메뉴 건너뛰기




Volumn 7, Issue 1, 2006, Pages 30-40

Neural plasticity in the ageing brain

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; AFTERHYPERPOLARIZATION; AGING; BEHAVIOR DISORDER; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN REGION; BRAIN WEIGHT; CALCIUM CONDUCTANCE; CALCIUM HOMEOSTASIS; CELL AGING; CELL INTERACTION; CELL STRUCTURE; COGNITION; DENDRITIC CELL; DENDRITIC SPINE; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; LEARNING; LONG TERM DEPRESSION; LONG TERM MEMORY; LONG TERM POTENTIATION; MEMORY; MENTAL DETERIORATION; MORPHOLOGY; NERVE CELL PLASTICITY; NERVOUS SYSTEM; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SPATIAL MEMORY; SYNAPSE; TEMPORAL LOBE;

EID: 29244439038     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn1809     Document Type: Review
Times cited : (1243)

References (168)
  • 1
    • 77049202076 scopus 로고
    • Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex
    • Brody, H. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J. Comp. Neurol. 102, 511-516 (1955).
    • (1955) J. Comp. Neurol. , vol.102 , pp. 511-516
    • Brody, H.1
  • 2
    • 0023472509 scopus 로고
    • Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
    • Coleman, P. D. & Flood, D. G. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol. Aging 8, 521-545 (1987).
    • (1987) Neurobiol. Aging , vol.8 , pp. 521-545
    • Coleman, P.D.1    Flood, D.G.2
  • 3
    • 0017358355 scopus 로고
    • Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study
    • Ball, M. J. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol. (Berl.) 37, 111-118 (1977).
    • (1977) Acta Neuropathol. (Berl.) , vol.37 , pp. 111-118
    • Ball, M.J.1
  • 4
    • 0019291824 scopus 로고
    • Localization of cellular changes within multimodal sensory regions in aged monkey brain: Possible implications for age-related cognitive loss
    • Brizzee, K. R., Ordy, J. M. & Bartus, R. T. Localization of cellular changes within multimodal sensory regions in aged monkey brain: possible implications for age-related cognitive loss. Neurobiol. Aging 1, 45-52 (1980).
    • (1980) Neurobiol. Aging , vol.1 , pp. 45-52
    • Brizzee, K.R.1    Ordy, J.M.2    Bartus, R.T.3
  • 5
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • Morrison, J. H. & Hof, P. R. Life and death of neurons in the aging brain. Science 278, 412-419 (1997).
    • (1997) Science , vol.278 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 6
    • 0027194462 scopus 로고
    • New stereological methods for counting neurons
    • West, M. J. New stereological methods for counting neurons. Neurobiol. Aging 14, 275-285 (1993).
    • (1993) Neurobiol. Aging , vol.14 , pp. 275-285
    • West, M.J.1
  • 7
    • 0030929886 scopus 로고    scopus 로고
    • Neocortical neuron number in humans: Effect of sex and age
    • Pakkenberg, B. & Gundersen, H. J. Neocortical neuron number in humans: effect of sex and age. J. Comp. Neurol. 384, 312-320 (1997).
    • (1997) J. Comp. Neurol. , vol.384 , pp. 312-320
    • Pakkenberg, B.1    Gundersen, H.J.2
  • 8
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West, M. J., Coleman, P. D., Flood, D. G. & Troncoso, J. C. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344, 769-772 (1994). A stereologically controlled investigation reporting preserved neuron number in most subregions of the hippocampus of healthy aged humans, which is distinct from individuals with Alzheimer's disease who show a significant decline in cell number.
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 9
    • 0034601285 scopus 로고    scopus 로고
    • Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates
    • Merrill, D. A., Roberts, J. A. & Tuszynski, M. H. Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates. J. Comp. Neurol. 422, 396-401 (2000).
    • (2000) J. Comp. Neurol. , vol.422 , pp. 396-401
    • Merrill, D.A.1    Roberts, J.A.2    Tuszynski, M.H.3
  • 10
    • 0028568245 scopus 로고
    • The effects of aging on area 46 of the frontal cortex of the rhesus monkey
    • Peters, A., Leahu, D., Moss, M. B. & McNally, K. J. The effects of aging on area 46 of the frontal cortex of the rhesus monkey. Cereb. Cortex 4, 621-635 (1994).
    • (1994) Cereb. Cortex , vol.4 , pp. 621-635
    • Peters, A.1    Leahu, D.2    Moss, M.B.3    McNally, K.J.4
  • 11
    • 0030713391 scopus 로고    scopus 로고
    • Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys
    • Gazzaley, A. H., Thakker, M. M., Hof, P. R. & Morrison, J. H. Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. Neurobiol. Aging 18, 549-553 (1997).
    • (1997) Neurobiol. Aging , vol.18 , pp. 549-553
    • Gazzaley, A.H.1    Thakker, M.M.2    Hof, P.R.3    Morrison, J.H.4
  • 12
    • 0037213369 scopus 로고    scopus 로고
    • Preservation of hippocampal neuron numbers in aged rhesus monkeys
    • Keuker, J. I., Luiten, P. G. & Fuchs, E. Preservation of hippocampal neuron numbers in aged rhesus monkeys. Neurobiol. Aging 24, 157-165 (2003).
    • (2003) Neurobiol. Aging , vol.24 , pp. 157-165
    • Keuker, J.I.1    Luiten, P.G.2    Fuchs, E.3
  • 13
    • 0035479759 scopus 로고    scopus 로고
    • Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats
    • Merrill, D. A., Chiba, A. A. & Tuszynski, M. H. Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats. J. Comp. Neurol. 438, 445-456 (2001).
    • (2001) J. Comp. Neurol. , vol.438 , pp. 445-456
    • Merrill, D.A.1    Chiba, A.A.2    Tuszynski, M.H.3
  • 14
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp, P. R. & Gallagher, M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc. Natl Acad. Sci. USA 93, 9926-9930 (1996). Similar to findings in humans, this stereologically controlled experiment reveals that aged rats have no neuronal loss and so cell death cannot account for age-related behavioural impairments.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 15
    • 0030053883 scopus 로고    scopus 로고
    • Memory impaired aged rats: No loss of principal hippocampal and subicular neurons
    • Rasmussen, T., Schliemann, T., Sorensen, J. C., Zimmer, J. & West, M. J. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol. Aging 17, 143-147 (1996).
    • (1996) Neurobiol. Aging , vol.17 , pp. 143-147
    • Rasmussen, T.1    Schliemann, T.2    Sorensen, J.C.3    Zimmer, J.4    West, M.J.5
  • 16
    • 2342612629 scopus 로고    scopus 로고
    • Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons
    • Smith, D. E., Rapp, P. R., McKay, H. M., Roberts, J. A. & Tuszynski, M. H. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J. Neurosci. 24, 4373-4381 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 4373-4381
    • Smith, D.E.1    Rapp, P.R.2    McKay, H.M.3    Roberts, J.A.4    Tuszynski, M.H.5
  • 17
    • 0017173036 scopus 로고
    • Progressive dendritic changes in the aging human limbic system
    • Scheibel, M. E., Lindsay, R. D., Tomiyasu, U. & Scheibel, A. B. Progressive dendritic changes in the aging human limbic system. Exp. Neurol. 53, 420-430 (1976).
    • (1976) Exp. Neurol. , vol.53 , pp. 420-430
    • Scheibel, M.E.1    Lindsay, R.D.2    Tomiyasu, U.3    Scheibel, A.B.4
  • 18
    • 0018218935 scopus 로고
    • The hippocampus: Organizational patterns in health and senescence
    • Scheibel, A. B. The hippocampus: organizational patterns in health and senescence. Mech. Ageing Dev. 9, 89-102 (1979).
    • (1979) Mech. Ageing Dev. , vol.9 , pp. 89-102
    • Scheibel, A.B.1
  • 19
    • 0019482861 scopus 로고
    • Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia
    • Buell, S. J. & Coleman, P. D. Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia. Brain Res. 214, 23-41 (1981).
    • (1981) Brain Res. , vol.214 , pp. 23-41
    • Buell, S.J.1    Coleman, P.D.2
  • 20
    • 0018726532 scopus 로고
    • Dendritic growth in the aged human brain and failure of growth in senile dementia
    • Buell, S. J. & Coleman, P. D. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science 206, 854-856 (1979).
