-
1
-
-
0035997908
-
T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
-
Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM (2002) T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 3(6):549–557
-
(2002)
Nat Immunol
, vol.3
, Issue.6
, pp. 549-557
-
-
Afkarian, M.1
Sedy, J.R.2
Yang, J.3
Jacobson, N.G.4
Cereb, N.5
Yang, S.Y.6
Murphy, T.L.7
Murphy, K.M.8
-
2
-
-
0033667895
-
Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
-
Agarwal S, Avni O, Rao A (2000) Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12(6):643–652
-
(2000)
Immunity
, vol.12
, Issue.6
, pp. 643-652
-
-
Agarwal, S.1
Avni, O.2
Rao, A.3
-
3
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL (2003) Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278(3):1910–1914
-
(2003)
J Biol Chem
, vol.278
, Issue.3
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.H.3
De Sauvage, F.J.4
Gurney, A.L.5
-
4
-
-
68149125188
-
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
-
Ahyi AN, Chang HC, Dent AL, Nutt SL, Kaplan MH (2009) IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immun 183(3):1598–1606
-
(2009)
J Immun
, vol.183
, Issue.3
, pp. 1598-1606
-
-
Ahyi, A.N.1
Chang, H.C.2
Dent, A.L.3
Nutt, S.L.4
Kaplan, M.H.5
-
5
-
-
34447634411
-
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
-
Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27(1):89–99
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 89-99
-
-
Amsen, D.1
Antov, A.2
Jankovic, D.3
Sher, A.4
Radtke, F.5
Souabni, A.6
Busslinger, M.7
Mccright, B.8
Gridley, T.9
Flavell, R.A.10
-
6
-
-
0032711223
-
Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo
-
Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, Boothby MR (1999) Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immun 163(9):5116–5124
-
(1999)
J Immun
, vol.163
, Issue.9
, pp. 5116-5124
-
-
Aronica, M.A.1
Mora, A.L.2
Mitchell, D.B.3
Finn, P.W.4
Johnson, J.E.5
Sheller, J.R.6
Boothby, M.R.7
-
7
-
-
84883396890
-
Notch signaling regulates follicular helper T cell differentiation
-
Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, Favre S, Wilson A, Trottein F, Alexander J, Luther SA, MacDonald HR, Radtke F, Tacchini-Cottier F (2013) Notch signaling regulates follicular helper T cell differentiation. J Immun 191(5):2344–2350
-
(2013)
J Immun
, vol.191
, Issue.5
, pp. 2344-2350
-
-
Auderset, F.1
Schuster, S.2
Fasnacht, N.3
Coutaz, M.4
Charmoy, M.5
Koch, U.6
Favre, S.7
Wilson, A.8
Trottein, F.9
Alexander, J.10
Luther, S.A.11
Macdonald, H.R.12
Radtke, F.13
Tacchini-Cottier, F.14
-
8
-
-
84880729295
-
Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals
-
Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS (2013) Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity 39(1):148–159
-
(2013)
Immunity
, vol.39
, Issue.1
, pp. 148-159
-
-
Bailis, W.1
Yashiro-Ohtani, Y.2
Fang, T.C.3
Hatton, R.D.4
Weaver, C.T.5
Artis, D.6
Pear, W.S.7
-
9
-
-
84861423126
-
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
-
Ballesteros-Tato A, Leon B, Graf BA, Moquin A, Adams PS, Lund FE, Randall TD (2012) Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36(5):847–856
-
(2012)
Immunity
, vol.36
, Issue.5
, pp. 847-856
-
-
Ballesteros-Tato, A.1
Leon, B.2
Graf, B.A.3
Moquin, A.4
Adams, P.S.5
Lund, F.E.6
Randall, T.D.7
-
10
-
-
67650650890
-
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
-
Bending D, De la Pena H, Veldhoen M, Phillips JM, Uyttenhove C, Stockinger B, Cooke A (2009) Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 119(3):565–572
-
(2009)
J Clin Invest
, vol.119
, Issue.3
, pp. 565-572
-
-
Bending, D.1
De La Pena, H.2
Veldhoen, M.3
Phillips, J.M.4
Uyttenhove, C.5
Stockinger, B.6
Cooke, A.7
-
11
-
-
84861451140
-
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency
-
Bettini ML, Pan F, Bettini M, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM, Vignali DA (2012) Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity 36(5):717–730
-
(2012)
Immunity
, vol.36
, Issue.5
, pp. 717-730
-
-
Bettini, M.L.1
Pan, F.2
Bettini, M.3
Finkelstein, D.4
Rehg, J.E.5
Floess, S.6
Bell, B.D.7
Ziegler, S.F.8
Huehn, J.9
Pardoll, D.M.10
Vignali, D.A.11
-
12
-
-
73249136480
-
IRF4 and its regulators: Evolving insights into the pathogenesis of inflammatory arthritis?
-
Biswas PS, Bhagat G, Pernis AB (2010) IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev 233(1):79–96
-
(2010)
Immunol Rev
, vol.233
, Issue.1
, pp. 79-96
-
-
Biswas, P.S.1
Bhagat, G.2
Pernis, A.B.3
-
13
-
-
0037090336
-
The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells
-
Brogdon JL, Leitenberg D, Bottomly K (2002) The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol 168(8):3825–3832
-
(2002)
J Immunol
, vol.168
, Issue.8
, pp. 3825-3832
-
-
Brogdon, J.L.1
Leitenberg, D.2
Bottomly, K.3
-
14
-
-
0035162560
-
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27(1):68–73
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
Paeper, B.4
Clark, L.B.5
Yasayko, S.A.6
Wilkinson, J.E.7
Galas, D.8
Ziegler, S.F.9
Ramsdell, F.10
-
15
-
-
70449706325
-
Runx proteins regulate Foxp3 expression
-
Bruno L, Mazzarella L, Hoogenkamp M, Hertweck A, Cobb BS, Sauer S, Hadjur S, Leleu M, Naoe Y, Telfer JC, Bonifer C, Taniuchi I, Fisher AG, Merkenschlager M (2009) Runx proteins regulate Foxp3 expression. J Exp Med 206(11):2329–2337
-
(2009)
J Exp Med
, vol.206
, Issue.11
, pp. 2329-2337
-
-
Bruno, L.1
Mazzarella, L.2
Hoogenkamp, M.3
Hertweck, A.4
Cobb, B.S.5
Sauer, S.6
Hadjur, S.7
Leleu, M.8
Naoe, Y.9
Telfer, J.C.10
Bonifer, C.11
Taniuchi, I.12
Fisher, A.G.13
Merkenschlager, M.14
-
16
-
-
34548128307
-
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
-
Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M (2007) The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 8(9):958–966
-
(2007)
Nat Immunol
, vol.8
, Issue.9
, pp. 958-966
-
-
Brustle, A.1
Heink, S.2
Huber, M.3
Rosenplanter, C.4
Stadelmann, C.5
Yu, P.6
Arpaia, E.7
Mak, T.W.8
Kamradt, T.9
Lohoff, M.10
-
17
-
-
37849008688
-
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
-
Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA (2008) Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28(1):112–121
-
(2008)
Immunity
, vol.28
, Issue.1
, pp. 112-121
-
-
Burchill, M.A.1
Yang, J.2
Vang, K.B.3
Moon, J.J.4
Chu, H.H.5
Lio, C.W.6
Vegoe, A.L.7
Hsieh, C.S.8
Jenkins, M.K.9
Farrar, M.A.10
-
18
-
-
33845935950
-
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
-
Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA (2007) IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280–290
-
(2007)
J Immunol
, vol.178
, Issue.1
, pp. 280-290
-
-
Burchill, M.A.1
Yang, J.2
Vogtenhuber, C.3
Blazar, B.R.4
Farrar, M.A.5
-
19
-
-
77953413308
-
RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter
-
Burgler S, Mantel PY, Bassin C, Ouaked N, Akdis CA, Schmidt-Weber CB (2010) RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter. J Immunol 184(11):6161–6169
-
(2010)
J Immunol
, vol.184
, Issue.11
, pp. 6161-6169
-
-
Burgler, S.1
Mantel, P.Y.2
Bassin, C.3
Ouaked, N.4
Akdis, C.A.5
Schmidt-Weber, C.B.6
-
20
-
-
0034283962
-
Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
-
Cai G, Radzanowski T, Villegas EN, Kastelein R, Hunter CA (2000) Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii. J Immunol 165(5):2619–2627
-
(2000)
J Immunol
, vol.165
, Issue.5
, pp. 2619-2627
-
-
Cai, G.1
Radzanowski, T.2
Villegas, E.N.3
Kastelein, R.4
Hunter, C.A.5
-
21
-
-
77952584843
-
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
-
Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH (2010) The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol 11(6):527–534
-
(2010)
Nat Immunol
, vol.11
, Issue.6
, pp. 527-534
-
-
Chang, H.C.1
Sehra, S.2
Goswami, R.3
Yao, W.4
Yu, Q.5
Stritesky, G.L.6
Jabeen, R.7
Mckinley, C.8
Ahyi, A.N.9
Han, L.10
Nguyen, E.T.11
Robertson, M.J.12
Perumal, N.B.13
Tepper, R.S.14
Nutt, S.L.15
Kaplan, M.H.16
-
22
-
-
20444502955
-
PU.1 expression delineates heterogeneity in primary Th2 cells
-
Chang HC, Zhang S, Thieu VT, Slee RB, Bruns HA, Laribee RN, Klemsz MJ, Kaplan MH (2005) PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 22(6):693–703
-
(2005)
Immunity
, vol.22
, Issue.6
, pp. 693-703
-
-
Chang, H.C.1
Zhang, S.2
Thieu, V.T.3
Slee, R.B.4
Bruns, H.A.5
Laribee, R.N.6
Klemsz, M.J.7
Kaplan, M.H.8
-
23
-
-
34250762587
-
Dynamic changes in histone-methylation ‘marks’ across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells
-
Chang S, Aune TM (2007) Dynamic changes in histone-methylation ‘marks’ across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol 8(7):723–731
-
(2007)
Nat Immunol
, vol.8
, Issue.7
, pp. 723-731
-
-
Chang, S.1
Aune, T.M.2
-
24
-
-
58849088509
-
T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation
-
Chang S, Collins PL, Aune TM (2008) T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J Immun 181(12):8372–8381
-
(2008)
J Immun
, vol.181
, Issue.12
, pp. 8372-8381
-
-
Chang, S.1
Collins, P.L.2
Aune, T.M.3
-
25
-
-
70049113279
-
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
-
Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY (2009) CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326(5955):986–991
-
(2009)
Science
, vol.326
, Issue.5955
, pp. 986-991
-
-
Chaudhry, A.1
Rudra, D.2
Treuting, P.3
Samstein, R.M.4
Liang, Y.5
Kas, A.6
Rudensky, A.Y.7
-
26
-
-
79961146064
-
C-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation
-
Chen A, Lee SM, Gao B, Shannon S, Zhu Z, Fang D (2011a) c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation. Mol Cell Biol 31(16):3445–3456
-
(2011)
Mol Cell Biol31
, Issue.16
, pp. 3445-3456
-
-
Chen, A.1
Lee, S.M.2
Gao, B.3
Shannon, S.4
Zhu, Z.5
Fang, D.6
-
27
-
-
80555133361
-
The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis
-
Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S, Daley S, Shannon MF (2011b) The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol 187(9):4483–4491
-
(2011)
J Immunol
, vol.187
, Issue.9
, pp. 4483-4491
-
-
Chen, G.1
Hardy, K.2
Pagler, E.3
Ma, L.4
Lee, S.5
Gerondakis, S.6
Daley, S.7
Shannon, M.F.8
-
28
-
-
84875417243
-
Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation
-
Choi YS, Eto D, Yang JA, Lao C, Crotty S (2013) Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. J Immunol 190(7):3049–3053
-
(2013)
J Immunol
, vol.190
, Issue.7
, pp. 3049-3053
-
-
Choi, Y.S.1
Eto, D.2
Yang, J.A.3
Lao, C.4
Crotty, S.5
-
29
-
-
2942755979
-
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
-
Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, Rolph MS, Mackay CR (2004) T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 173(1):68–78
-
(2004)
J Immunol
, vol.173
, Issue.1
, pp. 68-78
-
-
Chtanova, T.1
Tangye, S.G.2
Newton, R.3
Frank, N.4
Hodge, M.R.5
Rolph, M.S.6
Mackay, C.R.7
-
30
-
-
79961158055
-
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
-
Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, Rawal S, Wang YH, Lim H, Reynolds JM, Zhou XH, Fan HM, Liu ZM, Neelapu SS, Dong C (2011) Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17(8):983–988
-
(2011)
Nat Med
, vol.17
, Issue.8
, pp. 983-988
-
-
Chung, Y.1
Tanaka, S.2
Chu, F.3
Nurieva, R.I.4
Martinez, G.J.5
Rawal, S.6
Wang, Y.H.7
Lim, H.8
Reynolds, J.M.9
Zhou, X.H.10
Fan, H.M.11
Liu, Z.M.12
Neelapu, S.S.13
Dong, C.14
-
31
-
-
84867581744
-
A validated regulatory network for Th17 cell specification
-
Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR (2012) A validated regulatory network for Th17 cell specification. Cell 151(2):289–303
-
(2012)
Cell
, vol.151
, Issue.2
, pp. 289-303
-
-
Ciofani, M.1
Madar, A.2
Galan, C.3
Sellars, M.4
Mace, K.5
Pauli, F.6
Agarwal, A.7
Huang, W.8
Parkurst, C.N.9
Muratet, M.10
Newberry, K.M.11
Meadows, S.12
Greenfield, A.13
Yang, Y.14
Jain, P.15
Kirigin, F.K.16
Birchmeier, C.17
Wagner, E.F.18
Murphy, K.M.19
Myers, R.M.20
Bonneau, R.21
Littman, D.R.22
more..
