 scopus 로고
    • Interleukin-6 and α2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
    • 173. Bauer J, Strauss S, Schreiter-Gasser U, et al. 1991. Interleukin-6 and α2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett. 285:111-14
    • (1991) FEBS Lett. , vol.285 , pp. 111-114
    • Bauer, J.1    Strauss, S.2    Schreiter-Gasser, U.3
  • 174
    • 0025265675 scopus 로고
    • α1-Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of α1-antichymotrypsin
    • 174. Abraham CR, Shirahama T, Potter H. 1990. α1-Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of α1-antichymotrypsin. Neurobiol. Aging 11:123-26
    • (1990) Neurobiol. Aging , vol.11 , pp. 123-126
    • Abraham, C.R.1    Shirahama, T.2    Potter, H.3
  • 175
    • 0027453380 scopus 로고
    • Cytokine indices in Alzheimer's temporal cortex: No changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein
    • 175. Wood JA, Wood PL, Ryan R, et al. 1993. Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein. Brain Res. 629(2):245-52
    • (1993) Brain Res. , vol.629 , Issue.2 , pp. 245-252
    • Wood, J.A.1    Wood, P.L.2    Ryan, R.3
  • 176
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's disease and de novo parkinson's disease patients
    • 176. Blum-Degen D, Muller T, Kuhn W, et al. 1995. Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's disease and de novo Parkinson's disease patients. Neurosci. Lett. 202(1-2):17-20
    • (1995) Neurosci. Lett. , vol.202 , Issue.1-2 , pp. 17-20
    • Blum-Degen, D.1    Muller, T.2    Kuhn, W.3
  • 177
    • 0028938729 scopus 로고
    • Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia
    • 177. Yamada K, Kono K, Umegaki H, et al. 1995. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Neurosci. Lett. 186(2-3):219-21
    • (1995) Neurosci. Lett. , vol.186 , Issue.2-3 , pp. 219-221
    • Yamada, K.1    Kono, K.2    Umegaki, H.3
  • 178
    • 0028465427 scopus 로고
    • Serum cytokine levels in patients with Alzheimer's disease
    • 178. Chao CC, Ala TA, Hu S, et al. 1994. Serum cytokine levels in patients with Alzheimer's disease. Clin. Diagn. Lab. Immunol. 1(4):433-36
    • (1994) Clin. Diagn. Lab. Immunol. , vol.1 , Issue.4 , pp. 433-436
    • Chao, C.C.1    Ala, T.A.2    Hu, S.3
  • 179
    • 0025129231 scopus 로고
    • Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease
    • 179. van Duijn CM, Hofman A, Nagelkerken L. 1990. Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease. Neurosci. Lett. 108:350-54
    • (1990) Neurosci. Lett. , vol.108 , pp. 350-354
    • Van Duijn, C.M.1    Hofman, A.2    Nagelkerken, L.3
  • 180
    • 0028000830 scopus 로고
    • Regulation of the release of interleukin-6 from human astrocytoma cells
    • 180. Cadman ED, Witte DG, Lee CM. 1994. Regulation of the release of interleukin-6 from human astrocytoma cells. J. Neurochem. 63(3):980-87
    • (1994) J. Neurochem. , vol.63 , Issue.3 , pp. 980-987
    • Cadman, E.D.1    Witte, D.G.2    Lee, C.M.3
  • 181
    • 0027156783 scopus 로고
    • In vitro production of IL-6, IL-1β, and tumor necrosis factor-α by human embryonic microglial and neural cells
    • 181. Sebire G, Emilie D, Wallon C, et al. 1993. In vitro production of IL-6, IL-1β, and tumor necrosis factor-α by human embryonic microglial and neural cells. J. Immunol. 150:1517-23
    • (1993) J. Immunol. , vol.150 , pp. 1517-1523
    • Sebire, G.1    Emilie, D.2    Wallon, C.3
  • 182
    • 0028946146 scopus 로고
    • Reciprocal control of inflammatory cytokines, IL-1, IL-6 and beta-amyloid production in cultures
    • 182. Del Bo R, Angeretti N, Lucca E, et al. 1995. Reciprocal control of inflammatory cytokines, IL-1, IL-6 and beta-amyloid production in cultures. Neurosci. Lett. 188(1):70-74
    • (1995) Neurosci. Lett. , vol.188 , Issue.1 , pp. 70-74
    • Del Bo, R.1    Angeretti, N.2    Lucca, E.3
  • 183
    • 0030014561 scopus 로고    scopus 로고
    • The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease
    • 183. Hull M, Strauss S, Berger M, et al. 1996. The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease. Behav. Brain Res. 78(1):37-41
    • (1996) Behav. Brain Res. , vol.78 , Issue.1 , pp. 37-41
    • Hull, M.1    Strauss, S.2    Berger, M.3
  • 184
    • 0029051259 scopus 로고
    • Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients
    • 184. Huell M, Strauss S, Volk B, et al. 1995. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients. Acta Neuropathol. 89(6):544-51
    • (1995) Acta Neuropathol. , vol.89 , Issue.6 , pp. 544-551
    • Huell, M.1    Strauss, S.2    Volk, B.3
  • 185
    • 0026334998 scopus 로고
    • Interleukin 1 in Alzheimer's disease and multi-infarct dementia: Neurophysiological correlations
    • 185. Cacabelos R, Franco-Maside A, Alvarez XA. 1991. Interleukin 1 in Alzheimer's disease and multi-infarct dementia: neurophysiological correlations. Methods Exp. Clin. Pharmacol. 13:703-8