    • (1979) Science , vol.206 , pp. 854-856
    • Buell, S.J.1    Coleman, P.D.2
  • 21
    • 0022385709 scopus 로고
    • Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the 'oldest old'
    • Flood, D. G., Buell, S. J., Defiore, C. H., Horwitz, G. J. & Coleman, P. D. Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the 'oldest old'. Brain Res. 345, 366-368 (1985).
    • (1985) Brain Res. , vol.345 , pp. 366-368
    • Flood, D.G.1    Buell, S.J.2    Defiore, C.H.3    Horwitz, G.J.4    Coleman, P.D.5
  • 22
    • 0023156372 scopus 로고
    • Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia
    • Flood, D. G., Buell, S. J., Horwitz, G. J. & Coleman, P. D. Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia. Brain Res. 402, 205-216 (1987).
    • (1987) Brain Res. , vol.402 , pp. 205-216
    • Flood, D.G.1    Buell, S.J.2    Horwitz, G.J.3    Coleman, P.D.4
  • 23
    • 0026082894 scopus 로고
    • Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus
    • Hanks, S. D. & Flood, D. G. Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus. Brain Res. 540, 63-82 (1991).
    • (1991) Brain Res. , vol.540 , pp. 63-82
    • Hanks, S.D.1    Flood, D.G.2
  • 24
    • 0023214421 scopus 로고
    • Dendritic extent in human CA2-3 hippocampal pyramidal neurons in normal aging and senile dementia
    • Flood, D. G., Guarnaccia, M. & Coleman, P. D. Dendritic extent in human CA2-3 hippocampal pyramidal neurons in normal aging and senile dementia. Brain Res. 409, 88-96 (1987).
    • (1987) Brain Res. , vol.409 , pp. 88-96
    • Flood, D.G.1    Guarnaccia, M.2    Coleman, P.D.3
  • 25
    • 0026032513 scopus 로고
    • Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. II. Subiculum
    • Flood, D. G. Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. II. Subiculum. Brain Res. 540, 83-95 (1991).
    • (1991) Brain Res. , vol.540 , pp. 83-95
    • Flood, D.G.1
  • 26
    • 0027490565 scopus 로고
    • Critical issues in the analysis of dendritic extent in aging humans, primates, and rodents
    • Flood, D. G. Critical issues in the analysis of dendritic extent in aging humans, primates, and rodents. Neurobiol. Aging 14, 649-654 (1993).
    • (1993) Neurobiol. Aging , vol.14 , pp. 649-654
    • Flood, D.G.1
  • 27
    • 0025780197 scopus 로고
    • Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats
    • Turner, D. A. & Deupree, D. L. Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats. Neurobiol. Aging 12, 201-210 (1991).
    • (1991) Neurobiol. Aging , vol.12 , pp. 201-210
    • Turner, D.A.1    Deupree, D.L.2
  • 28
    • 0029812884 scopus 로고    scopus 로고
    • Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats
    • Pyapali, G. K. & Turner, D. A. Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats. Neurobiol. Aging 17, 601-611 (1996).
    • (1996) Neurobiol. Aging , vol.17 , pp. 601-611
    • Pyapali, G.K.1    Turner, D.A.2
  • 29
    • 14844329881 scopus 로고    scopus 로고
    • Sexually dimorphic aging of dendritic morphology in CA1 of hippocampus
    • Markham, J. A., McKian, K. P., Stroup, T. S. & Juraska, J. M. Sexually dimorphic aging of dendritic morphology in CA1 of hippocampus. Hippocampus 15, 97-103 (2005).
    • (2005) Hippocampus , vol.15 , pp. 97-103
    • Markham, J.A.1    McKian, K.P.2    Stroup, T.S.3    Juraska, J.M.4
  • 30
    • 0037165871 scopus 로고    scopus 로고
    • Age-related and laminar-specific dendritic changes in the medial frontal cortex of the rat
    • Grill, J. D. & Riddle, D. R. Age-related and laminar-specific dendritic changes in the medial frontal cortex of the rat. Brain Res. 937, 8-21 (2002).
    • (2002) Brain Res. , vol.937 , pp. 8-21
    • Grill, J.D.1    Riddle, D.R.2
  • 31
    • 0036247060 scopus 로고    scopus 로고
    • Aging and sex influence the anatomy of the rat anterior cingulate cortex
    • Markham, J. A. & Juraska, J. M. Aging and sex influence the anatomy of the rat anterior cingulate cortex. Neurobiol. Aging 23, 579-588 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 579-588
    • Markham, J.A.1    Juraska, J.M.2
  • 32
    • 0031824046 scopus 로고    scopus 로고
    • Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex
    • de Brabander, J. M., Kramers, R. J. & Uylings, H. B. Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex. Eur. J. Neurosci. 10, 1261-1269 (1998).
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 1261-1269
    • De Brabander, J.M.1    Kramers, R.J.2    Uylings, H.B.3
  • 33
    • 0036343699 scopus 로고    scopus 로고
    • Neuronal changes in normal human aging and Alzheimer's disease
    • Uylings, H. B. & de Brabander, J. M. Neuronal changes in normal human aging and Alzheimer's disease. Brain Cogn. 49, 268-276 (2002).
    • (2002) Brain Cogn. , vol.49 , pp. 268-276
    • Uylings, H.B.1    De Brabander, J.M.2
  • 34
    • 0022856693 scopus 로고
    • Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease
    • Williams, R. S. & Matthysse, S. Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease. Prog. Brain Res. 70, 49-67 (1986).
    • (1986) Prog. Brain Res. , vol.70 , pp. 49-67
    • Williams, R.S.1    Matthysse, S.2
  • 35
    • 0020954786 scopus 로고
    • Stability of synaptic density and spine volume in dentate gyrus of aged rats
    • Curcio, C. A. & Hinds, J. W. Stability of synaptic density and spine volume in dentate gyrus of aged rats. Neurobiol. Aging 4, 77-87 (1983).
    • (1983) Neurobiol. Aging , vol.4 , pp. 77-87
    • Curcio, C.A.1    Hinds, J.W.2
  • 36
    • 0021946217 scopus 로고
    • Age-related changes in the subiculum of Macaca mulatta: Synaptic density
    • Uemura, E. Age-related changes in the subiculum of Macaca mulatta: synaptic density. Exp. Neurol. 87, 403-411 (1985).
    • (1985) Exp. Neurol. , vol.87 , pp. 403-411
    • Uemura, E.1
  • 37
    • 0028107456 scopus 로고
    • Normal aging: Regionally specific changes in hippocampal synaptic transmission
    • Barnes, C. A. Normal aging: regionally specific changes in hippocampal synaptic transmission. Trends Neurosci. 17, 13-18 (1994). A comprehensive review of hippocampal region-specific changes in synaptic transmission, along with functional sparing, which challenged the traditional concept of ageing as a process of general deterioration.
    • (1994) Trends Neurosci. , vol.17 , pp. 13-18
    • Barnes, C.A.1
  • 38
    • 0018344553 scopus 로고
    • Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat
    • Barnes, C. A. Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat J. Comp. Physiol. Psychol. 93, 74-104 (1979). The first report in aged rats of an increased LTP decay rate at the perforant path-granule cell synapse that correlates with the rate of forgetting a spatial problem on the Barnes circular platform task.
    • (1979) J. Comp. Physiol. Psychol. , vol.93 , pp. 74-104
    • Barnes, C.A.1
  • 39
    • 0026938051 scopus 로고
    • Region-specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1
    • Barnes, C. A., Rao, G., Foster, T. C. & McNaughton, B. L. Region-specific age effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1. Hippocampus 2, 457-468 (1992).
    • (1992) Hippocampus , vol.2 , pp. 457-468
    • Barnes, C.A.1    Rao, G.2    Foster, T.C.3    McNaughton, B.L.4
  • 40
    • 0020365875 scopus 로고
    • Changes in neurotransmitter actions in the aged rat hippocampus
    • Segal, M. Changes in neurotransmitter actions in the aged rat hippocampus. Neurobiol. Aging 3, 121-124 (1982).
    • (1982) Neurobiol. Aging , vol.3 , pp. 121-124
    • Segal, M.1
  • 42
    • 0023839002 scopus 로고
    • Reversed ethanol effects on potassium conductances in aged hippocampal dentate granule neurons
    • Niesen, C. E., Baskys, A. & Carlen, P. L. Reversed ethanol effects on potassium conductances in aged hippocampal dentate granule neurons. Brain Res. 445, 137-141 (1988).
