Expression of Helios in peripherally induced Foxp3 + regulatory T cells

Journal of Immunology

Volumn 188, Issue 3, 2012, Pages 976-980

  Gottschalk, Rachel A ^a,b   Corse, Emily ^a   Allison, James P ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR HELIOS; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELL KINETICS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE TRANSFER; MALE; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; FORKHEAD TRANSCRIPTION FACTORS; IKAROS TRANSCRIPTION FACTOR; MICE; MICE, TRANSGENIC; PEPTIDES; T-LYMPHOCYTES, REGULATORY; TISSUE DISTRIBUTION;

EID: 84856567623     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102964     Document Type: Article

References (28)

1. Zheng, Y., and A. Y. Rudensky. 2007. Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 8: 457-462. (Pubitemid 46605910)
2. Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono. 2008. Regulatory T cells and immune tolerance. Cell 133: 775-787. (Pubitemid 351707693)
3. + regulatory T cells: more of the same or a division of labor? Immunity 30: 626-635.
4. Josefowicz, S. Z., and A. Rudensky. 2009. Control of regulatory T cell lineage commitment and maintenance. Immunity 30: 616-625.
5. + T regulatory cells. J. Immunol. 184: 3433-3441.
6. Cobb, B. S., and S. T. Smale. 2005. Ikaros-family proteins: in search of molecular functions during lymphocyte development. Curr. Top. Microbiol. Immunol. 290: 29-47. (Pubitemid 40299559)
7. Merkenschlager, M. 2010. Ikaros in immune receptor signaling, lymphocyte differentiation, and function. FEBS Lett. 584: 4910-4914.
8. Kelley, C. M., T. Ikeda, J. Koipally, N. Avitahl, L. Wu, K. Georgopoulos, and B. A. Morgan. 1998. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 8: 508-515. (Pubitemid 28203070)
9. Hahm, K., B. S. Cobb, A. S. McCarty, K. E. Brown, C. A. Klug, R. Lee, K. Akashi, I. L. Weissman, A. G. Fisher, and S. T. Smale. 1998. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12: 782-796. (Pubitemid 28150880)
10. Sridharan, R., and S. T. Smale. 2007. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J. Biol. Chem. 282: 30227-30238. (Pubitemid 350035244)
11. Quirion, M. R., G. D. Gregory, S. E. Umetsu, S. Winandy, and M. A. Brown. 2009. Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J. Immunol. 182: 741-745.
12. Thomas, R. M., C. Chen, N. Chunder, L. Ma, J. Taylor, E. J. Pearce, and A. D. Wells. 2010. Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation. J. Biol. Chem. 285: 2545-2553.
13. + T cells. J. Immunol. 183: 5518-5525.
14. + regulatory T cells. Mol. Immunol. 47: 1595-1600.
15. + natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol. 18: 1197-1209.
16. Hill, J. A., M. Feuerer, K. Tash, S. Haxhinasto, J. Perez, R. Melamed, D. Mathis, and C. Benoist. 2007. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27: 786-800. (Pubitemid 350110546)
17. Serre, K., C. Bénézech, G. Desanti, S. Bobat, K. M. Toellner, R. Bird, S. Chan, P. Kastner, A. F. Cunningham, I. C. Maclennan, and E. Mohr. 2011. Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression. PLoS ONE 6: e20731.
18. Akimova, T., U. H. Beier, L. Wang, M. H. Levine, and W. W. Hancock. 2011. Helios expression is a marker of T cell activation and proliferation. PLoS ONE 6: e24226.
19. + T regulatory cells." J. Immunol. 185: 7129, author reply 7130.
20. Gottschalk, R. A., E. Corse, and J. P. Allison. 2010. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J. Exp. Med. 207: 1701-1711.
21. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
22. - cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J. Immunol. 172: 5213-5221.
23. Davidson, T. S., R. J. DiPaolo, J. Andersson, and E. M. Shevach. 2007. Cutting edge: IL-2 is essential for TGF-β-mediated induction of Foxp3+ T regulatory cells. J. Immunol. 178: 4022-4026. (Pubitemid 46492349)
24. Davis, M. M., J. J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien. 1998. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16: 523-544.
25. Kretschmer, K., I. Apostolou, D. Hawiger, K. Khazaie, M. C. Nussenzweig, and H. von Boehmer. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6: 1219-1227. (Pubitemid 43045633)
26. Sun, C. M., J. A. Hall, R. B. Blank, N. Bouladoux, M. Oukka, J. R. Mora, and Y. Belkaid. 2007. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204: 1775-1785. (Pubitemid 47236316)
27. + T cell receptors. Immunity 21: 267-277.
28. Hsieh, C. S., Y. Zheng, Y. Liang, J. D. Fontenot, and A. Y. Rudensky. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7: 401-410.