Notch1 augments NF-κB activity by facilitating its nuclear retention

EMBO Journal

Volumn 25, Issue 1, 2006, Pages 129-138

  Hyun, Mu Shin ^a   Minter, Lisa M ^a   Ok, Hyun Cho ^a   Gottipati, Sridevi ^a   Fauq, Abdul H ^b   Golde, Todd E ^b   Sonenshein, Gail E ^c   Osborne, Barbara A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b MAYO CLINIC   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

I B ; Interferon ; NF B; Notch1

Indexed keywords

CELL PROTEIN; GAMMA INTERFERON; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH1 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CHEMICAL ANALYSIS; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES; ANTIGENS, CD28; ANTIGENS, CD3; CELL NUCLEUS; CYTOSOL; GENE EXPRESSION REGULATION; I-KAPPA B PROTEINS; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-REL; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES;

ANIMALIA;

EID: 30444450802     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600902     Document Type: Article

References (47)

1. Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS (2003) Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol 171: 2896-2903
2. Aguilera C, Hoya-Arias R, Haegeman G, Espinosa L, Bigas A (2004) Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Proc Natl Acad Sci USA 101: 16537-16542
3. Arenzana-Seisdedos F, Turpin P, Rodriguez M, Thomas D, Hay RT, Virelizier JL, Dargemont C (1997) Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm. J Cell Sci 110: 369-378
4. Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284 :770-776
5. Artis D, Speirs K, Joyce K, Goldschmidt M, Caamano J, Hunter CA, Scott P (2003) NF-kappa B1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania major. J Immunol 170: 1995-2003
6. Bash J, Zong WX, Banga S, Rivera A, Ballard DW, Ron Y, Gelinas C (1999) Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J 18: 2803-2811
7. Beinke S, Ley SC (2004) Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 382: 393-409
8. Bellavia D, Campese AF, Alesse E, Vacca A, Felli MP, Balestri A, Stoppacciaro A, Tiveron C, Tatangelo L, Giovarelli M, Gaetano C, Ruco L, Hoffman ES, Hayday AC, Lendahl U, Frati L, Gulino A, Screpanti I (2000) Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J 19: 3337-3348
9. Beverly LJ, Capobianco AJ (2004) Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost. Trends Mol Med 10: 591-598
10. Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (1993) The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 72: 729-739
11. Caamano J, Hunter CA (2002) NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions. Clin Microbiol Rev 15: 414-429
12. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM (1997) Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol 17: 6265-6273
13. Cheng P, Zlobin A, Volgina V, Gottipati S, Osborne B, Simel EJ, Miele L, Gabrilovich DI (2001) Notch-1 regulates NF-kappa B activity in hemopoietic progenitor cells. J Immunol 167: 4458-4467
14. Cross SL, Halden NF, Lenardo MJ, Leonard WJ (1989) Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes. Science 244: 466-469
15. Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE (2005) Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 24: 6333-6344
16. Espinosa L, Ingles-Esteve J, Robert-Moreno A, Bigas A (2003) IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways. Mol Biol Cell 14: 491-502
17. Ferreira V, Sidenius N, Tarantino N, Hubert P, Chatenoud L, Blasi F, Korner M (1999) In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J Immunol 162: 6442-6450
18. Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D (1993) The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 7: 1354-1363
19. Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck JY, Grumont RJ (1996) Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA 93: 3405-3409
20. Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl): S81-S96
21. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T (1996) T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J Exp Med 183: 2025-2032
22. Himes SR, Coles LS, Reeves R, Shannon MF (1996) High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. Immunity 5: 479-489
23. Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298: 1241-1245
24. Jeffries S, Capobianco AJ (2000) Neoplastic transformation by Notch requires nuclear localization. Mol Cell Biol 20: 3928-3941
25. Kane LP, Lin J, Weiss A (2002) It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. Trends Immunol 23: 413-420
26. Lee H, Arsura M, Wu M, Duyao M, Buckler AJ, Sonenshein GE (1995) Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J Exp Med 181: 1169-1177
27. Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2: 725-734
28. Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA (2005) Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol 6: 680-688
29. Mizutani T, Taniguchi Y, Aoki T, Hashimoto N, Honjo T (2001) Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. Proc Natl Acad Sci USA 98: 9026-9031
30. Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MR (2004) Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science 306: 704-708
31. Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA (2003) Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J Biol Chem 278: 24359-24370
32. Oswald F, Liptay S, Adler G, Schmid RM (1998) NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol 18: 2077-2088
33. Palaga T, Miele L, Golde TE, Osborne BA (2003) TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol 171: 3019-3024
34. Penix LA, Sweetser MT, Weaver WM, Hoeffler JP, Kerppola TK, Wilson CB (1996) The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. J Biol Chem 271: 31964-31972
35. Qin JZ, Chaturvedi V, Denning MF, Choubey D, Diaz MO, Nickoloff BJ (1999) Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes. J Biol Chem 274: 37957-37964
36. Rayet B, Gelinas C (1999) Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938-6947
37. Robey EA, Bluestone JA (2004) Notch signaling in lymphocyte development and function. Curr Opin Immunol 16: 360-366
38. Rodriguez MS, Thompson J, Hay RT, Dargemont C (1999) Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem 274: 9108-9115
39. Schmitz ML, Bacher S, Dienz O (2003) NF-kappaB activation pathways induced by T cell costimulation. FASEB J 17: 2187-2193
40. Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393: 382-386
41. Schwartz RH (1997) T cell clonal anergy. Curr Opin Immunol 9: 351-357
42. Sica A, Dorman L, Viggiano V, Cippitelli M, Ghosh P, Rice N, Young HA (1997) Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 272: 30412-30420
43. Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E (2001) Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain. J Immunol 167: 289-295
44. Weng AP, Ferrando AA, Lee W, Morris IV JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306: 269-271
45. Zheng Y, Ouaaz F, Bruzzo P, Singh V, Gerondakis S, Beg AA (2001) NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death. J Immunol 166: 4949-4957
46. Zheng Y, Vig M, Lyons J, Van Parijs L, Beg AA (2003) Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J Exp Med 197: 861-874
47. Zhou XY, Yashiro-Ohtani Y, Nakahira M, Park WR, Abe R, Hamaoka T, Naramura M, Gu H, Fujiwara H (2002) Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation. J Immunol 168: 3847-3854