Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer

Journal of Experimental Medicine

Volumn 204, Issue 8, 2007, Pages 1749-1755

  Naoe, Yoshinori ^a   Setoguchi, Ruka ^a   Akiyama, Kaori ^a,b   Muroi, Sawako ^b   Kuroda, Masahiko ^c   Hatam, Farah ^d   Littman, Dan R ^d   Taniuchi, Ichiro ^a,b  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE BINDING FACTOR BETA; DEOXYRIBONUCLEASE I; IMMUNOGLOBULIN E; INTERLEUKIN 4; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RUNX;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL SPECIFICITY; CONTROLLED STUDY; DEFENSE MECHANISM; ENZYME REPRESSION; HELPER CELL; HYPERSENSITIVITY; IMMUNOGLOBULIN BLOOD LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; TH1 CELL;

ANIMALS; ANTIGENS, CD28; ASTHMA; CCAAT-BINDING FACTOR; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 2 SUBUNIT; ENHANCER ELEMENTS (GENETICS); GENE SILENCING; IMMUNE SYSTEM; INTERLEUKIN-4; MICE; PROTEIN BINDING; T-LYMPHOCYTES; TH1 CELLS;

EID: 34547727747     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20062456     Document Type: Article

References (22)

1. Reiner, S.L., and R.M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
2. Rudikoff, D., and M. Lebwohl. 1998. Atopic dermatitis. Lancet. 351:1715-1721.
3. Szabo, S.J., S.T. Kim, G.L. Costa, X. Zhang, C.G. Fathman, and L.H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:655-669.
4. Zheng, W., and R.A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 89:587-596.
5. Kubo, M., J. Ransom, D. Webb, Y. Hashimoto, T. Tada, and T. Nakayama. 1997. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J. 16:4007-4020.
6. Lee, G.R., S.T. Kim, C.G. Spilianakis, P.E. Fields, and R.A. Flavell. 2006. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity. 24:369-379.
7. Ansel, K.M., R.J. Greenwald, S. Agarwal, C.H. Bassing, S. Monticelli, J. Interlandi, I.M. Djuretic, D.U. Lee, A.H. Sharpe, F.W. Alt, and A. Rao. 2004. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat. Immunol. 5:1251-1259.
8. Zou, Y.R., M.J. Sunshine, I. Taniuchi, F. Hatam, N. Killeen, and D.R. Littman. 2001. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat. Genet. 29:332-336.
9. Taniuchi, I., M. Osato, T. Egawa, M.J. Sunshine, S.C. Bae, T. Komori, Y. Ito, and D.R. Littman. 2002. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 111:621-633.
10. Speck, N.A. 2001. Core binding factor and its role in normal hematopoietic development. Curr. Opin. Hematol. 8:192-196.
11. Woolf, E., C. Xiao, O. Fainaru, J. Lotem, D. Rosen, V. Negreanu, Y. Bernstein, D. Goldenberg, O. Brenner, G. Berke, et al. 2003. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc. Natl. Acad. Sci. USA. 100:7731-7736.
12. + T cells into the Th2 lineage by repressing GATA3 expression. J. Exp. Med. 198:51-61.
13. Fainaru, O., E. Woolf, J. Lotem, M. Yarmus, O. Brenner, D. Goldenberg, V. Negreanu, Y. Bernstein, D. Levanon, S. Jung, and Y. Groner. 2004. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J. 23:969-979.
14. Fainaru, O., D. Shseyov, S. Hantisteanu, and Y. Groner. 2005. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc. Natl. Acad. Sci. USA. 102:10598-10603.
15. Haagerup, A., T. Bjerke, P.O. Schiotz, H.G. Binderup, R. Dahl, and T.A. Kruse. 2002. Asthma and atopy-a total genome scan for susceptibility genes. Allergy. 57:680-686.
16. Wang, Q., T. Stacy, J.D. Miller, A.F. Lewis, T.L. Gu, X. Huang, J.H. Bushweller, J.C. Bories, F.W. Alt, G. Ryan, et al. 1996. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 87:697-708.
17. Li, Q.L., K. Ito, C. Sakakura, H. Fukamachi, K. Inoue, X.Z. Chi, K.Y. Lee, S. Nomura, C.W. Lee, S.B. Han, et al. 2002. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell. 109:113-124.
18. Levanon, D., D. Bettoun, C. Harris-Cerruti, E. Woolf, V. Negreanu, R. Eilam, Y. Bernstein, D. Goldenberg, C. Xiao, M. Fliegauf, et al. 2002. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 21:3454-3463.
19. Ouyang, W., S.H. Ranganath, K. Weindel, D. Bhattacharya, T.L. Murphy, W.C. Sha, and K.M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity. 9:745-755.
20. Lee, H.J., N. Takemoto, H. Kurata, Y. Kamogawa, S. Miyatake, A. O'Garra, and N. Arai. 2000. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J. Exp. Med. 192:105-115.
21. Djuretic, I.M., D. Levanon, V. Negreanu, Y. Groner, A. Rao, and K.M. Ansel. 2007. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat. Immunol. 8:145-153.
22. Yano, T., K. Ito, H. Fukamachi, X.Z. Chi, H.J. Wee, K. Inoue, H. Ida, P. Bouillet, A. Strasser, S.C. Bae, and Y. Ito. 2006. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol. Cell. Biol. 26:4474-4488.