NF-κB pathway activators as potential ageing biomarkers: Targets for new therapeutic strategies

Immunity and Ageing

Volumn 10, Issue 1, 2013, Pages

  Balistreri, Carmela R ^a   Candore, Giuseppina ^a   Accardi, Giulia ^a   Colonna Romano, Giuseppina ^a   Lio, Domenico ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Biological ageing process; Inflammatory biomarkers; Inflammatory network and its effects in ageing; NF B signaling pathway as hub of inflammatory ageing network

Indexed keywords

C REACTIVE PROTEIN; CHAPERONIN 60; CHEMOKINE; DEFENSIN; GROWTH FACTOR; HEAT SHOCK PROTEIN 70; HIGH MOBILITY GROUP B1 PROTEIN; I KAPPA B ALPHA; I KAPPA B BETA; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; METALLOPROTEINASE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN P52; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; THIOREDOXIN; THIOREDOXIN INTERACTING PROTEIN; TOLL LIKE RECEPTOR 1; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

AGING; ASTROCYTE; ATHEROSCLEROSIS; CELL CYCLE; CELL DEATH; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; ENDOTHELIUM CELL; EPITHELIUM CELL; GENOTYPE; HAIR COLOR; HUMAN; HYPERGLYCEMIA; INFLAMMATION; MOLECULAR MECHANICS; MUSCLE STRENGTH; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROADIPOCYTE; QUALITY OF LIFE; REVIEW; RISK FACTOR; SENESCENCE; SIGNAL TRANSDUCTION; VISION; WRINKLE;

EID: 84879120185     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/1742-4933-10-24     Document Type: Review

References (119)

