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Volumn 31, Issue 3, 2011, Pages 1081-1092

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CELL PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MACROPHAGE ANTIGEN COMPLEX 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; UNCLASSIFIED DRUG;

EID: 78751502344     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3732-10.2011     Document Type: Article
Times cited : (304)

References (67)
  • 2
    • 36749051047 scopus 로고    scopus 로고
    • Chronic microglial activation and progressive dopaminergic neurotoxicity
    • Block ML, Hong JS (2007) Chronic microglial activation and progressive dopaminergic neurotoxicity. Biochem Soc Trans 35:1127-1132.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1127-1132
    • Block, M.L.1    Hong, J.S.2
  • 3
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 9
    • 0027212363 scopus 로고
    • Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes
    • Fan ST, Edgington TS (1993) Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes. J Immunol 150:2972-2980.
    • (1993) J Immunol , vol.150 , pp. 2972-2980
    • Fan, S.T.1    Edgington, T.S.2
  • 10
    • 14944385354 scopus 로고    scopus 로고
    • Beta-Amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
    • DOI 10.1523/JNEUROSCI.4998-04.2005
    • Floden AM, Li S, Combs CK (2005) Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci 25:2566-2575. (Pubitemid 40365168)
    • (2005) Journal of Neuroscience , vol.25 , Issue.10 , pp. 2566-2575
    • Floden, A.M.1    Li, S.2    Combs, C.K.3
  • 11
    • 47749126515 scopus 로고    scopus 로고
    • Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
    • Gao HM, Hong JS (2008) Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 29:357-365.
    • (2008) Trends Immunol , vol.29 , pp. 357-365
    • Gao, H.M.1    Hong, J.S.2
  • 12
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao HM, Hong JS, Zhang W, Liu B (2002a) Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 22:782-790. (Pubitemid 34141759)
    • (2002) Journal of Neuroscience , vol.22 , Issue.3 , pp. 782-790
    • Gao, H.-M.1    Hong, J.-S.2    Zhang, W.3    Liu, B.4
  • 13
    • 0036316772 scopus 로고    scopus 로고
    • Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: Relevance to Parkinson's disease
    • Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B (2002b) Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 81:1285-1297.
    • (2002) J Neurochem , vol.81 , pp. 1285-1297
    • Gao, H.M.1    Jiang, J.2    Wilson, B.3    Zhang, W.4    Hong, J.S.5    Liu, B.6
  • 14
    • 84863116750 scopus 로고    scopus 로고
    • Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
    • Gao HM, Liu B, Zhang W, Hong JS (2003a) Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J 17:1954-1956.
    • (2003) FASEB J , vol.17 , pp. 1954-1956
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 15
    • 0043162103 scopus 로고    scopus 로고
    • Novel anti-inflammatory therapy for Parkinson's disease
    • Gao HM, Liu B, Zhang W, Hong JS (2003b) Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci 24:395-401.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 395-401
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 16
    • 0037203948 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: Roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide
    • Gayle DA, Ling Z, Tong C, Landers T, Lipton JW, Carvey PM (2002) Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res Dev Brain Res 133:27-35.
    • (2002) Brain Res Dev Brain Res , vol.133 , pp. 27-35
    • Gayle, D.A.1    Ling, Z.2    Tong, C.3    Landers, T.4    Lipton, J.W.5    Carvey, P.M.6
  • 17
  • 18
    • 0030879929 scopus 로고    scopus 로고
    • Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide
    • Goodwin JL, Kehrli ME Jr, Uemura E (1997) Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide. Brain Res 768:279-286.
    • (1997) Brain Res , vol.768 , pp. 279-286
    • Goodwin, J.L.1    Kehrli Jr., M.E.2    Uemura, E.3
  • 19
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: A target for neuroprotection?
    • Hirsch EC, Hunot S (2009) Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol 8:382-397.
    • (2009) Lancet Neurol , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 20
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298:1241-1245.
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 23
    • 33745788420 scopus 로고    scopus 로고
    • HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
    • Kim JB, Sig Choi J, Yu YM, Nam K, Piao CS, Kim SW, Lee MH, Han PL, Park JS, Lee JK (2006) HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci 26:6413-6421.
    • (2006) J Neurosci , vol.26 , pp. 6413-6421
    • Kim, J.B.1    Sig Choi, J.2    Yu, Y.M.3    Nam, K.4    Piao, C.S.5    Kim, S.W.6    Lee, M.H.7    Han, P.L.8    Park, J.S.9    Lee, J.K.10
  • 24
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14:504-506.
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 25
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 26
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 46:598-605.
