Caloric restriction delays disease onset and mortality in rhesus monkeys

Science

Volumn 325, Issue 5937, 2009, Pages 201-204

  Colman, Ricki J ^a   Anderson, Rozalyn M ^a   Johnson, Sterling C ^a,b,c   Kastman, Erik K ^b,c   Kosmatka, Kristopher J ^b,c   Beasley, T Mark ^d   Allison, David B ^d   Cruzen, Christina ^a   Simmons, Heather A ^a   Kemnitz, Joseph W ^a,b,e   Weindruch, Richard ^a,b,c  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGING; BRAIN; CANCER; CARDIOVASCULAR DISEASE; DIABETES; DISEASE INCIDENCE; DISEASE RESISTANCE; MALNUTRITION; MORTALITY; PATHOLOGY; PRIMATE; SPECIES CONSERVATION; SURVIVAL;

AGING; ANIMAL EXPERIMENT; ARTICLE; BRAIN ATROPHY; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GASTROINTESTINAL CARCINOMA; INCIDENCE; LONGITUDINAL STUDY; MALE; MORTALITY; NEOPLASM; NONHUMAN; ONSET AGE; PATHOLOGY; PRIORITY JOURNAL; RHESUS MONKEY;

AGING; ANIMALS; ATROPHY; BODY WEIGHT; BRAIN; CALORIC RESTRICTION; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; FEMALE; GLUCOSE; INCIDENCE; LONGEVITY; MACACA MULATTA; MALE; NEOPLASMS;

NORTH AMERICA; UNITED STATES; WISCONSIN;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 67650439330     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1173635     Document Type: Article

References (21)

1. C. M. McCay, M. F. Crowell, L. A. Maynard, Nutrition 5, 155 (1935).
2. R. H. Weindruch, R. L. Walford, The Retardation of Aging and Disease by Dietary Restriction (Charles C. Thomas, Springfield, IL, 1988).
3. B. K. Kennedy, K. K. Steffen, M. Kaeberlein, Cell. Mol. Life Sci. 64, 1323 (2007).
4. R. M. Anderson, R. Weindruch, Interdiscip. Top. Gerontol. 35, 18 (2007).
5. W. Mair, A. Dillin, Anna. Rev. Biochem. 77, 727 (2008).
6. A. J. Vita, R. B. Terry, H. B. Hubert, J. F. Fries, N. Engl. J. Med. 338, 1035 (1998).
7. Detailed information is supplied as supporting material on Science Online.
8. J. W. Kemnitz et al., J. Gerontol. 48, B17 (1993).
9. J. J. Ramsey et al., Exp. Gerontol. 35, 1131 (2000).
10. H. Uno, Age (Omaha) 20, 1 (1997).
11. R. J. Colman, E. B. Roecker, J. J. Ramsey, J. W. Kemnitz, Aging (Milano) 10, 83 (1998).
12. R. J. Colman, T. M. Beasley, D. B. Allison, R. Weindruch, J. Gerontol. A Biol. Sci. Med. Sci. 63, 556 (2008).
13. T. A. Gresl et al., Am. J. Physiol. Endocrinol. Metab. 281, E 757 (2001).
14. N. A. Rodriguez et al., J. Med. Primatol. 31, 74 (2002).
15. B. A. Yankner, T. Lu, P. Loerch, Annu. Rev. Pathol. 3, 41 (2008).
16. C. D. Good et al., Neuroimage 14, 21 (2001).
17. G. E. Alexander et al., J. Neurosci. 28, 2710 (2008).
18. N. L Bodkin, T. M. Alexander, H. K. Ortmeyer, E. Johnson, B. C. Hansen, J. Gerontol. A Biol. Sci. Med. Sci. 58, 212 (2003).
19. J. A. Mattison, M. A. Lane, G. S. Roth, D. K. Ingram, Exp. Gerontol. 38, 35 (2003).
20. J. O. Holloszy, L. Fontana, Exp. Gerontol. 42, 709 (2007).
21. We acknowledge the excellent technical assistance provided by S. Baum, J. Christensen, J. A. Adriansjach, C. E. Armstrong, D. G. McLaren, C. Dizack, D. Shanmuganayagam, J. Root, and the Animal Care, Veterinary and Pathology Staff of the WNPRC. R.W. is a cofounder and member of the board of LifeGen Technologies, a company focused on nutritional genomics, including the impact of dietary interventions on the aging process. This work was supported by NIH grants P01 AG-11915 and P51 RR000167. This research was conducted in part at the WNPRC, which received support from Research Facilities Improvement Program grant numbers RR15459-01 and RR020141-01. This research was supported in part by facilities and resources at the William S. Middleton Memorial Veterans Hospital.