Sirt1 extends life span and delays aging in mice through the regulation of Nk2 Homeobox 1 in the DMH and LH

Cell Metabolism

Volumn 18, Issue 3, 2013, Pages 416-430

  Satoh, Akiko ^a   Brace, Cynthia S ^a   Rensing, Nick ^a   Cliften, Paul ^a   Wozniak, David F ^a   Herzog, Erik D ^a   Yamada, Kelvin A ^a   Imai, Shin Ichiro ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN 2 RECEPTOR; PROTEIN C FOS; SIRTUIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.1; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN NERVE CELL; CANCER MORTALITY; CONTROLLED STUDY; DEACETYLATION; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; FEMALE; GENE EXPRESSION; GENE PRODUCT; GENE SILENCING; LATERAL HYPOTHALAMUS; LIFESPAN; LIGHT DARK CYCLE; LONGEVITY; MALE; METABOLIC REGULATION; MOUSE; MUSCLE FUNCTION; MUSCLE MITOCHONDRION; NONHUMAN; OXYGEN CONSUMPTION; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SLEEP QUALITY; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE;

AGING; ANIMALS; BODY TEMPERATURE; FEMALE; HYPOTHALAMUS; LONGEVITY; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR ACTIVITY; MUSCLE, SKELETAL; NUCLEAR PROTEINS; OREXIN RECEPTORS; PHENOTYPE; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84883476818     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.07.013     Document Type: Article

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