Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

Nature Immunology

Volumn 6, Issue 7, 2005, Pages 680-688

  Minter, Lisa M ^a   Turley, Danielle M ^b   Das, Pritam ^c   Shin, Hyun Mu ^a   Joshi, Ila ^a   Lawlor, Rebecca G ^a   Cho, Ok Hyun ^a   Palaga, Tanapat ^d   Gottipati, Sridevi ^a   Telfer, Janice C ^a   Kostura, Lisa ^c   Fauq, Abdul H ^c   Simpson, Katherine ^c   Such, Kimberly A ^a   Miele, Lucio ^e   Golde, Todd E ^c   Miller, Stephen D ^b   Osborne, Barbara A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

^d CHULALONGKORN UNIVERSITY   (Thailand)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA SECRETASE INHIBITOR; LY 411575; MEMBRANE PROTEIN; NOTCH RECEPTOR; PROTEIN TBX21; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; CELL SURFACE RECEPTOR; CYTOKINE; DNA BINDING PROTEIN; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; PROTEINASE; PROTEINASE INHIBITOR; SECRETASE; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL POLARITY; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; UPREGULATION; ALLERGIC ENCEPHALOMYELITIS; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DELAYED HYPERSENSITIVITY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; GENETICS; IMMUNOBLOTTING; IMMUNOLOGY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CYTOKINES; DNA-BINDING PROTEINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HYPERSENSITIVITY, DELAYED; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; PROTEASE INHIBITORS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; T-BOX DOMAIN PROTEINS; TH1 CELLS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 22144492615     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1209x     Document Type: Article

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