    • (1988) Brain Res. , vol.445 , pp. 137-141
    • Niesen, C.E.1    Baskys, A.2    Carlen, P.L.3
  • 43
    • 0024433594 scopus 로고
    • Corticosteroid modulation of hippocampal potentials: Increased effect with aging
    • Kerr, D. S., Campbell, L. W., Hao, S. Y. & Landfield, P. W. Corticosteroid modulation of hippocampal potentials: increased effect with aging. Science 245, 1505-1509 (1989).
    • (1989) Science , vol.245 , pp. 1505-1509
    • Kerr, D.S.1    Campbell, L.W.2    Hao, S.Y.3    Landfield, P.W.4
  • 44
    • 0027463866 scopus 로고
    • Age-related alterations in the properties of hippocampal pyramidal neurons among rat strains
    • Potier, B., Lamour, Y. & Dutar, P. Age-related alterations in the properties of hippocampal pyramidal neurons among rat strains. Neurobiol. Aging 14, 17-25 (1993).
    • (1993) Neurobiol. Aging , vol.14 , pp. 17-25
    • Potier, B.1    Lamour, Y.2    Dutar, P.3
  • 45
    • 0026650079 scopus 로고
    • Alterations in the properties of hippocampal pyramidal neurons in the aged rat
    • Potier, B., Rascol, O., Jazat, F., Lamour, Y. & Dutar, P. Alterations in the properties of hippocampal pyramidal neurons in the aged rat. Neuroscience 48, 793-806 (1992).
    • (1992) Neuroscience , vol.48 , pp. 793-806
    • Potier, B.1    Rascol, O.2    Jazat, F.3    Lamour, Y.4    Dutar, P.5
  • 46
    • 0025097883 scopus 로고
    • Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons
    • Pitler, T. A. & Landfield, P. W. Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons. Brain Res. 508, 1-6 (1990).
    • (1990) Brain Res. , vol.508 , pp. 1-6
    • Pitler, T.A.1    Landfield, P.W.2
  • 47
    • 0019225823 scopus 로고
    • Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence
    • Barnes, C. A. & McNaughton, B. L. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence. J. Physiol. (Lond.) 309, 473-485 (1980).
    • (1980) J. Physiol. (Lond.) , vol.309 , pp. 473-485
    • Barnes, C.A.1    McNaughton, B.L.2
  • 48
    • 0024531606 scopus 로고
    • Diminished calcium currents in aged hippocampal dentate gyrus granule neurones
    • Reynolds, J. N. & Carlen, P. L. Diminished calcium currents in aged hippocampal dentate gyrus granule neurones. Brain Res. 479, 384-390 (1989).
    • (1989) Brain Res. , vol.479 , pp. 384-390
    • Reynolds, J.N.1    Carlen, P.L.2
  • 49
    • 0038301590 scopus 로고    scopus 로고
    • Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey
    • Luebke, J. I. & Rosene, D. L. Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey. J. Comp. Neurol. 460, 573-584 (2003).
    • (2003) J. Comp. Neurol. , vol.460 , pp. 573-584
    • Luebke, J.I.1    Rosene, D.L.2
  • 50
    • 0027070788 scopus 로고
    • Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner
    • Moyer, J. R. Jr, Thompson, L. T., Black, J. P. & Disterhoft, J. F. Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner. J. Neurophysiol. 68, 2100-2109 (1992).
    • (1992) J. Neurophysiol. , vol.68 , pp. 2100-2109
    • Moyer Jr., J.R.1    Thompson, L.T.2    Black, J.P.3    Disterhoft, J.F.4
  • 51
  • 53
    • 0031451847 scopus 로고    scopus 로고
    • 2+-dependent processes: Relation to hippocampal synaptic plasticity
    • 2+-dependent processes: relation to hippocampal synaptic plasticity. Hippocampus 7, 602-612 (1997).
    • (1997) Hippocampus , vol.7 , pp. 602-612
    • Foster, T.C.1    Norris, C.M.2
  • 54
    • 0024158607 scopus 로고
    • Hippocampal neurobiological mechanisms of age-related memory dysfunction
    • Landfield, P. W. Hippocampal neurobiological mechanisms of age-related memory dysfunction. Neurobiol. Aging 9, 571-579 (1988).
    • (1988) Neurobiol. Aging , vol.9 , pp. 571-579
    • Landfield, P.W.1
  • 55
    • 14944380610 scopus 로고    scopus 로고
    • The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats
    • Tombaugh, G. C., Rowe, W. B. & Rose, G. M. The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats. J. Neurosci. 25, 2609-2616 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 2609-2616
    • Tombaugh, G.C.1    Rowe, W.B.2    Rose, G.M.3
  • 56
    • 0021080848 scopus 로고
    • Loss of place specificity in hippocampal complex spike cells of senescent rat
    • Barnes, C. A., McNaughton, B. L. & O'Keefe, J. Loss of place specificity in hippocampal complex spike cells of senescent rat. Neurobiol. Aging 4, 113-119 (1983).
    • (1983) Neurobiol. Aging , vol.4 , pp. 113-119
    • Barnes, C.A.1    McNaughton, B.L.2    O'Keefe, J.3
  • 57
    • 0028029502 scopus 로고
    • Spatial information content and reliability of hippocampal CA1 neurons: Effects of visual input
    • Markus, E. J., Barnes, C. A., McNaughton, B. L., Gladden, V. L. & Skaggs, W. E. Spatial information content and reliability of hippocampal CA1 neurons: effects of visual input. Hippocampus 4, 410-421 (1994).
    • (1994) Hippocampus , vol.4 , pp. 410-421
    • Markus, E.J.1    Barnes, C.A.2    McNaughton, B.L.3    Gladden, V.L.4    Skaggs, W.E.5
  • 58
    • 0029974070 scopus 로고    scopus 로고
    • Redistribution of spatial representation in the hippocampus of aged rats performing a spatial memory task
    • Mizumori, S. J., Lavoie, A. M. & Kalyani, A. Redistribution of spatial representation in the hippocampus of aged rats performing a spatial memory task. Behav. Neurosci. 110, 1006-1016 (1996).
    • (1996) Behav. Neurosci. , vol.110 , pp. 1006-1016
    • Mizumori, S.J.1    Lavoie, A.M.2    Kalyani, A.3
  • 59
    • 0030854720 scopus 로고    scopus 로고
    • Multistability of cognitive maps in the hippocampus of old rats
    • Barnes, C. A., Suster, M. S., Shen, J. & McNaughton, B. L. Multistability of cognitive maps in the hippocampus of old rats. Nature 388, 272-275 (1997). The first report of altered stability of hippocampal place maps in aged rats, which correlates with the bimodal performance of aged rats on the spatial version of the Morris swim task.
    • (1997) Nature , vol.388 , pp. 272-275
    • Barnes, C.A.1    Suster, M.S.2    Shen, J.3    McNaughton, B.L.4
  • 60
    • 16944363524 scopus 로고    scopus 로고
    • The effect of aging on experience-dependent plasticity of hippocampal place cells
    • Shen, J., Barnes, C. A., McNaughton, B. L., Skaggs, W. E. & Weaver, K. L. The effect of aging on experience-dependent plasticity of hippocampal place cells. J. Neurosci. 17, 6769-6782 (1997). Many hippocampal place cells were recorded simultaneously in young and aged rats to reveal that behaviourally induced plasticity mechanisms are defective in aged rats.
    • (1997) J. Neurosci. , vol.17 , pp. 6769-6782
    • Shen, J.1    Barnes, C.A.2    McNaughton, B.L.3    Skaggs, W.E.4    Weaver, K.L.5
  • 61
    • 0030915192 scopus 로고    scopus 로고
    • Brain aging: Changes in the nature of information coding by the hippocampus
    • Tanila, H., Shapiro, M., Gallagher, M. & Eichenbaum, H. Brain aging: changes in the nature of information coding by the hippocampus. J. Neurosci. 17, 5155-5166 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 5155-5166
    • Tanila, H.1    Shapiro, M.2    Gallagher, M.3    Eichenbaum, H.4
  • 62
    • 0034722598 scopus 로고    scopus 로고
    • Effect of age on burst firing characteristics of rat hippocampal pyramidal cells
    • Smith, A. C., Gerrard, J. L., Barnes, C. A. & McNaughton, B. L. Effect of age on burst firing characteristics of rat hippocampal pyramidal cells. Neuroreport 11, 3865-3871 (2000).