1. Hayflick L. Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both. PLoS Genet 2007, 3:e220. 10.1371/journal.pgen.0030220, 2134939, 18085826.
2. Salminen A, Kaarniranta K. Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process. Ageing Res Rev 2010, 9:298-314. 10.1016/j.arr.2009.11.001, 19903538.
3. Kirkwood TB, Holliday R. The evolution of ageing and longevity. Proc R Soc Lond B Biol Sci 1979, 205:531-546. 10.1098/rspb.1979.0083, 42059.
4. Kirkwood TBL. A systematic look at an old problem. Nature 2008, 451:644-647. 10.1038/451644a, 18256658.
5. Bostock CV, Soiza RL, Whalley LJ. Genetic determinants of ageing processes and diseases in later life. Maturitas 2009, 62:225-229. 10.1016/j.maturitas.2008.12.012, 19203848.
6. Longo VD, Finch CE. Genetics of aging and disease. Arch Neurol 2002, 59:1706-1709. 10.1001/archneur.59.11.1706, 12433254.
7. Finch CE, Ruvkun G. The genetics of aging. Annu Rev Genomics Hum Genet 2001, 2:435-462. 10.1146/annurev.genom.2.1.435, 11701657.
8. McGue M, Vaupel JW, Holm N, Harvald B. Longevity is moderately heritable in a sample of Danish Twins born 1870-1880. J Geront Biol Sci 1993, 348:B237-B244.
9. Herskind AM, McGue M, Holm NV, Sorensen TI, Harvard B, Vaupel JW. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet 1996, 97:319-323. 10.1007/BF02185763, 8786073.
10. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639. 10.1038/nature02621, 3091392, 15295589.
11. Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 2001, 98:10505-10508. 10.1073/pnas.181337598, 56990, 11526246.
12. Capri M, Salvioli S, Sevini F, Valensin S, Celani L, Monti D, Pawelec G, De Benedictis G, Gonos ES, Franceschi C. The genetics of human longevity. Ann N Y Acad Sci 2006, 1067:252-263. 10.1196/annals.1354.033, 16803995.
13. Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med Genet 2007, 19:8.
14. de Magalhães JP, Curado J, Church GM. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 2009, 25:875-881. 10.1093/bioinformatics/btp073, 2732303, 19189975.
15. Troen BR. The biology of aging. Mt Sinai J Med. 2003, 70:3-22.
16. Sprott RL. Biomarkers of aging and disease: introduction and definitions. Exp Gerontol 2010, 45:2-4. 10.1016/j.exger.2009.07.008, 19651201.
17. Crimmins E, Vasunilashorn S, Kim JK, Alley D. Biomarkers related to aging in human populations. Adv Clin Chem 2008, 46:161-216.
18. Simm A, Johnson TE. Biomarkers of ageing: A challenge for the future. Exp Gerontol 2010, 45:731-732. 10.1016/j.exger.2010.08.006, 20727403.
19. Euser SM, van Bemmel T, Schram MT, Gussekloo J, Hofman A, Westendorp RG, Breteler MM. The effect of age on the association between blood pressure and cognitive function later in life. J Am Geriatr Soc 2009, 57:1232-1237. 10.1111/j.1532-5415.2009.02264.x, 19453303.
20. van Bemmel T, Vinkers DJ, Macfarlane PW, Gussekloo J, Westendorp RG. Markers of autonomic tone on a standard ECG are predictive of mortality in old age. Int J Cardiol 2006, 107:36-41. 10.1016/j.ijcard.2005.02.031, 16337495.
21. Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, Von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann Neurol 2006, 60:174-180. 10.1002/ana.20869, 16685698.
22. Rodríguez RM, López-Vázquez A, López-Larrea C. Immune systems evolution. Adv Exp Med Biol 2012, 739:237-251. 10.1007/978-1-4614-1704-0_15, 22399406.
23. Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol 2010, 28:321-342. 10.1146/annurev-immunol-030409-101311, 20307211.
24. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, Listi F, Nuzzo D, Lio D, Caruso C. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007, 128:83-91. 10.1016/j.mad.2006.11.015, 17118425.
25. Gilmore TD, Wolenski FS. NF-κB: where did it come from and why?. Immunol Rev 2012, 246:14-35. 10.1111/j.1600-065X.2012.01096.x, 22435545.
26. Newton K, Dixit VM. Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol 2012, 4:1-19.
27. Balistreri CR, Caruso C, Listì F, Colonna-Romano G, Lio D, Candore G. LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects. Mech Ageing Dev 2011, 132:86-92. 10.1016/j.mad.2010.12.005, 21238472.
28. Mitchell RN, Cotran RS. Acute and chronic inflammation, in Robbins Basic Pathology 2003, 30-56. Philadelphia, USA: Saunderrs.
29. Lio D, Caruso C. IL-10, genetic polymorphism and its relevance to age related diseases. Interleukin-10 2006, 93-106. Georgetown, TX, USA: Eureka.com, Marincola FM.
30. Candore G, Caruso C, Colonna-Romano G. Inflammation, genetic background and longevity. Biogerontology 2010, 11:565-573. 10.1007/s10522-010-9286-3, 20549353.
31. Franceschi C, Bonafe' M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000, 908:244-254.
32. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005, 2:8. 10.1186/1742-4933-2-8, 1166571, 15904534.
33. Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm 2010, 2010:1-19.
34. Balistreri CR, Colonna-Romano G, Lio D, Candore G, Caruso C. TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. J Clin Immunol 2009, 29:406-415. 10.1007/s10875-009-9297-5, 19459036.
35. Balistreri CR, Candore G, Accardi G, Bova M, Buffa S, Bulati M, Forte GI, Listì F, Martorana A, Palmeri M, Pellicanò M, Vaccarino L, Scola L, Lio D. Colonna-Romano G. Genetics of longevity. data from the studies on Sicilian centenarians. Immun Ageing. 2012, 9:8.
36. Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 2012, 24:835-845. 10.1016/j.cellsig.2011.12.006, 22182507.
37. Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 2013, 123:966-972. 10.1172/JCI64098, 23454759.
38. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev 2011, 25:2125-2136. 10.1101/gad.17276711, 3205583, 21979375.
39. Crescenzi E, Pacifico F, Lavorgna A, De Palma R, D'Aiuto E, Palumbo G, Formisano S, Leonardi A. NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells. Oncogene 2011, 30:2707-2717. 10.1038/onc.2011.1, 21278794.
40. Rovillain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema RH, Hummerich H, Jat PS. Activation of nuclear factor-kappa B signalling promotes cellular senescence. Oncogene 2011, 30:2356-2366. 10.1038/onc.2010.611, 3080811, 21242976.
41. Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: disturbed interplay between autophagy and inflammasomes 2012, 166-175. Albany NY: Aging, 4.
42. Campisi J, Andersen JK, Kapahi P, Melov S. Cellular senescence: a link between cancer and age-related degenerative disease?. Semin Cancer Biol 2011, 21:354-359. 3230665, 21925603.
43. Ishii T, Miyazawa M, Onouchi H, Yasuda K, Hartman PS, Ishii N. Model animals for the study of oxidative stress from complex II. Biochim Biophys Acta 1827, 2013:588-597.
44. Jacob KD, Hooten NN, Trzeciak AR, Evans MK. Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev 2013, 134:139-157. 10.1016/j.mad.2013.02.008, 23428415.
45. Dai DF, Rabinovitch PS, Ungvari Z. Mitochondria and cardiovascular aging. Circ Res 2012, 110:1109-1124. 10.1161/CIRCRESAHA.111.246140, 22499901.
46. Morán M, Moreno-Lastres D, Marín-Buera L, Arenas J, Martín MA, Ugalde C. Mitochondrial respiratory chain dysfunction: implications in neurodegeneration. Free Radic Biol Med 2012, 53:595-609. 10.1016/j.freeradbiomed.2012.05.009, 22595027.
47. Ma ZA, Zhao Z, Turk J. Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus. Exp Diabetes Res 2012, 2012:703538. 3216264, 22110477.
48. Weinberg F, Chandel NS. Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci 2009, 66:3663-3673. 10.1007/s00018-009-0099-y, 19629388.
49. Salminen A, Ojala J, Kaarniranta K, Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci 2012, 69:2999-3013. 10.1007/s00018-012-0962-0, 22446749.
50. Deretic V. Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr Opinion Immunol 2011, 24:1-11.
51. West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol 2011, 11:389-402. 10.1038/nri2975, 21597473.
52. Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol 2009, 27:229-265. 10.1146/annurev.immunol.021908.132715, 19302040.
53. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435. 10.1038/nature07201, 18650913.
54. Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225. 10.1038/nature09663, 21124315.
55. Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging. Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002, 269:1996-2002.
56. Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Science. 2011, 333:1109-1112.
57. Rubinsztein DC, Marino G, Kroemer G. Autophagy and aging Cell 2011, 146:682-695.
58. Cianfanelli V, Cecconi F. Autophagy-dependent NFκB regulation. Cell Cycle 2012, 11:436-437.
59. Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012, 149:274-293. 10.1016/j.cell.2012.03.017, 3331679, 22500797.
60. Olivieri F, Rippo MR, Prattichizzo F, Babini L, Graciotti L, Recchioni R, Procopio AD. Toll like receptor signaling in " inflammaging" : microRNA as new players. Immun Ageing 2013, 10:11. 10.1186/1742-4933-10-11, 3618188, 23506673.
61. Tomoiu A, Larbi A, Fortin C, Dupuis G, Fulop T. Do membrane rafts contribute to human immunosenescence?. Ann N Y Acad Sci 2007, 1100:98-110. 10.1196/annals.1395.008, 17460168.
62. Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity 2003, 18:655-664. 10.1016/S1074-7613(03)00092-X, 12753742.