-
32
-
-
84865425772
-
Cutting edge: Influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells
-
Collier SP, Collins PL, Williams CL, Boothby MR, Aune TM (2012) Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol 189(5):2084–2088
-
(2012)
J Immunol
, vol.189
, Issue.5
, pp. 2084-2088
-
-
Collier, S.P.1
Collins, P.L.2
Williams, C.L.3
Boothby, M.R.4
Aune, T.M.5
-
33
-
-
0030963614
-
Induction of Th1 and Th2 CD4+ T cell responses: The alternative approaches
-
Constant SL, Bottomly K (1997) Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 15:297–322
-
(1997)
Annu Rev Immunol
, vol.15
, pp. 297-322
-
-
Constant, S.L.1
Bottomly, K.2
-
34
-
-
0041589416
-
T ell-intrinsic requirement for NF-kappa B induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response
-
Corn RA, Aronica MA, Zhang F, Tong Y, Stanley SA, Kim SR, Stephenson L, Enerson B, McCarthy S, Mora A, Boothby M (2003) T ell-intrinsic requirement for NF-kappa B induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response. J Immunol 171(4):1816–1824
-
(2003)
J Immunol
, vol.171
, Issue.4
, pp. 1816-1824
-
-
Corn Aronica, R.A.M.A.1
Zhang, F.2
Tong, Y.3
Stanley, S.A.S.R.L.4
Enerson, B.5
Mccarthy, S.6
Mora, A.7
Boothby, M.8
-
35
-
-
23444461535
-
Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation
-
Corn RA, Hunter C, Liou HC, Siebenlist U, Boothby MR (2005) Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J Immunol 175(4):2102–2110
-
(2005)
J Immunol
, vol.175
, pp. 2102-2110
-
-
Corn, R.A.1
Hunter, C.2
Liou, H.C.3
Siebenlist, U.4
Boothby, M.R.5
-
36
-
-
1642398043
-
Interleukin 2 plays a central role in Th2 differentiation
-
Cote-Sierra J, Foucras G, Guo L, Chiodetti L, Young HA, Hu-Li J, Zhu J, Paul WE (2004) Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci U.S.A 101(11):3880–3885
-
(2004)
Proc Natl Acad Sci U.S.A
, vol.101
, Issue.11
, pp. 3880-3885
-
-
Cote-Sierra, J.1
Foucras, G.2
Guo, L.3
Chiodetti, L.4
Young, H.A.5
Hu-Li, J.6
Zhu, J.7
Paul, W.E.8
-
37
-
-
79952675131
-
Follicular helper CD4 T cells (TFH)
-
Crotty S (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29:621–663
-
(2011)
Annu Rev Immunol
, vol.29
, pp. 621-663
-
-
Crotty, S.1
-
38
-
-
75649136214
-
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
-
Crotty S, Johnston RJ, Schoenberger SP (2010) Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol 11(2):114–120
-
(2010)
Nat Immunol
, vol.11
, Issue.2
, pp. 114-120
-
-
Crotty, S.1
Johnston, R.J.2
Schoenberger, S.P.3
-
39
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146(5):772–784
-
(2011)
Cell
, vol.146
, Issue.5
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
Luo, W.11
Zeller, K.12
Shimoda, L.13
Topalian, S.L.14
Semenza, G.L.15
Dang, C.V.16
Pardoll, D.M.17
Pan, F.18
-
40
-
-
0035222187
-
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
-
Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A (2001) A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2(1):45–50
-
(2001)
Nat Immunol
, vol.2
, Issue.1
, pp. 45-50
-
-
Das, J.1
Chen, C.H.2
Yang, L.3
Cohn, L.4
Ray, P.5
Ray, A.6
-
41
-
-
60549105041
-
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
-
Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M (2009) The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med 206(1):69–78
-
(2009)
J Exp Med
, vol.206
, Issue.1
, pp. 69-78
-
-
Dienz, O.1
Eaton, S.M.2
Bond, J.P.3
Neveu, W.4
Moquin, D.5
Noubade, R.6
Briso, E.M.7
Charland, C.8
Leonard, W.J.9
Ciliberto, G.10
Teuscher, C.11
Haynes, L.12
Rincon, M.13
-
42
-
-
33846489173
-
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
-
Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM (2007) Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8(2):145–153
-
(2007)
Nat Immunol
, vol.8
, Issue.2
, pp. 145-153
-
-
Djuretic, I.M.1
Levanon, D.2
Negreanu, V.3
Groner, Y.4
Rao, A.5
Ansel, K.M.6
-
43
-
-
67651154105
-
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
-
Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F (2009) Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 10(8):857–863
-
(2009)
Nat Immunol
, vol.10
, Issue.8
, pp. 857-863
-
-
Duhen, T.1
Geiger, R.2
Jarrossay, D.3
Lanzavecchia, A.4
Sallusto, F.5
-
44
-
-
77953293952
-
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
-
Durant L, Watford WT, Ramos HL, Laurence A, Vahedi G, Wei L, Takahashi H, Sun HW, Kanno Y, Powrie F, O’Shea JJ (2010) Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 32(5):605–615
-
(2010)
Immunity
, vol.32
, Issue.5
, pp. 605-615
-
-
Durant, L.1
Watford, W.T.2
Ramos, H.L.3
Laurence, A.4
Vahedi, G.5
Wei, L.6
Takahashi, H.7
Sun, H.W.8
Kanno, Y.9
Powrie, F.10
O’Shea, J.J.11
-
45
-
-
63849275584
-
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
-
Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O, Andris F (2009) Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113(11):2426–2433
-
(2009)
Blood
, vol.113
, Issue.11
, pp. 2426-2433
-
-
Eddahri, F.1
Denanglaire, S.2
Bureau, F.3
Spolski, R.4
Leonard, W.J.5
Leo, O.6
Ris, F.7
-
46
-
-
84859997488
-
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
-
Elyaman W, Bassil R, Bradshaw EM, Orent W, Lahoud Y, Zhu B, Radtke F, Yagita H, Khoury SJ (2012) Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity 36(4):623–634
-
(2012)
Immunity
, vol.36
, Issue.4
, pp. 623-634
-
-
Elyaman, W.1
Bassil, R.2
Bradshaw, E.M.3
Orent, W.4
Lahoud, Y.5
Zhu, B.6
Radtke, F.7
Yagita, H.8
Khoury, S.J.9
-
47
-
-
34447642439
-
Notch directly regulates Gata3 expression during T helper 2 cell differentiation
-
Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27(1):100–110
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 100-110
-
-
Fang, T.C.1
Yashiro-Ohtani, Y.2
Del Bianco, C.3
Knoblock, D.M.4
Blacklow, S.C.5
Pear, W.S.6
-
48
-
-
0034162535
-
Stat6 regulation of in vivo IL-4 responses
-
Finkelman FD, Morris SC, Orekhova T, Mori M, Donaldson D, Reiner SL, Reilly NL, Schopf L, Urban JF Jr (2000) Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303–2310
-
(2000)
J Immunol
, vol.164
, Issue.5
, pp. 2303-2310
-
-
Finkelman, F.D.1
Morris, S.C.2
Orekhova, T.3
Mori, M.4
Donaldson, D.5
Reiner, S.L.6
Reilly, N.L.7
Schopf, L.8
Urban, J.F.9
-
49
-
-
0037385330
-
Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 4(4):330–336
-
(2003)
Nat Immunol
, vol.4
, Issue.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
50
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY (2007) Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445(7129):771–775
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 771-775
-
-
Gavin, M.A.1
Rasmussen, J.P.2
Fontenot, J.D.3
Vasta, V.4
Manganiello, V.C.5
Beavo, J.A.6
Rudensky, A.Y.7
-
51
-
-
77958584113
-
Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling
-
Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O’Shea JJ (2010) Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 467(7318):967–971
-
(2010)
Nature
, vol.467
, Issue.7318
, pp. 967-971
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
Tato, C.M.4
Mcgeachy, M.J.5
Konkel, J.E.6
Ramos, H.L.7
Wei, L.8
Davidson, T.S.9
Bouladoux, N.10
Grainger, J.R.11
Chen, Q.12
Kanno, Y.13
Watford, W.T.14
Sun, H.W.15
Eberl, G.16
Shevach, E.M.17
Belkaid, Y.18
Cua, D.J.19
Chen, W.20
O’Shea, J.J.21
more..
-
52
-
-
84869116884
-
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes
-
Glasmacher E, Agrawal S, Chang AB, Murphy TL, Zeng W, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM, Singh H (2012) A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science 338(6109):975–980
-
(2012)
Science
, vol.338
, Issue.6109
, pp. 975-980
-
-
Glasmacher, E.1
Agrawal, S.2
Chang, A.B.3
Murphy, T.L.4
Zeng, W.5
Vander Lugt, B.6
Khan, A.A.7
Ciofani, M.8
Spooner, C.J.9
Rutz, S.10
Hackney, J.11
Nurieva, R.12
Escalante, C.R.13
Ouyang, W.14
Littman, D.R.15
Murphy, K.M.16
Singh, H.17
-
53
-
-
33846514266
-
T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity
-
Gocke AR, Cravens PD, Ben LH, Hussain RZ, Northrop SC, Racke MK, Lovett-Racke AE (2007) T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J Immunol 178(3):1341–1348
-
(2007)
J Immunol
, vol.178
, Issue.3
, pp. 1341-1348
-
-
Gocke, A.R.1
Cravens, P.D.2
Ben, L.H.3
Hussain, R.Z.4
Northrop, S.C.5
Racke, M.K.6
Lovett-Racke, A.E.7
-
54
-
-
84874025014
-
The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-gamma locus
-
Gomez JA, Wapinski OL, Yang YW, Bureau JF, Gopinath S, Monack DM, Chang HY, Brahic M, Kirkegaard K (2013) The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-gamma locus. Cell 152(4):743–754
-
(2013)
Cell
, vol.152
, Issue.4
, pp. 743-754
-
-
Gomez, J.A.1
Wapinski, O.L.2
Yang, Y.W.3
Bureau, J.F.4
Gopinath, S.5
Monack, D.M.6
Chang, H.Y.7
Brahic, M.8
Kirkegaard, K.9
-
55
-
-
70349743977
-
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase
-
Gomez-Rodriguez J, Sahu N, Handon R, Davidson TS, Anderson SM, Kirby MR, August A, Schwartzberg PL (2009) Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity 31(4):587–597
-
(2009)
Immunity
, vol.31
, Issue.4
, pp. 587-597
-
-
Gomez-Rodriguez, J.1
Sahu, N.2
Handon, R.3
Davidson, T.S.4
Erson, S.M.5
Kirby, M.R.6
August, A.7
Schwartzberg, P.L.8
-
56
-
-
84863010992
-
STAT6-dependent regulation of Th9 development
-
Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, Kaplan MH (2012) STAT6-dependent regulation of Th9 development. J Immunol 188(3):968–975
-
(2012)
J Immunol
, vol.188
, Issue.3
, pp. 968-975
-
-
Goswami, R.1
Jabeen, R.2
Yagi, R.3
Pham, D.4
Zhu, J.5
Goenka, S.6
Kaplan, M.H.7
-
57
-
-
84856567623
-
Expression of Helios in peripherally induced Foxp3+ regulatory T cells
-
Gottschalk RA, Corse E, Allison JP (2012) Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol 188(3):976–980
-
(2012)
J Immunol
, vol.188
, Issue.3
, pp. 976-980
-
-
Gottschalk, R.A.1
Corse, E.2
Allison, J.P.3
-
58
-
-
14244251950
-
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
-
Grenningloh R, Kang BY, Ho IC (2005) Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med 201(4):615–626
-
(2005)
J Exp Med
, vol.201
, Issue.4
, pp. 615-626
-
-
Grenningloh, R.1
Kang, B.Y.2
Ho, I.C.3
-
59
-
-
69449106110
-
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
-
Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U.S.A 106(32):13463–13468
-
(2009)
Proc Natl Acad Sci U.S.A
, vol.106
, Issue.32
, pp. 13463-13468
-
-
Guo, L.1
Wei, G.2
Zhu, J.3
Liao, W.4
Leonard, W.J.5
Zhao, K.6
Paul, W.7
-
60
-
-
77954395996
-
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
-
Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC (2010) Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 207(7):1381–1391
-
(2010)
J Exp Med
, vol.207
, Issue.7
, pp. 1381-1391
-
-
Harada, Y.1
Harada, Y.2
Elly, C.3
Ying, G.4
Paik, J.H.5
Depinho, R.A.6
Liu, Y.C.7
-
61
-
-
37749021324
-
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
-
Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG (2007) Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol 179(7):4313–4317
-
(2007)
J Immunol
, vol.179
, Issue.7
, pp. 4313-4317
-
-
Harris, T.J.1
Grosso, J.F.2
Yen, H.R.3
Xin, H.4
Kortylewski, M.5
Albesiano, E.6
Hipkiss, E.L.7
Getnet, D.8
Goldberg, M.V.9
Maris, C.H.10
Housseau, F.11
Yu, H.12
Pardoll, D.M.13
Drake, C.G.14
-
62
-
-
84856641109
-
NF-kappaB, the first quarter-century: Remarkable progress and outstanding questions
-
Hayden MS, Ghosh S (2012) NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 26(3):203–234
-
(2012)
Genes Dev
, vol.26
, Issue.3
, pp. 203-234
-
-
Hayden, M.S.1
Ghosh, S.2
-
63
-
-
74549179138
-
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
-
Hegazy AN, Peine M, Helmstetter C, Panse I, Frohlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Lohning M (2010) Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32(1):116–128
-
(2010)
Immunity
, vol.32
, Issue.1
, pp. 116-128
-
-
Hegazy, A.N.1
Peine, M.2
Helmstetter, C.3
Panse, I.4
Frohlich, A.5
Bergthaler, A.6
Flatz, L.7
Pinschewer, D.D.8
Radbruch, A.9
Lohning, M.10
-
64
-
-
84869882206
-
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORgammat binding to the Il17a promoter
-
Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, Muller M, Roth L, Katopodis A, Baier G (2012) Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORgammat binding to the Il17a promoter. J Autoimmun 39(4):428–440
-
(2012)
J Autoimmun
, vol.39
, Issue.4
, pp. 428-440
-
-
Hermann-Kleiter, N.1
Meisel, M.2
Fresser, F.3
Thuille, N.4
Muller, M.5
Roth, L.6
Katopodis, A.7
Baier, G.8
-
65
-
-
79951677394
-
Fate mapping of IL-17-producing T cells in inflammatory responses