    • (2000) Neuroreport , vol.11 , pp. 3865-3871
    • Smith, A.C.1    Gerrard, J.L.2    Barnes, C.A.3    McNaughton, B.L.4
  • 63
    • 0033920579 scopus 로고    scopus 로고
    • Age-related deficits in the ability to encode contextual change: A place cell analysis
    • Oler, J. A. & Markus, E. J. Age-related deficits in the ability to encode contextual change: a place cell analysis. Hippocampus 10, 338-350 (2000).
    • (2000) Hippocampus , vol.10 , pp. 338-350
    • Oler, J.A.1    Markus, E.J.2
  • 64
    • 22544475288 scopus 로고    scopus 로고
    • Age-associated alterations in place cells are subregion specific
    • Wilson, I. A., Ikonen, S., Gallagher, M., Eichenbaum, H. & Tanila, H. Age-associated alterations in place cells are subregion specific. J. Neurosci. 25, 6877-6886 (2005). The first paper to report a distinction between the impact of ageing on CA1 and CA3 networks. This makes it clear that these areas cannot be combined when age comparisons are made.
    • (2005) J. Neurosci. , vol.25 , pp. 6877-6886
    • Wilson, I.A.1    Ikonen, S.2    Gallagher, M.3    Eichenbaum, H.4    Tanila, H.5
  • 65
    • 15244346712 scopus 로고    scopus 로고
    • Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    • Chang, Y. M., Rosene, D. L., Killiany, R. J., Mangiamele, L. A. & Luebke, J. I. Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys. Cereb. Cortex 15, 409-418 (2005).
    • (2005) Cereb. Cortex , vol.15 , pp. 409-418
    • Chang, Y.M.1    Rosene, D.L.2    Killiany, R.J.3    Mangiamele, L.A.4    Luebke, J.I.5
  • 66
    • 0017232487 scopus 로고
    • Loss of synapses in the dentate gyrus of the senescent rat
    • Bondareff, W. & Geinisman, Y. Loss of synapses in the dentate gyrus of the senescent rat. Am. J. Anat. 145, 129-136 (1976).
    • (1976) Am. J. Anat. , vol.145 , pp. 129-136
    • Bondareff, W.1    Geinisman, Y.2
  • 67
    • 0017671349 scopus 로고
    • Partial deafferentation of neurons in the dentate gyrus of the senescent rat
    • Geinisman, Y., Bondareff, W. & Dodge, J. T. Partial deafferentation of neurons in the dentate gyrus of the senescent rat. Brain Res. 134, 541-545 (1977).
    • (1977) Brain Res. , vol.134 , pp. 541-545
    • Geinisman, Y.1    Bondareff, W.2    Dodge, J.T.3
  • 68
    • 0043258253 scopus 로고
    • Loss of perforated synapses in the dentate gyrus: Morphological substrate of memory deficit in aged rats
    • Geinisman, Y., de Toledo-Morrell, L. & Morrell, F. Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats. Proc. Natl Acad. Sci. USA 83, 3027-3031 (1986).
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3027-3031
    • Geinisman, Y.1    De Toledo-Morrell, L.2    Morrell, F.3
  • 69
    • 0026938047 scopus 로고
    • Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique
    • Geinisman, Y., de Toledo-Morrell, L., Morrell, F., Persina, I. S. & Rossi, M. Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus 2, 437-444 (1992).
    • (1992) Hippocampus , vol.2 , pp. 437-444
    • Geinisman, Y.1    De Toledo-Morrell, L.2    Morrell, F.3    Persina, I.S.4    Rossi, M.5
  • 70
    • 0034282068 scopus 로고    scopus 로고
    • LTP induction threshold change in old rats at the perforant path-granule cell synapse
    • Barnes, C. A., Rao, G. & Houston, F. P. LTP induction threshold change in old rats at the perforant path-granule cell synapse. Neurobiol. Aging 21, 613-620 (2000).
    • (2000) Neurobiol. Aging , vol.21 , pp. 613-620
    • Barnes, C.A.1    Rao, G.2    Houston, F.P.3
  • 71
    • 0025942963 scopus 로고
    • Increase in perforant path quantal size in aged F-344 rats
    • Foster, T. C., Barnes, C. A., Rao, G. & McNaughton, B. L. Increase in perforant path quantal size in aged F-344 rats. Neurobiol. Aging 12, 441-448 (1991).
    • (1991) Neurobiol. Aging , vol.12 , pp. 441-448
    • Foster, T.C.1    Barnes, C.A.2    Rao, G.3    McNaughton, B.L.4
  • 72
    • 0023198851 scopus 로고
    • Increased electrotonic coupling in aged rat hippocampus: A possible mechanism for cellular excitability changes
    • Barnes, C. A., Rao, G. & McNaughton, B. L. Increased electrotonic coupling in aged rat hippocampus: a possible mechanism for cellular excitability changes. J. Comp. Neurol. 259, 549-558 (1987).
    • (1987) J. Comp. Neurol. , vol.259 , pp. 549-558
    • Barnes, C.A.1    Rao, G.2    McNaughton, B.L.3
  • 73
    • 1242338796 scopus 로고    scopus 로고
    • Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum
    • Geinisman, Y. et al. Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol. Aging 25, 407-416 (2004).
    • (2004) Neurobiol. Aging , vol.25 , pp. 407-416
    • Geinisman, Y.1
  • 74
    • 4444293175 scopus 로고    scopus 로고
    • Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments
    • Nicholson, D. A., Yoshida, R., Berry, R. W., Gallagher, M. & Geinisman, Y. Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments. J. Neurosci. 24, 7648-7653 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 7648-7653
    • Nicholson, D.A.1    Yoshida, R.2    Berry, R.W.3    Gallagher, M.4    Geinisman, Y.5
  • 75
    • 0022558769 scopus 로고
    • 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats
    • 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. J. Neurophysiol. 56, 797-811 (1986).
    • (1986) J. Neurophysiol. , vol.56 , pp. 797-811
    • Landfield, P.W.1    Pitler, T.A.2    Applegate, M.D.3
  • 76
    • 0027193830 scopus 로고
    • Age-related alterations in potentiation in the CA1 region in F344 rats
    • Deupree, D. L., Bradley, J. & Turner, D. A. Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol. Aging 14, 249-258 (1993).
    • (1993) Neurobiol. Aging , vol.14 , pp. 249-258
    • Deupree, D.L.1    Bradley, J.2    Turner, D.A.3
  • 77
    • 0030755342 scopus 로고    scopus 로고
    • R-mediated excitatory postsynaptic potential in hippocampal region CA1
    • R-mediated excitatory postsynaptic potential in hippocampal region CA1. Neurobiol. Aging 18, 445-452 (1997).
    • (1997) Neurobiol. Aging , vol.18 , pp. 445-452
    • Barnes, C.A.1    Rao, G.2    Shen, J.3
  • 78
    • 0030686555 scopus 로고    scopus 로고
    • Role of temporal summation in age-related long-term potentiation- induction deficits
    • Rosenzweig, E. S., Rao, G., McNaughton, B. L. & Barnes, C. A. Role of temporal summation in age-related long-term potentiation-induction deficits. Hippocampus 7, 549-558 (1997).
    • (1997) Hippocampus , vol.7 , pp. 549-558
    • Rosenzweig, E.S.1    Rao, G.2    McNaughton, B.L.3    Barnes, C.A.4
  • 79
    • 0033757922 scopus 로고    scopus 로고
    • Age-related decrease in the Schaffer collateral-evoked EPSP in awake, freely behaving rats
    • Barnes, C. A., Rao, G. & Orr, G. Age-related decrease in the Schaffer collateral-evoked EPSP in awake, freely behaving rats. Neural Plast. 7, 167-178 (2000).
    • (2000) Neural Plast. , vol.7 , pp. 167-178
    • Barnes, C.A.1    Rao, G.2    Orr, G.3
  • 80
    • 0037112195 scopus 로고    scopus 로고
    • Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats
    • Tombaugh, G. C., Rowe, W. B., Chow, A. R., Michael, T. H. & Rose, G. M. Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats. J. Neurosci. 22, 9932-9940 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 9932-9940
    • Tombaugh, G.C.1    Rowe, W.B.2    Chow, A.R.3    Michael, T.H.4    Rose, G.M.5
  • 81
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss, T. V. & Collingridge, G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39 (1993).
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 82
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • Malinow, R. & Malenka, R. C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25, 103-126 (2002).
    • (2002) Annu. Rev. Neurosci. , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 83
    • 0028210970 scopus 로고
    • Age and strain differences in rat place learning and hippocampal dentate gyrus frequency-potentiation
    • Diana, G., Domenici, M. R., Loizzo, A., Scotti de Carolis, A. & Sagratella, S. Age and strain differences in rat place learning and hippocampal dentate gyrus frequency-potentiation. Neurosci. Lett. 171, 113-116 (1994).
