-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan,D. and Weinberg,R.A. (2000) The hallmarks of cancer. Cell, 100, 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
0038049143
-
Cancer and ageing: Rival demons?
-
Campisi,J. (2003) Cancer and ageing: Rival demons? Nat. Rev., 3 339-349.
-
(2003)
Nat. Rev
, vol.3
, pp. 339-349
-
-
Campisi, J.1
-
3
-
-
14544271073
-
Genetics of longevity and aging
-
Vijg,J. and Suh,Y. (2005) Genetics of longevity and aging. Annu. Rev. Med., 56, 193-212.
-
(2005)
Annu. Rev. Med
, vol.56
, pp. 193-212
-
-
Vijg, J.1
Suh, Y.2
-
4
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner,S.D., Venkatachalam,S., Choi,J., Jones,S., Ghebranious,N., Igelmann,H., Lu,X., Soron,G., Cooper,B. et al. (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature, 415, 45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
-
5
-
-
33846921755
-
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
-
Dumble,M., Moore,L., Chambers,S.M., Geiger,H., Van Zant,G., Goodell,M.A. and Donehower,L.A. (2007) The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood, 109, 1736-1742.
-
(2007)
Blood
, vol.109
, pp. 1736-1742
-
-
Dumble, M.1
Moore, L.2
Chambers, S.M.3
Geiger, H.4
Van Zant, G.5
Goodell, M.A.6
Donehower, L.A.7
-
6
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier,B., Gluba,W., Bernier,B., Turner,T., Mohammad,K., Guise,T., Sutherland,A., Thorner,M. and Scrable,H. (2004) Modulation of mammalian life span by the short isoform of p53. Genes Dev., 18, 306-319.
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
Sutherland, A.7
Thorner, M.8
Scrable, H.9
-
7
-
-
23144462546
-
Cancer and ageing: A nexus at several levels
-
Balducci,L. and Ershler,W.B. (2005) Cancer and ageing: A nexus at several levels. Nat. Rev., 5, 655-662.
-
(2005)
Nat. Rev
, vol.5
, pp. 655-662
-
-
Balducci, L.1
Ershler, W.B.2
-
8
-
-
0036719103
-
Dying of old age: An examination of death certificates of Minnesota centenarians
-
Gessert,C.E., Elliott,B.A. and Haller,I.V. (2002) Dying of old age: An examination of death certificates of Minnesota centenarians. J. Am. Geriatr. Soc., 50, 1561-1565.
-
(2002)
J. Am. Geriatr. Soc
, vol.50
, pp. 1561-1565
-
-
Gessert, C.E.1
Elliott, B.A.2
Haller, I.V.3
-
9
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
-
Sedelnikova,O.A., Horikawa,I., Zimonjic,D.B., Popescu,N.C., Bonner,W.M. and Barrett,J.C. (2004) Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6, 168-170.
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
Horikawa, I.2
Zimonjic, D.B.3
Popescu, N.C.4
Bonner, W.M.5
Barrett, J.C.6
-
10
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig,U., Ferreira,M., Condel,L., Carey,D. and Sedivy,J.M. (2006) Cellular senescence in aging primates. Science (New York, N. Y.), 311, 1257.
-
(2006)
Science (New York, N. Y.)
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
11
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan,J.C., Ferreira,M., Sedivy,J.M. and Herbig,U. (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev., 128, 36-44.
-
(2007)
Mech. Ageing Dev
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
12
-
-
0037198009
-
Large genome rearrangements as a primary cause of aging
-
Vijg,J. and Dolle,M.E. (2002) Large genome rearrangements as a primary cause of aging. Mech. Ageing Dev., 123, 907-915.
-
(2002)
Mech. Ageing Dev
, vol.123
, pp. 907-915
-
-
Vijg, J.1
Dolle, M.E.2
-
13
-
-
33745532801
-
Increased cell-to-cell variation in gene expression in ageing mouse heart
-
Bahar,R., Hartmann,C.H., Rodriguez,K.A., Denny,A.D., Busuttil,R.A., Dolle,M.E., Calder,R.B., Chisholm,G.B., Pollock,B.H. et al. (2006) Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature, 441, 1011-1014.
-
(2006)
Nature
, vol.441
, pp. 1011-1014
-
-
Bahar, R.1
Hartmann, C.H.2
Rodriguez, K.A.3
Denny, A.D.4
Busuttil, R.A.5
Dolle, M.E.6
Calder, R.B.7
Chisholm, G.B.8
Pollock, B.H.9
-
14
-
-
34248354983
-
Loss of stem cell regenerative capacity within aged niches
-
Carlson,M.E. and Conboy,I.M. (2007) Loss of stem cell regenerative capacity within aged niches. Aging Cell, 6, 371-382.