-
Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ, Ahlfors H, Wilhelm C, Tolaini M, Menzel U, Garefalaki A, Potocnik AJ, Stockinger B (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12(3):255–263
-
(2011)
Nat Immunol
, vol.12
, Issue.3
, pp. 255-263
-
-
Hirota, K.1
Duarte, J.H.2
Veldhoen, M.3
Hornsby, E.4
Li, Y.5
Cua, D.J.6
Ahlfors, H.7
Wilhelm, C.8
Tolaini, M.9
Menzel, U.10
Garefalaki, A.11
Potocnik, A.J.12
Stockinger, B.13
-
66
-
-
84875473675
-
Plasticity of Th17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses
-
Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B (2013) Plasticity of Th17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 14(4):372–379
-
(2013)
Nat Immunol
, vol.14
, Issue.4
, pp. 372-379
-
-
Hirota, K.1
Turner, J.E.2
Villa, M.3
Duarte, J.H.4
Demengeot, J.5
Steinmetz, O.M.6
Stockinger, B.7
-
67
-
-
0042466572
-
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses
-
Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH (2003) Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J 22(16):4237–4248
-
(2003)
EMBO J
, vol.22
, Issue.16
, pp. 4237-4248
-
-
Hoey, T.1
Zhang, S.2
Schmidt, N.3
Yu, Q.4
Ramchandani, S.5
Xu, X.6
Naeger, L.K.7
Sun, Y.L.8
Kaplan, M.H.9
-
68
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299(5609):1057–1061
-
(2003)
Science
, vol.299
, Issue.5609
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
69
-
-
0026648380
-
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system
-
Hsieh CS, Heimberger AB, Gold JS, O’Garra A, Murphy KM (1992) Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci U.S.A 89(13):6065–6069
-
(1992)
Proc Natl Acad Sci U.S.A
, vol.89
, Issue.13
, pp. 6065-6069
-
-
Hsieh, C.S.1
Heimberger, A.B.2
Gold, J.S.3
O’Garra, A.4
Murphy, K.M.5
-
70
-
-
84886724189
-
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
-
Hu G, Tang Q, Sharma S, Yu F, Escobar TM, Muljo SA, Zhu J, Zhao K (2013) Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation. Nat Immunol 14(11):1190–1198
-
(2013)
Nat Immunol
, vol.14
, Issue.11
, pp. 1190-1198
-
-
Hu, G.1
Tang, Q.2
Sharma, S.3
Yu, F.4
Escobar, T.M.5
Muljo, S.A.6
Zhu, J.7
Zhao, K.8
-
71
-
-
0034665507
-
An intron transcriptional enhancer element regulates IL-4 gene locus accessibility in mast cells
-
Hural JA, Kwan M, Henkel G, Hock MB, Brown MA (2000) An intron transcriptional enhancer element regulates IL-4 gene locus accessibility in mast cells. J Immunol 165(6):3239–3249
-
(2000)
J Immunol
, vol.165
, Issue.6
, pp. 3239-3249
-
-
Hural, J.A.1
Kwan, M.2
Henkel, G.3
Hock, M.B.4
Brown, M.A.5
-
72
-
-
27744461314
-
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
-
Hwang ES, Hong JH, Glimcher LH (2005a) IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med 202(9):1289–1300
-
(2005)
J Exp Med
, vol.202
, Issue.9
, pp. 1289-1300
-
-
Hwang, E.S.1
Hong, J.H.2
Glimcher, L.H.3
-
73
-
-
12344269852
-
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
-
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH (2005b) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307(5708):430–433
-
(2005)
Science
, vol.307
, Issue.5708
, pp. 430-433
-
-
Hwang, E.S.1
Szabo, S.J.2
Schwartzberg, P.L.3
Glimcher, L.H.4
-
74
-
-
47749124186
-
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
-
Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T (2008) Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 283(25):17003–17008
-
(2008)
J Biol Chem
, vol.283
, Issue.25
, pp. 17003-17008
-
-
Ichiyama, K.1
Yoshida, H.2
Wakabayashi, Y.3
Chinen, T.4
Saeki, K.5
Nakaya, M.6
Takaesu, G.7
Hori, S.8
Yoshimura, A.9
Kobayashi, T.10
-
75
-
-
73949090725
-
C-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
-
,
-
Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S (2009) c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med 206(13):3001–3014
-
(2009)
J Exp Med
, vol.206
, Issue.13
, pp. 3001-3014
-
-
Isomura, I.1
Palmer, S.2
Grumont, R.J.3
Bunting, K.4
Hoyne, G.5
Wilkinson, N.6
Banerjee, A.7
Proietto, A.8
Gugasyan, R.9
Wu, L.10
Mcnally, A.11
Steptoe, R.J.12
Thomas, R.13
Shannon, M.F.14
Gerondakis, S.15
-
76
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126(6):1121–1133
-
(2006)
Cell
, vol.126
, Issue.6
, pp. 1121-1133
-
-
Ivanov, I.I.1
Mckenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
77
-
-
84862665298
-
The symphony of the ninth: The development and function of Th9 cells
-
Jabeen R, Kaplan MH (2012) The symphony of the ninth: the development and function of Th9 cells. Curr Opin Immunol 24(3):303–307
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.3
, pp. 303-307
-
-
Jabeen, R.1
Kaplan, M.H.2
-
78
-
-
0034653932
-
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
-
Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Paul WE, Sher A (2000) Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol 164(6):3047–3055
-
(2000)
J Immunol
, vol.164
, Issue.6
, pp. 3047-3055
-
-
Jankovic, D.1
Kullberg, M.C.2
Noben-Trauth, N.3
Caspar, P.4
Paul, W.E.5
Sher, A.6
-
79
-
-
70449571945
-
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
-
Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM (2009) The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U.S.A 106(42):17876–17881
-
(2009)
Proc Natl Acad Sci U.S.A
, vol.106
, Issue.42
, pp. 17876-17881
-
-
Jenner, R.G.1
Townsend, M.J.2
Jackson, I.3
Sun, K.4
Bouwman, R.D.5
Young, R.A.6
Glimcher, L.H.7
Lord, G.M.8
-
80
-
-
84863116170
-
STAT5 is a potent negative regulator of TFH cell differentiation
-
Johnston RJ, Choi YS, Diamond JA, Yang JA, Crotty S (2012) STAT5 is a potent negative regulator of TFH cell differentiation. J Exp Med 209(2):243–250
-
(2012)
J Exp Med
, vol.209
, Issue.2
, pp. 243-250
-
-
Johnston, R.J.1
Choi, Y.S.2
Diamond, J.A.3
Yang, J.A.4
Crotty, S.5
-
81
-
-
69249109601
-
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
-
Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S (2009) Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325(5943):1006–1010
-
(2009)
Science
, vol.325
, Issue.5943
, pp. 1006-1010
-
-
Johnston, R.J.1
Poholek, A.C.2
Ditoro, D.3
Yusuf, I.4
Eto, D.5
Barnett, B.6
Dent, A.L.7
Craft, J.8
Crotty, S.9
-
82
-
-
0037371474
-
Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells
-
Jorritsma PJ, Brogdon JL, Bottomly K (2003) Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells. J Immunol 170(5):2427–2434
-
(2003)
J Immunol
, vol.170
, Issue.5
, pp. 2427-2434
-
-
Jorritsma, P.J.1
Brogdon, J.L.2
Bottomly, K.3
-
83
-
-
84859416933
-
Regulatory T cells: Mechanisms of differentiation and function
-
Josefowicz SZ, Lu LF, Rudensky AY (2012) Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 30:531–564
-
(2012)
Annu Rev Immunol
, vol.30
, pp. 531-564
-
-
Josefowicz, S.Z.1
Lu, L.F.2
Rudensky, A.Y.3
-
84
-
-
0035871883
-
Stat5a regulates T helper cell differentiation by several distinct mechanisms
-
Kagami S, Nakajima H, Suto A, Hirose K, Suzuki K, Morita S, Kato I, Saito Y, Kitamura T, Iwamoto I (2001) Stat5a regulates T helper cell differentiation by several distinct mechanisms. Blood 97(8):2358–2365
-
(2001)
Blood
, vol.97
, Issue.8
, pp. 2358-2365
-
-
Kagami, S.1
Nakajima, H.2
Suto, A.3
Hirose, K.4
Suzuki, K.5
Morita, S.6
Kato, I.7
Saito, Y.8
Kitamura, T.9
Iwamoto, I.10
-
85
-
-
84871783406
-
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
-
Kanhere A, Hertweck A, Bhatia U, Gokmen MR, Perucha E, Jackson I, Lord GM, Jenner RG (2012) T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. Nat Commun 3:1268
-
(2012)
Nat Commun
, vol.3
, pp. 1268
-
-
Kanhere, A.1
Hertweck, A.2
Bhatia, U.3
Gokmen, M.R.4
Perucha, E.5
Jackson, I.6
Lord, G.M.7
Jenner, R.G.8
-
86
-
-
0029876629
-
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
-
Kaplan MH, Schindler U, Smiley ST, Grusby MJ (1996a) Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4(3):313–319
-
(1996)
Immunity
, vol.4
, Issue.3
, pp. 313-319
-
-
Kaplan, M.H.1
Schindler, U.2
Smiley, S.T.3
Grusby, M.J.4
-
87
-
-
0029937270
-
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
-
Kaplan MH, Sun YL, Hoey T, Grusby MJ (1996b) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382(6587):174–177
-
(1996)
Nature
, vol.382
, Issue.6587
, pp. 174-177
-
-
Kaplan, M.H.1
Sun, Y.L.2
Hoey, T.3
Grusby, M.J.4
-
88
-
-
0032555904
-
A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
-
Kaplan MH, Wurster AL, Grusby MJ (1998) A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J Exp Med 188(6):1191–1196
-
(1998)
J Exp Med
, vol.188
, Issue.6
, pp. 1191-1196
-
-
Kaplan, M.H.1
Wurster, A.L.2
Grusby, M.J.3
-
89
-
-
0035469827
-
Regulation of interferon-gamma gene expression by nuclear factor of activated T cells
-
Kiani A, Garcia-Cozar FJ, Habermann I, Laforsch S, Aebischer T, Ehninger G, Rao A (2001) Regulation of interferon-gamma gene expression by nuclear factor of activated T cells. Blood 98(5):1480–1488
-
(2001)
Blood
, vol.98
, Issue.5
, pp. 1480-1488
-
-
Kiani, A.1
Garcia-Cozar, F.J.2
Habermann, I.3
Laforsch, S.4
Aebischer, T.5
Ehninger, G.6
Rao, A.7
-
90
-
-
0031415048
-
Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1
-
Kiani A, Viola JP, Lichtman AH, Rao A (1997) Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 7(6):849–860
-
(1997)
Immunity
, vol.7
, Issue.6
, pp. 849-860
-
-
Kiani, A.1
Viola, J.P.2
Lichtman, A.H.3
Rao, A.4
-
91
-
-
47749107262
-
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
-
Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T (2008) Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U.S.A 105(28):9721–9726
-
(2008)
Proc Natl Acad Sci U.S.A
, vol.105
, Issue.28
, pp. 9721-9726
-
-
Kimura, A.1
Naka, T.2
Nohara, K.3
Fujii-Kuriyama, Y.4
Kishimoto, T.5
-
92
-
-
70349741295
-
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells
-
Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I, Sakaguchi S (2009) Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity 31(4):609–620
-
(2009)
Immunity
, vol.31
, Issue.4
, pp. 609-620
-
-
Kitoh, A.1
Ono, M.2
Naoe, Y.3
Ohkura, N.4
Yamaguchi, T.5
Yaguchi, H.6
Kitabayashi, I.7
Tsukada, T.8
Nomura, T.9
Miyachi, Y.10
Taniuchi, I.11
Sakaguchi, S.12
-
93
-
-
73349115263
-
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
-
Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Ruckert B, Meiler F, Akdis M, Littman DR, Akdis CA (2009) Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med 206(12):2701–2715
-
(2009)
J Exp Med
, vol.206
, Issue.12
, pp. 2701-2715
-
-
Klunker, S.1
Chong, M.M.2
Mantel, P.Y.3
Palomares, O.4
Bassin, C.5
Ziegler, M.6
Ruckert, B.7
Meiler, F.8
Akdis, M.9
Littman, D.R.10
Akdis, C.A.11
-
94
-
-
76249110300
-
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3
-
Kohu K, Ohmori H, Wong WF, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, Satake M (2009) The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J Immunol 183(12):7817–7824
-
(2009)
J Immunol
, vol.183
, Issue.12
, pp. 7817-7824
-
-
Kohu, K.1
Ohmori, H.2
Wong, W.F.3
Onda, D.4
Wakoh, T.5
Kon, S.6
Yamashita, M.7
Nakayama, T.8
Kubo, M.9
Satake, M.10
-
95
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448(7152):484–487
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
Awasthi, A.4
Jager, A.5
Strom, T.B.6
Oukka, M.7
Kuchroo, V.K.8
-
97
-
-
0033427612
-
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells
-
Kurata H, Lee HJ, O’Garra A, Arai N (1999) Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11(6):677–688
-
(1999)
Immunity
, vol.11
, Issue.6
, pp. 677-688
-
-
Kurata, H.1
Lee, H.J.2
O’Garra, A.3
Arai, N.4
-
98
-
-
71749089605
-
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
-
Kwon H, Thierry-Mieg D, Thierry-Mieg J, Kim HP, Oh J, Tunyaplin C, Carotta S, Donovan CE, Goldman ML, Tailor P, Ozato K, Levy DE, Nutt SL, Calame K, Leonard WJ (2009) Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 31(6):941–952
-
(2009)
Immunity
, vol.31
, Issue.6
, pp. 941-952
-
-
Kwon, H.1
Thierry-Mieg, D.2
Thierry-Mieg, J.3
Kim, H.P.4
Oh, J.5
Tunyaplin, C.6
Carotta, S.7
Donovan, C.E.8
Goldman, M.L.9
Tailor, P.10
Ozato, K.11
Levy, D.E.12
Nutt, S.L.13
Calame, K.14
Leonard, W.J.15
-
99
-
-
79960429950
-
Transcriptional control of rapid recall by memory CD4 T cells
-
Lai W, Yu M, Huang MN, Okoye F, Keegan AD, Farber DL (2011) Transcriptional control of rapid recall by memory CD4 T cells. J Immunol 187(1):133–140
-
(2011)
J Immunol
, vol.187
, Issue.1
, pp. 133-140
-
-
Lai, W.1
Yu, M.2
Huang, M.N.3
Okoye, F.4
Keegan, A.D.5
Farber, D.L.6
-
100
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O’Shea JJ (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26(3):371–381