    • (1994) Neurosci. Lett. , vol.171 , pp. 113-116
    • Diana, G.1    Domenici, M.R.2    Loizzo, A.3    Scotti De Carolis, A.4    Sagratella, S.5
  • 84
    • 0028086523 scopus 로고
    • Selective reduction of hippocampal dentate frequency potentiation in aged rats with impaired place learning
    • Diana, G., Scotti de Carolis, A., Frank, C., Domenici, M. R. & Sagratella, S. Selective reduction of hippocampal dentate frequency potentiation in aged rats with impaired place learning. Brain Res. Bull. 35, 107-111 (1994).
    • (1994) Brain Res. Bull. , vol.35 , pp. 107-111
    • Diana, G.1    Scotti De Carolis, A.2    Frank, C.3    Domenici, M.R.4    Sagratella, S.5
  • 85
    • 0017669091 scopus 로고
    • Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats
    • Landfield, P. W. & Lynch, G. Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats. J. Gerontol. 32, 523-533 (1977).
    • (1977) J. Gerontol. , vol.32 , pp. 523-533
    • Landfield, P.W.1    Lynch, G.2
  • 86
    • 0018146937 scopus 로고
    • Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats
    • Landfield, P. W., McGaugh, J. L. & Lynch, G. Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats. Brain Res. 150, 85-101 (1978).
    • (1978) Brain Res. , vol.150 , pp. 85-101
    • Landfield, P.W.1    McGaugh, J.L.2    Lynch, G.3
  • 87
    • 1542373722 scopus 로고    scopus 로고
    • Aging impairs the late phase of long-term potentiation at the medial perforant path-CA3 synapse in awake rats
    • Dieguez, D. Jr & Barea-Rodriguez, E. J. Aging impairs the late phase of long-term potentiation at the medial perforant path-CA3 synapse in awake rats. Synapse 52, 53-61 (2004).
    • (2004) Synapse , vol.52 , pp. 53-61
    • Dieguez Jr., D.1    Barea-Rodriguez, E.J.2
  • 88
    • 0034282068 scopus 로고    scopus 로고
    • LTP induction threshold change in old rats at the perforant pathgranule cell synapse
    • Barnes, C. A., Rao, G. & Houston, F. P. LTP induction threshold change in old rats at the perforant pathgranule cell synapse. Neurobiol. Aging 21, 613-620 (2000).
    • (2000) Neurobiol. Aging , vol.21 , pp. 613-620
    • Barnes, C.A.1    Rao, G.2    Houston, F.P.3
  • 89
    • 0029976891 scopus 로고    scopus 로고
    • Functional integrity of NMDA-dependent LTP induction mechanisms across the lifespan of F-344 rats
    • Barnes, C. A., Rao, G. & McNaughton, B. L. Functional integrity of NMDA-dependent LTP induction mechanisms across the lifespan of F-344 rats. Learn. Mem. 3, 124-137 (1996).
    • (1996) Learn. Mem. , vol.3 , pp. 124-137
    • Barnes, C.A.1    Rao, G.2    McNaughton, B.L.3
  • 90
    • 0025771085 scopus 로고
    • Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats
    • Deupree, D. L., Turner, D. A. & Watters, C. L. Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats. Brain Res. 554, 1-9 (1991).
    • (1991) Brain Res. , vol.554 , pp. 1-9
    • Deupree, D.L.1    Turner, D.A.2    Watters, C.L.3
  • 91
    • 0027298841 scopus 로고
    • Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area CA1 of aged Fischer 344 rats
    • Moore, C. I., Browning, M. D. & Rose, G. M. Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area CA1 of aged Fischer 344 rats. Hippocampus 3, 57-66 (1993). In contrast to earlier reports of intact hippocampal LTP induction (see references 38 and 83), the results of this study suggest that engaging plasticity-inducing mechanisms around threshold becomes more difficult with age.
    • (1993) Hippocampus , vol.3 , pp. 57-66
    • Moore, C.I.1    Browning, M.D.2    Rose, G.M.3
  • 92
    • 0023224483 scopus 로고
    • A physiological basis for a theory of synapse modification
    • Bear, M. F., Cooper, L. N. & Ebner, F. F. A physiological basis for a theory of synapse modification. Science 237, 42-48 (1987).
    • (1987) Science , vol.237 , pp. 42-48
    • Bear, M.F.1    Cooper, L.N.2    Ebner, F.F.3
  • 94
    • 0035892243 scopus 로고    scopus 로고
    • i and L-type calcium channel activity in aged hippocampal neurons: Relationship to impaired synaptic plasticity
    • i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. J. Neurosci. 21, 9744-9756 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 9744-9756
    • Thibault, O.1    Hadley, R.2    Landfield, P.W.3
  • 96
    • 11144265809 scopus 로고    scopus 로고
    • Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging
    • Kumar, A. & Foster, T. C. Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging. Brain Res. 1031, 125-128 (2005).
    • (2005) Brain Res. , vol.1031 , pp. 125-128
    • Kumar, A.1    Foster, T.C.2
  • 97
    • 0023193514 scopus 로고
    • Mapping patterns of c-fos expression in the central nervous system after seizure
    • Morgan, J. I., Cohen, D. R., Hempstead, J. L. & Curran, T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237, 192-197 (1987).
    • (1987) Science , vol.237 , pp. 192-197
    • Morgan, J.I.1    Cohen, D.R.2    Hempstead, J.L.3    Curran, T.4
  • 98
    • 0024403534 scopus 로고
    • Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
    • Cole, A. J., Saffen, D. W., Baraban, J. M. & Worley, P. F. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 340, 474-476 (1989).
    • (1989) Nature , vol.340 , pp. 474-476
    • Cole, A.J.1    Saffen, D.W.2    Baraban, J.M.3    Worley, P.F.4
  • 99
    • 0024371937 scopus 로고
    • Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats
    • Dragunow, M. et al. Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats. Neurosci. Lett. 101, 274-280 (1989).
    • (1989) Neurosci. Lett. , vol.101 , pp. 274-280
    • Dragunow, M.1
  • 100
    • 0025271411 scopus 로고
    • Differential expression of immediate early genes in the hippocampus and spinal cord
    • Wisden, W. et al. Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4, 603-614 (1990).
    • (1990) Neuron , vol.4 , pp. 603-614
    • Wisden, W.1
  • 101
    • 0033490104 scopus 로고    scopus 로고
    • Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
    • Cuzowski, J. F., McNaughton, B. L., Barnes, C. A. & Worley, P. F. Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nature Neurosci. 2, 1120-1124 (1999).
    • (1999) Nature Neurosci. , vol.2 , pp. 1120-1124
    • Cuzowski, J.F.1    McNaughton, B.L.2    Barnes, C.A.3    Worley, P.F.4
  • 102
    • 0034674485 scopus 로고    scopus 로고
    • Molecular mechanisms associated with long-term consolidation of the NMDA signals
    • Platenik, J., Kuramoto, N. & Yoneda, Y. Molecular mechanisms associated with long-term consolidation of the NMDA signals. Life Sci. 67, 335-364 (2000).
    • (2000) Life Sci. , vol.67 , pp. 335-364
    • Platenik, J.1    Kuramoto, N.2    Yoneda, Y.3
  • 103
    • 0033743078 scopus 로고    scopus 로고
    • The genomic action potential
    • Clayton, D. F. The genomic action potential. Neurobiol. Learn. Mem. 74, 185-216 (2000).
    • (2000) Neurobiol. Learn. Mem. , vol.74 , pp. 185-216
    • Clayton, D.F.1
  • 104
    • 0035126793 scopus 로고    scopus 로고
    • A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
    • Jones, M. W. et al. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nature Neurosci. 4, 289-296 (2001).
    • (2001) Nature Neurosci. , vol.4 , pp. 289-296
    • Jones, M.W.1
  • 105
    • 0036679292 scopus 로고    scopus 로고
    • Prominent Narp expression in projection pathways and terminal fields
    • Reti, I. M., Reddy, R., Worley, P. F. & Baraban, J. M. Prominent Narp expression in projection pathways and terminal fields. J. Neurochem. 82, 935-944 (2002).
    • (2002) J. Neurochem. , vol.82 , pp. 935-944
    • Reti, I.M.1    Reddy, R.2    Worley, P.F.3    Baraban, J.M.4
  • 106
    • 0033153155 scopus 로고    scopus 로고
    • Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp
    • O'Brien, R. J. et al. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 23, 309-323 (1999).