-
(2007)
Aging Cell
, vol.6
, pp. 371-382
-
-
Carlson, M.E.1
Conboy, I.M.2
-
15
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi,D.J., Bryder,D., Seita,J., Nussenzweig,A., Hoeijmakers,J. and Weissman,I.L. (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature, 447, 725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
16
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba,S., Kang,J.G., Patino,W.D., Wragg,A., Boehm,M., Gavrilova,O., Hurley,P.J., Bunz,F. and Hwang,P.M. (2006) p53 regulates mitochondrial respiration. Science (New York, N. Y.), 312, 1650-1653.
-
(2006)
Science (New York, N. Y.)
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
17
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad,K., Tsuruta,A., Selak,M.A., Vidal,M.N., Nakano,K., Bartrons,R., Gottlieb,E. and Vousden,K.H. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell, 126, 107-120.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
18
-
-
28644447272
-
The antioxidant function of the p53 tumor suppressor
-
Sablina,A.A., Budanov,A.V., Ilyinskaya,G.V., Agapova,L.S., Kravchenko,J.E. and Chumakov,P.M. (2005) The antioxidant function of the p53 tumor suppressor. Nat. Med., 11, 1306-1313.
-
(2005)
Nat. Med
, vol.11
, pp. 1306-1313
-
-
Sablina, A.A.1
Budanov, A.V.2
Ilyinskaya, G.V.3
Agapova, L.S.4
Kravchenko, J.E.5
Chumakov, P.M.6
-
19
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban,R.S., Nemoto,S. and Finkel,T. (2005) Mitochondria, oxidants, and aging. Cell, 120, 483-495.
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
20
-
-
8344282655
-
The role of oxidative damage and stress in aging
-
Bokov,A., Chaudhuri,A. and Richardson,A. (2004) The role of oxidative damage and stress in aging. Mech. Ageing Dev., 125, 811-826.
-
(2004)
Mech. Ageing Dev
, vol.125
, pp. 811-826
-
-
Bokov, A.1
Chaudhuri, A.2
Richardson, A.3
-
21
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin,D., Li,F.P., Strong,L.C., Fraumeni,J.F.Jr, Nelson,C.E., Kim,D.H., Kassel,J., Gryka,M.A., Bischoff,F.Z. et al. (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science (New York, N. Y.), 250, 1233-1238.
-
(1990)
Science (New York, N. Y.)
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
Li, F.P.2
Strong, L.C.3
Fraumeni Jr, J.F.4
Nelson, C.E.5
Kim, D.H.6
Kassel, J.7
Gryka, M.A.8
Bischoff, F.Z.9
-
22
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower,L.A., Harvey,M., Slagle,B.L., McArthur,M.J., Montgomery,C.A.Jr, Butel,J.S. and Bradley,A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature, 356, 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery Jr, C.A.5
Butel, J.S.6
Bradley, A.7
-
23
-
-
10344229445
-
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
-
Wu,C., Miloslavskaya,J., Demontis,S., Maestro,R. and Galaktionov,K. (2004) Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature, 432, 640-645.
-
(2004)
Nature
, vol.432
, pp. 640-645
-
-
Wu, C.1
Miloslavskaya, J.2
Demontis, S.3
Maestro, R.4
Galaktionov, K.5
-
24
-
-
33846128155
-
The DNA damage signaling pathway is critical mediator of oncogene-induced senescence
-
Mallette,F.A., Gaumont-Leclerc,M.F. and Ferbeyre,G. (2007) The DNA damage signaling pathway is critical mediator of oncogene-induced senescence. Genes Dev., 21, 43-48.
-
(2007)
Genes Dev
, vol.21
, pp. 43-48
-
-
Mallette, F.A.1
Gaumont-Leclerc, M.F.2
Ferbeyre, G.3
-
25
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco,R., Fumagalli,M., Cicalese,A., Piccinin,S., Gasparini,P., Luise,C., Schurra,C., Garre,M., Nuciforo,P.G. et al. (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature, 444, 638-642.
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
Piccinin, S.4
Gasparini, P.5
Luise, C.6
Schurra, C.7
Garre, M.8
Nuciforo, P.G.9
-
26
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova,J., Rezaei,N., Liontos,M., Karakaidos,P., Kletsas,D., Issaeva,N., Vassiliou,L.V., Kolettas,E., Niforou,K. et al. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature, 444, 633-637.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
Vassiliou, L.V.7
Kolettas, E.8
Niforou, K.9
-
27
-
-
33745713432
-
p53 and metabolism: Inside the TIGAR
-
Green,D.R. and Chipuk,J.E. (2006) p53 and metabolism: Inside the TIGAR. Cell, 126, 30-32.
-
(2006)
Cell
, vol.126
, pp. 30-32
-
-
Green, D.R.1
Chipuk, J.E.2
-
28
-
-
3142534591
-
Initiating cellular stress responses
-
Bakkenist,C.J. and Kastan,M.B. (2004) Initiating cellular stress responses. Cell, 118, 9-17.
-
(2004)
Cell
, vol.118
, pp. 9-17
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
29
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition, of RPA-ssDNA complexes
-
Zou,L. and Elledge,S.J. (2003) Sensing DNA damage through ATRIP recognition, of RPA-ssDNA complexes. Seience (New York, N.Y.), 300, 1542-1548.