    • (1999) Ann Neurol , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 27
    • 0037103252 scopus 로고    scopus 로고
    • Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively
    • Le Cabec V, Carréno S, Moisand A, Bordier C, Maridonneau-Parini I (2002) Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively. J Immunol 169:2003-2009. (Pubitemid 34857664)
    • (2002) Journal of Immunology , vol.169 , Issue.4 , pp. 2003-2009
    • Le, C.V.1    Carreno, S.2    Moisand, A.3    Bordier, C.4    Maridonneau-Parini, I.5
  • 30
    • 33745243255 scopus 로고    scopus 로고
    • Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally
    • Ling Z, Zhu Y, Tong C, Snyder JA, Lipton JW, Carvey PM (2006) Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally. Exp Neurol 199:499-512.
    • (2006) Exp Neurol , vol.199 , pp. 499-512
    • Ling, Z.1    Zhu, Y.2    Tong, C.3    Snyder, J.A.4    Lipton, J.W.5    Carvey, P.M.6
  • 31
    • 0037677549 scopus 로고    scopus 로고
    • Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: Role of neuroinflammation
    • Liu B, Gao HM, Hong JS (2003) Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect 111:1065-1073.
    • (2003) Environ Health Perspect , vol.111 , pp. 1065-1073
    • Liu, B.1    Gao, H.M.2    Hong, J.S.3
  • 32
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5:331-342.
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 33
    • 0032711991 scopus 로고    scopus 로고
    • "Outside-in" signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils
    • Lynch OT, Giembycz MA, Barnes PJ, Hellewell PG, Lindsay MA (1999) "Outside-in" signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils. Br J Pharmacol 128:1149-1158.
    • (1999) Br J Pharmacol , vol.128 , pp. 1149-1158
    • Lynch, O.T.1    Giembycz, M.A.2    Barnes, P.J.3    Hellewell, P.G.4    Lindsay, M.A.5
  • 36
    • 20644444103 scopus 로고    scopus 로고
    • Neutrophil beta2 integrins: Moderators of life or death decisions
    • Mayadas TN, Cullere X (2005) Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol 26:388-395.
    • (2005) Trends Immunol , vol.26 , pp. 388-395
    • Mayadas, T.N.1    Cullere, X.2
  • 38
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 39
    • 0242384667 scopus 로고    scopus 로고
    • Presence of reactive microglia in monkey substantia nigra after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration
    • McGeer PL, Schwab C, Parent A, Doudet D (2003) Presence of reactive microglia in monkey substantia nigra after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine administration. Ann Neurol 54:599-604.
    • (2003) Ann Neurol , vol.54 , pp. 599-604
    • McGeer, P.L.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 40
    • 33344461775 scopus 로고    scopus 로고
    • Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease
    • DOI 10.1016/j.neurobiolaging.2005.08.012, PII S0197458005002356, Protein Misfolding in Alzheimer's and Other Age-Related Neurodegenerative Diseases
    • McNaught KS, Olanow CW (2006) Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease. Neurobiol Aging 27:530-545. (Pubitemid 43290522)
    • (2006) Neurobiology of Aging , vol.27 , Issue.4 , pp. 530-545
    • McNaught, K.S.P.1    Olanow, C.W.2
  • 42
  • 43
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi M, Harada M, Kondo T, Riederer P, Inagaki H, Minami M, Nagatsu T (1994) Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett 180:147-150.
    • (1994) Neurosci Lett , vol.180 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Riederer, P.4    Inagaki, H.5    Minami, M.6    Nagatsu, T.7
  • 44
    • 44149103168 scopus 로고    scopus 로고
    • Neuroinflammation and peripheral immune infiltration in Parkinson's disease: An autoimmune hypothesis
    • Monahan AJ, Warren M, Carvey PM (2008) Neuroinflammation and peripheral immune infiltration in Parkinson's disease: an autoimmune hypothesis. Cell Transplant 17:363-372.
    • (2008) Cell Transplant , vol.17 , pp. 363-372
    • Monahan, A.J.1    Warren, M.2    Carvey, P.M.3
  • 46
    • 0036518997 scopus 로고    scopus 로고
    • Innate immunity: The missing link in neuroprotection and neurodegeneration?
    • Nguyen MD, Julien JP, Rivest S (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 3:216-227.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 216-227
    • Nguyen, M.D.1    Julien, J.P.2    Rivest, S.3
  • 48
    • 77953416308 scopus 로고    scopus 로고
    • Inflammation and Parkinson's disease pathogenesis
    • Przedborski S (2010) Inflammation and Parkinson's disease pathogenesis. Mov Disord 25 [Suppl 1]:S55-S57.
    • (2010) Mov Disord , vol.25 , Issue.SUPPL. 1
    • Przedborski, S.1
  • 50
    • 0033836315 scopus 로고    scopus 로고
    • Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein
    • Ross GD (2000) Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein. Crit Rev Immunol 20:197-222.