63. Larbi A, Muti E, Giacconi R, Mocchegiani E, Fülöp T. Role of lipid rafts in activation-induced cell death: the fas pathway in aging. Adv Exp Med Biol 2006, 584:137-155. 10.1007/0-387-34132-3_11, 16802605.
64. Fessler MB, Parks JS. Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling. J Immunol 2011, 187:1529-1535. 10.4049/jimmunol.1100253, 3151145, 21810617.
65. Tewari R, Choudhury SR, Mehta VS, Sen E. TNFα regulates the localization of CD40 in lipid rafts of glioma cells. Mol Biol Rep 2012, 39:8695-8699. 10.1007/s11033-012-1726-5, 22699883.
66. Martins JO, Zanoni FL, Martins DO, Coimbra R, Krieger JE, Jancar S, Sannomiya P. Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor-kappaB activation in LPS-induced acute lung injury in rats. Shock 2009, 31:404-409. 10.1097/SHK.0b013e318186275e, 18791499.
67. Schumacher B, Garinis GA, Hoeijmakers JH. Age to survive: DNA damage and aging. Trends Genet 2008, 2:77-85.
68. Wu ZH, Miyamoto S. Many faces of NF-kappaB signaling induced by genotoxic stress. J Mol Med (Berl) 2007, 85:1187-1202.
69. Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?. Biochem Biophys Res Commun 2008, 367:715-718. 10.1016/j.bbrc.2007.11.189, 18201555.
70. Beneke S. Poly(ADP-ribose) polymerase activity in different pathologies-the link to inflammation and infarction. Exp Gerontol 2008, 43:605-614. 10.1016/j.exger.2008.04.008, 18511226.
71. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120:513-522. 10.1016/j.cell.2005.02.003, 15734683.
72. Balistreri CR, Pisano C, Merlo D, Fattouch K, Caruso M, Incalcaterra E, Colonna-Romano G, Candore G. Is the mean blood leukocyte telomere length a predictor for sporadic thoracic aortic aneurysm?. Data from a preliminary study Rejuvenation Res 2012, 1:170-173.
73. Lemke G, Rothlin CV. Immunobiology of the TAM receptors Nat Rev Immunol 2008, 8:327-336.
74. Ridker PM. The JUPITER trial: results, controversies, and implications for prevention. Circ Cardiovasc Qual Outcomes 2009, 2:279-285. 10.1161/CIRCOUTCOMES.109.868299, 20031849.
75. Speakman JR, Mitchell SE. Caloric restriction. Mol Aspects Med 2011, 32:159-221. 10.1016/j.mam.2011.07.001, 21840335.
76. Ash CE, Merry BJ. The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation. Mech Ageing Dev 2011, 132:43-54. 10.1016/j.mad.2010.12.001, 21172374.
77. Nisoli E, Tonetto C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317. 10.1126/science.1117728, 16224023.
78. Sauve AA, Youn DY. Sirtuins: NAD(+)-dependent deacetylase mechanism and regulation. Curr Opin Chem Biol 2012, 16:535-543. 10.1016/j.cbpa.2012.10.003, 23102634.
79. Guarente L. Sirtuins and calorie restriction. Nat Rev Mol Cell Biol 2012, 13:207.
80. Geng YQ, Li TT, Liu XY, Li ZH, Fu YC. SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction. J Cell Biochem 2011, 112:3755-3761. 10.1002/jcb.23315, 21826711.
81. Huang W, Shang WL, Wang HD, Wu WW, Hou SX. Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway. Acta Pharmacol Sin 2012, 33:668-674. 10.1038/aps.2011.189, 22447223.
82. Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Lee SY, Han MK, Kim DH, Kim W. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells. Biochem Biophys Res Commun 2012, 419:206-210. 10.1016/j.bbrc.2012.01.148, 22330808.
83. Anderson RM, Weindruch R. The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol 2012, 24:101-106. 10.1002/ajhb.22243, 22290875.
84. Kennedy BK, Steffen KK, Kaeberlein M. Ruminations on dietary restriction and aging. Cell Mol Life Sci 2007, 64:1323-1328. 10.1007/s00018-007-6470-y, 17396225.
85. Piper MD, Bartke A. Diet and aging. Cell Metab 2008, 8:99-104. 10.1016/j.cmet.2008.06.012, 18680711.
86. Roth GS, Ingram DK, Lane MA. Caloric restriction in primates and relevance to humans. Ann N Y Acad Sci 2001, 928:305-315.
87. Walford RL, Mock D, Verdery R, MacCallum T. Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J Gerontol A Biol Sci Med Sci 2002, 57:B211-B224. 10.1093/gerona/57.6.B211, 12023257.
88. Ribarič S. Diet and aging. Oxid Med Cell Longevity 2012, 2012:741468.
89. Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 2004, 101:6659-6663. 10.1073/pnas.0308291101, 404101, 15096581.
90. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab 2007, 293(1):E197-E202. 10.1152/ajpendo.00102.2007, 17389710, Washington University School of Medicine CALERIE Group.
91. Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol 2007, 42:709-712. 10.1016/j.exger.2007.03.009, 2020845, 17482403.
92. Rochon J, Bales CW, Ravussin E, Redman LM, Holloszy JO, Racette SB, Roberts SB, Das SK, Romashkan S, Galan KM, Hadley EC, Kraus WE, CALERIE Study Group Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. J Gerontol A Biol Sci Med Sci 2011, 66:97-108. 3032519, 20923909, CALERIE Study Group.
93. Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L. Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell 2012, 11:644-650. 10.1111/j.1474-9726.2012.00825.x, 22510429.
94. Madeo F, Tavernarakis N, Kroemer G. Can autophagy promote longevity?. Nat Cell Biol 2010, 12:842-846. 10.1038/ncb0910-842, 20811357.
95. Berstein LM. Metformin in obesity, cancer and aging: addressing controversies 2012, 320-329. Albany NY: Aging, 4.
96. Van Meter M, Seluanov A, Gorbunova V. Forever young? Exploring the link between rapamycin, longevity and cancer. Cell Cycle 2012, 11:4296-4297. 10.4161/cc.22868, 3552905, 23152185.
97. Pallauf K, Rimbach G. Autophagy, polyphenols and healthy ageing. Ageing Res Rev 2012, 12:237-252.
98. Zhang C, Lin G, Wan W, Li X, Zeng B, Yang B, Huang C. Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway. Int J Mol Med 2012, 29:557-563. 3573765, 22246136.
99. Relja B, Töttel E, Breig L, Henrich D, Schneider H, Marzi I, Lehnert M. Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats. Eur J Nutr 2012, 51:311-321. 10.1007/s00394-011-0216-1, 21698494.
100. Calabrese E, Iavicoli I, Calabrese V. Hormesis: its impact on medicine and health. Hum Exp Toxicol 2012, 13:215-235.
101. Chirumbolo S. Possible role of NF-κB in hormesis during ageing. Biogerontology 2012, 13:637-646. 10.1007/s10522-012-9402-7, 23053821.
102. Salvioli S, Sikora E, Cooper EL, Franceschi C. Curcumin in cell death processes: a challenge for CAM of age-related pathologies. Evid Based Complement Alternat Med. 2007, 4:181-190. 10.1093/ecam/nem043, 1876609, 17549234.
103. Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K. The promise of slow down ageing may come from curcumin. Curr Pharm Des 2010, 16:884-892. 10.2174/138161210790883507, 20388102.
104. Mosieniak G, Adamowicz M, Alster O, Jaskowiak H, Szczepankiewicz AA, Wilczynski GM, Ciechomska IA, Sikora E. Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy. Mech Ageing Dev 2012, 133:444-455. 10.1016/j.mad.2012.05.004, 22613224.
105. Quitschke WW. Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation. PLoS One 2012, 7:e39568. 10.1371/journal.pone.0039568, 3383725, 22768090.
106. Ali RE, Rattan SI. Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. Ann N Y Acad Sci 2006, 1067:394-399. 10.1196/annals.1354.056, 16804017.
107. Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2013, 68:6-16. 10.1093/gerona/gls070, 22451473.
108. Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, Fleshner M, Green C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A, Simon P. Position statement. Part one: immune function and exercise. Exerc Immunol Rev 2011, 17:6-63.
109. Kay SJ, Fiatarone Singh MA. The influence of physical activity on abdominal fat: a systematic review of the literature. Obes Rev 2006, 7:183-200. 10.1111/j.1467-789X.2006.00250.x, 16629874.
110. Brandt C, Pedersen BK. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol 2010, 2010:520258. Epub 2010 Mar 9, 2836182, 20224659.
111. Ambarish V, Chandrashekara S, Suresh KP. Moderate regular exercises reduce inflammatory response for physical stress. Indian J Physiol Pharmacol 2012, 56:7-14.
112. Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listi' F, Scola L, Vasto S, Caruso C. Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuvenation Res 2008, 11:425-432. 10.1089/rej.2008.0662, 18442326.
113. Balistreri CR, Accardi G, Candore G. Probiotics and prebiotics: health promotion by immune modulation in the elderly. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases 2013, 257-269. San Diego: Academic Press, Watson RR, Preedy VR.
114. Liu L, Rando TA. Manifestations and mechanisms of stem cell aging. J Cell Biol 2011, 193:257-266. 10.1083/jcb.201010131, 3080271, 21502357.
115. Rando TA, Chang HY. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 2012, 148:46-57. 10.1016/j.cell.2012.01.003, 3336960, 22265401.
116. Tacutu R, Budovsky A, Yanai H, Fraifeld VE. Molecular links between cellular senescence, longevity and age-related diseases-a systems biology perspective. Aging (Albany NY) 2011, 3:1178-1191.
117. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676. 10.1016/j.cell.2006.07.024, 16904174.
118. Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R, Shiraishi H, Arai T, Nakamura KN. Changes of telomere length with aging. Geriatr Gerontol Int 2010, 10(Suppl. 1):S197-S206.
119. Balistreri CR, Accardi G, Buffa S, Bulati M, Bova M, Candore G, Colonna-Romano G, Lio D, Martorana A, Caruso C. Centenarian Offspring: a model for Understanding Longevity. Curr Vasc Pharm 2012, in press.