-
(2003)
Seience (New York, N.Y.)
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
30
-
-
18244401922
-
Unwind and slow down: Checkpoint activation by helicase and polymerase uncoupling
-
Cortez,D. (2005) Unwind and slow down: Checkpoint activation by helicase and polymerase uncoupling. Genes Dev., 19, 1007-1012.
-
(2005)
Genes Dev
, vol.19
, pp. 1007-1012
-
-
Cortez, D.1
-
31
-
-
33751256575
-
DNA nucleotide excision repair-qependent signaling to checkpoint activation
-
Marini,F., Nardo,T., Giannattasio,M., Minuzzo,M., Stefanini,M., Plevani,P. and Falconi,M.M. (2006) DNA nucleotide excision repair-qependent signaling to checkpoint activation. Proc. Natl Acad Sci. USA, 103, 17325-17330.
-
(2006)
Proc. Natl Acad Sci. USA
, vol.103
, pp. 17325-17330
-
-
Marini, F.1
Nardo, T.2
Giannattasio, M.3
Minuzzo, M.4
Stefanini, M.5
Plevani, P.6
Falconi, M.M.7
-
32
-
-
33645223728
-
Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences
-
Jiang,G. and Sancar,A. (2006) Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences. Mol. Cell. Biol., 26, 39-49.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 39-49
-
-
Jiang, G.1
Sancar, A.2
-
33
-
-
3242881500
-
The cellular response to general and programmed DNA double strand breaks
-
Bassing,C.H. and Alt,F.W. (2004) The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst), 3, 781-796.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 781-796
-
-
Bassing, C.H.1
Alt, F.W.2
-
34
-
-
0035841951
-
Genotoxic and non-genotoxic pathways of p53 induction
-
Pluquet,O. and Hainaut,P. (2001) Genotoxic and non-genotoxic pathways of p53 induction. Cancer Lett., 174, 1-15.
-
(2001)
Cancer Lett
, vol.174
, pp. 1-15
-
-
Pluquet, O.1
Hainaut, P.2
-
35
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
Celeste,A., Petersen,S., Romanienko,P.J., Fernandez-Capetillo,O., Chen,H.T., Sedelnikova,O.A., Reina-San-Martin,B., Coppola,V., Meffre,E. et al. (2002) Genomic instability in mice lacking histone H2AX. Science (New York, N.Y.), 296, 922-927.
-
(2002)
Science (New York, N.Y.)
, vol.296
, pp. 922-927
-
-
Celeste, A.1
Petersen, S.2
Romanienko, P.J.3
Fernandez-Capetillo, O.4
Chen, H.T.5
Sedelnikova, O.A.6
Reina-San-Martin, B.7
Coppola, V.8
Meffre, E.9
-
36
-
-
33646757232
-
The complexity of p53 stabilization and activation
-
Lavin,M.F. and Gueven,N. (2006) The complexity of p53 stabilization and activation. Cell Death Differ., 13, 941-950.
-
(2006)
Cell Death Differ
, vol.13
, pp. 941-950
-
-
Lavin, M.F.1
Gueven, N.2
-
37
-
-
0034717014
-
Death signal-induced localization of p53 protein to mitocbondria. A potential role in apoptotic signaling
-
Marchenko,N.D., Zaika,A. and Moll,U.M. (2000) Death signal-induced localization of p53 protein to mitocbondria. A potential role in apoptotic signaling. J. Biol. Chem., 275, 16202-16212.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 16202-16212
-
-
Marchenko, N.D.1
Zaika, A.2
Moll, U.M.3
-
38
-
-
13144281734
-
p53 moves to mitochondria: A turn on the path to apoptosis
-
Murphy,M.E., Leu,J.I. and George,D.L. (2004) p53 moves to mitochondria: a turn on the path to apoptosis. Cell cycle (Georgetown, Tex.), 3, 836-839.
-
(2004)
Cell cycle (Georgetown, Tex.)
, vol.3
, pp. 836-839
-
-
Murphy, M.E.1
Leu, J.I.2
George, D.L.3
-
39
-
-
28244443670
-
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo
-
Al Rashid,S.T., Dellaire,G., Cuddihy,A., Jalali,F., Vaid,M., Coackley,C., Folkard,M., Xu,Y., Chen,B.P. et al. (2005) Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res., 65, 10810-10821.
-
(2005)
Cancer Res
, vol.65
, pp. 10810-10821
-
-
Al Rashid, S.T.1
Dellaire, G.2
Cuddihy, A.3
Jalali, F.4
Vaid, M.5
Coackley, C.6
Folkard, M.7
Xu, Y.8
Chen, B.P.9
-
40
-
-
0038751837
-
Transcriptional repression mediated by the p53 tumour suppressor
-
Ho,J. and Benchimol,S. (2003) Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ., 10, 404-408.
