IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

Journal of Biological Chemistry

Volumn 282, Issue 48, 2007, Pages 34605-34610

  Wei, Lai ^a,b   Laurence, Arian ^a   Elias, Kevin M ^a,b   O'Shea, John J ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOCRINE FACTOR; CYTOKINES;

BIOCHEMISTRY; BIOSYNTHESIS; CELLS; TRANSCRIPTION FACTORS;

BIOMOLECULES;

INTERLEUKIN 17; INTERLEUKIN 21; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RORGAMMAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEOMICS; TH17 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; GENE EXPRESSION REGULATION; INTERLEUKIN-17; INTERLEUKINS; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; SPLEEN; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES;

EID: 36849036211     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705100200     Document Type: Article

References (28)

1. O'Garra, A., and Vieira, P. (2004) Nat. Med. 10, 801-805
2. Murphy, K. M., Ouyang, W., Farrar, J. D., Yang, J., Ranganath, S., Asnagli, H., Afkarian, M., and Murphy, T. L. (2000) Annu. Rev. Immunol. 18, 451-494
3. Szabo, S. J., Sullivan, B. M., Peng, S. L., and Glimcher, L. H. (2003) Annu. Rev. Immunol. 21, 713-758
4. Ansel, K. M., Djuretic, I., Tanasa, B., and Rao, A. (2006) Annu. Rev. Immunol. 24, 607-656
5. Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., and Murphy, K. M. (2006) Immunity 24, 677-688
6. Fedele, G., Stefanelli, P., Spensieri, F., Fazio, C., Mastrantonio, P., and Ausiello, C. M. (2005) Infect. Immun. 73, 1590-1597
7. Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S., and Kolls, J. K. (2005) J. Exp. Med. 202, 761-769
8. Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., and Weaver, C. T. (2006) Nature 441, 231-234
9. Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., and Cua, D. J. (2005) J. Exp. Med. 201, 233-240
10. Zheng, Y., Danilenko, D. M., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., and Ouyang, W. (2007) Nature 445, 648-651
11. Weaver, C. T., Hatton, R. D., Mangan, P. R., and Harrington, L. E. (2007) Annu. Rev. Immunol. 25, 821-852
12. Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B. M., Tato, C., Yoshimura, A., Hennighausen, L., and O'Shea, J. J. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 8137-8142
13. Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., and Dong, C. (2007) J. Biol. Chem. 282, 9358-9363
14. Ivanov, II, McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., and Littman, D. R. (2006) Cell 126, 1121-1133
15. Pfeffer, L. M., Kim, J. G., Pfeffer, S. R., Carrigan, D. J., Baker, D. P., Wei, L., and Homayouni, R. (2004) J. Biol. Chem. 279, 31304-31311
16. Zeng, R., Spolski, R., Casas, E., Zhu, W., Levy, D. E., and Leonard, W. J. (2007) Blood 109, 4135-4142
17. Kovanen, P. E., and Leonard, W. J. (2004) Immunol. Rev. 202, 67-83
18. Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., Cohen, J. I., and Spriggs, M. K. (1995) Immunity 3, 811-821
19. Kim, H. P., Korn, L. L., Gamero, A. M., and Leonard, W. J. (2005) J. Biol. Chem. 280, 25291-25297
20. Ozaki, K., Spolski, R., Feng, C. G., Qi, C. F., Cheng, J., Sher, A., Morse, H. C., 3rd, Liu, C., Schwartzberg, P. L., and Leonard, W. J. (2002) Science 298, 1630-1634
21. Ettinger, R., Sims, G. P., Fairhurst, A. M., Robbins, R., da Silva, Y. S., Spolski, R., Leonard, W. J., and Lipsky, P. E. (2005) J. Immunol. 175, 7867-7879
22. Zeng, R., Spolski, R., Finkelstein, S. E., Oh, S., Kovanen, P. E., Hinrichs, C. S., Pise-Masison, C. A., Radonovich, M. F., Brady, J. N., Restifo, N. P., Berzofsky, J. A., and Leonard, W. J. (2005) J. Exp. Med. 201, 139-148
23. Wurster, A. L., Rodgers, V. L., Satoskar, A. R., Whitters, M. J., Young, D. A., Collins, M., and Grusby, M. J. (2002) J. Exp. Med. 196, 969-977
24. Pesce, J., Kaviratne, M., Ramalingam, T. R., Thompson, R. W., Urban, J. F., Jr., Cheever, A. W., Young, D. A., Collins, M., Grusby, M. J., and Wynn, T. A. (2006) J. Clin. Investig. 116, 2044-2055
25. Frohlich, A., Marsland, B. J., Sonderegger, I., Kurrer, M., Hodge, M. R., Harris, N. L., and Kopf, M. (2007) Blood 109, 2023-2031
26. Suto, A., Wurster, A. L., Reiner, S. L., and Grusby, M. J. (2006) J. Immunol. 177, 3721-3727
27. Herber, D., Brown, T. P., Liang, S., Young, D. A., Collins, M., and Dunussi-Joannopoulos, K. (2007) J. Immunol. 178, 3822-3830
28. Young, D. A., Hegen, M., Ma, H. L., Whitters, M. J., Albert, L. M., Lowe, L., Senices, M., Wu, P. W., Sibley, B., Leathurby, Y., Brown, T. P., Nickerson-Nutter, C., Keith, J. C., Jr., and Collins, M. (2007) Arthritis Rheum. 56, 1152-1163