    • (1999) Neuron , vol.23 , pp. 309-323
    • O'Brien, R.J.1
  • 107
    • 0032191909 scopus 로고    scopus 로고
    • Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites
    • Steward, O., Wallace, C. S., Lyford, G. L. & Worley, P. F. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron 21, 741-751 (1998).
    • (1998) Neuron , vol.21 , pp. 741-751
    • Steward, O.1    Wallace, C.S.2    Lyford, G.L.3    Worley, P.F.4
  • 108
    • 0028853459 scopus 로고
    • Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
    • Lyford, C. L. et al. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14, 433-445 (1995).
    • (1995) Neuron , vol.14 , pp. 433-445
    • Lyford, C.L.1
  • 109
    • 0034213297 scopus 로고    scopus 로고
    • Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
    • Guzowski, J. F. et al. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20, 3993-4001 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 3993-4001
    • Guzowski, J.F.1
  • 110
    • 0035852759 scopus 로고    scopus 로고
    • The effects of aging on gene expression in the hypothalamus and cortex of mice
    • Jiang, C. H., Tsien, J. Z., Schultz, P. G. & Hu, Y. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc. Natl Acad. Sci. USA 98, 1930-1934 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 1930-1934
    • Jiang, C.H.1    Tsien, J.Z.2    Schultz, P.G.3    Hu, Y.4
  • 111
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee, C. K., Weindruch, R. & Prolla, T. A. Gene-expression profile of the ageing brain in mice. Nature Genet 25, 294-297 (2000).
    • (2000) Nature Genet , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 112
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment
    • Blalock, E. M. et al. Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 23, 3807-3819 (2003). A report of the first gene-expression microarray experiment in behaviourally characterized rats, which shows an age-associated change in the resting levels of expression of several genes that correlates with cognitive decline.
    • (2003) J. Neurosci. , vol.23 , pp. 3807-3819
    • Blalock, E.M.1
  • 113
    • 0035174076 scopus 로고    scopus 로고
    • Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus
    • Smith, D. R., Hoyt, E. C., Gallagher, M., Schwabe, R. F. & Lund, P. K. Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus. Neurobiol. Aging 22, 773-786 (2001).
    • (2001) Neurobiol. Aging , vol.22 , pp. 773-786
    • Smith, D.R.1    Hoyt, E.C.2    Gallagher, M.3    Schwabe, R.F.4    Lund, P.K.5
  • 114
    • 0030988498 scopus 로고    scopus 로고
    • Selective alteration of long-term potentiation-induced transcriptional response in hippocampus of aged, memory-impaired rats
    • Lanahan, A., Lyford, G., Stevenson, G. S., Worley, P. F. & Barnes, C. A. Selective alteration of long-term potentiation-induced transcriptional response in hippocampus of aged, memory-impaired rats. J. Neurosci. 17, 2876-2885 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 2876-2885
    • Lanahan, A.1    Lyford, G.2    Stevenson, G.S.3    Worley, P.F.4    Barnes, C.A.5
  • 115
    • 2342557824 scopus 로고    scopus 로고
    • Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
    • Small, S. A., Chawla, M. K., Buonocore, M., Rapp, P. R. & Barnes, C. A. Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proc. Natl Acad. Sci. USA 101, 7181-7186 (2004). The authors used different imaging methods in rats and monkeys and report a cross-species consensus that the dentate gyrus of the hippocampus is particularly vulnerable to the impact of ageing. These results are consistent with a previous report in humans.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 7181-7186
    • Small, S.A.1    Chawla, M.K.2    Buonocore, M.3    Rapp, P.R.4    Barnes, C.A.5
  • 116
    • 0036194064 scopus 로고    scopus 로고
    • Imaging hippocampal function across the human life span: Is memory decline normal or not?
    • Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R. & Stern, Y. Imaging hippocampal function across the human life span: is memory decline normal or not? Ann. Neurol. 51, 290-295 (2002).
    • (2002) Ann. Neurol. , vol.51 , pp. 290-295
    • Small, S.A.1    Tsai, W.Y.2    DeLaPaz, R.3    Mayeux, R.4    Stern, Y.5
  • 117
    • 0032568888 scopus 로고    scopus 로고
    • Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade
    • Kentros, C. et al. Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. Science 280, 2121-2126 (1998).
    • (1998) Science , vol.280 , pp. 2121-2126
    • Kentros, C.1
  • 118
    • 0035974793 scopus 로고    scopus 로고
    • NMDA receptor antagonism blocks experience-dependent expansion of hippocampal 'place fields'
    • Ekstrom, A. D., Meltzer, J., McNaughton, B. L. & Barnes, C. A. NMDA receptor antagonism blocks experience-dependent expansion of hippocampal 'place fields'. Neuron 31, 631-638 (2001).
    • (2001) Neuron , vol.31 , pp. 631-638
    • Ekstrom, A.D.1    Meltzer, J.2    McNaughton, B.L.3    Barnes, C.A.4
  • 119
    • 0015145985 scopus 로고
    • The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
    • O'Keefe, J. & Dostrovsky J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res. 34, 171-175 (1971).
    • (1971) Brain Res. , vol.34 , pp. 171-175
    • O'Keefe, J.1    Dostrovsky, J.2
  • 120
    • 0027156030 scopus 로고
    • Spatial selectivity of unit activity in the hippocampal granular layer
    • Jung, M. W. & McNaughton, B. L. Spatial selectivity of unit activity in the hippocampal granular layer. Hippocampus 3, 165-182 (1993).
    • (1993) Hippocampus , vol.3 , pp. 165-182
    • Jung, M.W.1    McNaughton, B.L.2
  • 121
    • 0027440875 scopus 로고
    • Dynamics of the hippocampal ensemble code for space
    • Wilson, M. A. & McNaughton, B. L. Dynamics of the hippocampal ensemble code for space. Science 261, 1055-1058 (1993).
    • (1993) Science , vol.261 , pp. 1055-1058
    • Wilson, M.A.1    McNaughton, B.L.2
  • 122
    • 0020618244 scopus 로고
    • The contributions of position, direction, and velocity to single unit activity in the hippocampus of freely-moving rats
    • McNaughton, B. L., Barnes, C. A. & O'Keefe, J. The contributions of position, direction, and velocity to single unit activity in the hippocampus of freely-moving rats. Exp. Brain Res. 52, 41-49 (1983).
    • (1983) Exp. Brain Res. , vol.52 , pp. 41-49
    • McNaughton, B.L.1    Barnes, C.A.2    O'Keefe, J.3
  • 123
    • 0028081394 scopus 로고
    • On the directional firing properties of hippocampal place cells
    • Muller, R. U., Bostock, E., Taube, J. S. & Kubie, J. L. On the directional firing properties of hippocampal place cells. J. Neurosci. 14, 7235-7251 (1994).
    • (1994) J. Neurosci. , vol.14 , pp. 7235-7251
    • Muller, R.U.1    Bostock, E.2    Taube, J.S.3    Kubie, J.L.4
  • 124
    • 0028839248 scopus 로고
    • Interactions between location and task affect the spatial and directional firing of hippocampal neurons
    • Markus, E. J. et al. Interactions between location and task affect the spatial and directional firing of hippocampal neurons. J. Neurosci. 15, 7079-7094 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 7079-7094
    • Markus, E.J.1
  • 125
    • 0030744211 scopus 로고    scopus 로고
    • Experience-dependent, asymmetric expansion of hippocampal place fields
    • Mehta, M. R., Barnes, C. A. & McNaughton, B. L. Experience-dependent, asymmetric expansion of hippocampal place fields. Proc. Natl Acad. Sci. USA 94, 8918-8921 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8918-8921
    • Mehta, M.R.1    Barnes, C.A.2    McNaughton, B.L.3
  • 127
    • 0025174797 scopus 로고
    • Long-term stability of the place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats
    • Thompson, L. T. & Best, P. J. Long-term stability of the place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats. Brain Res. 509, 299-308 (1990).