-
(2003)
Cell Death Differ
, vol.10
, pp. 404-408
-
-
Ho, J.1
Benchimol, S.2
-
41
-
-
0038075338
-
Decision making by p53: Life, death and cancer
-
Oren,M. (2003) Decision making by p53: Life, death and cancer. Cell Death Differ., 10, 431-442.
-
(2003)
Cell Death Differ
, vol.10
, pp. 431-442
-
-
Oren, M.1
-
42
-
-
0029023560
-
Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: Blocking p53-induced apoptosis unmasks G1 arrest
-
Guillouf,C., Grana,X., Selvakumaran,M., De Luca,A., Giordano,A., Hoffman,B. and Liebermann,D.A. (1995) Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: Blocking p53-induced apoptosis unmasks G1 arrest. Blood, 85, 2691-2698.
-
(1995)
Blood
, vol.85
, pp. 2691-2698
-
-
Guillouf, C.1
Grana, X.2
Selvakumaran, M.3
De Luca, A.4
Giordano, A.5
Hoffman, B.6
Liebermann, D.A.7
-
43
-
-
0842281645
-
Cell death: Critical control points
-
Danial,N.N. and Korsmeyer,S.J. (2004) Cell death: Critical control points. Cell, 116, 205-219.
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
44
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe,S.W., Schmitt,E.M., Smith,S.W., Osborne,B.A. and Jacks,T. (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
45
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
-
Di Leonardo,A., Linke,S.P., Clarkin,K. and Wahl,G.M. (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev., 8, 2540-2551.
-
(1994)
Genes Dev
, vol.8
, pp. 2540-2551
-
-
Di Leonardo, A.1
Linke, S.P.2
Clarkin, K.3
Wahl, G.M.4
-
46
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi,J. (2005) Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell, 120, 513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
47
-
-
0041966056
-
Reversal of human cellular senescence: Roles of the p53 and p16 pathways
-
Beausejour,C.M., Krtolica,A., Galimi,F., Narita,M., Lowe,S.W., Yaswen,P. and Campisi,J. (2003) Reversal of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J., 22, 4212-4222.
-
(2003)
EMBO J
, vol.22
, pp. 4212-4222
-
-
Beausejour, C.M.1
Krtolica, A.2
Galimi, F.3
Narita, M.4
Lowe, S.W.5
Yaswen, P.6
Campisi, J.7
-
48
-
-
3242714885
-
Functional aging and gradual senescence in zebrafish
-
Kishi,S. (2004) Functional aging and gradual senescence in zebrafish. Ann. NY Acad. Sci., 1019, 521-526.
-
(2004)
Ann. NY Acad. Sci
, vol.1019
, pp. 521-526
-
-
Kishi, S.1
-
49
-
-
0037850928
-
Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
-
Melk,A., Kittikowit,W., Sandhu,I., Halloran,K.M., Grimm,P., Schmidt,B.M. and Halloran,P.F. (2003) Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int., 63, 2134-2143.
-
(2003)
Kidney Int
, vol.63
, pp. 2134-2143
-
-
Melk, A.1
Kittikowit, W.2
Sandhu, I.3
Halloran, K.M.4
Grimm, P.5
Schmidt, B.M.6
Halloran, P.F.7
-
50
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri,G.P., Lee,X., Basile,G., Acosta,M., Scott,G., Roskelley,C., Medrano,E.E., Linskens,M., Rubelj,I. et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA, 92, 9363-9367.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
-
51
-
-
30144439380
-
Total body irradiation selectively induces murine hematopoietic stem cell senescence
-
Wang,Y., Schulte,B.A., LaRue,A.C., Ogawa,M. and Zhou,D. (2006) Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood, 107, 358-366.
-
(2006)
Blood
, vol.107
, pp. 358-366
-
-
Wang, Y.1
Schulte, B.A.2
LaRue, A.C.3
Ogawa, M.4
Zhou, D.5
-
52
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p161NK4a
-
Janzen,V., Forkert,R., Flerning,H.E., Saito,Y., Waring,M.T., Dombkowski,D.M., Cheng,T., DePinho,R.A., Sharpless,N.E. et al. (2006) Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p161NK4a. Nature, 443, 421-426.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Flerning, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
Cheng, T.7
DePinho, R.A.8
Sharpless, N.E.9
-
53
-
-
33749171885
-
Increasing p161NK4a expression decreases forebrain progenitors and neurogenesis during ageing
-
Molofsky,A.V., Slutsky,S.G., Joseph,N.M., He,S., Pardal,R., Krishnamurthy,J., Sharpless,N.E. and Morrison,S.J. (2006) Increasing p161NK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature, 443, 448-452.
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
He, S.4
Pardal, R.5
Krishnamurthy, J.6
Sharpless, N.E.7
Morrison, S.J.8
-
54
-
-
13944260728
-
Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
-
Parrinello,S., Coppe,J.P., Krtolica,A. and Campisi,J. (2005) Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci., 118, 485-496.
-
(2005)
J. Cell Sci
, vol.118
, pp. 485-496
-
-
Parrinello, S.1
Coppe, J.P.2
Krtolica, A.3
Campisi, J.4
-
55
-
-
34248197982
-
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
-
Liu,D. and Hornsby,P.J. (2007) Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res., 67, 3117-3126.
