Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury

Journal of Immunology

Volumn 187, Issue 5, 2011, Pages 2626-2631

  Xu, Jun ^a   Zhang, Xiaomei ^b   Monestier, Marc ^c   Esmon, Naomi L ^a   Esmon, Charles T ^a,b,d  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CONCANAVALIN A; HISTONE; PARACETAMOL; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CHEMICALLY INDUCED DISORDER; CONTROLLED STUDY; EXTRACELLULAR SPACE; FATALITY; HEPATITIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNITY; LIVER CELL DAMAGE; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; HISTONES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 80051882006     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003930     Document Type: Article

References (27)

1. Opal, S. M., and C. T. Esmon. 2003. Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis. Crit. Care 7: 23-38. (Pubitemid 36204267)
2. Borgel, D., C. Bornstain, P. H. Reitsma, N. Lerolle, S. Gandrille, F. Dali-Ali, C. T. Esmon, J. Y. Fagon, M. Aiach, and J. L. Diehl. 2007. A comparative study of the protein C pathway in septic and nonseptic patients with organ failure. Am. J. Respir. Crit. Care Med. 176: 878-885. (Pubitemid 350097077)
3. Zeerleder, S., B. Zwart, W. A. Wuillemin, L. A. Aarden, A. B. Groeneveld, C. Caliezi, A. E. Van Nieuwenhuijze, G. J. Van Mierlo, A. J. Eerenberg, B. Lämmle, and C. E. Hack. 2003. Elevated nucleosome levels in systemic inflammation and sepsis. Crit. Care Med. 31: 1947-1951. (Pubitemid 36900748)
4. Brinkmann, V., U. Reichard, C. Goosmann, B. Fauler, Y. Uhlemann, D. S. Weiss, Y. Weinrauch, and A. Zychlinsky. 2004. Neutrophil extracellular traps kill bacteria. Science 303: 1532-1535. (Pubitemid 38314426)
5. Fuchs, T. A., A. Brill, D. Duerschmied, D. Schatzberg, M. Monestier, D. D. Myers, Jr., S. K. Wrobleski, T. W. Wakefield, J. H. Hartwig, and D. D. Wagner. 2010. Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. USA 107: 15880-15885.
6. Massberg, S., L. Grahl, M. L. Von Bruehl, D. Manukyan, S. Pfeiler, C. Goosmann, V. Brinkmann, M. Lorenz, K. Bidzhekov, A. B. Khandagale, et al. 2010. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat. Med. 16: 887-896.
7. Zeerleder, S., B. Zwart, H. te Velthuis, R. Manoe, I. Bulder, I. Rensink, and L. A. Aarden. 2007. A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells. FEBS Lett. 581: 5382-5388. (Pubitemid 350110435)
8. Xu, J., X. M. Zhang, R. Pelayo, M. Monestier, C. T. Ammollo, F. Semeraro, F. B. Taylor, N. L. Esmon, F. Lupu, and C. T. Esmon. 2009. Extracellular histones are major mediators of death in sepsis. Nat. Med. 15: 1318-1321.
9. Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90: 196-203.
10. Wang, Y., S. K. Subudhi, R. A. Anders, J. Lo, Y. Sun, S. Blink, Y. Wang, J. Wang, X. Liu, K. Mink, et al. 2005. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J. Clin. Invest. 115: 711-717. (Pubitemid 40322246)
11. Imaeda, A. B., A. Watanabe, M. A. Sohail, S. Mahmood, M. Mohamadnejad, F. S. Sutterwala, R. A. Flavell, and W. Z. Mehal. 2009. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J. Clin. Invest. 119: 305-314.
12. Martin-Murphy, B. V., M. P. Holt, and C. Ju. 2010. The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol. Lett. 192: 387-394.
13. Yohe, H. C., K. A. O'Hara, J. A. Hunt, T. J. Kitzmiller, S. G. Wood, J. L. Bement, W. J. Bement, J. G. Szakacs, S. A. Wrighton, J. M. Jacobs, et al. 2006. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G1269-G1279. (Pubitemid 43788310)
14. Maher, J. J. 2009. DAMPs ramp up drug toxicity. J. Clin. Invest. 119: 246-249.
15. Tsujimoto, H., S. Ono, P. A. Efron, P. O. Scumpia, L. L. Moldawer, and H. Mochizuki. 2008. Role of Toll-like receptors in the development of sepsis. Shock 29: 315-321. (Pubitemid 351271701)
16. Midwood, K., S. Sacre, A. M. Piccinini, J. Inglis, A. Trebaul, E. Chan, S. Drexler, N. Sofat, M. Kashiwagi, G. Orend, et al. 2009. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat. Med. 15: 774-780.
17. Yu, M., H. Wang, A. Ding, D. T. Golenbock, E. Latz, C. J. Czura, M. J. Fenton, K. J. Tracey, and H. Yang. 2006. HMGB1 signals through Toll-like receptor (TLR) 4 and TLR2. Shock 26: 174-179. (Pubitemid 44162504)
18. Holdenrieder, S., and P. Stieber. 2009. Clinical use of circulating nucleosomes. Crit. Rev. Clin. Lab. Sci. 46: 1-24.
19. Kim, H. S., M. S. Han, K. W. Chung, S. Kim, E. Kim, M. J. Kim, E. Jang, H. A. Lee, J. Youn, S. Akira, and M. S. Lee. 2007. Toll-like receptor 2 senses b-cell death and contributes to the initiation of autoimmune diabetes. Immunity 27: 321-333. (Pubitemid 47284922)
20. Lartigue, A., N. Colliou, S. Calbo, A. François, S. Jacquot, C. Arnoult, F. Tron, D. Gilbert, and P. Musette. 2009. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J. Immunol. 183: 6207-6216.
21. Mullick, A. E., P. S. Tobias, and L. K. Curtiss. 2005. Modulation of atherosclerosis in mice by Toll-like receptor 2. J. Clin. Invest. 115: 3149-3156. (Pubitemid 41567579)
22. Shigeoka, A. A., T. D. Holscher, A. J. King, F. W. Hall, W. B. Kiosses, P. S. Tobias, N. Mackman, and D. B. McKay. 2007. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J. Immunol. 178: 6252-6258. (Pubitemid 46717408)
23. Hawksworth, J. S., A. Stojadinovic, F. A. Gage, D. K. Tadaki, P. W. Perdue, J. Forsberg, T. A. Davis, J. R. Dunne, J. W. Denobile, T. S. Brown, and E. A. Elster. 2009. Inflammatory biomarkers in combat wound healing. Ann. Surg. 250: 1002-1007.
24. McCarter, M. D., V. E. Mack, J. M. Daly, H. A. Naama, and S. E. Calvano. 1998. Trauma-induced alterations in macrophage function. Surgery 123: 96-101. (Pubitemid 28063665)
25. Lam, N. Y. L., T. H. Rainer, L. Y. S. Chan, G. M. Joynt, and Y. M. D. Lo. 2003. Time course of early and late changes in plasma DNA in trauma patients. Clin. Chem. 49: 1286-1291. (Pubitemid 36900614)
26. Lo, Y. M. D., T. H. Rainer, L. Y. S. Chan, N. M. Hjelm, and R. A. Cocks. 2000. Plasma DNA as a prognostic marker in trauma patients. Clin. Chem. 46: 319-323. (Pubitemid 30152256)
27. Zhang, Q., M. Raoof, Y. Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, and C. J. Hauser. 2010. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464: 104-107.