    • (1990) Brain Res. , vol.509 , pp. 299-308
    • Thompson, L.T.1    Best, P.J.2
  • 128
    • 1542723389 scopus 로고    scopus 로고
    • The long-term stability of new hippocampal place fields requires new protein synthesis
    • Agnihotri, N. T., Hawkins, R. D., Kandel, E. R. & Kentros, C. The long-term stability of new hippocampal place fields requires new protein synthesis. Proc. Natl Acad. Sci. USA 101, 3656-3661 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3656-3661
    • Agnihotri, N.T.1    Hawkins, R.D.2    Kandel, E.R.3    Kentros, C.4
  • 129
    • 0030963161 scopus 로고    scopus 로고
    • Brain aging: Impaired coding of novel environmental cues
    • Tanila, H., Sipila, P., Shapiro, M. & Eichenbaum, H. Brain aging: impaired coding of novel environmental cues. J. Neurosci. 17, 5167-5174 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 5167-5174
    • Tanila, H.1    Sipila, P.2    Shapiro, M.3    Eichenbaum, H.4
  • 130
    • 3242799836 scopus 로고    scopus 로고
    • Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3
    • Lee, I., Yoganarasimha, D., Rao, G. & Knierim, J. J. Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature 430, 456-459 (2004).
    • (2004) Nature , vol.430 , pp. 456-459
    • Lee, I.1    Yoganarasimha, D.2    Rao, G.3    Knierim, J.J.4
  • 131
    • 4344616877 scopus 로고    scopus 로고
    • Distinct ensemble codes in hippocampal areas CA3 and CA1
    • Leutgeb, S., Leutgeb, J. K., Treves, A., Moser, M. B. & Moser, E. I. Distinct ensemble codes in hippocampal areas CA3 and CA1. Science 305, 1295-1298 (2004).
    • (2004) Science , vol.305 , pp. 1295-1298
    • Leutgeb, S.1    Leutgeb, J.K.2    Treves, A.3    Moser, M.B.4    Moser, E.I.5
  • 132
    • 3242802723 scopus 로고    scopus 로고
    • Differences in hippocampal neuronal population responses to modifications of an environmental context: Evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles
    • Vazdarjanova, A. & Guzowski, J. F. Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles. J. Neurosci. 24, 6489-6496 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 6489-6496
    • Vazdarjanova, A.1    Guzowski, J.F.2
  • 133
    • 0015083717 scopus 로고
    • Simple memory: A theory for archicortex
    • Marr, D. Simple memory: a theory for archicortex. Phil. Trans. R. Soc. Lond. B 262, 23-81 (1971).
    • (1971) Phil. Trans. R. Soc. Lond. B , vol.262 , pp. 23-81
    • Marr, D.1
  • 134
    • 0023620017 scopus 로고
    • Hippocampal synaptic enhancement and information storage within a distributed memory system
    • McNaughton, B. L. & Morris, R. G. Hippocampal synaptic enhancement and information storage within a distributed memory system. Trends Neurosci. 10, 408-415 (1987).
    • (1987) Trends Neurosci. , vol.10 , pp. 408-415
    • McNaughton, B.L.1    Morris, R.G.2
  • 135
    • 0029554696 scopus 로고
    • Differential effects of aging on memory for content and context: A meta-analysis
    • Spencer, W. D. & Raz, N. Differential effects of aging on memory for content and context: a meta-analysis. Psychol. Aging 10, 527-539 (1995).
    • (1995) Psychol. Aging , vol.10 , pp. 527-539
    • Spencer, W.D.1    Raz, N.2
  • 136
    • 0023359112 scopus 로고
    • Age differences in memory for item and source information
    • McIntyre, J. S. & Craik, F. I. Age differences in memory for item and source information. Can. J. Psychol. 41, 175-192 (1987).
    • (1987) Can. J. Psychol. , vol.41 , pp. 175-192
    • McIntyre, J.S.1    Craik, F.I.2
  • 137
    • 1842326807 scopus 로고    scopus 로고
    • Age-related differences in an ecologically based study of route learning
    • Wilkniss, S. M., Jones, M. G., Korol, D. L., Gold, P. E. & Manning, C. A. Age-related differences in an ecologically based study of route learning. Psychol. Aging 12, 372-375 (1997).
    • (1997) Psychol. Aging , vol.12 , pp. 372-375
    • Wilkniss, S.M.1    Jones, M.G.2    Korol, D.L.3    Gold, P.E.4    Manning, C.A.5
  • 138
    • 0033835539 scopus 로고    scopus 로고
    • Spatial memory and aging: Performance on a human analog of the Morris water maze
    • Newman, M. & Kasznaik, A. Spatial memory and aging: performance on a human analog of the Morris water maze. Aging Neuropsychol. Cogn. 7, 86-93 (2000). Similar to rats and monkeys, in a dry version of the Morris swim task, healthy aged humans are impaired in remembering the location of a landmark in relation to room cues.
    • (2000) Aging Neuropsychol. Cogn. , vol.7 , pp. 86-93
    • Newman, M.1    Kasznaik, A.2
  • 139
    • 0029593470 scopus 로고
    • Executive system dysfunction in the aged monkey: Spatial and object reversal learning
    • Lai, Z. C., Moss, M. B., Killiany, R. J., Rosene, D. L. & Herndon, J. G. Executive system dysfunction in the aged monkey: spatial and object reversal learning. Neurobiol. Aging 16, 947-954 (1995).
    • (1995) Neurobiol. Aging , vol.16 , pp. 947-954
    • Lai, Z.C.1    Moss, M.B.2    Killiany, R.J.3    Rosene, D.L.4    Herndon, J.G.5
  • 140
    • 0030795673 scopus 로고    scopus 로고
    • Impaired spatial information processing in aged monkeys with preserved recognition memory
    • Rapp, P. R., Kansky, M. T. & Roberts, J. A. Impaired spatial information processing in aged monkeys with preserved recognition memory. Neuroreport 8, 1923-1928 (1997). These results reveal substantial correspondence between rat and monkey data, showing that aged animals are impaired in tasks that test spatial memory.
    • (1997) Neuroreport , vol.8 , pp. 1923-1928
    • Rapp, P.R.1    Kansky, M.T.2    Roberts, J.A.3
  • 141
    • 0028784660 scopus 로고
    • Spatial learning and memory as a function of age in the dog
    • Head, E. et al. Spatial learning and memory as a function of age in the dog. Behav. Neurosci. 109, 851-858 (1995).
    • (1995) Behav. Neurosci. , vol.109 , pp. 851-858
    • Head, E.1
  • 142
    • 0024332271 scopus 로고
    • Individual differences in aging: Behavioral and neurobiological correlates
    • Markowska, A. L. et al. Individual differences in aging: behavioral and neurobiological correlates. Neurobiol. Aging 10, 31-43 (1989).
    • (1989) Neurobiol. Aging , vol.10 , pp. 31-43
    • Markowska, A.L.1
  • 143
    • 0030639472 scopus 로고    scopus 로고
    • The use of animal models to study the effects of aging on cognition
    • Callagher, M. & Rapp, P. R. The use of animal models to study the effects of aging on cognition. Annu. Rev. Psychol. 48, 339-370 (1997).
    • (1997) Annu. Rev. Psychol. , vol.48 , pp. 339-370
    • Callagher, M.1    Rapp, P.R.2
  • 144
    • 0033609045 scopus 로고    scopus 로고
    • Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
    • Bach, M. E. et al. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc. Natl Acad. Sci. USA 96, 5280-5285 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5280-5285
    • Bach, M.E.1
  • 145
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function: Plasticity, network dynamics, and cognition
    • Rosenzweig, E. S. & Barnes, C. A. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog. Neurobiol. 69, 143-179 (2003).
    • (2003) Prog. Neurobiol. , vol.69 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 146
    • 0344758980 scopus 로고    scopus 로고
    • Neural substrates of eyeblink conditioning: Acquisition and retention
    • Christian, K. M. & Thompson, R. F. Neural substrates of eyeblink conditioning: acquisition and retention. Learn. Mem. 10, 427-455 (2003).
    • (2003) Learn. Mem. , vol.10 , pp. 427-455
    • Christian, K.M.1    Thompson, R.F.2
  • 147
    • 0035968922 scopus 로고    scopus 로고
    • Age-dependent impairment of delay and trace eyeblink conditioning in mice
    • Kishimoto, Y., Suzuki, M., Kawahara, S. & Kirino, Y. Age-dependent impairment of delay and trace eyeblink conditioning in mice. Neuroreport 12, 3349-3352 (2001).
    • (2001) Neuroreport , vol.12 , pp. 3349-3352
    • Kishimoto, Y.1    Suzuki, M.2    Kawahara, S.3    Kirino, Y.4
  • 149
    • 0029787589 scopus 로고    scopus 로고
    • Trace eyeblink conditioning in rabbits demonstrates heterogeneity of learning ability both between and within age groups
    • Thompson, L. T., Moyer, J. R. Jr & Disterhoft, J. F. Trace eyeblink conditioning in rabbits demonstrates heterogeneity of learning ability both between and within age groups. Neurobiol. Aging 17, 619-629 (1996).