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, R.B.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
Shevach, E.M.11
O’Shea, J.J.12
-
101
-
-
78650306567
-
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat
-
Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH (2011) T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat. Nat Immunol 12(1):96–104
-
(2011)
Nat Immunol
, vol.12
, Issue.1
, pp. 96-104
-
-
Lazarevic, V.1
Chen, X.2
Shim, J.H.3
Hwang, E.S.4
Jang, E.5
Bolm, A.N.6
Oukka, M.7
Kuchroo, V.K.8
Glimcher, L.H.9
-
102
-
-
0025082313
-
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
-
Le Gros G, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE (1990) Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 172(3):921–929
-
(1990)
J Exp Med
, vol.172
, Issue.3
, pp. 921-929
-
-
Le Gros, G.1
Ben-Sasson, S.Z.2
Seder, R.3
Finkelman, F.D.4
Paul, W.E.5
-
103
-
-
8644220507
-
Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3
-
Lee DU, Rao A (2004) Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U.S.A 101(45):16010–16015
-
(2004)
Proc Natl Acad Sci U.S.A
, vol.101
, Issue.45
, pp. 16010-16015
-
-
Lee, D.U.1
Rao, A.2
-
104
-
-
0000344022
-
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
-
Lee HJ, Takemoto N, Kurata H, Kamogawa Y, Miyatake S, O’Garra A, Arai N (2000) GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med 192(1):105–115
-
(2000)
J Exp Med
, vol.192
, Issue.1
, pp. 105-115
-
-
Lee, H.J.1
Takemoto, N.2
Kurata, H.3
Kamogawa, Y.4
Miyatake, S.5
O’Garra, A.6
Arai, N.7
-
105
-
-
84869213212
-
Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
-
Lee SK, Silva DG, Martin JL, Pratama A, Hu X, Chang PP, Walters G, Vinuesa CG (2012a) Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 37(5):880–892
-
(2012)
Immunity
, vol.37
, Issue.5
, pp. 880-892
-
-
Lee, S.K.1
Silva, D.G.2
Martin, J.L.3
Pratama, A.4
Hu, X.5
Chang, P.P.6
Walters, G.7
Vinuesa, C.G.8
-
106
-
-
84866532132
-
Induction and molecular signature of pathogenic TH17 cells
-
Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK (2012b) Induction and molecular signature of pathogenic TH17 cells. Nat Immunol 13(10):991–999
-
(2012)
Nat Immunol
, vol.13
, Issue.10
, pp. 991-999
-
-
Lee, Y.1
Awasthi, A.2
Yosef, N.3
Quintana, F.J.4
Xiao, S.5
Peters, A.6
Wu, C.7
Kleinewietfeld, M.8
Kunder, S.9
Hafler, D.A.10
Sobel, R.A.11
Regev, A.12
Kuchroo, V.K.13
-
107
-
-
58149251898
-
Late developmental plasticity in the T helper 17 lineage
-
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT (2009) Late developmental plasticity in the T helper 17 lineage. Immunity 30(1):92–107
-
(2009)
Immunity
, vol.30
, Issue.1
, pp. 92-107
-
-
Lee, Y.K.1
Turner, H.2
Maynard, C.L.3
Oliver, J.R.4
Chen, D.5
Elson, C.O.6
Weaver, C.T.7
-
108
-
-
0031919849
-
Jaks and STATs: Biological implications
-
Leonard WJ, O’Shea JJ (1998) Jaks and STATs: biological implications. Annu Rev Immunol 16:293–322
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 293-322
-
-
Leonard, W.J.1
O’Shea, J.J.2
-
109
-
-
78649539346
-
IFN-gamma and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells
-
Lexberg MH, Taubner A, Albrecht I, Lepenies I, Richter A, Kamradt T, Radbruch A, Chang HD (2010) IFN-gamma and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells. Eur J Immunol 40(11):3017–3027
-
(2010)
Eur J Immunol
, vol.40
, Issue.11
, pp. 3017-3027
-
-
Lexberg, M.H.1
Taubner, A.2
Albrecht, I.3
Lepenies, I.4
Richter, A.5
Kamradt, T.6
Radbruch, A.7
Chang, H.D.8
-
110
-
-
34248379172
-
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
-
Li B, Samanta A, Song X, Iacono KT, Bembas K, Tao R, Basu S, Riley JL, Hancock WW, Shen Y, Saouaf SJ, Greene MI (2007a) FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U.S.A 104(11):4571–4576
-
(2007)
Proc Natl Acad Sci U.S.A
, vol.104
, Issue.11
, pp. 4571-4576
-
-
Li, B.1
Samanta, A.2
Song, X.3
Iacono, K.T.4
Bembas, K.5
Tao, R.6
Basu, S.7
Riley, J.L.8
Hancock, W.W.9
Shen, Y.10
Saouaf, S.J.11
Greene, M.I.12
-
111
-
-
0344196985
-
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation
-
Li B, Tournier C, Davis RJ, Flavell RA (1999) Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J 18(2):420–432
-
(1999)
EMBO J
, vol.18
, Issue.2
, pp. 420-432
-
-
Li, B.1
Tournier, C.2
Davis, R.J.3
Flavell, R.A.4
-
112
-
-
34248592104
-
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
-
Li MO, Wan YY, Flavell RA (2007b) T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26(5):579–591
-
(2007)
Immunity
, vol.26
, Issue.5
, pp. 579-591
-
-
Li, M.O.1
Wan, Y.Y.2
Flavell, R.A.3
-
113
-
-
84867861268
-
BATF-JUN is critical for IRF4-mediated transcription in T cells
-
Li P, Spolski R, Liao W, Wang L, Murphy TL, Murphy KM, Leonard WJ (2012) BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 490(7421):543–546
-
(2012)
Nature
, vol.490
, Issue.7421
, pp. 543-546
-
-
Li, P.1
Spolski, R.2
Liao, W.3
Wang, L.4
Murphy, T.L.5
Murphy, K.M.6
Leonard, W.J.7
-
114
-
-
54549103162
-
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression
-
Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ (2008) Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol 9(11):1288–1296
-
(2008)
Nat Immunol
, vol.9
, Issue.11
, pp. 1288-1296
-
-
Liao, W.1
Schones, D.E.2
Oh, J.3
Cui, Y.4
Cui, K.5
Roh, T.Y.6
Zhao, K.7
Leonard, W.J.8
-
115
-
-
0035910037
-
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
-
Lighvani AA, Frucht DM, Jankovic D, Yamane H, Aliberti J, Hissong BD, Nguyen BV, Gadina M, Sher A, Paul WE, O’Shea JJ (2001) T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U.S.A 98(26):15137–15142
-
(2001)
Proc Natl Acad Sci U.S.A
, vol.98
, Issue.26
, pp. 15137-15142
-
-
Lighvani, A.A.1
Frucht, D.M.2
Jankovic, D.3
Yamane, H.4
Aliberti, J.5
Hissong, B.D.6
Nguyen, B.V.7
Gadina, M.8
Sher, A.9
Paul, W.E.10
O’Shea, J.J.11
-
116
-
-
77149122105
-
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
-
Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, Hogan JJ, Verma NK, Smyth MJ, Rigby RJ, Vinuesa CG (2010) IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 207(2):353–363
-
(2010)
J Exp Med
, vol.207
, Issue.2
, pp. 353-363
-
-
Linterman, M.A.1
Beaton, L.2
Yu, D.3
Ramiscal, R.R.4
Srivastava, M.5
Hogan, J.J.6
Verma, N.K.7
Smyth, M.J.8
Rigby, R.J.9
Vinuesa, C.G.10
-
117
-
-
79961151137
-
Foxp3+ follicular regulatory T cells control the germinal center response
-
Linterman MA, Pierson W, Lee SK, Kallies A, Kawamoto S, Rayner TF, Srivastava M, Divekar DP, Beaton L, Hogan JJ, Fagarasan S, Liston A, Smith KG, Vinuesa CG (2011) Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med 17(8):975–982
-
(2011)
Nat Med
, vol.17
, Issue.8
, pp. 975-982
-
-
Linterman, M.A.1
Pierson, W.2
Lee, S.K.3
Kallies, A.4
Kawamoto, S.5
Rayner, T.F.6
Srivastava, M.7
Divekar, D.P.8
Beaton, L.9
Hogan, J.J.10
Fagarasan, S.11
Liston, A.12
Smith, K.G.13
Vinuesa, C.G.14
-
118
-
-
8544226105
-
Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17
-
Liu XK, Lin X, Gaffen SL (2004) Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17. J Biol Chem 279(50):52762–52771
-
(2004)
J Biol Chem
, vol.279
, Issue.50
, pp. 52762-52771
-
-
Liu, X.K.1
Lin, X.2
Gaffen, S.L.3
-
119
-
-
45149109643
-
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
-
Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, Riethmacher D, Si-Tahar M, Di Santo JP, Eberl G (2008) In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 205(6):1381–1393
-
(2008)
J Exp Med
, vol.205
, Issue.6
, pp. 1381-1393
-
-
Lochner, M.1
Peduto, L.2
Cherrier, M.3
Sawa, S.4
Langa, F.5
Varona, R.6
Riethmacher, D.7
Si-Tahar, M.8
Di Santo, J.P.9
Eberl, G.10
-
120
-
-
0037015052
-
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
-
Lohoff M, Mittrucker HW, Prechtl S, Bischof S, Sommer F, Kock S, Ferrick DA, Duncan GS, Gessner A, Mak TW (2002) Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci U.S.A 99(18):11808–11812
-
(2002)
Proc Natl Acad Sci U.S.A
, vol.99
, Issue.18
, pp. 11808-11812
-
-
Lohoff, M.1
Mittrucker, H.W.2
Prechtl, S.3
Bischof, S.4
Sommer, F.5
Kock, S.6
Ferrick, D.A.7
Duncan, G.S.8
Gessner, A.9
Mak, T.W.10
-
121
-
-
30744457828
-
T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression
-
Long M, Slaiby AM, Hagymasi AT, Mihalyo MA, Lichtler AC, Reiner SL, Adler AJ (2006) T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression. J Immunology 176(2):1036–1045
-
(2006)
J Immunology
, vol.176
, Issue.2
, pp. 1036-1045
-
-
Long, M.1
Slaiby, A.M.2
Hagymasi, A.T.3
Mihalyo, M.A.4
Lichtler, A.C.5
Reiner, S.L.6
Adler, A.J.7
-
122
-
-
8444226727
-
Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes
-
Lovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ, Ratts RB, Sikder D, Racke MK (2004) Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 21(5):719–731
-
(2004)
Immunity
, vol.21
, Issue.5
, pp. 719-731
-
-
Lovett-Racke, A.E.1
Rocchini, A.E.2
Choy, J.3
Northrop, S.C.4
Hussain, R.Z.5
Ratts, R.B.6
Sikder, D.7
Racke, M.K.8
-
123
-
-
2442711457
-
Early target genes of IL-12 and STAT4 signaling in th cells
-
Lund RJ, Chen Z, Scheinin J, Lahesmaa R (2004) Early target genes of IL-12 and STAT4 signaling in th cells. J Immunol 172(11):6775–6782
-
(2004)
J Immunol
, vol.172
, Issue.11
, pp. 6775-6782
-
-
Lund, R.J.1
Chen, Z.2
Scheinin, J.3
Lahesmaa, R.4
-
124
-
-
84859897308
-
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
-
Luthje K, Kallies A, Shimohakamada Y, Belz GT, Light A, Tarlinton DM, Nutt SL (2012) The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 13(5):491–498
-
(2012)
Nat Immunol
, vol.13
, Issue.5
, pp. 491-498
-
-
Luthje, K.1
Kallies, A.2
Shimohakamada, Y.3
Belz, G.T.4
Light, A.5
Tarlinton, D.M.6
Nutt, S.L.7
-
125
-
-
46949089128
-
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
-
Ma CS, Chew GY, Simpson N, Priyadarshi A, Wong M, Grimbacher B, Fulcher DA, Tangye SG, Cook MC (2008) Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med 205(7):1551–1557
-
(2008)
J Exp Med
, vol.205
, Issue.7
, pp. 1551-1557
-
-
Ma, C.S.1
Chew, G.Y.2
Simpson, N.3
Priyadarshi, A.4
Wong, M.5
Grimbacher, B.6
Fulcher, D.A.7
Tangye, S.G.8
Cook, M.C.9
-
126
-
-
20644466433
-
NFAT proteins: Key regulators of T-cell development and function
-
Macian F (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5(6):472–484
-
(2005)
Nat Rev Immunol
, vol.5
, Issue.6
, pp. 472-484
-
-
Macian, F.1
-
127
-
-
33644844341
-
Molecular mechanisms underlying FOXP3 induction in human T cells
-
Mantel PY, Ouaked N, Ruckert B, Karagiannidis C, Welz R, Blaser K, Schmidt-Weber CB (2006) Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 176(6):3593–3602
-
(2006)
J Immunol
, vol.176
, Issue.6
, pp. 3593-3602
-
-
Mantel, P.Y.1
Ouaked, N.2
Ruckert, B.3
Karagiannidis, C.4
Welz, R.5
Blaser, K.6
Schmidt-Weber, C.B.7
-
128
-
-
27144526101
-
Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression
-
Martins GA, Hutchins AS, Reiner SL (2005) Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression. J Immunol 175(9):5981–5985
-
(2005)
J Immunol
, vol.175
, Issue.9
, pp. 5981-5985
-
-
Martins, G.A.1
Hutchins, A.S.2
Reiner, S.L.3
-
129
-
-
33748174156
-
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
-
Mathur AN, Chang HC, Zisoulis DG, Kapur R, Belladonna ML, Kansas GS, Kaplan MH (2006) T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood 108(5):1595–1601
-
(2006)
Blood
, vol.108
, Issue.5
, pp. 1595-1601
-
-
Mathur, A.N.1
Chang, H.C.2
Zisoulis, D.G.3
Kapur, R.4
Belladonna, M.L.5
Kansas, G.S.6
Kaplan, M.H.7
-
130
-
-
34247122412
-
Stat3 and Stat4 direct development of IL-17-secreting Th cells
-
Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O’Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH (2007) Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 178(8):4901–4907
-
(2007)
J Immunol
, vol.178
, Issue.8
, pp. 4901-4907
-
-
Mathur, A.N.1
Chang, H.C.2
Zisoulis, D.G.3
Stritesky, G.L.4
Yu, Q.5
O’Malley, J.T.6
Kapur, R.7
Levy, D.E.8
Kansas, G.S.9
Kaplan, M.H.10
-
131
-
-
33947190910
-
Temporal dissection of T-bet functions
-
Matsuda JL, George TC, Hagman J, Gapin L (2007) Temporal dissection of T-bet functions. J Immunol 178(6):3457–3465
-
(2007)
J Immunol
, vol.178
, Issue.6
, pp. 3457-3465
-
-
Matsuda, J.L.1
George, T.C.2
Hagman, J.3
Gapin, L.4
-
132
-
-
60749107176
-
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
-
McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O’Shea JJ, Cua DJ (2009) The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 10(3):314–324
-
(2009)
Nat Immunol
, vol.10
, Issue.3
