Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

Human Molecular Genetics

Volumn 10, Issue 14, 2001, Pages 1511-1518

  Cummings, Christopher J ^a,e   Sun, Yaling ^a   Opal, Puneet ^a   Antalffy, Barbara ^a   Mestril, Ruben ^b   Orr, Harry T ^c   Dillmann, Wolfgang H ^d   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e AGY Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CELL PROTEIN; CHAPERONE; CYTOSINE; GLUTAMINE; GUANINE; HEAT SHOCK PROTEIN 70; POLYGLUTAMINE; PROTEASOME; UBIQUITIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; BRAIN STEM; CELL DEGENERATION; CELL NUCLEUS INCLUSION BODY; CLEARANCE; CONTROLLED STUDY; CROSS BREEDING; CYTOTOXICITY; DEGENERATIVE DISEASE; ENZYME SUBUNIT; FEMALE; GENETIC TRANSFECTION; HYPOTHESIS; INVERTEBRATE; MALE; MAMMAL; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; MUTATION; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PHENOTYPE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PURKINJE CELL; SPINOCEREBELLAR DEGENERATION; TRINUCLEOTIDE REPEAT;

ANIMALIA; ATAXIA; INVERTEBRATA; MAMMALIA;

EID: 0035394668     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.14.1511     Document Type: Article

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