-
(2007)
Cancer Res
, vol.67
, pp. 3117-3126
-
-
Liu, D.1
Hornsby, P.J.2
-
56
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe,S.W., Ruley,H.E., Jacks,T. and Housman,D.E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
57
-
-
0027283604
-
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
-
Lotem,J. and Sachs,L. (1993) Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood, 82, 1092-1096.
-
(1993)
Blood
, vol.82
, pp. 1092-1096
-
-
Lotem, J.1
Sachs, L.2
-
58
-
-
22844445705
-
Temporal dissection of p53 function in vitro and in vivo
-
Christophorou,M.A., Martin-Zanca,D., Soucek,L., Lawfor,E.R., Brown-Swigart,L., Verschuren,E.W. and Evan,G.I. (2005) Temporal dissection of p53 function in vitro and in vivo. Nat. Genet., 37, 718-726.
-
(2005)
Nat. Genet
, vol.37
, pp. 718-726
-
-
Christophorou, M.A.1
Martin-Zanca, D.2
Soucek, L.3
Lawfor, E.R.4
Brown-Swigart, L.5
Verschuren, E.W.6
Evan, G.I.7
-
59
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou,M.A., Ringshausen,I., Finch,A.J., Swigart,L.B. and Evan,G.I. (2006) The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature, 443, 214-217.
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
60
-
-
2442681614
-
Dual effect of p53 on radiation sensitivity in vivo: P53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
-
Komarova,E.A., Kondratov,R.V., Wang,K., Christov,K., Golovkina,T.V., Goldblum,J.R. and Gudkov,A.V. (2004) Dual effect of p53 on radiation sensitivity in vivo: P53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene, 23, 3265-3271.
-
(2004)
Oncogene
, vol.23
, pp. 3265-3271
-
-
Komarova, E.A.1
Kondratov, R.V.2
Wang, K.3
Christov, K.4
Golovkina, T.V.5
Goldblum, J.R.6
Gudkov, A.V.7
-
61
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel,H., Lim,D.S., Karsenty,G., Finegold,M. and Hasty,P. (1999) Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl Acad. Sci. USA, 96, 10770-10775.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
62
-
-
0034626769
-
The age of cancer
-
DePinho,R.A. (2000) The age of cancer. Nature, 408, 248-254.
-
(2000)
Nature
, vol.408
, pp. 248-254
-
-
DePinho, R.A.1
-
63
-
-
0035061863
-
Disease model: Human aging
-
Kuro-o,M. (2001) Disease model: Human aging. Trends Mol. Med., 7, 179-181.
-
(2001)
Trends Mol. Med
, vol.7
, pp. 179-181
-
-
Kuro-o, M.1
-
64
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
de Boer,J., Andressoo,J.O., de Wit,J., Huijmans,J., Beems,R.B., van Steeg,H., Weeda,G., van der Horst,G.T., van Leeuwen,W. et al. (2002) Premature aging in mice deficient in DNA repair and transcription. Science (New York, N.Y.), 296, 1276-1279.
-
(2002)
Science (New York, N.Y.)
, vol.296
, pp. 1276-1279
-
-
de Boer, J.1
Andressoo, J.O.2
de Wit, J.3
Huijmans, J.4
Beems, R.B.5
van Steeg, H.6
Weeda, G.7
van der Horst, G.T.8
van Leeuwen, W.9
-
65
-
-
0034941698
-
Role of DNA-dependent protein kinase in neuronal survival
-
Chechlacz,M., Vemuri,M.C. and Naegele,J.R. (2001) Role of DNA-dependent protein kinase in neuronal survival. J. Neurochem., 78, 141-154.
-
(2001)
J. Neurochem
, vol.78
, pp. 141-154
-
-
Chechlacz, M.1
Vemuri, M.C.2
Naegele, J.R.3
-
66
-
-
0034106125
-
Analysis of ku80-mutant mice and cells with deficient levels of p53
-
Lim,D.S., Vogel,H., Willerford,D.M., Sands,A.T., Platt,K.A. and Hasty,P. (2000) Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol. Cell. Biol., 20, 3772-3780.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 3772-3780
-
-
Lim, D.S.1
Vogel, H.2
Willerford, D.M.3
Sands, A.T.4
Platt, K.A.5
Hasty, P.6
-
67
-
-
19444383162
-
Dyskeratosis congenita: Telomerase, telomeres and anticipation
-
Marrone,A., Walne,A. and Dokal,I. (2005) Dyskeratosis congenita: telomerase, telomeres and anticipation. Curr. Opin. Genet. Dev., 15, 249-257.
-
(2005)
Curr. Opin. Genet. Dev
, vol.15
, pp. 249-257
-
-
Marrone, A.1
Walne, A.2
Dokal, I.3
-
68
-
-
14644422668
-
Cancer and aging: The importance of telomeres in genome maintenance
-
Rodier,F., Kim,S.H., Nijar,T., Yaswen,P. and Campisi,J. (2005) Cancer and aging: The importance of telomeres in genome maintenance. Int J. Biochem. Cell Boil., 37, 977-990.