, pp. 314-324
-
-
Mcgeachy, M.J.1
Chen, Y.2
Tato, C.M.3
Laurence, A.4
Joyce-Shaikh, B.5
Blumenschein, W.M.6
Mcclanahan, T.K.7
O’Shea, J.J.8
Cua, D.J.9
-
133
-
-
84871840494
-
Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf
-
Miao T, Raymond M, Bhullar P, Ghaffari E, Symonds AL, Meier UC, Giovannoni G, Li S, Wang P (2013) Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf. J Immunol 190(1):58–65
-
(2013)
J Immunol
, vol.190
, Issue.1
, pp. 58-65
-
-
Miao, T.1
Raymond, M.2
Bhullar, P.3
Ghaffari, E.4
Symonds, A.L.5
Meier, U.C.6
Giovannoni, G.7
Li, S.8
Wang, P.9
-
134
-
-
31144446876
-
Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation
-
Mikhalkevich N, Becknell B, Caligiuri MA, Bates MD, Harvey R, Zheng WP (2006) Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation. J Immunol 176(3):1553–1560
-
(2006)
J Immunol
, vol.176
, Issue.3
, pp. 1553-1560
-
-
Mikhalkevich, N.1
Becknell, B.2
Caligiuri, M.A.3
Bates, M.D.4
Harvey, R.5
Zheng, W.P.6
-
135
-
-
55749090506
-
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression
-
Miller SA, Huang AC, Miazgowicz MM, Brassil MM, Weinmann AS (2008) Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev 22(21):2980–2993
-
(2008)
Genes Dev
, vol.22
, Issue.21
, pp. 2980-2993
-
-
Miller, S.A.1
Huang, A.C.2
Miazgowicz, M.M.3
Brassil, M.M.4
Weinmann, A.S.5
-
136
-
-
78649263390
-
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression
-
Miller SA, Mohn SE, Weinmann AS (2010) Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol cell 40(4):594–605
-
(2010)
Mol Cell
, vol.40
, Issue.4
, pp. 594-605
-
-
Miller, S.A.1
Mohn, S.E.2
Weinmann, A.S.3
-
137
-
-
41449110468
-
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
-
Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O’Shea J, Holland SM, Paul WE, Douek DC (2008) Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452(7188):773–776
-
(2008)
Nature
, vol.452
, Issue.7188
, pp. 773-776
-
-
Milner, J.D.1
Brenchley, J.M.2
Laurence, A.3
Freeman, A.F.4
Hill, B.J.5
Elias, K.M.6
Kanno, Y.7
Spalding, C.8
Elloumi, H.Z.9
Paulson, M.L.10
Davis, J.11
Hsu, A.12
Asher, A.I.13
O’Shea, J.14
Holland, S.M.15
Paul, W.E.16
Douek, D.C.17
-
138
-
-
22144492615
-
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
-
Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA (2005) Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol 6(7):680–688
-
(2005)
Nat Immunol
, vol.6
, Issue.7
, pp. 680-688
-
-
Minter, L.M.1
Turley, D.M.2
Das, P.3
Shin, H.M.4
Joshi, I.5
Lawlor, R.G.6
Cho, O.H.7
Palaga, T.8
Gottipati, S.9
Telfer, J.C.10
Kostura, L.11
Fauq, A.H.12
Simpson, K.13
Such, K.A.14
Miele, L.15
Golde, T.E.16
Miller, S.D.17
Osborne, B.A.18
-
139
-
-
36548999223
-
Ets-1 is a negative regulator of Th17 differentiation
-
Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC (2007) Ets-1 is a negative regulator of Th17 differentiation. J Exp Med 204(12):2825–2835
-
(2007)
J Exp Med
, vol.204
, Issue.12
, pp. 2825-2835
-
-
Moisan, J.1
Grenningloh, R.2
Bettelli, E.3
Oukka, M.4
Ho, I.C.5
-
140
-
-
84868548958
-
T cell receptor/CARMA1/ NF-kappaB signaling controls T-helper (Th) 17 differentiation
-
Molinero LL, Cubre A, Mora-Solano C, Wang Y, Alegre ML (2012) T cell receptor/CARMA1/ NF-kappaB signaling controls T-helper (Th) 17 differentiation. Proc Natl Acad Sci U.S.A 109(45):18529–18534
-
(2012)
Proc Natl Acad Sci U.S.A
, vol.109
, Issue.45
, pp. 18529-18534
-
-
Molinero, L.L.1
Cubre, A.2
Mora-Solano, C.3
Wang, Y.4
Alegre, M.L.5
-
141
-
-
67649216137
-
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
-
Mukherjee S, Schaller MA, Neupane R, Kunkel SL, Lukacs NW (2009) Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J Immunol 182(12):7381–7388
-
(2009)
J Immunol
, vol.182
, Issue.12
, pp. 7381-7388
-
-
Mukherjee, S.1
Schaller, M.A.2
Neupane, R.3
Kunkel, S.L.4
Lukacs, N.W.5
-
142
-
-
0035827347
-
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
-
Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL (2001) Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292(5523):1907–1910
-
(2001)
Science
, vol.292
, Issue.5523
, pp. 1907-1910
-
-
Mullen, A.C.1
High, F.A.2
Hutchins, A.S.3
Lee, H.W.4
Villarino, A.V.5
Livingston, D.M.6
Kung, A.L.7
Cereb, N.8
Yao, T.P.9
Yang, S.Y.10
Reiner, S.L.11
-
143
-
-
0036301997
-
Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction
-
Mullen AC, Hutchins AS, High FA, Lee HW, Sykes KJ, Chodosh LA, Reiner SL (2002) Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol 3(7):652–658
-
(2002)
Nat Immunol
, vol.3
, Issue.7
, pp. 652-658
-
-
Mullen, A.C.1
Hutchins, A.S.2
High, F.A.3
Lee, H.W.4
Sykes, K.J.5
Chodosh, L.A.6
Reiner, S.L.7
-
144
-
-
34547727747
-
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
-
Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, Littman DR, Taniuchi I (2007) Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med 204(8):1749–1755
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1749-1755
-
-
Naoe, Y.1
Setoguchi, R.2
Akiyama, K.3
Muroi, S.4
Kuroda, M.5
Hatam, F.6
Littman, D.R.7
Taniuchi, I.8
-
145
-
-
0035879115
-
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo
-
Nawijn MC, Dingjan GM, Ferreira R, Lambrecht BN, Karis A, Grosveld F, Savelkoul H, Hendriks RW (2001) Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo. J Immunol 167(2):724–732
-
(2001)
J Immunol
, vol.167
, Issue.2
, pp. 724-732
-
-
Nawijn, M.C.1
Dingjan, G.M.2
Ferreira, R.3
Lambrecht, B.N.4
Karis, A.5
Grosveld, F.6
Savelkoul, H.7
Hendriks, R.W.8
-
146
-
-
34447511609
-
IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state
-
Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano T (2007) IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int Immunol 19(6):695–702
-
(2007)
Int Immunol
, vol.19
, Issue.6
, pp. 695-702
-
-
Nishihara, M.1
Ogura, H.2
Ueda, N.3
Tsuruoka, M.4
Kitabayashi, C.5
Tsuji, F.6
Aono, H.7
Ishihara, K.8
Huseby, E.9
Betz, U.A.10
Murakami, M.11
Hirano, T.12
-
147
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448(7152):480–483
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
Schluns, K.7
Tian, Q.8
Watowich, S.S.9
Jetten, A.M.10
Dong, C.11
-
148
-
-
46749151286
-
-
Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138–149
-
(2008)
Generation of T Follicular Helper Cells is Mediated by Interleukin-21 but Independent of T Helper 1, 2, Or 17 Cell Lineages. Immunity
, vol.29
, Issue.1
, pp. 138-149
-
-
Nurieva, R.I.1
Chung, Y.2
Hwang, D.3
Yang, X.O.4
Kang, H.S.5
Ma, L.6
Wang, Y.H.7
Watowich, S.S.8
Jetten, A.M.9
Tian, Q.10
Dong, C.11
-
149
-
-
69249101229
-
Bcl6 mediates the development of T follicular helper cells
-
Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C (2009) Bcl6 mediates the development of T follicular helper cells. Science 325(5943): 1001–1005
-
(2009)
Science
, vol.325
, Issue.5943
, pp. 1
-
-
Nurieva, R.I.1
Chung, Y.2
Martinez, G.J.3
Yang, X.O.4
Tanaka, S.5
Matskevitch, T.D.6
Wang, Y.H.7
Dong, C.8
-
150
-
-
84859487740
-
STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function
-
Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D (2012) STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem 287(14):11234–11239
-
(2012)
J Biol Chem
, vol.287
, Issue.14
, pp. 11234-11239
-
-
Nurieva, R.I.1
Podd, A.2
Chen, Y.3
Alekseev, A.M.4
Yu, M.5
Qi, X.6
Huang, H.7
Wen, R.8
Wang, J.9
Li, H.S.10
Watowich, S.S.11
Qi, H.12
Dong, C.13
Wang, D.14
-
151
-
-
84859972127
-
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
-
O’Shea JJ, Plenge R (2012) JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 36(4):542–550
-
(2012)
Immunity
, vol.36
, Issue.4
, pp. 542-550
-
-
O’Shea, J.J.1
Plenge, R.2
-
152
-
-
79956201473
-
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
-
Oestreich KJ, Huang AC, Weinmann AS (2011) The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Medicine 208(5):1001–1013
-
(2011)
J Exp Medicine
, vol.208
, Issue.5
, pp. 1001-1013
-
-
Oestreich, K.J.1
Huang, A.C.2
Weinmann, A.S.3
-
153
-
-
84858706847
-
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile
-
Oestreich KJ, Mohn SE, Weinmann AS (2012) Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol 13(4):405–411
-
(2012)
Nat Immunol
, vol.13
, Issue.4
, pp. 405-411
-
-
Oestreich, K.J.1
Mohn, S.E.2
Weinmann, A.S.3
-
154
-
-
77951877914
-
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors
-
Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Muta T, Takayanagi H (2010) IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature 464(7293):1381–1385
-
(2010)
Nature
, vol.464
, Issue.7293
, pp. 1381-1385
-
-
Okamoto, K.1
Iwai, Y.2
Oh-Hora, M.3
Yamamoto, M.4
Morio, T.5
Aoki, K.6
Ohya, K.7
Jetten, A.M.8
Akira, S.9
Muta, T.10
Takayanagi, H.11
-
155
-
-
34247215187
-
Foxp3 controls regulatory T-cell function by interacting with AML1/ Runx1
-
Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S (2007) Foxp3 controls regulatory T-cell function by interacting with AML1/ Runx1. Nature 446(7136):685–689
-
(2007)
Nature
, vol.446
, Issue.7136
, pp. 685-689
-
-
Ono, M.1
Yaguchi, H.2
Ohkura, N.3
Kitabayashi, I.4
Nagamura, Y.5
Nomura, T.6
Miyachi, Y.7
Tsukada, T.8
Sakaguchi, S.9
-
156
-
-
78149322622
-
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells
-
Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, Nakayama T (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207(11):2493–2506
-
(2010)
J Exp Med
, vol.207
, Issue.11
, pp. 2493-2506
-
-
Onodera, A.1
Yamashita, M.2
Endo, Y.3
Kuwahara, M.4
Tofukuji, S.5
Hosokawa, H.6
Kanai, A.7
Suzuki, Y.8
Nakayama, T.9
-
157
-
-
77953811224
-
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
-
Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO (2010) Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 11(7):618–627
-
(2010)
Nat Immunol
, vol.11
, Issue.7
, pp. 618-627
-
-
Ouyang, W.1
Beckett, O.2
Ma, Q.3
Paik, J.H.4
Depinho, R.A.5
Li, M.O.6
-
158
-
-
0033973582
-
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
-
Ouyang W, Lohning M, Gao Z, Assenmacher M, Ranganath S, Radbruch A, Murphy KM (2000) Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12(1):27–37
-
(2000)
Immunity
, vol.12
, Issue.1
, pp. 27-37
-
-
Ouyang, W.1
Lohning, M.2
Gao, Z.3
Assenmacher, M.4
Ranganath, S.5
Radbruch, A.6
Murphy, K.M.7
-
159
-
-
84875785000
-
Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation
-
Pagani M, Rossetti G, Panzeri I, de Candia P, Bonnal RJ, Rossi RL, Geginat J, Abrignani S (2013) Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation. Immunol Rev 253(1):82–96
-
(2013)
Immunol Rev
, vol.253
, Issue.1
, pp. 82-96
-
-
Pagani, M.1
Rossetti, G.2
Panzeri, I.3
De Candia, P.4
Bonnal, R.J.5
Rossi, R.L.6
Geginat, J.7
Abrignani, S.8
-
160
-
-
1242274405
-
GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
-
Pai SY, Truitt ML, Ho IC (2004) GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci U.S.A 101(7):1993–1998
-
(2004)
Proc Natl Acad Sci U.S.A
, vol.101
, Issue.7
, pp. 1993-1998
-
-
Pai, S.Y.1
Truitt, M.L.2
Ho, I.C.3
-
161
-
-
69549120242
-
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
-
Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, Jinasena D, Sharma SM, McCadden EM, Getnet D, Drake CG, Liu JO, Ostrowski MC, Pardoll DM (2009) Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science 325(5944):1142–1146
-
(2009)
Science
, vol.325
, Issue.5944
, pp. 1142-1146
-
-
Pan, F.1
Yu, H.2
Dang, E.V.3
Barbi, J.4
Pan, X.5
Grosso, J.F.6
Jinasena, D.7
Sharma, S.M.8
Mccadden, E.M.9
Getnet, D.10
Drake, C.G.11
Liu, J.O.12
Ostrowski, M.C.13
Pardoll, D.M.14
-
162
-
-
0035129248
-
NFATc1 and NFATc2 together control both T and B cell activation and differentiation
-
Peng SL, Gerth AJ, Ranger AM, Glimcher LH (2001) NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 14(1):13–20
-
(2001)
Immunity
, vol.14
, Issue.1
, pp. 13-20
-
-
Peng, S.L.1
Gerth, A.J.2
Ranger, A.M.3
Glimcher, L.H.4
-
163
-
-
78149408519
-
Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
-
Polansky JK, Schreiber L, Thelemann C, Ludwig L, Kruger M, Baumgrass R, Cording S, Floess S, Hamann A, Huehn J (2010) Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med 88(10):1029–1040
-
(2010)
J Mol Med
, vol.88
, Issue.10
, pp. 1029-1040
-
-
Polansky, J.K.1
Schreiber, L.2
Thelemann, C.3
Ludwig, L.4
Kruger, M.5
Baumgrass, R.6
Cording, S.7
Floess, S.8
Hamann, A.9
Huehn, J.10
-
164
-
-
0037093955
-
Sustained NFAT signaling promotes a Th1-like pattern of gene expression in primary murine CD4+ T cells
-
Porter CM, Clipstone NA (2002) Sustained NFAT signaling promotes a Th1-like pattern of gene expression in primary murine CD4+ T cells. J Immunol 168(10):4936–4945
