GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling

Nature Immunology

Volumn 14, Issue 7, 2013, Pages 714-722

  Wang, Yunqi ^a,b   Misumi, Ichiro ^b   Gu, Ai Di ^a,b   Curtis, T Anthony ^a,b   Su, Lishan ^a,b   Whitmire, Jason K ^b   Wan, Yisong Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; INTERLEUKIN 7 RECEPTOR; ONCOPROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOREGULATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TH2 CELL; VIRUS INFECTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; FLOW CYTOMETRY; GATA3 TRANSCRIPTION FACTOR; GRAFT VS HOST DISEASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 84879414890     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2623     Document Type: Article

References (48)

1. + T cells: foot soldiers of the immune system. Immunity 35, 161-168 (2011).
2. Cantrell, D. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14, 259-274 (1996). (Pubitemid 26130185)
3. Miyajima, A., Kitamura, T., Harada, N., Yokota, T. & Arai, K. Cytokine receptors and signal transduction. Annu. Rev. Immunol. 10, 295-331 (1992).
4. Zheng, W. & Flavell, R.A. The transcription factor GATA-3 is necessary and suffcient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997). (Pubitemid 27511769)
5. H2 responses. Nat. Immunol. 5, 1157-1165 (2004). (Pubitemid 39549630)
6. + T cells. Nat. Immunol. 9, 1122-1130 (2008).
7. Ting, C.N., Olson, M.C., Barton, K.P. & Leiden, J.M. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384, 474-478 (1996).
8. Pai, S.Y. et al. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19, 863-875 (2003).
9. Vosshenrich, C.A. et al. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat. Immunol. 7, 1217-1224 (2006). (Pubitemid 44594318)
10. Samson, S.I. et al. GATA-3 promotes maturation, IFN-γ production, and liver-specifc homing of NK cells. Immunity 19, 701-711 (2003). (Pubitemid 37490795)
11. Wang, Y., Su, M.A. & Wan, Y.Y. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35, 337-348 (2011).
12. + regulatory T cell fate during infammation in mice. J. Clin. Invest. 121, 4503-4515 (2011).
13. reg cells. Nature 486, 549-553 (2012).
14. Hoyler, T. et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37, 634-648 (2012).
15. Mjösberg, J. et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37, 649-659 (2012).
16. Sanda, T. et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in Human T cell acute lymphoblastic leukemia. Cancer Cell 22, 209-221 (2012).
17. van Hamburg, J.P. et al. Cooperation of Gata3, c-Myc and Notch in malignant transformation of double positive thymocytes. Mol. Immunol. 45, 3085-3095 (2008).
18. Hernández-Hoyos, G., Anderson, M.K., Wang, C., Rothenberg, E.V. & Alberola-Ila, J. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19, 83-94 (2003). (Pubitemid 36859903)
19. Guo, L. et al. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. USA 106, 13463-13468 (2009).
20. Lee, P.P. et al. A Critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763-774 (2001). (Pubitemid 34008504)
21. Amsen, D. et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27, 89-99 (2007). (Pubitemid 47096801)
22. Kieper, W.C. & Jameson, S.C. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proc. Natl. Acad. Sci. USA 96, 13306-13311 (1999).
23. + T cells in lymphopenic hosts. Immunity 11, 183-190 (1999). (Pubitemid 29428811)
24. Shapiro-Shelef, M., Lin, K.I., Savitsky, D., Liao, J. & Calame, K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J. Exp. Med. 202, 1471-1476 (2005). (Pubitemid 41746593)
25. Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1, 426-432 (2000).
26. Yamashita, M. et al. Identifcation of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J. Biol. Chem. 277, 42399-42408 (2002). (Pubitemid 35257563)
27. Murali-Krishna, K. et al. Counting antigen-specifc CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177-187 (1998). (Pubitemid 28123745)
28. Shlomchik, W.D. Graft-versus-host disease. Nat. Rev. Immunol. 7, 340-352 (2007). (Pubitemid 46674485)
29. Welniak, L.A., Blazar, B.R. & Murphy, W.J. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu. Rev. Immunol. 25, 139-170 (2007). (Pubitemid 46697905)
30. Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011).
31. Nie, Z. et al. c-Myc is a universal amplifer of expressed genes in lymphocytes and embryonic stem cells. Cell 151, 68-79 (2012).
32. Peschon, J.J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-defcient mice. J. Exp. Med. 180, 1955-1960 (1994).
33. Kerdiles, Y.M. et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat. Immunol. 10, 176-184 (2009).
34. Ouyang, W., Beckett, O., Flavell, R.A. & Li, M.O. An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 30, 358-371 (2009).
35. Kaech, S.M. et al. Selective expression of the interleukin 7 receptor identifes effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191-1198 (2003). (Pubitemid 37540688)
36. Tzachanis, D. et al. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat. Immunol. 2, 1174-1182 (2001). (Pubitemid 33130153)
37. Buckley, A.F., Kuo, C.T. & Leiden, J.M. Transcription factor LKLF is suffcient to program T cell quiescence via a c-Myc-dependent pathway. Nat. Immunol. 2, 698-704 (2001). (Pubitemid 32747158)
38. Potvin, E. et al. Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specifc contribution of GATA3. Mol. Cell. Biol. 30, 5348-5363 (2010).
39. Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9, 745-755 (1998). (Pubitemid 28557602)
40. Yu, Q. et al. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ. Nat. Immunol. 10, 992-999 (2009).
41. Amsen, D. et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117, 515-526 (2004). (Pubitemid 38610236)
42. + T cell-mediated airway hyperresponsiveness and infammation. J. Exp. Med. 205, 1087-1097 (2008). (Pubitemid 351679684)
43. + memory stem cells. Nat. Med. 15, 808-813 (2009).
44. + T cells is required for the development of protective memory responses against liver stages of malaria parasites. J. Exp. Med. 202, 551-560 (2005). (Pubitemid 41186953)
45. Ku, C.J., Hosoya, T., Maillard, I. & Engel, J.D. GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood 119, 2242-2251 (2012).
46. Liang, H.E. et al. Divergent expression patterns of IL-4 and IL-13 defne unique functions in allergic immunity. Nat. Immunol. 13, 58-66 (2012).
47. Lee, C.C., Huang, H.Y. & Chiang, B.L. Lentiviral-mediated GATA-3 RNAi decreases allergic airway infammation and hyperresponsiveness. Mol. Ther. 16, 60-65 (2008).
48. Sel, S. et al. Effective prevention and therapy of experimental allergic asthma using a GATA-3-specifc DNAzyme. J. Allergy Clin. Immunol. 121, 910-916 e915 (2008).