-
(2005)
Int J. Biochem. Cell Boil
, vol.37
, pp. 977-990
-
-
Rodier, F.1
Kim, S.H.2
Nijar, T.3
Yaswen, P.4
Campisi, J.5
-
69
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna,F., Reaper,P.M., Clay-Farrace,L., Fiegler,H., Carr,P., Von Zglinicki,T., Saretzki,G., Carter,N.P. and Jackson,S.P. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
70
-
-
10944257464
-
Human cell senescence as a DNA damage response
-
von Zglinicki,T., Saretzki,G., Ladhoff,J., d'Adda di Fagagna,F. and Jackson,S.P. (2005) Human cell senescence as a DNA damage response. Mech. Ageing Dev., 126, 111-117.
-
(2005)
Mech. Ageing Dev
, vol.126
, pp. 111-117
-
-
von Zglinicki, T.1
Saretzki, G.2
Ladhoff, J.3
d'Adda di Fagagna, F.4
Jackson, S.P.5
-
71
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco,M.A., Lee,H.W., Hande,M.P., Samper,E., Lansdorp,P.M., DePinho,R.A. and Greider,C.W. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell, 91, 25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
Greider, C.W.7
-
72
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph,K.L., Chang,S., Lee,H.W., Blasco,M., Gottlieb,G.J., Greider,C. and DePinho,R.A. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell, 96, 701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
DePinho, R.A.7
-
73
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin,L., Artandi,S.E., Shen,Q., Tam,A., Lee,S.L., Gottlieb,G.J., Greider,C.W. and DePinho,R.A. (1999) p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell, 97, 527-538.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
Greider, C.W.7
DePinho, R.A.8
-
74
-
-
0033615969
-
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
-
Sullivan,T., Escalante-Alcalde,D., Bhatt,H., Anver,M., Bhat,N., Nagashima,K., Stewart,C.L. and Burke,B. (1999) Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J. Cell. Biol., 147, 913-920.
-
(1999)
J. Cell. Biol
, vol.147
, pp. 913-920
-
-
Sullivan, T.1
Escalante-Alcalde, D.2
Bhatt, H.3
Anver, M.4
Bhat, N.5
Nagashima, K.6
Stewart, C.L.7
Burke, B.8
-
75
-
-
0036578920
-
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
-
Pendas,A.M., Zhou,Z., Cadinanos,J., Freije,J.M., Wang,J., Hultenby,K., Astudillo,A., Wernerson,A., Rodriguez,F. et al. (2002) Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat. Genet., 31, 94-99.
-
(2002)
Nat. Genet
, vol.31
, pp. 94-99
-
-
Pendas, A.M.1
Zhou, Z.2
Cadinanos, J.3
Freije, J.M.4
Wang, J.5
Hultenby, K.6
Astudillo, A.7
Wernerson, A.8
Rodriguez, F.9
-
76
-
-
0036791026
-
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
-
Bergo,M.O., Gavino,B., Ross,J., Schmidt,W.K., Hong,C., Kendall,L.V., Mohr,A., Meta,M., Genant,H. et al. (2002) Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc. Natl Acad. Sci. USA, 99, 13049-13054.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 13049-13054
-
-
Bergo, M.O.1
Gavino, B.2
Ross, J.3
Schmidt, W.K.4
Hong, C.5
Kendall, L.V.6
Mohr, A.7
Meta, M.8
Genant, H.9
-
77
-
-
0042736696
-
LMNA mutations in atypical Werner's syndrome
-
Chen,L., Lee,L., Kudlow,B.A., Dos Santos,H.G., Sletvold,O., Shafeghati,Y., Botha,E.G., Garg,A., Hanson,N.B. et al. (2003) LMNA mutations in atypical Werner's syndrome. Lancet, 362, 440-445.
-
(2003)
Lancet
, vol.362
, pp. 440-445
-
-
Chen, L.1
Lee, L.2
Kudlow, B.A.3
Dos Santos, H.G.4
Sletvold, O.5
Shafeghati, Y.6
Botha, E.G.7
Garg, A.8
Hanson, N.B.9
-
78
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
Eriksson,M., Brown,W.T., Gordon,L.B., Glynn,M.W., Singer,J., Scott,L., Erdos,M.R., Robbins,C.M., Moses,T.Y. et al. (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature, 423, 293-298.
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
Erdos, M.R.7
Robbins, C.M.8
Moses, T.Y.9
-
79
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
Varela,I., Cadinanos,J., Pendas,A.M., Gutierrez-Fernandez,A., Folgueras,A.R., Sanchez,L.M., Zhou,Z., Rodriguez,F.J., Stewart,C.L. et al. (2005) Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature, 437 564-568.
