Sir2 links chromatin silencing, metabolism, and aging

Genes and Development

Volumn 14, Issue 9, 2000, Pages 1021-1026

  Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CALORIC INTAKE; CHROMATIN; DNA DAMAGE; GENE EXPRESSION; GENE FUNCTION; GENE LOSS; GENE SILENCING; GENETIC CONSERVATION; GENETIC LINKAGE; METABOLIC RATE; METABOLISM; PRIORITY JOURNAL; REVIEW;

AGING; ANIMALS; CHROMATIN; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; METABOLISM; NAD; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TRANS-ACTIVATORS;

EID: 0034193776     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Bi, X. and J. Broach. 1997. DNA in transcriptionally silenced chromatin assumes a distinct topology that is sensitive to cell cycle progression. Mol. Cell Biol. 17: 7077-7087.
2. Boulton, S.J. and S.P. Jackson. 1998. Identification of a S. cerevisiae Ku80 homolog: Roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24: 4639-4648.
3. Brachmann, C.B., J.M. Sherman, S.E. Devine, E.E. Cameron, L. Pillus, and J.D. Boeke. 1995. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes & Dev. 9: 2888-2902.
4. Braunstein, M., A.B. Rose, S.G. Holmes, C.D. Allis, and J.R. Broach. 1993. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes & Dev. 7: 592-604.
5. Braunstein, M., R.E. Sobel, C.D. Allis, B.M. Turner, and J.R. Broach. 1996. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol. Cell. Biol 16: 4349-4356.
6. Bryk, M., M. Banerjee, M. Murphy, K.E. Knudsen, D.J. Garfinkel, and M.J. Curcio. 1997. Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes & Dev. 11: 255-269.
7. Finch, C. 1990. Longevity, senescence, and the genome. University of Chicago Press, Chicago, IL.
8. Frye, R.A. 1999. Characterization of five human cDNAs with homology to yeast SIR2 gene: Sir2-like proteins (Sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260: 273-279.
9. Gottlieb, S. and R.E. Esposito. 1989. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771-776.
10. Gottschling, D.E., O.M. Aparicio, B.L. Billington, and V.A. Zakian. 1990. Position effect at S. cerevisiae telomeres: Reversible repression of Pol 11 transcription. Cell 63: 751-762.
11. Harman, D. 1981. The aging process. Proc. Natl. Acad. Sci. 78: 7124-7128.
12. Hecht, A., T. Laroche, S. Strahl-Bolsinger, S.M. Gasser, and M. Grunstein. 1995. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast. Cell 80: 583-592.
13. Howard, B. 1996. Replicative senescence: Considerations relating to the stability of heterochromatin domains. Exp. Gerontol. 31: 281-293.
14. Imai, S.-I. and H. Kitano. 1998. Heterochromatin islands and their dynamic reorganization: A hypothesis for three distinctive features of cellular aging. Exp. Gerontol. 33: 555-570.
15. Imai, S., C. Armstrong, and L. Guarente. 2000. Silencing and aging protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
16. Kaeberlein, M., M. McVey, and L. Guarente. 1999. The SIR2/ 3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes & Dev. 13: 2570-2580.
17. Kennedy, B.K., N.R. Austriaco, J. Zhang, and L. Guarente. 1995. Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80: 485-496.
18. Kreimeyer, A., K. Wielckens, P. Adamietz, and H. Hilz. 1984. DNA repair-associated ADP-ribosylation in vivo: Modification of histone H1 differs from that of the principal acceptor proteins. J. Biol. Chem. 259: 890-896.
19. Lakowski, B. and S. Hekimi. 1998. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. 95: 13091-13096.
20. Lee, C.M., R. Weindruch, and J.M. Aiken. 1997. Age-associated alteration of the mitochondrial genome. Free Radic. Biol. Med. 22: 1259-1269.
21. Loo, S. and J. Rine. 1994. Silencers and domains of generalized repression. Science 264: 1768-1771.
