Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury

Journal of Immunology

Volumn 191, Issue 5, 2013, Pages 2665-2679

  Huang, Hai ^a   Chen, Hui Wei ^a   Evankovich, John ^a   Yan, Wei ^a   Rosborough, Brian R ^a   Nace, Gary W ^a   Ding, Qing ^a   Loughran, Patricia ^a,b   Beer Stolz, Donna ^b   Billiar, Timothy R ^a   Esmon, Charles T ^c,d   Tsung, Allan ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c Cardiovascular Biology Research Program   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; HISTONE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENE DELETION; IMMUNOCOMPETENT CELL; KUPFFER CELL; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; IMMUNITY, INNATE; INFLAMMASOMES; KUPFFER CELLS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84883367417     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202733     Document Type: Article

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