CD4+ regulatory T cells control TH17 responses in a stat3-dependent manner

Science

Volumn 326, Issue 5955, 2009, Pages 986-991

  Chaudhry, Ashutosh ^a,b   Rudra, Dipayan ^a,b   Treuting, Piper ^b   Samstein, Robert M ^a   Liang, Yuqiong ^a   Kas, Arnold ^b   Rudensky, Alexander Y ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ENVIRONMENTAL CUE; IMMUNITY; PATHOGENICITY; PROTEIN; RODENT;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; COLON DISEASE; CONTROLLED STUDY; ENTERITIS; FEMALE; HEPATITIS; LIPIDOSIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECTUM PROLAPSE; REGULATORY T LYMPHOCYTE; SPLENOMEGALY; TH17 CELL; WEIGHT REDUCTION;

ANIMALS; CELL LINEAGE; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; INFLAMMATORY BOWEL DISEASES; INTERFERON-GAMMA; INTERLEUKIN-17; INTESTINE, LARGE; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; RECEPTORS, CCR6; SPLEEN; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 70049113279     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1172702     Document Type: Article

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29. fl/fl mice; and J. Renauld for antibody to IL-22. This work was supported by NIH grants AI-061816 and AI-034206. A.C. is supported by the Cancer Research Institute, and D.R. is supported by the Arthritis Foundation. A.Y.R. is an investigator with the Howard Hughes Medical Institute. Gene expression microarray data have been deposited in the NCBI Gene Expression Omnibus repository with the accession code GSE17962.