-
(2002)
J Immunol
, vol.168
, Issue.10
, pp. 4936-4945
-
-
Porter, C.M.1
Clipstone, N.A.2
-
165
-
-
42649095378
-
Control of T(Reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
-
Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL (2008) Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453(7191):65–71
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 65-71
-
-
Quintana, F.J.1
Basso, A.S.2
Iglesias, A.H.3
Korn, T.4
Farez, M.F.5
Bettelli, E.6
Caccamo, M.7
Oukka, M.8
Weiner, H.L.9
-
166
-
-
84864146433
-
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
-
Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK (2012) Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol 13(8):770–777
-
(2012)
Nat Immunol
, vol.13
, Issue.8
, pp. 770-777
-
-
Quintana, F.J.1
Jin, H.2
Burns, E.J.3
Nadeau, M.4
Yeste, A.5
Kumar, D.6
Rangachari, M.7
Zhu, C.8
Xiao, S.9
Seavitt, J.10
Georgopoulos, K.11
Kuchroo, V.K.12
-
167
-
-
60549093926
-
Cutting edge: Ikaros is a regulator of Th2 cell differentiation
-
Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA (2009) Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol 182(2):741–745
-
(2009)
J Immunol
, vol.182
, Issue.2
, pp. 741-745
-
-
Quirion, M.R.1
Gregory, G.D.2
Umetsu, S.E.3
Winandy, S.4
Brown, M.A.5
-
168
-
-
0031933037
-
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
-
Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH (1998a) Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 8(1):125–134
-
(1998)
Immunity
, vol.8
, Issue.1
, pp. 125-134
-
-
Ranger, A.M.1
Hodge, M.R.2
Gravallese, E.M.3
Oukka, M.4
Davidson, L.5
Alt, F.W.6
De La Brousse, F.C.7
Hoey, T.8
Grusby, M.9
Glimcher, L.H.10
-
169
-
-
0032212631
-
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
-
Ranger AM, Oukka M, Rengarajan J, Glimcher LH (1998b) Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 9(5):627–635
-
(1998)
Immunity
, vol.9
, Issue.5
, pp. 627-635
-
-
Ranger, A.M.1
Oukka, M.2
Rengarajan, J.3
Glimcher, L.H.4
-
170
-
-
0037089575
-
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
-
Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH (2002a) Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 195(8):1003–1012
-
(2002)
J Exp Med
, vol.195
, Issue.8
, pp. 1003-1012
-
-
Rengarajan, J.1
Mowen, K.A.2
Mcbride, K.D.3
Smith, E.D.4
Singh, H.5
Glimcher, L.H.6
-
171
-
-
0036144744
-
NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naive T(H)cells
-
Rengarajan J, Tang B, Glimcher LH (2002b) NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naive T(H)cells. Nat Immunol 3(1):48–54
-
(2002)
Nat Immunol
, vol.3
, Issue.1
, pp. 48-54
-
-
Rengarajan, J.1
Tang, B.2
Glimcher, L.H.3
-
172
-
-
71749094333
-
Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome
-
Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH (2009) Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity 31(6):932–940
-
(2009)
Immunity
, vol.31
, Issue.6
, pp. 932-940
-
-
Ruan, Q.1
Kameswaran, V.2
Tone, Y.3
Li, L.4
Liou, H.C.5
Greene, M.I.6
Tone, M.7
Chen, Y.H.8
-
173
-
-
84866548843
-
Transcription factor Foxp3 and its protein partners form a complex regulatory network
-
Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY (2012) Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol 13(10):1010–1019
-
(2012)
Nat Immunol
, vol.13
, Issue.10
, pp. 1010-1019
-
-
Rudra, D.1
Deroos, P.2
Chaudhry, A.3
Niec, R.E.4
Arvey, A.5
Samstein, R.M.6
Leslie, C.7
Shaffer, S.A.8
Goodlett, D.R.9
Rudensky, A.Y.10
-
174
-
-
70350451993
-
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
-
Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY (2009) Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol 10(11):1170–1177
-
(2009)
Nat Immunol
, vol.10
, Issue.11
, pp. 1170-1177
-
-
Rudra, D.1
Egawa, T.2
Chong, M.M.3
Treuting, P.4
Littman, D.R.5
Rudensky, A.Y.6
-
175
-
-
52649179291
-
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells
-
Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA (2008) Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 112(5):1813–1821
-
(2008)
Blood
, vol.112
, Issue.5
, pp. 1813-1821
-
-
Samon, J.B.1
Champhekar, A.2
Minter, L.M.3
Telfer, J.C.4
Miele, L.5
Fauq, A.6
Das, P.7
Golde, T.E.8
Osborne, B.A.9
-
176
-
-
84866975037
-
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
-
Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY (2012) Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell 151(1):153–166
-
(2012)
Cell
, vol.151
, Issue.1
, pp. 153-166
-
-
Samstein, R.M.1
Arvey, A.2
Josefowicz, S.Z.3
Peng, X.4
Reynolds, A.5
Sandstrom, R.6
Neph, S.7
Sabo, P.8
Kim, J.M.9
Liao, W.10
Li, M.O.11
Leslie, C.12
Stamatoyannopoulos, J.A.13
Rudensky, A.Y.14
-
177
-
-
67651001561
-
The AP-1 transcription factor Batf controls T(H)17 differentiation
-
Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM (2009) The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 460(7253):405–409
-
(2009)
Nature
, vol.460
, Issue.7253
, pp. 405-409
-
-
Schraml, B.U.1
Hildner, K.2
Ise, W.3
Lee, W.L.4
Smith, W.A.5
Solomon, B.6
Sahota, G.7
Sim, J.8
Mukasa, R.9
Cemerski, S.10
Hatton, R.D.11
Stormo, G.D.12
Weaver, C.T.13
Russell, J.H.14
Murphy, T.L.15
Murphy, K.M.16
-
178
-
-
65549118531
-
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
-
Schulz EG, Mariani L, Radbruch A, Hofer T (2009) Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 30(5):673–683
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 673-683
-
-
Schulz, E.G.1
Mariani, L.2
Radbruch, A.3
Hofer, T.4
-
179
-
-
0026712313
-
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
-
Seder RA, Paul WE, Davis MM, de St Groth BF (1992) The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 176(4):1091–1098
-
(1992)
J Exp Med
, vol.176
, Issue.4
, pp. 1091-1098
-
-
Seder, R.A.1
Paul, W.E.2
Davis, M.M.3
De St Groth, B.F.4
-
180
-
-
2442588675
-
IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation
-
Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, Izuhara K, Brombacher F, Kubo M (2004) IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation. J Immunol 172(10):6158–6166
-
(2004)
J Immunol
, vol.172
, Issue.10
, pp. 6158-6166
-
-
Seki, N.1
Miyazaki, M.2
Suzuki, W.3
Hayashi, K.4
Arima, K.5
Myburgh, E.6
Izuhara, K.7
Brombacher, F.8
Kubo, M.9
-
181
-
-
79953769170
-
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
-
Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A (2011) The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nat Commun 2:269
-
(2011)
Nat Commun
, vol.2
, pp. 269
-
-
Sekiya, T.1
Kashiwagi, I.2
Inoue, N.3
Morita, R.4
Hori, S.5
Waldmann, H.6
Rudensky, A.Y.7
Ichinose, H.8
Metzger, D.9
Chambon, P.10
Yoshimura, A.11
-
183
-
-
58149190437
-
Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells
-
Shi G, Cox CA, Vistica BP, Tan C, Wawrousek EF, Gery I (2008) Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J Immunol 181(10):7205–7213
-
(2008)
J Immunol
, vol.181
, Issue.10
, pp. 7205-7213
-
-
Shi, G.1
Cox, C.A.2
Vistica, B.P.3
Tan, C.4
Wawrousek, E.F.5
Gery, I.6
-
184
-
-
15844374279
-
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
-
Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN (1996) Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380(6575):630–633
-
(1996)
Nature
, vol.380
, Issue.6575
, pp. 630-633
-
-
Shimoda, K.1
Van Deursen, J.2
Sangster, M.Y.3
Sarawar, S.R.4
Carson, R.T.5
Tripp, R.A.6
Chu, C.7
Quelle, F.W.8
Nosaka, T.9
Vignali, D.A.10
Doherty, P.C.11
Grosveld, G.12
Paul, W.E.13
Ihle, J.N.14
-
185
-
-
30444450802
-
Notch1 augments NF-kappaB activity by facilitating its nuclear retention
-
Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA (2006) Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J 25(1):129–138
-
(2006)
EMBO J
, vol.25
, Issue.1
, pp. 129-138
-
-
Shin, H.M.1
Minter, L.M.2
Cho, O.H.3
Gottipati, S.4
Fauq, A.H.5
Golde, T.E.6
Sonenshein, G.E.7
Osborne, B.A.8
-
186
-
-
0030613857
-
Interaction of NF-kappaB and NFAT with the interferon-gamma promoter
-
Sica A, Dorman L, Viggiano V, Cippitelli M, Ghosh P, Rice N, Young HA (1997) Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 272(48):30412–30420
-
(1997)
J Biol Chem
, vol.272
, Issue.48
, pp. 30412-30420
-
-
Sica, A.1
Dorman, L.2
Viggiano, V.3
Cippitelli, M.4
Ghosh, P.5
Rice, N.6
Young, H.A.7
-
187
-
-
1342321662
-
GATA-3 in human T cell helper type 2 development
-
Skapenko A, Leipe J, Niesner U, Devriendt K, Beetz R, Radbruch A, Kalden JR, Lipsky PE, Schulze-Koops H (2004) GATA-3 in human T cell helper type 2 development. J Exp Med 199(3):423–428
-
(2004)
J Exp Med
, vol.199
, Issue.3
, pp. 423-428
-
-
Skapenko, A.1
Leipe, J.2
Niesner, U.3
Devriendt, K.4
Beetz, R.5
Radbruch, A.6
Kalden, J.R.7
Lipsky, P.E.8
Schulze-Koops, H.9
-
188
-
-
5444237577
-
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
-
Spilianakis CG, Flavell RA (2004) Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol 5(10):1017–1027
-
(2004)
Nat Immunol
, vol.5
, Issue.10
, pp. 1017-1027
-
-
Spilianakis, C.G.1
Flavell, R.A.2
-
189
-
-
77955902281
-
TaubeC,Dehzad N,BeckerM, StassenM, SteinbornA, LohoffM, Schild H, Schmitt E, Bopp T
-
Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, TaubeC,Dehzad N,BeckerM, StassenM, SteinbornA, LohoffM, Schild H, Schmitt E, Bopp T (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33(2):192–202
-
(2010)
Interferon-Regulatory Factor 4 is Essential for the Developmental Program of T Helper 9 Cells. Immunity
, vol.33
, Issue.2
, pp. 192-202
-
-
Staudt, V.1
Bothur, E.2
Klein, M.3
Lingnau, K.4
Reuter, S.5
Grebe, N.6
Gerlitzki, B.7
Hoffmann, M.8
Ulges, A.9
-
190
-
-
0025222698
-
IL-4 directs the development of Th2-like helper effectors
-
Swain SL, Weinberg AD, English M, Huston G (1990) IL-4 directs the development of Th2-like helper effectors. J Immunol 145(11):3796–3806
-
(1990)
J Immunol
, vol.145
, Issue.11
, pp. 3796-3806
-
-
Swain, S.L.1
Weinberg, A.D.2
English, M.3
Huston, G.4
-
191
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100(6):655–669
-
(2000)
Cell
, vol.100
, Issue.6
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
192
-
-
0037059462
-
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
-
Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295(5553):338–342
-
(2002)
Science
, vol.295
, Issue.5553
, pp. 338-342
-
-
Szabo, S.J.1
Sullivan, B.M.2
Stemmann, C.3
Satoskar, A.R.4
Sleckman, B.P.5
Glimcher, L.H.6
-
193
-
-
15844404509
-
Essential role of Stat6 in IL-4 signalling
-
Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S (1996) Essential role of Stat6 in IL-4 signalling. Nature 380(6575):627–630
-
(1996)
Nature
, vol.380
, Issue.6575
, pp. 627-630
-
-
Takeda, K.1
Tanaka, T.2
Shi, W.3
Matsumoto, M.4
Minami, M.5
Kashiwamura, S.6
Nakanishi, K.7
Yoshida, N.8
Kishimoto, T.9
Akira, S.10
-
194
-
-
77951643783
-
FoxP3+RORgammat+T helper intermediates display suppressive function against autoimmune diabetes
-
Tartar DM, VanMorlan AM, Wan X, Guloglu FB, Jain R, Haymaker CL, Ellis JS, Hoeman CM, Cascio JA, Dhakal M, Oukka M, Zaghouani H (2010) FoxP3+RORgammat+T helper intermediates display suppressive function against autoimmune diabetes. J Immunol 184(7):3377–3385
-
(2010)
J Immunol
, vol.184
, Issue.7
, pp. 3377-3385
-
-
Tartar, D.M.1
Vanmorlan, A.M.2
Wan, X.3
Guloglu, F.B.4
Jain, R.5
Haymaker, C.L.6
Ellis, J.S.7
Hoeman, C.M.8
Cascio, J.A.9
Dhakal, M.10
Oukka, M.11
Zaghouani, H.12
-
195
-
-
15844396183
-
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
-
Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN (1996) Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382(6587):171–174
-
(1996)
Nature
, vol.382
, Issue.6587
, pp. 171-174
-
-
Thierfelder, W.E.1
Van Deursen, J.M.2
Yamamoto, K.3
Tripp, R.A.4
Sarawar, S.R.5
Carson, R.T.6
Sangster, M.Y.7
Vignali, D.A.8
Doherty, P.C.9
Grosveld, G.C.10
Ihle, J.N.11
-
196
-
-
55349117409
-
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination
-
Thieu VT, Yu Q, Chang HC, Yeh N, Nguyen ET, Sehra S, Kaplan MH (2008) Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity 29(5):679–690
-
(2008)
Immunity
, vol.29
, Issue.5
, pp. 679-690
-
-
Thieu, V.T.1
Yu, Q.2
Chang, H.C.3
Yeh, N.4
Nguyen, E.T.5
Sehra, S.6
Kaplan, M.H.7
-
197
-
-
77449135194
-
Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation
-
Thomas RM, Chen C, Chunder N, Ma L, Taylor J, Pearce EJ, Wells AD (2010) Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation. J Biol Chem 285(4):2545–2553
-
(2010)
J Biol Chem
, vol.285
, Issue.4
