Adapting proteostasis for disease intervention

Science

Volumn 319, Issue 5865, 2008, Pages 916-919

  Balch, William E ^a   Morimoto, Richard I ^b   Dillin, Andrew ^c   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOME;

CYTOLOGY; DISEASE TREATMENT; EUKARYOTE; HOMEOSTASIS; PROTEIN; PROTEOMICS;

AGING; CARDIOVASCULAR DISEASE; DEGENERATIVE DISEASE; HOMEOSTASIS; METABOLIC DISORDER; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW;

AGING; ANIMALS; CELL LINE; CELL PHYSIOLOGY; DRUG THERAPY; HOMEOSTASIS; HUMANS; INFECTION; METABOLIC DISEASES; METABOLIC NETWORKS AND PATHWAYS; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TRANSPORT; PROTEINS; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 39349083915     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1141448     Document Type: Review

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42. We thank D. Fowler, A. Murray, C. Fearns, L. Wiseman, and E. Powers for their critical comments on the manuscript, and E. Powers and J. Zhu for help with the figures. Discussions about proteostasis with S. Lindquist, U. Hartl, P. Walter, A. Horwich, J. Brodsky, and J. Frydman helped clarify our thinking. We appreciate support from NIH (DK46336, NS50636, DK75295, AG04342, AG 18917, GM38109, and AG026647); the Skaggs Institute of Chemical Biology; and the Lita Annenberg Hazen, Bundy, Ellison, and McKnight Foundations, whose collective support enabled the research that led to the ideas outlined here. J.K. is a founder of, holds equity in, and has a paid consulting relationship with FoldRx Pharmaceuticals, Inc., a biotechnology company that specializes in the discovery and development of drug therapies for diseases of protein misfolding and amyloidosis