RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides

Cell

Volumn 97, Issue 7, 1999, Pages 889-901

  Hofmann, Marion A ^a   Drury, Steven ^a   Fu, Caifeng ^a   Qu, Wu ^a   Taguchi, Akihiko ^a   Lu, Yan ^a   Avila, Cecilia ^a   Kambham, Neeraja ^a   Bierhaus, Angelika ^c   Nawroth, Peter ^c   Neurath, Markus F ^d   Slattery, Timothy ^b   Beach, Dale ^b   McClary, John ^b   Nagashima, Mariko ^b   Morser, John ^b   Stern, David ^a   Schmidt, Ann Marie ^a  

^a Columbia University ^*  (United States)

^b BAYER AG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; CALGRANULIN; CELL SURFACE RECEPTOR; PROTEIN S 100; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOCYTE; MEDIATOR RELEASE; MOLECULAR DYNAMICS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALIA; MURINAE;

EID: 0033603241     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80801-6     Document Type: Article

References (42)

1. Brownlee, M., Cerami, A., and Vlassara, H. (1988). Advanced glycosylation endproducts in tissue and the biochemical basis of diabetic complications. N. Engl. J. Med. 318, 1315-1320.
2. Dell'Angelica, E.C., Schleicher, C.H., and Santome, J.A. (1994). Primary structure and binding properties of calgranulin C, a novel S100-like calcium-binding protein from pig granulocytes. J. Biol. Chem. 269, 28929-28936.
3. Dunn, C.J., Galinet, LA., Wu, H., Nugent, R.A., Schlachter, S.T., Staite, N.D., Aspar, D.G., Elliott, G.A., Essani, N.A., Rohloff, N.A., and Smith, R.J. (1993). Demonstration of novel anti-arthritic and anti-inflammatory effects of Diphosphonates. J. Pharmacol. Exp. Ther. 266, 1691-1698.
4. Geczy, C. (1996). Regulation and proinflammatory properties of chemotactic protein, CP-10. Biochim. Biophys. Acta 1313, 246-252.
5. Gimmi, C.D., Freeman, G.J., Gribben, J.G., Sugita, K., Freedman, A.S., Morimoto, C., Nadler, L.M (1991). B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin-2. Proc. Natl. Acad. Sci. USA 88, 6575-6579.
6. Gottsch, J.D., Stark, W.J., and Liu, S.H. (1997). Cloning and sequence analysis of human and bovine corneal antigen (CO-Ag) cDNA: identification of host-parasite protein calgranulin C. Trans. Am. Opthalmol. Soc. 14, 111-129.
7. Hitomi, H., Yamaguchi, K., Kikuchi, Y., Kimura, T., Maruyama, K., and Nagasaki, K. (1996). A novel calcium-binding protein in amniotic fluid, CAAF1 : its molecular cloning and tissue distribution. J. Cell Sci. 109, 805-815.
8. Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J., Nagashima, M., Nitecki, D., Morser, J., Stern, D., and Schmidt, A.M. (1995). The receptor for advanced glycation endproducts (RAGE) is a cellular binding site for amphoterin: mediation of neurite outgrowth and coexpression of RAGE and amphoterin in the developing nervous system. J. Biol. Chem. 270, 25752-25761.
9. Ilg, E.C., Troxler, H., Buergisser, D.M., Kuster, T., Markert, M., Guignard, F., Hunziker, P., Birchler, N., and Heinzmann, C.W. (1996). Amino acid sequence determination of human S100A12 (p6, Calgranulin C, CGRP, CAAF1) by tandem mass spectrometry. Biochem. Biophys. Res. Comm. 225, 146-150.
10. King, G., and Brownlee, M. (1996). The cellular and molecular mechanisms of diabetic complications. Endocrin. Metab. Clin. North Am. 25, 255-270.
11. Klotz, I., and Hunston, D. (1984). Mathematical models for ligand-receptor binding. J. Biol. Chem. 259, 10060-10062.
12. Krieger, M., and Herz, J. (1994). Structure and function of multiligand lipoprotein receptors: macrophage scavengers and LDL receptor-related protein. Annu. Rev. Biochem. 63, 601-637.
13. Kuehn, R., Loehler, J., Rennick, D., Rajewsky, K., and Mueller, W. (1993). Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274.
14. Lander, H.L., Tauras, J.M., Ogiste, J.S., Moss, R.A., and A.M. Schmidt. (1997). Activation of the receptor for advanced glycation endproducts triggers a MAP kinase pathway regulated by oxidant stress. J. Biol. Chem. 272, 17810-17814.
15. Li, J., and Schmidt, A.M. (1997). Characterization and functional analysis of the promotor of RAGE, the receptor for advanced glycation endproducts. J. Biol. Chem. 271, 16498-16506.
16. Li, H., Cybulsky, M., Gimbrone, M., and Libby, P. (1993). An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule in rabbit aortic endothelium. Arterioscler. Thromb. 13, 197-204.
17. Li, J., Qu, X., and Schmidt, A.M. (1998). Sp1 binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells. J. Biol. Chem. 273, 30870-30878.
18. Lugering, N., Stoll, R., Schmid, K.W., Kucharzik, T., Stein, H., Burgmeister, G., Sorg, C., and Domschke, W. (1995). The myeloic related protein MRP8/14 (27E10 antigen) usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function. Eur. J. Clin. Invest. 25, 659-664.
19. Mackic, J.B., Stins, M., McComb, J.G., Calero, M., Ghiso, J., Kim, K.S., Yan, S.D., Stern, D., Schmidt, A.M., Frangione, B., and Zlokovic, B.V. (1998). Human blood-brain barrier receptors for Alzheimer's amyloid-β1-40: asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J. Clin. Invest. 102, 734-743.
