Release and activity of histone in diseases

Cell Death and Disease

Volumn 5, Issue 8, 2014, Pages

  Chen, R ^a,b   Kang, R ^b   Fan, X G ^a   Tang, D ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; NUCLEOSOME;

ANIMAL; APOPTOSIS; AUTOIMMUNE DISEASE; CHEMISTRY; GENETIC EPIGENESIS; HUMAN; METABOLISM; NUCLEOSOME; PANCREATITIS; PATHOLOGY; PERITONITIS; PROTEIN PROCESSING; SEPSIS; THROMBOSIS;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; EPIGENESIS, GENETIC; HISTONES; HUMANS; NUCLEOSOMES; PANCREATITIS; PERITONITIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEPSIS; THROMBOSIS;

EID: 84906859591     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.337     Document Type: Review

References (84)

1. Campos EI, Reinberg D. Histones: annotating chromatin. Annu Rev Genet 2009; 43: 559-599.
2. Bhaumik SR, Smith E, Shilatifard A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 2007; 14: 1008-1016.
3. Zentner GE, Henikoff S. Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 2013; 20: 259-266.
4. Strahl BD, Allis CD. The language of covalent histone modifications. Nature 2000; 403: 41-45.
5. Allam R, Kumar SV, Darisipudi MN, Anders HJ. Extracellular histones in tissue injury and inflammation. J Mol Med (Berl) 2014; 92: 465-472.
6. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F et al. Extracellular histones are major mediators of death in sepsis. Nat Med 2009; 15: 1318-1321.
7. Hou W, Zhang Q, Yan Z, Chen R, Zeh Iii HJ, Kang R et al. Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis 2013; 4: e966.
8. Tang D, Kang R, Coyne CB, Zeh HJ, Lotze MT. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev 2012; 249: 158-175.
9. Zhang Q, Kang R, Zeh 3rd HJ, Lotze MT, Tang D. DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy 2013; 9: 451-458.
10. Andrews AJ, Luger K. Nucleosome structure(s) and stability: variations on a theme. Annu Rev Biophys 2011; 40: 99-117.
11. Jiang C, Pugh BF. Nucleosome positioning and gene regulation: advances through genomics. Nat Rev Genet 2009; 10: 161-172.
12. Latham JA, Dent SY. Cross-regulation of histone modifications. Nat Struct Mol Biol 2007; 14: 1017-1024.
13. Bird A. Perceptions of epigenetics. Nature 2007; 447: 396-398.
14. Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Mol Cell 2009; 33: 1-13.
15. Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010; 28: 1057-1068.
16. Watson K, Edwards RJ, Shaunak S, Parmelee DC, Sarraf C, Gooderham NJ et al. Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells. Biochem Pharmacol 1995; 50: 299-309.
17. Gabler C, Blank N, Hieronymus T, Schiller M, Berden JH, Kalden JR et al. Extranuclear detection of histones and nucleosomes in activated human lymphoblasts as an early event in apoptosis. Ann Rheum Dis 2004; 63: 1135-1144.
18. Hefeneider SH, Cornell KA, Brown LE, Bakke AC, McCoy SL, Bennett RM. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin Immunol Immunopathol 1992; 63: 245-251.
19. Brix K, Summa W, Lottspeich F, Herzog V. Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages. J Clin Invest 1998; 102: 283-293.
20. Bolton SJ, Perry VH. Histone H1; a neuronal protein that binds bacterial lipopolysaccharide. J Neurocytol 1997; 26: 823-831.
21. Mishra B, von der Ohe M, Schulze C, Bian S, Makhina T, Loers G et al. Functional role of the interaction between polysialic acid and extracellular histone H1. J Neurosci 2010; 30: 12400-12413.
22. Klein B, Lutz-Meindl U, Kerschbaum HH. From the nucleus to the plasma membrane: translocation of the nuclear proteins histone H3 and lamin B1 in apoptotic microglia. Apoptosis 2014; 19: 759-775.
23. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532-1535.
24. von Kockritz-Blickwede M, Goldmann O, Thulin P, Heinemann K, Norrby-Teglund A, Rohde M et al. Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood 2008; 111: 3070-3080.
25. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001; 61: 1659-1665.
26. Allam R, Darisipudi MN, Tschopp J, Anders HJ. Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur J Immunol 2013; 43: 3336-3342.
27. Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology 2011; 54: 999-1008.
28. Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J et al. Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice. Gastroenterology 2014; 146: 1097-1107.