    • (2000) Crit Rev Immunol , vol.20 , pp. 197-222
    • Ross, G.D.1
  • 51
    • 0027160034 scopus 로고
    • CR3 (CD11b, CD18): A phagocyte and NK cell membrane receptor with multiple ligand specificities and functions
    • Ross GD, Větvicka V (1993) CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions. Clin Exp Immunol 92:181-184.
    • (1993) Clin Exp Immunol , vol.92 , pp. 181-184
    • Ross, G.D.1    Větvicka, V.2
  • 52
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418:191-195.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 53
    • 0036949006 scopus 로고    scopus 로고
    • Autoimmunity as the body's defense mechanism against the enemy within: Development of therapeutic vaccines for neurodegenerative disorders
    • Schwartz M (2002) Autoimmunity as the body's defense mechanism against the enemy within: development of therapeutic vaccines for neurodegenerative disorders. J Neurovirol 8:480-485.
    • (2002) J Neurovirol , vol.8 , pp. 480-485
    • Schwartz, M.1
  • 54
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses
    • Seong SY, Matzinger P (2004) Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol 4:469-478.
    • (2004) Nat Rev Immunol , vol.4 , pp. 469-478
    • Seong, S.Y.1    Matzinger, P.2
  • 55
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49:489-502.
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 57
    • 10644273486 scopus 로고    scopus 로고
    • High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity
    • Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S (2004) High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. J Neurosci Res 78:880-891.
    • (2004) J Neurosci Res , vol.78 , pp. 880-891
    • Takata, K.1    Kitamura, Y.2    Tsuchiya, D.3    Kawasaki, T.4    Taniguchi, T.5    Shimohama, S.6
  • 58
    • 60349100558 scopus 로고    scopus 로고
    • Neuronal regulation of immune responses in the central nervous system
    • Tian L, Rauvala H, Gahmberg CG (2009) Neuronal regulation of immune responses in the central nervous system. Trends Immunol 30:91-99.
    • (2009) Trends Immunol , vol.30 , pp. 91-99
    • Tian, L.1    Rauvala, H.2    Gahmberg, C.G.3
  • 59
    • 34250312421 scopus 로고    scopus 로고
    • Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease
    • Wahner AD, Sinsheimer JS, Bronstein JM, Ritz B (2007) Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease. Arch Neurol 64:836-840.
    • (2007) Arch Neurol , vol.64 , pp. 836-840
    • Wahner, A.D.1    Sinsheimer, J.S.2    Bronstein, J.M.3    Ritz, B.4
  • 60
    • 0043136678 scopus 로고    scopus 로고
    • Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer
    • Wang L, Duke L, Zhang PS, Arlinghaus RB, Symmans WF, Sahin A, Mendez R, Dai JL (2003) Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer. Cancer Res 63:4724-4730.
    • (2003) Cancer Res , vol.63 , pp. 4724-4730
    • Wang, L.1    Duke, L.2    Zhang, P.S.3    Arlinghaus, R.B.4    Symmans, W.F.5    Sahin, A.6    Mendez, R.7    Dai, J.L.8
  • 61
    • 0023026362 scopus 로고
    • Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide
    • Wright SD, Jong MT (1986) Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. J Exp Med 164:1876-1888.
    • (1986) J Exp Med , vol.164 , pp. 1876-1888
    • Wright, S.D.1    Jong, M.T.2
  • 62
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease-a double-edged sword
    • Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease-a double-edged sword. Neuron 35:419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 63
    • 0026680616 scopus 로고
    • Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins
    • Yamada T, McGeer PL, McGeer EG (1992) Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins. Acta Neuropathol 84:100-104.
    • (1992) Acta Neuropathol , vol.84 , pp. 100-104
    • Yamada, T.1    McGeer, P.L.2    McGeer, E.G.3
  • 64
    • 77952411101 scopus 로고    scopus 로고
    • Inhibition of IκB kinase-β(IKK-β) protects dopamine neurons against lipopolysaccharide-induced neurotoxicity
    • Zhang F, Qian L, Flood PM, Shi JS, Hong JS, GaoHM (2010) Inhibition of IκB kinase-β(IKK-β) protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J Pharmacol Exp Ther 333:822-833.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 822-833
    • Zhang, F.1    Qian, L.2    Flood, P.M.3    Shi, J.S.4    Hong, J.S.5    Gao, H.M.6
  • 65
    • 0035164415 scopus 로고    scopus 로고
    • Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity
    • Zhang G, Ghosh S (2001) Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 107:13-19.
    • (2001) J Clin Invest , vol.107 , pp. 13-19
    • Zhang, G.1    Ghosh, S.2
  • 67
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance
    • Zhou C, Huang Y, Przedborski S (2008) Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 1147:93-104.
    • (2008) Ann N Y Acad Sci , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski, S.3


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