20. Marshak, D.R., Pesce, S.A., Stanley, L.C., and Griffin, W.S. (1992) Increased S100 beta neurotrophic activity in Alzheimer's disease temporal lobe. Neurobiol. Aging 13, 1-7.
21. Miyata, T., O.Hori, J.H., Zhang, S.D., Yan, L., Ferran, Y., Iida, and Schmidt, A.M. (1996). The receptor for advanced glycation endproducts (RAGE) mediates the interaction of AGE-β2-microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway: implications for the pathogenesis of dialysis-related amyloidosis. J. Clin. Invest. 98, 1088-1094.
22. Neeper, M., Schmidt, A.M., Brett, J., Yan, S.D., Wang, F., Pan, Y.C., Elliston, K., Stern, D., and Shaw, A. (1992). Cloning and expression of RAGE: a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267, 14998-15004.
23. Neish, A.S., Williams, A.J., Palmer, H.J., Whitley, M.Z., and Collins, T. (1992). Functional analysis of the human vascular cell adhesion molecule-1 promoter. J. Exp. Med. 176, 1583-1593.
24. Park, L., Raman, K.G., Lee, K.J., Yan, L., Ferran, L.J., Chow, W.S., Stern, D., and Schmidt, A.M. (1998). Suppression of accelerated diabetic atherosclerosis by soluble receptor for AGE (sRAGE). Nat. Med. 4, 1025-1031.
25. Rammes, A., Roth, J., Goebeler, M., Klempt, M., Hartmann, M., and Sorg, C. (1997). Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J. Biol. Chem. 272, 9496-9502.
26. Rauvala, H., and Pihlaskari, R. (1987). Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons. J. Biol. Chem. 262, 16625-16635.
27. Ross, R. (1999). Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340, 115-126.
28. Schafer, B.W., and Heinzmann, C.W. (1996). The S100 family of EF-hand calcium-binding proteins: functions and pathology. TIBS 27, 134-140.
29. Schmidt, A.M., Vianna, M., Gerlach, M., Brett, J., Ryan, J., Kao, J., Esposito, C., Hegarty, H., Hurley, W., Clauss, M., et al. (1992). Isolation and characterization of binding proteins for advanced glycosylation endproducts from lung tissue which are present on the endothelial cell surface. J. Biol. Chem. 267, 14987-14997.
30. Schmidt, A-M., Hori, O., Chen, J., Li, J., Crandall, J., Zhang, J., Cao, R., Yan, S.D., Brett, J., and Stern, D. (1995). Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1): a potential mechanism for the accelerated vasculopathy of diabetes. J. Clin. Invest. 96, 1395-1403.
31. Schmidt, A.M., Wautier, J.-L., Stern, D., and Yan, S.D. (1998). RAGE: a receptor with a taste for multiple ligands and varied pathophysiologic states. Horm. Signal. 1, 41-63.
32. Selkoe, D. (1994). Alzheimer's disease: a central role for amyloid. J. Neuropathol. Exp. Neurol. 53, 438-447.
33. Springer, T. (1990). Adhesion receptors of the immune system. Nature 346, 425-434.
34. Sugaya, K., Fukagawa, T., Matsumoto, K., Mita, K., Takahashi, E., Ando, A., Inoko, H., and Ikemura, T. (1994). Three genes in the human MHC class III region near the junction with the class II: gene for receptor for advanced glycosylation end products, PBX2 homeobox 2 gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. Genomics 23, 408-419.
35. Voraberger, G., Schafer, R., and Stratowa, C. (1991). Cloning of the human gene for intercellular adhesion molecule 1 and analysis of the 5′-regulatory region. Induction by cytokines and phorbol ester. J. Immunol. 147, 2777-2786.
36. Wautier, J-L., Zoukourian, C., Chappey, O., Wautier, M.P., Guillausseau, P.J., Cao, R., Hori, O., Stern, D., and Schmidt, A.M. (1996). Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy: soluble receptor for advanced glycation endproducts blocks hyperpermeability. J. Clin. Invest. 97, 238-243.
37. Wicki, R., Marenholz, I., Mischke, D., Schaefer, B.W., Heinzmann, C.W. (1996). Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. Cell Calcium 20, 459-464.
38. Yamamura, T., Hitomi, J., Nagasaki, K., Suzuki, M., Takahashi, E., Saito, S., Tsukada, T., and Yamaguchi, K. (1996). Human CAAF1 gene-molecular cloning, gene structure, and chromosome mapping. Biochem. Biophys. Res. Comm. 221, 356-360.
39. Yan, S.D., Schmidt, A.-M., Anderson, G., Zhang, J., Brett, J., Zou, Y.-S., Pinsky, D., and Stern, D. (1994). Enhanced cellular oxidant stress by the interaction of advanced glycation endproducts with their receptors/binding proteins. J. Biol. Chem. 269, 9889-9897.
40. Yan, S.D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Nagashima, M., Morser, J., Migheli, A., et al. (1996). RAGE and amyloid beta peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691.
41. Yan, S.D., Zhu, H., Fu, J., Yan S.F., Roher, A., Tourtellotte, W., Rajavashisth, T., Chen, X., Stern, D., and Schmidt, A.M. (1997). Amyloidbeta peptide-RAGE interaction elicits neuronal expression of M-CSF: a proinflammatory pathway in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 94, 5296-5301.
42. Zimmer, D.B., Cornwall, E.H., Landar, A., and Song, W. (1995). The S100 protein family: history, function, and expression. Brain Res. Bull. 37, 417-429.