22. Luger, K., A. Mader, R.K. Richmond, D. Sargent, and T.J. Richmond. 1997. Crystal structure of the nucleosome particle at 2.8 A resolution. Nature 389: 251-260.
23. Martin, S.G., T. Laroche, N. Suka, M. Grunstein, and S.M. Gasser. 1999. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97: 621-633.
24. Melov, S., J.M. Shoffner, A. Kaufman, and D.C. Wallace. 1995. Marked Increase in the Number and variety of mitchondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res. 23: 4122-4126.
25. Meyer, T. and H. Hilz. 1986. Production of anti-(ADP-ribose) antibodies with the aid of a dinucleotide-pyrophosphatase-resident hapten and their application for the detection of mono(ADP-ribosyl)ated polypeptides. Eur. J. Biochem. 155: 157-165.
26. Mills, K.D., D.A. Sinclair, and L. Guarente. 1999. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97: 609-620.
27. Mortimer, R.K. and J.R. Johnston. 1959. Life span of individual yeast cells. Nature 183: 1751-1752.
28. Muller, I., M. Zimmermann, D. Becker, and M. Flomer. 1980. Calendar life span versus budding life span of Saccharomyces cerevisiae. Mech. Aging Dev. 12: 47-52.
29. Ono, T and R.G. Cutler. 1978. Age-dependent relaxation of gene repression: Increrase of endogenous murine leukemia virus related and globin related RNA in brain and liver of mice. Proc. Natl. Acad. Sci. 75: 4431-4435
30. Pero, R.W., K. Holmgren, and L. Persson. 1985. Gamma-radiation induced ADP-ribosyltransferase activity and mammalian longevity. Mutat. Res. 142: 69-73.
31. Rine, J. and I. Herskowitz. 1987. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116: 9-22.
32. Roth, G.S. 1999. Calorie restriction in primates: Will it work and how will we know? J. Am. Geriatr. Soc. 47: 896-903.
33. Savitsky, K., A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D.A. Tagle, S. Smith, T. Uziel, S. Sfez et al. 1995. A single ataxia telangiextasia gene with a product similar to PI-3 kinase. Science 23: 1749-1753.
34. Sinclair, D.A. and L. Guarente. 1997. Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 91: 1-20.
35. Smith, J.S. and J.D. Boeke. 1997. An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes & Dev. 11: 241-254.
36. Tanny, J.C., G.J. Dowd, J. Huang, H. Hilz, and D. Moazed. 1999. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99: 735-745.
37. Thompson, J.S., X. Ling, and M. Grunstein. 1994. Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast. Nature 369: 245-247.
38. Tsang, A.W. and J.C. Escalante-Semerena. 1998. CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2. J. Biol. Chem. 273: 31788-31794.
39. Tsukamoto, Y., J. Kato, and H. Ikeda. 1997. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388: 900-903.
40. Vijg, J. 2000. Somatic mutations and aging: A re-evaluation. Mutat. Res. 447: 117-135.
41. Villeponteau, B. 1997. The heterochromatin loss model of aging. Exp. Gerontol. 32: 383-394.
42. Wakayama, T., A.C. Perry, M. Zuccotti, K.R. Johnson, and R. Yanagimachi. 1998. Full term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 394: 369-374.
43. Wakimoto, B.T. 1998. Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila. Cell 93: 321-324.
44. Weindruch, R.H., R.L. Walford, S. Fligiel, and D. Guthrie. 1986. The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity, and lifetime energy intake. J. Nutrit. 116: 641-654.
45. Wilmut, I., A.E. Schnieke, J. McWhir, A.J. Kind, and K.H.S. Campbell. 1997. Viable offspring derived from fetal and adult mammalian cells. Nature 385: 810-813.
46. Yu, C.E., J. Oshima, Y.H. Fu, E.M. Wijsman, F. Hisama, R. Alisch, S. Matthews, J. Nakura, T. Miki, S. Ouais et al. 1996. Positional cloning of the Wemer's Syndrome gene. Science 272: 258-262.