29. Wen Z, Liu Y, Li F, Ren F, Chen D, Li X et al. Circulating histones exacerbate inflammation in mice with acute liver failure. J Cell Biochem 2013; 114: 2384-2391.
30. Xu J, Zhang X, Monestier M, Esmon NL, Esmon CT. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol 2011; 187: 2626-2631.
31. De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD. Extracellular chromatin is an important mediator of ischemic stroke in mice. Arterioscler Thromb Vasc Biol 2012; 32: 1884-1891.
32. Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood 2011; 118: 1952-1961.
33. Pemberton AD, Brown JK. In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. PLoS One 2010; 5: e9884.
34. Henriquez JP, Casar JC, Fuentealba L, Carey DJ, Brandan E. Extracellular matrix histone H1 binds to perlecan, is present in regenerating skeletal muscle and stimulates myoblast proliferation. J Cell Sci 2002; 115(Pt 10): 2041-2051.
35. Hampton RY, Golenbock DT, Raetz CR. Lipid A binding sites in membranes of macrophage tumor cells. J Biol Chem 1988; 263: 14802-14807.
36. Duce JA, Smith DP, Blake RE, Crouch PJ, Li QX, Masters CL et al. Linker histone H1 binds to disease associated amyloid-like fibrils. J Mol Biol 2006; 361: 493-505.
37. Currie JR, Chen-Hwang MC, Denman R, Smedman M, Potempska A, Ramakrishna N et al. Reduction of histone cytotoxicity by the Alzheimer beta-amyloid peptide precursor. Biochim Biophys Acta 1997; 1355: 248-258.
38. Urbonaviciute V, Furnrohr BG, Meister S, Munoz L, Heyder P, De Marchis F et al. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med 2008; 205: 3007-3018.
39. Wu D, Ingram A, Lahti JH, Mazza B, Grenet J, Kapoor A et al. Apoptotic release of histones from nucleosomes. J Biol Chem 2002; 277: 12001-12008.
40. Barrero CA, Perez-Leal O, Aksoy M, Moncada C, Ji R, Lopez Y et al. Histone 3.3 participates in a self-sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 188: 673-683.
41. Gilthorpe JD, Oozeer F, Nash J, Calvo M, Bennett DL, Lumsden A et al. Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia. F1000 Res 2013; 2: 148.
42. Shin SH, Joo HW, Kim MK, Kim JC, Sung YK. Extracellular histones inhibit hair shaft elongation in cultured human hair follicles and promote regression of hair follicles in mice. Exp Dermatol 2012; 21: 956-958.
43. Hirsch JG. Bactericidal action of histone. J Exp Med 1958; 108: 925-944.
44. Marti-Carvajal AJ, Sola I, Lathyris D, Cardona AF. Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev 2012; 3: CD004388.
45. Li Y, Liu Z, Liu B, Zhao T, Chong W, Wang Y et al. Citrullinated histone H3: A novel target for the treatment of sepsis. Surgery 2014; 156: 229-234.
46. Li Y, Liu B, Fukudome EY, Lu J, Chong W, Jin G et al. Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock. Surgery 2011; 150: 442-451.
47. Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med 2013; 187: 160-169.
48. Allam R, Scherbaum CR, Darisipudi MN, Mulay SR, Hagele H, Lichtnekert J et al. Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4. J Am Soc Nephrol 2012; 23: 1375-1388.
49. Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV et al. Extracellular histones are essential effectors of C5aR-and C5L2-mediated tissue damage and inflammation in acute lung injury. Faseb J 2013; 27: 5010-5021.
50. Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J Immunol 2013; 191: 2665-2679.
51. Huang H, Nace GW, McDonald KA, Tai S, Klune JR, Rosborough BR et al. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular HMGB1 in cellular protection. Hepatology 2014; 59: 1984-1997.
52. Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T et al. Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment. Lab Invest 2014; 94: 569-585.
53. Carestia A, Rivadeneyra L, Romaniuk MA, Fondevila C, Negrotto S, Schattner M. Functional responses and molecular mechanisms involved in histone-mediated platelet activation. Thromb Haemost 2013; 110: 1035-1045.
54. Fuchs TA, Bhandari AA, Wagner DD. Histones induce rapid and profound thrombocytopenia in mice. Blood 2011; 118: 3708-3714.
55. Wildhagen KC, Garcia de Frutos P, Reutelingsperger CP, Schrijver R, Areste C, Ortega-Gomez A et al. Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood 2014; 123: 1098-1101.
56. Ammollo CT, Semeraro F, Xu J, Esmon NL, Esmon CT. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost 2011; 9: 1795-1803.
57. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers Jr. DD et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA 2010; 107: 15880-15885.
58. Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut RE. Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res 2013; 132: 69-76.
59. Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF et al. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost 2012; 10: 136-144.
60. Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B et al. Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. PLoS One 2013; 8: e75961.
61. Monach PA, Hueber W, Kessler B, Tomooka BH, BenBarak M, Simmons BP et al. A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proc Natl Acad Sci USA 2009; 106: 15867-15872.
62. Hakkim A, Furnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci USA 2010; 107: 9813-9818.
63. Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 2009; 15: 623-625.
64. Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD. Neutrophils release extracellular DNA traps during storage of red blood cell units. Transfusion 2013; 53: 3210-3216.
65. Dwivedi N, Radic M. Citrullination of autoantigens implicates NETosis in the induction of autoimmunity. Ann Rheum Dis 2014; 73: 483-491.
66. Mortensen ES, Rekvig OP. Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes. J Am Soc Nephrol 2009; 20: 696-704.
67. Sadri-Vakili G, Cha JH. Mechanisms of disease: Histone modifications in Huntington's disease. Nat Clin Pract Neurol 2006; 2: 330-338.
68. Kazantsev AG, Thompson LM. Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 2008; 7: 854-868.
69. Holdenrieder S, Stieber P, Bodenmuller H, Busch M, Fertig G, Furst H et al. Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer 2001; 95: 114-120.
70. Zeerleder S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld AB, Caliezi C et al. Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med 2003; 31: 1947-1951.
71. Holdenrieder S, Eichhorn P, Beuers U, Samtleben W, Schoenermarck U, Zachoval R et al. Nucleosomal DNA fragments in autoimmune diseases. Ann NY Acad Sci 2006; 1075: 318-327.
72. Schmiedeke TM, Stockl FW, Weber R, Sugisaki Y, Batsford SR, Vogt A. Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J Exp Med 1989; 169: 1879-1894.
73. Geiger S, Holdenrieder S, Stieber P, Hamann GF, Bruening R, Ma J et al. Nucleosomes as a new prognostic marker in early cerebral stroke. J Neurol 2007; 254: 617-623.
74. Johansson PI, Windelov NA, Rasmussen LS, Sorensen AM, Ostrowski SR. Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma. J Emerg Trauma Shock 2013; 6: 171-175.
75. Holdenrieder S, Stieber P, Forg T, Kuhl M, Schulz L, Busch M et al. Apoptosis in serum of patients with solid tumours. Anticancer Res 1999; 19: 2721-2724.
76. Kuroi K, Tanaka C, Toi M. Plasma nucleosome levels in node-negative breast cancer patients. Breast Cancer 1999; 6: 361-364.
77. Holdenrieder S, Stieber P, von Pawel J, Raith H, Nagel D, Feldmann K et al. Circulating nucleosomes predict the response to chemotherapy in patients with advanced non-small cell lung cancer. Clin Cancer Res 2004; 10(18 Pt 1): 5981-5987.
78. Geiger S, Holdenrieder S, Stieber P, Hamann GF, Bruening R, Ma J et al. Nucleosomes in serum of patients with early cerebral stroke. Cerebrovasc Dis 2006; 21: 32-37.
79. Fahmueller YN, Nagel D, Hoffmann RT, Tatsch K, Jakobs T, Stieber P et al. Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy. BMC Cancer 2012; 12: 5.
80. Holdenrieder S, Nagel D, Schalhorn A, Heinemann V, Wilkowski R, von Pawel J et al. Clinical relevance of circulating nucleosomes in cancer. Ann NY Acad Sci 2008; 1137: 180-189.
81. Holdenrieder S, Mueller S, Stieber P. Stability of nucleosomal DNA fragments in serum. Clin Chem 2005; 51: 1026-1029.
82. Holdenrieder S, Stieber P, Bodenmuller H, Busch M, Von Pawel J, Schalhorn A et al. Circulating nucleosomes in serum. Ann NY Acad Sci 2001; 945: 93-102.
83. Kremer A, Wilkowski R, Holdenrieder S, Nagel D, Stieber P, Seidel D. Nucleosomes in pancreatic cancer patients during radiochemotherapy. Tumour Biol 2005; 26: 44-49.
84. Mueller S, Holdenrieder S, Stieber P, Haferlach T, Schalhorn A, Braess J et al. Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments. BMC Cancer 2006; 6: 143.