-
(2005)
Nature
, vol.437
, pp. 564-568
-
-
Varela, I.1
Cadinanos, J.2
Pendas, A.M.3
Gutierrez-Fernandez, A.4
Folgueras, A.R.5
Sanchez, L.M.6
Zhou, Z.7
Rodriguez, F.J.8
Stewart, C.L.9
-
80
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
Scaffidi,P. and Misteli,T. (2006) Lamin A-dependent nuclear defects in human aging. Science (New York, N.Y.), 312, 1059-1063.
-
(2006)
Science (New York, N.Y.)
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
81
-
-
22544466685
-
Genomic instability in laminopathy-based premature aging
-
Liu,B., Wang,J., Chan,K.M., Tjia,W.M., Deng,W., Guan,X., Huang,J.D., Li,K.M., Chau,P.Y. et al. (2005) Genomic instability in laminopathy-based premature aging. Nat. Med., 11, 780-785.
-
(2005)
Nat. Med
, vol.11
, pp. 780-785
-
-
Liu, B.1
Wang, J.2
Chan, K.M.3
Tjia, W.M.4
Deng, W.5
Guan, X.6
Huang, J.D.7
Li, K.M.8
Chau, P.Y.9
-
82
-
-
27644543144
-
The role of the BRCA1 tumor suppressor in DNA double-strand break repair
-
Zhang,J. and Powell,S.N. (2005) The role of the BRCA1 tumor suppressor in DNA double-strand break repair. Mol. Cancer Res., 3, 531-539.
-
(2005)
Mol. Cancer Res
, vol.3
, pp. 531-539
-
-
Zhang, J.1
Powell, S.N.2
-
83
-
-
0034946638
-
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
-
Xu,X., Qiao,W., Linke,S.P., Cao,L., Li,W.M., Furth,P.A., Harris,C.C. and Deng,C.X. (2001) Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat. Genet., 28, 266-271.
-
(2001)
Nat. Genet
, vol.28
, pp. 266-271
-
-
Xu, X.1
Qiao, W.2
Linke, S.P.3
Cao, L.4
Li, W.M.5
Furth, P.A.6
Harris, C.C.7
Deng, C.X.8
-
84
-
-
0037439071
-
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
-
Cao,L., Li,W., Kim,S., Brodie,S.G. and Deng,C.X. (2003) Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev., 17, 201-213.
-
(2003)
Genes Dev
, vol.17
, pp. 201-213
-
-
Cao, L.1
Li, W.2
Kim, S.3
Brodie, S.G.4
Deng, C.X.5
-
85
-
-
33646757879
-
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency
-
Cao,L., Kim,S., Xiao,C., Wang,R.H., Coumoul,X., Wang,X., Li,W.M., Xu,X.L., De Soto,J.A. et al. (2006) ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J., 25, 2167-2177.
-
(2006)
EMBO J
, vol.25
, pp. 2167-2177
-
-
Cao, L.1
Kim, S.2
Xiao, C.3
Wang, R.H.4
Coumoul, X.5
Wang, X.6
Li, W.M.7
Xu, X.L.8
De Soto, J.A.9
-
86
-
-
23844535164
-
Complicating the role of p53 in aging
-
Gentry,A. and Venkatachalam,S. (2005) Complicating the role of p53 in aging. Aging Cell, 4, 157-160.
-
(2005)
Aging Cell
, vol.4
, pp. 157-160
-
-
Gentry, A.1
Venkatachalam, S.2
-
87
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente,L. and Kenyon,C. (2000) Genetic pathways that regulate ageing in model organisms. Nature, 408, 255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
88
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Bluher,M., Kahn,B.B. and Kahn,C.R. (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (New York, N.Y.), 299, 572-574.
-
(2003)
Science (New York, N.Y.)
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
89
-
-
0037112844
-
Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao,I., Garcia-Cao,M., Martin-Caballero,J., Criado,L.M., Klatt,P., Flores,J.M., Weill,J.C., Blasco,M.A. and Serrano,M. (2002) "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J., 21, 6225-6235.
-
(2002)
EMBO J
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Martin-Caballero, J.3
Criado, L.M.4
Klatt, P.5
Flores, J.M.6
Weill, J.C.7
Blasco, M.A.8
Serrano, M.9
-
90
-
-
33745223517
-
Increased p53 activity does not accelerate telomere-driven ageing
-
Garcia-Cao,I., Garcia-Cao,M., Tomas-Loba,A., Martin-Caballero,J., Flores,J.M., Klatt,P., Blasco,M.A. and Serrano,M. (2006) Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep., 7, 546-552.
-
(2006)
EMBO Rep
, vol.7
, pp. 546-552
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Tomas-Loba, A.3
Martin-Caballero, J.4
Flores, J.M.5
Klatt, P.6
Blasco, M.A.7
Serrano, M.8
-
91
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
Matheu,A., Maraver,A., Klatt,P., Flores,I., Garcia-Cao,I., Borras,C., Flores,J.M., Vina,J., Blasco,M.A. et al. (2007) Delayed ageing through damage protection by the Arf/p53 pathway. Nature, 448 375-379.