    • (1991) Methods Exp. Clin. Pharmacol. , vol.13 , pp. 703-708
    • Cacabelos, R.1    Franco-Maside, A.2    Alvarez, X.A.3
  • 186
    • 0029061968 scopus 로고
    • IL-2 and IL-6 secretion in dementia: Correlation with type and severity of disease
    • 186. Huberman M, Sredni B, Stern L, et al. 1995. IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease. J. Neurol. Sci. 130(2):161-64
    • (1995) J. Neurol. Sci. , vol.130 , Issue.2 , pp. 161-164
    • Huberman, M.1    Sredni, B.2    Stern, L.3
  • 187
    • 0028341702 scopus 로고
    • Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients
    • 187. Shalit F, Sredni B, Stern L, et al. 1994. Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients. Neurosci. Lett. 174(2):130-32
    • (1994) Neurosci. Lett. , vol.174 , Issue.2 , pp. 130-132
    • Shalit, F.1    Sredni, B.2    Stern, L.3
  • 188
    • 0028829231 scopus 로고
    • IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage
    • 188. Fattori E, Lazzaro D, Musiani P, et al. 1995. IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage. Eur. J. Neurosci. 7(12):2441-49
    • (1995) Eur. J. Neurosci. , vol.7 , Issue.12 , pp. 2441-2449
    • Fattori, E.1    Lazzaro, D.2    Musiani, P.3
  • 189
    • 0028843876 scopus 로고
    • Reduced long term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6
    • 189. Bellinger FP, Madamba SG, Campbell IL, Siggins GR. 1995. Reduced long term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6. Neurosci. Lett. 198(2):95-98
    • (1995) Neurosci. Lett. , vol.198 , Issue.2 , pp. 95-98
    • Bellinger, F.P.1    Madamba, S.G.2    Campbell, I.L.3    Siggins, G.R.4
  • 190
    • 0028866623 scopus 로고
    • Evolution of neuropathologic abnormalities associated with blood brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes
    • 190. Brett FM, Mizisin AP, Powell HC, Campbell IL. 1995. Evolution of neuropathologic abnormalities associated with blood brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J. Neuropathol. Exp. Neurol. 54(6):766-75
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , Issue.6 , pp. 766-775
    • Brett, F.M.1    Mizisin, A.P.2    Powell, H.C.3    Campbell, I.L.4
  • 191
    • 0028598750 scopus 로고
    • Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice
    • 191. Chiang CS, Stalder A, Samimi A, Campbell IL. 1994. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev. Neurosci. 16(3-4):212-21
    • (1994) Dev. Neurosci. , vol.16 , Issue.3-4 , pp. 212-221
    • Chiang, C.S.1    Stalder, A.2    Samimi, A.3    Campbell, I.L.4
  • 192
    • 0028298627 scopus 로고
    • Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
    • 192. Steffensen SC, Campbell IL, Henriksen SJ. 1994. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res. 652(1): 149-53
    • (1994) Brain Res. , vol.652 , Issue.1 , pp. 149-153
    • Steffensen, S.C.1    Campbell, I.L.2    Henriksen, S.J.3
  • 193
    • 0027433102 scopus 로고
    • Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6
    • 193. Campbell IL, Abraham CR, Masilaah E, et al. 1993. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6. Proc. Natl. Acad. Sci. USA 90(21): 10061-65
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , Issue.21 , pp. 10061-10065
    • Campbell, I.L.1    Abraham, C.R.2    Masilaah, E.3
  • 194
    • 0030748719 scopus 로고    scopus 로고
    • A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: The Baltimore Longitudinal Study of Aging
    • 194. Kawas C, Resnick S, Morrison A, et al. 1997. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 48(6):1517-21
    • (1997) Neurology , vol.48 , Issue.6 , pp. 1517-1521
    • Kawas, C.1    Resnick, S.2    Morrison, A.3
  • 195
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • 195. Stewart WF, Kawas C, Corrada M, Metter EJ. 1997. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48(3):626-32
    • (1997) Neurology , vol.48 , Issue.3 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 196
    • 0027929955 scopus 로고
    • Effects of recombinant human interleukin-6 administration on bone in rhesus monkeys
    • 196. Binkley NC, Sun WH, Checovich MM, et al. 1994. Effects of recombinant human interleukin-6 administration on bone in rhesus monkeys. Lymphokine Cytokine Res. 13:221-26
    • (1994) Lymphokine Cytokine Res. , vol.13 , pp. 221-226
    • Binkley, N.C.1    Sun, W.H.2    Checovich, M.M.3
  • 197
    • 0030849677 scopus 로고    scopus 로고
    • The association of plasma IL-6 levels with functional disability in community dwelling elderly
    • 197. Cohen HJ, Pieper CF, Harris T, et al. 1997. The association of plasma IL-6 levels with functional disability in community dwelling elderly. J. Gerontol. Med. Sci. 52:M201-8
    • (1997) J. Gerontol. Med. Sci. , vol.52
    • Cohen, H.J.1    Pieper, C.F.2    Harris, T.3


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