PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

Nature Communications

Volumn 5, Issue , 2014, Pages

  Yang, Liangchun ^a   Xie, Min ^a   Yang, Minghua ^a   Yu, Yan ^a   Zhu, Shan ^a   Hou, Wen ^b   Kang, Rui ^b   Lotze, Michael T ^b   Billiar, Timothy R ^b   Wang, Haichao ^c   Cao, Lizhi ^a   Tang, Daolin ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLUCOSE TRANSPORTER 1; HIGH MOBILITY GROUP B1 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; LACTIC ACID; MESSENGER RNA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PYRUVATE KINASE; PYRUVATE KINASE M2; SHIKONIN; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CARRIER PROTEIN; MEMBRANE PROTEIN; THYROID HORMONE; THYROID HORMONE-BINDING PROTEINS;

ANAEROBIC GLYCOLYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVATION; LACTATE BLOOD LEVEL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; SEPSIS; SEPTIC SHOCK; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; ENDOTOXEMIA; GENETICS; GLYCOLYSIS; IMMUNOPRECIPITATION; METABOLISM; OXIDATIVE PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; ENDOTOXEMIA; GLYCOLYSIS; HMGB1 PROTEIN; IMMUNOPRECIPITATION; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; OXIDATIVE PHOSPHORYLATION; SEPSIS; THYROID HORMONES;

EID: 84904489275     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5436     Document Type: Article

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