Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 23, 2006, Pages 8822-8827

  Agrelo, Ruben ^a   Cheng, Wen Hsing ^b   Setien, Fernando ^a   Ropero, Santiago ^a   Espada, Jesus ^a   Fraga, Mario F ^a   Herranz, Michel ^a   Paz, Maria F ^a   Sanchez Cespedes, Montserrat ^a   Artiga, Maria Jesus ^a   Guerrero, David ^c   Castells, Antoni ^d   Von Kobbe, Cayetano ^a   Bohr, Vilhelm A ^b   Esteller, Manel ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

DNA methylation

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; EXONUCLEASE; HELICASE; IRINOTECAN; RECQ HELICASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER INCIDENCE; CANCER INHIBITION; CARCINOGENESIS; CELL DENSITY; CHROMOSOMAL INSTABILITY; COLONY FORMATION; CPG ISLAND; DNA METHYLATION; DRUG HYPERSENSITIVITY; ENZYME ACTIVITY; EPIGENETICS; FEMALE; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; WERNER SYNDROME; WRN GENE;

AGING, PREMATURE; ANIMALS; CAMPTOTHECIN; CELL LINE, TUMOR; COLONIC NEOPLASMS; CPG ISLANDS; DNA HELICASES; DNA METHYLATION; DNA TOPOISOMERASES, TYPE I; EPIGENESIS, GENETIC; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MICE, NUDE; PROMOTER REGIONS (GENETICS); RECQ HELICASES; RNA, MESSENGER; WERNER SYNDROME;

MUS MUSCULUS;

EID: 33745056414     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600645103     Document Type: Article

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