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Vina, J.8
Blasco, M.A.9
-
92
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones,S.N., Roe,A.E., Donehower,L.A. and Bradley,A. (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378, 206-208.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
93
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna,R., Wagner,D.S. and Lozano,G. (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378, 203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
94
-
-
33845185824
-
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
-
Ringshausen,I., O'Shea,C.C., Finch,A.J., Swigart,L.B. and Evan,G.I. (2006) Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell, 10, 501-514.
-
(2006)
Cancer Cell
, vol.10
, pp. 501-514
-
-
Ringshausen, I.1
O'Shea, C.C.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
95
-
-
29944447632
-
Tumor suppression and normal aging in mice with constitutively high p53 activity
-
Mendrysa,S.M., O'Leary,K.A., McElwee,M.K., Michalowski,J., Eisenman,R.N., Powell,D.A. and Perry,M.E. (2006) Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev., 20, 16-21.
-
(2006)
Genes Dev
, vol.20
, pp. 16-21
-
-
Mendrysa, S.M.1
O'Leary, K.A.2
McElwee, M.K.3
Michalowski, J.4
Eisenman, R.N.5
Powell, D.A.6
Perry, M.E.7
-
96
-
-
33645711615
-
Tumor suppression by p53 without accelerated aging: Just enough of a good thing?
-
Mendrysa,S.M. and Perry,M.E. (2006) Tumor suppression by p53 without accelerated aging: Just enough of a good thing? Cell cycle (Georgetown, Tex.), 5, 714-717.
-
(2006)
Cell cycle (Georgetown, Tex.)
, vol.5
, pp. 714-717
-
-
Mendrysa, S.M.1
Perry, M.E.2
-
97
-
-
24344448786
-
p53 isoforms can regulate p53 transcriptional activity
-
Bourdon,J.C., Fernandes,K., Murray-Zmijewski,F., Liu,G., Diot,A., Xirodimas,D.P., Saville,M.K. and Lane,D.P. (2005) p53 isoforms can regulate p53 transcriptional activity. Genes Dev., 19, 2122-2137.
-
(2005)
Genes Dev
, vol.19
, pp. 2122-2137
-
-
Bourdon, J.C.1
Fernandes, K.2
Murray-Zmijewski, F.3
Liu, G.4
Diot, A.5
Xirodimas, D.P.6
Saville, M.K.7
Lane, D.P.8
-
98
-
-
0023125537
-
Primary structure polymorphism at amino acid residue 72 of human p53
-
Matlashewski,G.J., Tuck,S., Pim,D., Lamb,P., Schneider,J. and Crawford,L.V. (1987) Primary structure polymorphism at amino acid residue 72 of human p53. Mol. Cell. Biol., 7, 961-963.
-
(1987)
Mol. Cell. Biol
, vol.7
, pp. 961-963
-
-
Matlashewski, G.J.1
Tuck, S.2
Pim, D.3
Lamb, P.4
Schneider, J.5
Crawford, L.V.6
-
99
-
-
4544334659
-
The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death
-
Bonafe,M., Salvioli,S., Barbi,C., Trapassi,C., Tocco,F., Storci,G., Invidia,L., Vannini,I, Rossi,M. et al. (2004) The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ. 11, 962-973.
-
(2004)
Cell Death Differ
, vol.11
, pp. 962-973
-
-
Bonafe, M.1
Salvioli, S.2
Barbi, C.3
Trapassi, C.4
Tocco, F.5
Storci, G.6
Invidia, L.7
Vannini, I.8
Rossi, M.9
-
100
-
-
0037372005
-
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
-
Dumont,P., Leu,J.I., Delia Pietra,A.C.III, George,D.L. and Murphy,M. (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet., 33, 357-365.
-
(2003)
Nat. Genet
, vol.33
, pp. 357-365
-
-
Dumont, P.1
Leu, J.I.2
Delia Pietra III, A.C.3
George, D.L.4
Murphy, M.5
-
101
-
-
12344273381
-
Variation in the human TP53 gene affects old age survival and cancer mortality
-
van Heemst,D., Mooijaart,S.P., Beekman,M., Schreuder,J., de Craen,A.J., Brandt,B.W., Slagboom,P.E. and Westendorp,R.G. (2005) Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol., 40, 11-15.
-
(2005)
Exp. Gerontol
, vol.40
, pp. 11-15
-
-
van Heemst, D.1
Mooijaart, S.P.2
Beekman, M.3
Schreuder, J.4
de Craen, A.J.5
Brandt, B.W.6
Slagboom, P.E.7
Westendorp, R.G.8
-
102
-
-
34250355147
-
Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
-
Orsted,D.D., Bojesen,S.E., Tybjaerg-Hansen,A. and Nordestgaard,B.G. (2007) Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population. J. Exp. Med. 204, 1295-1301.
-
(2007)
J. Exp. Med
, vol.204
, pp. 1295-1301
-
-
Orsted, D.D.1
Bojesen, S.E.2
Tybjaerg-Hansen, A.3
Nordestgaard, B.G.4
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