    • (1996) Neurobiol. Aging , vol.17 , pp. 619-629
    • Thompson, L.T.1    Moyer Jr., J.R.2    Disterhoft, J.F.3
  • 150
    • 0030006439 scopus 로고    scopus 로고
    • Classic conditioning in aged rabbits: Delay, trace, and long-delay conditioning
    • Solomon, P. R. & Groccia-Ellison, M. E. Classic conditioning in aged rabbits: delay, trace, and long-delay conditioning. Behav. Neurosci. 110, 427-435 (1996).
    • (1996) Behav. Neurosci. , vol.110 , pp. 427-435
    • Solomon, P.R.1    Groccia-Ellison, M.E.2
  • 151
    • 0026129188 scopus 로고
    • Classical eyeblink conditioning in adulthood: Effects of age and interstimulus interval on acquisition in the trace paradigm
    • Finkbiner, R. G. & Woodruff-Pak, D. S. Classical eyeblink conditioning in adulthood: effects of age and interstimulus interval on acquisition in the trace paradigm. Psychol. Aging 6, 109-117 (1991).
    • (1991) Psychol. Aging , vol.6 , pp. 109-117
    • Finkbiner, R.G.1    Woodruff-Pak, D.S.2
  • 152
    • 0027474440 scopus 로고
    • Dorsolateral prefrontal lesions and oculomotor delayed-response performance: Evidence for mnemonic 'scotomas'
    • Funahashi, S., Bruce, C. J. & Goldman-Rakic, P. S. Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic 'scotomas'. J. Neurosci. 13, 1479-1497 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 1479-1497
    • Funahashi, S.1    Bruce, C.J.2    Goldman-Rakic, P.S.3
  • 153
    • 0031655408 scopus 로고    scopus 로고
    • Lesions of the frontal cortex, hippocampus, and intralaminar thalamic nuclei have distinct effects on remembering in rats
    • Mair, R. G., Burk, J. A. & Porter, M. C. Lesions of the frontal cortex, hippocampus, and intralaminar thalamic nuclei have distinct effects on remembering in rats. Behav. Neurosci. 112, 772-792 (1998).
    • (1998) Behav. Neurosci. , vol.112 , pp. 772-792
    • Mair, R.G.1    Burk, J.A.2    Porter, M.C.3
  • 154
    • 0033050619 scopus 로고    scopus 로고
    • Control functions of the frontal lobes. Modularity of the central-supervisory system?
    • Godefroy, O., Cabaret, M., Petit-Chenal, V., Pruvo, J. P. & Rousseaux, M. Control functions of the frontal lobes. Modularity of the central-supervisory system? Cortex 35, 1-20 (1999).
    • (1999) Cortex , vol.35 , pp. 1-20
    • Godefroy, O.1    Cabaret, M.2    Petit-Chenal, V.3    Pruvo, J.P.4    Rousseaux, M.5
  • 156
    • 0024156833 scopus 로고
    • Effects of aging on visual recognition memory in the rhesus monkey
    • Moss, M. B., Rosene, D. L. & Peters, A. Effects of aging on visual recognition memory in the rhesus monkey. Neurobiol. Aging 9, 495-502 (1988).
    • (1988) Neurobiol. Aging , vol.9 , pp. 495-502
    • Moss, M.B.1    Rosene, D.L.2    Peters, A.3
  • 157
    • 0024439790 scopus 로고
    • Evidence for task-dependent memory dysfunction in the aged monkey
    • Rapp, P. R. & Amaral, D. G. Evidence for task-dependent memory dysfunction in the aged monkey. J. Neurosci. 9, 3568-3576 (1989).
    • (1989) J. Neurosci. , vol.9 , pp. 3568-3576
    • Rapp, P.R.1    Amaral, D.G.2
  • 159
    • 9644265444 scopus 로고    scopus 로고
    • Short- and long-term spatial delayed response performance across the lifespan
    • Lyons-Warren, A., Lillie, R. & Hershey, T. Short- and long-term spatial delayed response performance across the lifespan. Dev. Neuropsychol. 26, 661-678 (2004).
    • (2004) Dev. Neuropsychol. , vol.26 , pp. 661-678
    • Lyons-Warren, A.1    Lillie, R.2    Hershey, T.3
  • 160
    • 0031684821 scopus 로고    scopus 로고
    • Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat
    • Wiig, K. A. & Burwell, R. D. Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat. Behav. Neurosci. 112, 827-838 (1998).
    • (1998) Behav. Neurosci. , vol.112 , pp. 827-838
    • Wiig, K.A.1    Burwell, R.D.2
  • 161
    • 0033386138 scopus 로고    scopus 로고
    • Dissociation between the effects of damage to perirhinal cortex and area TE
    • Buffalo, E. A. et al. Dissociation between the effects of damage to perirhinal cortex and area TE. Learn. Mem. 6, 572-599 (1999).
    • (1999) Learn. Mem. , vol.6 , pp. 572-599
    • Buffalo, E.A.1
  • 162
    • 4344695179 scopus 로고    scopus 로고
    • Age-related differences in performance on the Wisconsin card sorting test: A meta-analytic review
    • Rhodes, M. G. Age-related differences in performance on the Wisconsin card sorting test: a meta-analytic review. Psychol. Aging 19, 482-494 (2004). When educational status and test modality are considered, compared with younger adults, aged humans show deficits on measures of executive function as assessed by the Wisconsin card sorting task, which correlates with an age-related decline in prefrontal cortex functioning.
    • (2004) Psychol. Aging , vol.19 , pp. 482-494
    • Rhodes, M.G.1
  • 163
    • 0037216101 scopus 로고    scopus 로고
    • Impairment in abstraction and set shifting in aged rhesus monkeys
    • Moore, T. L., Killiany, R. J., Herndon, J. G., Rosene, D. L. & Moss, M. B. Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiol. Aging 24, 125-134 (2003). Relative to young adult monkeys, aged monkeys are impaired on an animal analogue of the Wisconsin card sorting task, which suggests an age-related decline in prefrontal cortex functioning. This is consistent with human studies.
    • (2003) Neurobiol. Aging , vol.24 , pp. 125-134
    • Moore, T.L.1    Killiany, R.J.2    Herndon, J.G.3    Rosene, D.L.4    Moss, M.B.5
  • 165
    • 0030031462 scopus 로고    scopus 로고
    • Binding of hippocampal CA1 neural activity to multiple reference frames in a landmark-based navigation task
    • Gothard, K. M., Skaggs, W. E., Moore, K. M. & McNaughton, B. L. Binding of hippocampal CA1 neural activity to multiple reference frames in a landmark-based navigation task. J. Neurosci. 16, 823-835 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 823-835
    • Gothard, K.M.1    Skaggs, W.E.2    Moore, K.M.3    McNaughton, B.L.4
  • 166
    • 0020563433 scopus 로고
    • The stereotrode: A new technique for simultaneous isolation of several single units in the central nervous system from multiple unit records
    • McNaughton, B. L., O'Keefe, J. & Barnes, C. A. The stereotrode: a new technique for simultaneous isolation of several single units in the central nervous system from multiple unit records. J. Neurosci. Methods 8, 391-397 (1983).
    • (1983) J. Neurosci. Methods , vol.8 , pp. 391-397
    • McNaughton, B.L.1    O'Keefe, J.2    Barnes, C.A.3
  • 167
    • 0029623039 scopus 로고
    • Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex
    • Gray, C. M., Maldonado, P. E., Wilson, M. & McNaughton, B. Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex. J. Neurosci. Methods 63, 43-54 (1995).
    • (1995) J. Neurosci. Methods , vol.63 , pp. 43-54
    • Gray, C.M.1    Maldonado, P.E.2    Wilson, M.3    McNaughton, B.4
  • 168
    • 0022453460 scopus 로고
    • Intracellular fluorescent staining with carboxyfluorescein: A rapid and reliable method for quantifying dye-coupling in mammalian central nervous system
    • Rao, G., Barnes, C. A. & McNaughton, B. L. Intracellular fluorescent staining with carboxyfluorescein: a rapid and reliable method for quantifying dye-coupling in mammalian central nervous system. J. Neurosci. Methods 16, 251-263 (1986).
    • (1986) J. Neurosci. Methods , vol.16 , pp. 251-263
    • Rao, G.1    Barnes, C.A.2    McNaughton, B.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.