, pp. 2545-2553
-
-
Thomas, R.M.1
Chen, C.2
Chunder, N.3
Ma, L.4
Taylor, J.5
Pearce, E.J.6
Wells, A.D.7
-
198
-
-
77951638740
-
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
-
Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM (2010) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 184(7):3433–3441
-
(2010)
J Immunol
, vol.184
, Issue.7
, pp. 3433-3441
-
-
Thornton, A.M.1
Korty, P.E.2
Tran, D.Q.3
Wohlfert, E.A.4
Murray, P.E.5
Belkaid, Y.6
Shevach, E.M.7
-
199
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M (2008) Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol 9(2):194–202
-
(2008)
Nat Immunol
, vol.9
, Issue.2
, pp. 194-202
-
-
Tone, Y.1
Furuuchi, K.2
Kojima, Y.3
Tykocinski, M.L.4
Greene, M.I.5
Tone, M.6
-
200
-
-
77953962232
-
Ikaros is a regulator of Il10 expression in CD4+ T cells
-
Umetsu SE, Winandy S (2009) Ikaros is a regulator of Il10 expression in CD4+ T cells. J Immunol 183(9):5518–5525
-
(2009)
J Immunol
, vol.183
, Issue.9
, pp. 5518-5525
-
-
Umetsu, S.E.1
Winandy, S.2
-
201
-
-
0037342749
-
GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
-
Usui T, Nishikomori R, Kitani A, Strober W (2003) GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. Immunity 18(3):415–428
-
(2003)
Immunity
, vol.18
, Issue.3
, pp. 415-428
-
-
Usui, T.1
Nishikomori, R.2
Kitani, A.3
Strober, W.4
-
202
-
-
84867088968
-
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells
-
Vaeth M, Schliesser U, Muller G, Reissig S, Satoh K, Tuettenberg A, Jonuleit H, Waisman A, Muller MR, Serfling E, Sawitzki BS, Berberich-Siebelt F (2012) Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U.S.A 109(40):16258–16263
-
(2012)
Proc Natl Acad Sci U.S.A
, vol.109
, Issue.40
, pp. 16258-16263
-
-
Vaeth, M.1
Schliesser, U.2
Muller, G.3
Reissig, S.4
Satoh, K.5
Tuettenberg, A.6
Jonuleit, H.7
Waisman, A.8
Muller, M.R.9
Serfling, E.10
Sawitzki, B.S.11
Berberich-Siebelt, F.12
-
203
-
-
84882692382
-
Canonical wnt signaling negatively modulates regulatory T cell function
-
van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Grone A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ (2013) Canonical wnt signaling negatively modulates regulatory T cell function. Immunity 39(2):298–310
-
(2013)
Immunity
, vol.39
, Issue.2
, pp. 298-310
-
-
Van Loosdregt, J.1
Fleskens, V.2
Tiemessen, M.M.3
Mokry, M.4
Van Boxtel, R.5
Meerding, J.6
Pals, C.E.7
Kurek, D.8
Baert, M.R.9
Delemarre, E.M.10
Grone, A.11
Koerkamp, M.J.12
Sijts, A.J.13
Nieuwenhuis, E.E.14
Maurice, M.M.15
Van Es, J.H.16
Ten Berge, D.17
Holstege, F.C.18
Staal, F.J.19
Zaiss, D.M.20
Prakken, B.J.21
Coffer, P.J.22
more..
-
204
-
-
42649106556
-
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
-
Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B (2008) The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453(7191):106–109
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 106-109
-
-
Veldhoen, M.1
Hirota, K.2
Westendorf, A.M.3
Buer, J.4
Dumoutier, L.5
Renauld, J.C.6
Stockinger, B.7
-
205
-
-
78650671831
-
STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms
-
Villarino AV, Gallo E, Abbas AK (2010) STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunology 185(11): 6461–6471
-
(2010)
J Immunology
, vol.185
, Issue.11
, pp. 6461-6471
-
-
Villarino, A.V.1
Gallo, E.2
Abbas, A.K.3
-
206
-
-
46749115446
-
A fundamental role for interleukin-21 in the generation of T follicular helper cells
-
Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C (2008) A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29(1):127–137
-
(2008)
Immunity
, vol.29
, Issue.1
, pp. 127-137
-
-
Vogelzang, A.1
Mcguire, H.M.2
Yu, D.3
Sprent, J.4
Mackay, C.R.5
King, C.6
-
207
-
-
44049102724
-
A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
-
Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, Soumelis V (2008) A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9(6):650–657
-
(2008)
Nat Immunol
, vol.9
, Issue.6
, pp. 650-657
-
-
Volpe, E.1
Servant, N.2
Zollinger, R.3
Bogiatzi, S.I.4
Hupe, P.5
Barillot, E.6
Soumelis, V.7
-
208
-
-
84879414890
-
GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling
-
Wang Y, Misumi I, Gu AD, Curtis TA, Su L, Whitmire JK, Wan YY (2013) GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling. Nat Immunol 14(7):714–722
-
(2013)
Nat Immunol
, vol.14
, Issue.7
, pp. 714-722
-
-
Wang, Y.1
Misumi, I.2
Gu, A.D.3
Curtis, T.A.4
Su, L.5
Whitmire, J.K.6
Wan, Y.Y.7
-
209
-
-
80053130719
-
An essential role of the transcription factor GATA-3 for the function of regulatory T cells
-
Wang Y, Su MA, Wan YY (2011) An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35(3):337–348
-
(2011)
Immunity
, vol.35
, Issue.3
, pp. 337-348
-
-
Wang, Y.1
Su, M.A.2
Wan, Y.Y.3
-
210
-
-
78149326083
-
AnovelsubsetofCD4(+)T(H)2memory/effectorcellsthatproduceinflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
-
Wang YH, Voo KS, Liu B, Chen CY, Uygungil B, Spoede W, Bernstein JA, Huston DP, Liu YJ (2010) A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J Exp Med 207(11):2479–2491
-
(2010)
J Exp Med
, vol.207
, Issue.11
, pp. 2479-2491
-
-
Wang, Y.H.1
Voo, K.S.2
Liu, B.3
Chen, C.Y.4
Uygungil, B.5
Spoede, W.6
Bernstein, J.A.7
Huston, D.P.8
Liu, Y.J.9
-
211
-
-
80051885764
-
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types
-
Wei G, Abraham BJ, Yagi R, Jothi R, Cui K, Sharma S, Narlikar L, Northrup DL, Tang Q, Paul WE, Zhu J, Zhao K (2011) Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35(2):299–311
-
(2011)
Immunity
, vol.35
, Issue.2
, pp. 299-311
-
-
Wei, G.1
Abraham, B.J.2
Yagi, R.3
Jothi, R.4
Cui, K.5
Sharma, S.6
Narlikar, L.7
Northrup, D.L.8
Tang, Q.9
Paul, W.E.10
Zhu, J.11
Zhao, K.12
-
212
-
-
36849036211
-
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
-
Wei L, Laurence A, Elias KM, O’Shea JJ (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 282(48):34605–34610
-
(2007)
J Biol Chem
, vol.282
, Issue.48
, pp. 34605-34610
-
-
Wei, L.1
Laurence, A.2
Elias, K.M.3
O’Shea, J.J.4
-
213
-
-
0035163909
-
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
-
Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME (2001) X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 27(1):18–20
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 18-20
-
-
Wildin, R.S.1
Ramsdell, F.2
Peake, J.3
Faravelli, F.4
Casanova, J.L.5
Buist, N.6
Levy-Lahad, E.7
Mazzella, M.8
Goulet, O.9
Perroni, L.10
Bricarelli, F.D.11
Byrne, G.12
Mceuen, M.13
Proll, S.14
Appleby, M.15
Brunkow, M.E.16
-
214
-
-
34247271308
-
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
-
Williams LM, Rudensky AY (2007) Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8(3):277–284
-
(2007)
Nat Immunol
, vol.8
, Issue.3
, pp. 277-284
-
-
Williams, L.M.1
Rudensky, A.Y.2
-
215
-
-
80555136815
-
GATA3controlsFoxp3(+)regulatoryTcellfateduringinflammationinmice
-
Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y (2011) GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice. J Clin Invest 121(11):4503–4515
-
(2011)
Jclin Invest
, vol.121
, Issue.11
, pp. 4503-4515
-
-
Wohlfert, E.A.1
Grainger, J.R.2
Bouladoux, N.3
Konkel, J.E.4
Oldenhove, G.5
Ribeiro, C.H.6
Hall, J.A.7
Yagi, R.8
Naik, S.9
Bhairavabhotla, R.10
Paul, W.E.11
Bosselut, R.12
Wei, G.13
Zhao, K.14
Oukka, M.15
Zhu, J.16
Belkaid, Y.17
-
216
-
-
33746228122
-
FOXP3 controls regulatory T cell function through cooperation with NFAT
-
Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A (2006) FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126(2):375–387
-
(2006)
Cell
, vol.126
, Issue.2
, pp. 375-387
-
-
Wu, Y.1
Borde, M.2
Heissmeyer, V.3
Feuerer, M.4
Lapan, A.D.5
Stroud, J.C.6
Bates, D.L.7
Guo, L.8
Han, A.9
Ziegler, S.F.10
Mathis, D.11
Benoist, C.12
Chen, L.13
Rao, A.14
-
217
-
-
34249799285
-
Cutting edge: Regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
-
Xu L, Kitani A, Fuss I, Strober W (2007) Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol 178(11):6725–6729
-
(2007)
J Immunol
, vol.178
, Issue.11
, pp. 6725-6729
-
-
Xu, L.1
Kitani, A.2
Fuss, I.3
Strober, W.4
-
218
-
-
77957025756
-
Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
-
Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W (2010) Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity 33(3):313–325
-
(2010)
Immunity
, vol.33
, Issue.3
, pp. 313-325
-
-
Xu, L.1
Kitani, A.2
Stuelten, C.3
Mcgrady, G.4
Fuss, I.5
Strober, W.6
-
219
-
-
77951920474
-
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma
-
Yagi R, Junttila IS, Wei G, Urban JF Jr, Zhao K, Paul WE, Zhu J (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32(4):507–517
-
(2010)
Immunity
, vol.32
, Issue.4
, pp. 507-517
-
-
Yagi, R.1
Junttila, I.S.2
Wei, G.3
Urban, J.F.4
Zhao, K.5
Paul, W.E.6
Zhu, J.7
-
220
-
-
25144476332
-
Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment
-
Yamane H, Zhu J, Paul WE (2005) Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment. J Exp Med 202(6):793–804
-
(2005)
J Exp Med
, vol.202
, Issue.6
, pp. 793-804
-
-
Yamane, H.1
Zhu, J.2
Paul, W.E.3
-
221
-
-
3042598052
-
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci
-
Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem 279(26):26983–26990
-
(2004)
J Biol Chem
, vol.279
, Issue.26
, pp. 26983-26990
-
-
Yamashita, M.1
Ukai-Tadenuma, M.2
Miyamoto, T.3
Sugaya, K.4
Hosokawa, H.5
Hasegawa, A.6
Kimura, M.7
Taniguchi, M.8
Degregori, J.9
Nakayama, T.10
-
222
-
-
70449707113
-
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
-
Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C (2009) Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 10(12):1260–1266
-
(2009)
Nat Immunol
, vol.10
, Issue.12
, pp. 1260-1266
-
-
Yang, X.O.1
Angkasekwinai, P.2
Zhu, J.3
Peng, J.4
Liu, Z.5
Nurieva, R.6
Liu, X.7
Chung, Y.8
Chang, S.H.9
Sun, B.10
Dong, C.11
-
223
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C (2007) STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282(13):9358–9363
-
(2007)
J Biol Chem
, vol.282
, Issue.13
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
Chang, S.H.4
Wang, D.5
Watowich, S.S.6
Dong, C.7
-
224
-
-
37849048599
-
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
-
Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29–39
-
(2008)
Immunity
, vol.28
, Issue.1
, pp. 29-39
-
-
Yang, X.O.1
Pappu, B.P.2
Nurieva, R.3
Akimzhanov, A.4
Kang, H.S.5
Chung, Y.6
Ma, L.7
Shah, B.8
Panopoulos, A.D.9
Schluns, K.S.10
Watowich, S.S.11
Tian, Q.12
Jetten, A.M.13
Dong, C.14
-
225
-
-
79951682333
-
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
-
Yang XP, Ghoreschi K, Steward-Tharp SM, Rodriguez-Canales J, Zhu J, Grainger JR, Hirahara K, Sun HW, Wei L, Vahedi G, Kanno Y, O’Shea JJ, Laurence A (2011) Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol 12(3):247–254
-
(2011)
Nat Immunol
, vol.12
, Issue.3
, pp. 247-254
-
-
Yang, X.P.1
Ghoreschi, K.2
Steward-Tharp, S.M.3
Rodriguez-Canales, J.4
Zhu, J.5
Grainger, J.R.6
Hirahara, K.7
Sun, H.W.8
Wei, L.9
Vahedi, G.10
Kanno, Y.11
O’Shea, J.J.12
Laurence, A.13
-
226
-
-
34247564147
-
Nonredundant roles for Stat5a/b in directly regulating Foxp3
-
Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, Watford WT, Laurence A, Robinson GW, Shevach EM, Moriggl R, Hennighausen L, Wu C, O’Shea JJ (2007) Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109(10):4368–4375
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4368-4375
-
-
Yao, Z.1
Kanno, Y.2
Kerenyi, M.3
Stephens, G.4
Durant, L.5
Watford, W.T.6
Laurence, A.7
Robinson, G.W.8
Shevach, E.M.9
Moriggl, R.10
Hennighausen, L.11
Wu, C.12
O’Shea, J.J.13
-
227
-
-
84870393179
-
An update on the hyper-IgE syndromes
-
Yong PF, Freeman AF, Engelhardt KR, Holland S, Puck JM, Grimbacher B (2012) An update on the hyper-IgE syndromes. Arthritis Res Ther. 14(6):228
-
(2012)
Arthritis Res Ther
, vol.14
, Issue.6
, pp. 228
-
-
Yong, P.F.1
Freeman, A.F.2
Engelhardt, K.R.3
Holland, S.4
Puck, J.M.5
Grimbacher, B.6
-
228
-
-
84876806691
-
Dynamic regulatory network controlling TH17 cell differentiation
-
Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A (2013) Dynamic regulatory network controlling TH17 cell differentiation. Nature 496(7446):461–468
-
(2013)
Nature
, vol.496
, Issue.7446
, pp. 461-468
-
-
Yosef, N.1
Shalek, A.K.2
Gaublomme, J.T.3
Jin, H.4
Lee, Y.5
Awasthi, A.6
Wu, C.7
Karwacz, K.8
Xiao, S.9
Jorgolli, M.10
Gennert, D.11
Satija, R.12
Shakya, A.13
Lu, D.Y.14
Trombetta, J.J.15
Pillai, M.R.16
Ratcliffe, P.J.17
Coleman, M.L.18
Bix, M.19
Tantin, D.20
Park, H.21
Kuchroo, V.K.22
Regev, A.23
more..
