Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Nature

Volumn 469, Issue 7328, 2011, Pages 102-107

  Jaskelioff, Mariela ^a   Muller, Florian L ^a   Paik, Ji Hye ^a   Thomas, Emily ^a   Jiang, Shan ^a   Adams, Andrew C ^b   Sahin, Ergun ^a   Kost Alimova, Maria ^a   Protopopov, Alexei ^a   Cadiñanos, Juan ^a   Horner, James W ^a   Maratos Flier, Eleftheria ^b   Depinho, Ronald A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFIMOXIFENE; DNA; ESTROGEN RECEPTOR; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR SOX2;

AGING POPULATION; ALLELE; CELL ORGANELLE; ENZYME ACTIVITY; FITNESS; GENETIC ANALYSIS; GENOME; NUMERICAL MODEL; PHENOTYPE; RODENT; SIGNALING;

AGED; AGING; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME REACTIVATION; HOMOZYGOSITY; HYPOSMIA; INTERNEURON; INTESTINE; MATING; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OLFACTORY BULB; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; SPLEEN; SUBVENTRICULAR ZONE; TELOMERE; TESTIS; TISSUE DEGENERATION; TISSUE ENGINEERING; TRANSCRIPTION REGULATION;

AGING; ANIMALS; AVOIDANCE LEARNING; BRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DNA DAMAGE; ENZYME ACTIVATION; ENZYME REACTIVATORS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MYELIN SHEATH; NEURAL STEM CELLS; ORGAN SIZE; PHENOTYPE; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; REGENERATIVE MEDICINE; SMELL; TAMOXIFEN; TELOMERASE; TELOMERE;

MUS;

EID: 78650990326     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09603     Document Type: Article

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