-
229
-
-
0031951071
-
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
-
Yoshida H, Nishina H, Takimoto H, Marengere LE, Wakeham AC, Bouchard D, Kong YY, Ohteki T, Shahinian A, Bachmann M, Ohashi PS, Penninger JM, Crabtree GR, Mak TW (1998) The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 8(1):115–124
-
(1998)
Immunity
, vol.8
, Issue.1
, pp. 115-124
-
-
Yoshida, H.1
Nishina, H.2
Takimoto, H.3
Marengere, L.E.4
Wakeham, A.C.5
Bouchard, D.6
Kong, Y.Y.7
Ohteki, T.8
Shahinian, A.9
Bachmann, M.10
Ohashi, P.S.11
Penninger, J.M.12
Crabtree, G.R.13
Mak, T.W.14
-
230
-
-
70049101558
-
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
-
Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL, Srivastava M, Linterman M, Zheng L, Simpson N, Ellyard JI, Parish IA, Ma CS, Li QJ, Parish CR, Mackay CR, Vinuesa CG (2009a) The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31(3):457–468
-
(2009)
Immunity
, vol.31
, Issue.3
, pp. 457-468
-
-
Yu, D.1
Rao, S.2
Tsai, L.M.3
Lee, S.K.4
He, Y.5
Sutcliffe, E.L.6
Srivastava, M.7
Linterman, M.8
Zheng, L.9
Simpson, N.10
Ellyard, J.I.11
Parish, I.A.12
Ma, C.S.13
Li, Q.J.14
Parish, C.R.15
Mackay, C.R.16
Vinuesa, C.G.17
-
231
-
-
79955031250
-
T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomy-elitis
-
Yu Q, Sharma A, Ghosh A, Sen JM (2011) T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomy-elitis. J Immunol 186(7):3946–3952
-
(2011)
J Immunol
, vol.186
, Issue.7
, pp. 3946-3952
-
-
Yu, Q.1
Sharma, A.2
Ghosh, A.3
Sen, J.M.4
-
232
-
-
69049088648
-
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma
-
Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM (2009b) T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol 10(9):992–999
-
(2009)
Nat Immunol
, vol.10
, Issue.9
, pp. 992-999
-
-
Yu, Q.1
Sharma, A.2
Oh, S.Y.3
Moon, H.G.4
Hossain, M.Z.5
Salay, T.M.6
Leeds, K.E.7
Du, H.8
Wu, B.9
Waterman, M.L.10
Zhu, Z.11
Sen, J.M.12
-
233
-
-
77955280012
-
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
-
Yusuf I, Kageyama R, Monticelli L, Johnston RJ, Ditoro D, Hansen K, Barnett B, Crotty S (2010) Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol 185(1):190–202
-
(2010)
J Immunol
, vol.185
, Issue.1
, pp. 190-202
-
-
Yusuf, I.1
Kageyama, R.2
Monticelli, L.3
Johnston, R.J.4
Ditoro, D.5
Hansen, K.6
Barnett, B.7
Crotty, S.8
-
234
-
-
70349334306
-
Immune suppressive activity and lack of T helper differentiation are differentially regulated in natural regulatory T cells
-
Zeng WP, Chang C, Lai JJ (2009) Immune suppressive activity and lack of T helper differentiation are differentially regulated in natural regulatory T cells. J Immunol 183(6):3583–3590
-
(2009)
J Immunol
, vol.183
, Issue.6
, pp. 3583-3590
-
-
Zeng, W.P.1
Chang, C.2
Lai, J.J.3
-
235
-
-
0030764961
-
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
-
Zhang DH, Cohn L, Ray P, Bottomly K, Ray A (1997) Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem 272(34):21597–21603
-
(1997)
J Biol Chem
, vol.272
, Issue.34
, pp. 21597-21603
-
-
Zhang, D.H.1
Cohn, L.2
Ray, P.3
Bottomly, K.4
Ray, A.5
-
236
-
-
54549100120
-
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
-
Zhang F, Meng G, Strober W (2008) Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 9(11):1297–1306
-
(2008)
Nat Immunol
, vol.9
, Issue.11
, pp. 1297-1306
-
-
Zhang, F.1
Meng, G.2
Strober, W.3
-
237
-
-
0030810155
-
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
-
Zheng W, Flavell RA (1997) The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89(4):587–596
-
(1997)
Cell
, vol.89
, Issue.4
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
238
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458(7236):351–356
-
(2009)
Nature
, vol.458
, Issue.7236
, pp. 351-356
-
-
Zheng, Y.1
Chaudhry, A.2
Kas, A.3
Deroos, P.4
Kim, J.M.5
Chu, T.T.6
Corcoran, L.7
Treuting, P.8
Klein, U.9
Rudensky, A.Y.10
-
239
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463(7282):808–812
-
(2010)
Nature
, vol.463
, Issue.7282
, pp. 808-812
-
-
Zheng, Y.1
Josefowicz, S.2
Chaudhry, A.3
Peng, X.P.4
Forbush, K.5
Rudensky, A.Y.6
-
240
-
-
33847220736
-
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
-
Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445(7130):936–940
-
(2007)
Nature
, vol.445
, Issue.7130
, pp. 936-940
-
-
Zheng, Y.1
Josefowicz, S.Z.2
Kas, A.3
Chu, T.T.4
Gavin, M.A.5
Rudensky, A.Y.6
-
241
-
-
65549115862
-
Plasticity of CD4+ T cell lineage differentiation
-
Zhou L, Chong MM, Littman DR (2009) Plasticity of CD4+ T cell lineage differentiation. Immunity 30(5):646–655
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 646-655
-
-
Zhou, L.1
Chong, M.M.2
Littman, D.R.3
-
242
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8(9):967–974
-
(2007)
Nat Immunol
, vol.8
, Issue.9
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
243
-
-
43449135305
-
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
-
Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453(7192):236–240
-
(2008)
Nature
, vol.453
, Issue.7192
, pp. 236-240
-
-
Zhou, L.1
Lopes, J.E.2
Chong, M.M.3
Ivanov, I.I.4
Min, R.5
Victora, G.D.6
Shen, Y.7
Du, J.8
Rubtsov, Y.P.9
Rudensky, A.Y.10
Ziegler, S.F.11
Littman, D.R.12
-
244
-
-
0344064893
-
Stat5 activation plays a critical role in Th2 differentiation
-
Zhu J, Cote-Sierra J, Guo L, Paul WE (2003) Stat5 activation plays a critical role in Th2 differentiation. Immunity 19(5):739–748
-
(2003)
Immunity
, vol.19
, Issue.5
, pp. 739-748
-
-
Zhu, J.1
Cote-Sierra, J.2
Guo, L.3
Paul, W.E.4
-
245
-
-
63049109925
-
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells
-
Zhu J, Davidson TS, Wei G, Jankovic D, Cui K, Schones DE, Guo L, Zhao K, Shevach EM, Paul WE (2009) Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med 206(2):329–341
-
(2009)
J Exp Med
, vol.206
, Issue.2
, pp. 329-341
-
-
Zhu, J.1
Davidson, T.S.2
Wei, G.3
Jankovic, D.4
Cui, K.5
Schones, D.E.6
Guo, L.7
Zhao, K.8
Shevach, E.M.9
Paul, W.E.10
-
246
-
-
0036284957
-
Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation
-
Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE (2002) Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16(5):733–744
-
(2002)
Immunity
, vol.16
, Issue.5
, pp. 733-744
-
-
Zhu, J.1
Guo, L.2
Min, B.3
Watson, C.J.4
Hu-Li, J.5
Young, H.A.6
Tsichlis, P.N.7
Paul, W.E.8
-
247
-
-
0035877106
-
Stat6 is necessary and sufficient for IL-4’s role in Th2 differentiation and cell expansion
-
Zhu J, Guo L, Watson CJ, Hu-Li J, Paul WE (2001) Stat6 is necessary and sufficient for IL-4’s role in Th2 differentiation and cell expansion. J Immunology 166(12):7276–7281
-
(2001)
J Immunology
, vol.166
, Issue.12
, pp. 7276-7281
-
-
Zhu, J.1
Guo, L.2
Watson, C.J.3
Hu-Li, J.4
Paul, W.E.5
-
248
-
-
33845285520
-
Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion
-
Zhu J, Jankovic D, Grinberg A, Guo L, Paul WE (2006) Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion. Proc Natl Acad Sci U.S.A 103(48):18214–18219
-
(2006)
Proc Natl Acad Sci U.S.A
, vol.103
, Issue.48
, pp. 18214-18219
-
-
Zhu, J.1
Jankovic, D.2
Grinberg, A.3
Guo, L.4
Paul, W.E.5
-
249
-
-
84867827632
-
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
-
Zhu J, Jankovic D, Oler AJ, Wei G, Sharma S, Hu G, Guo L, Yagi R, Yamane H, Punkosdy G, Feigenbaum L, Zhao K, Paul WE (2012) The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity 37(4):660–673
-
(2012)
Immunity
, vol.37
, Issue.4
, pp. 660-673
-
-
Zhu, J.1
Jankovic, D.2
Oler, A.J.3
Wei, G.4
Sharma, S.5
Hu, G.6
Guo, L.7
Yagi, R.8
Yamane, H.9
Punkosdy, G.10
Feigenbaum, L.11
Zhao, K.12
Paul, W.E.13
-
250
-
-
9244263631
-
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
-
Zhu J, Min B, Hu-Li J, Watson CJ, Grinberg A, Wang Q, Killeen N, Urban JF Jr, Guo L, Paul WE (2004) Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol 5(11):1157–1165
-
(2004)
Nat Immunol
, vol.5
, Issue.11
, pp. 1157-1165
-
-
Zhu, J.1
Min, B.2
Hu-Li, J.3
Watson, C.J.4
Grinberg, A.5
Wang, Q.6
Killeen, N.7
Urban, J.F.8
Guo, L.9
Paul, W.E.10
-
251
-
-
77952313777
-
Differentiation of effector CD4 T cell populations (*)
-
Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 28:445–489
-
(2010)
Annu Rev Immunol
, vol.28
, pp. 445-489
-
-
Zhu, J.1
Yamane, H.2
Paul, W.E.3
-
252
-
-
77149142640
-
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
-
Zotos D, Coquet JM, Zhang Y, Light A, D’Costa K, Kallies A, Corcoran LM, Godfrey DI, Toellner KM, Smyth MJ, Nutt SL, Tarlinton DM (2010) IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 207(2):365–378
-
(2010)
J Exp Med
, vol.207
, Issue.2
, pp. 365-378
-
-
Zotos, D.1
Coquet, J.M.2
Zhang, Y.3
Light, A.4
D’Costa, K.5
Kallies, A.6
Corcoran, L.M.7
Godfrey, D.I.8
Toellner, K.M.9
Smyth, M.J.10
Nutt, S.L.11
Tarlinton, D.M.12
|