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Volumn 112, Issue 5, 2008, Pages 1813-1821

Notchi and TGF21 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GAMMA SECRETASE INHIBITOR; NOTCH1 RECEPTOR; PROTEIN CSL; SMAD PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ALANINE; AZEPINE DERIVATIVE; DRUG DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MUSCLE PROTEIN; N2 ((2S) 2 (3,5 DIFLUOROPHENYL) 2 HYDROXYETHANOYL) N1 ((7S) 5 METHYL 6 OXO 6,7 DIHYDRO 5H DIBENZO(B,D)AZEPIN 7 YL) L ALANINAMIDE; N2-((2S)-2-(3,5-DIFLUOROPHENYL)-2-HYDROXYETHANOYL)-N1-((7S)-5-METHYL-6-OXO-6,7-DIHYDRO-5H-DIBENZO(B,D)AZEPIN-7-YL)-L-ALANINAMIDE; NOTCH1 PROTEIN, MOUSE; PRIMER DNA; PROTEINASE INHIBITOR; SECRETASE; SMPX PROTEIN, MOUSE;

EID: 52649179291     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-03-144980     Document Type: Article
Times cited : (168)

References (51)
  • 1
    • 33845894709 scopus 로고    scopus 로고
    • Notch signalling during peripheral T-cell activation and differentiation
    • Osborne BA. Minter LM. Notch signalling during peripheral T-cell activation and differentiation. Nat Rev Immunol. 2007;7:64-75.
    • (2007) Nat Rev Immunol , vol.7 , pp. 64-75
    • Osborne, B.A.1    Minter, L.M.2
  • 2
    • 33847021476 scopus 로고    scopus 로고
    • Presenilin diversifies its portfolio
    • Parks AL, Curtis D. Presenilin diversifies its portfolio. Trends Genet. 2007;23:140-150.
    • (2007) Trends Genet , vol.23 , pp. 140-150
    • Parks, A.L.1    Curtis, D.2
  • 3
    • 33644695239 scopus 로고    scopus 로고
    • Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: New insights, questions, and opportunities
    • Aster JG. Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities. Int J Hematol. 2005;82:295-301.
    • (2005) Int J Hematol , vol.82 , pp. 295-301
    • Aster, J.G.1
  • 4
    • 33645013015 scopus 로고    scopus 로고
    • Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease
    • Siemers ER, Quinn JF. Kaye J. et al. Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease. Neurology. 2006;66:602-604.
    • (2006) Neurology , vol.66 , pp. 602-604
    • Siemers, E.R.1    Quinn, J.F.2    Kaye, J.3
  • 5
    • 34447634411 scopus 로고    scopus 로고
    • Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    • Amsen D, Antov A, Jankovic D, et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 2007;27:89-99.
    • (2007) Immunity , vol.27 , pp. 89-99
    • Amsen, D.1    Antov, A.2    Jankovic, D.3
  • 7
    • 22144492615 scopus 로고    scopus 로고
    • Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
    • Minter LM, Turley DM, Das P, et al. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol. 2005;6:680-688.
    • (2005) Nat Immunol , vol.6 , pp. 680-688
    • Minter, L.M.1    Turley, D.M.2    Das, P.3
  • 8
    • 10744222828 scopus 로고    scopus 로고
    • expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
    • Anastasi E, CampeseAF, Bellavia D, et al. expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol. 2003;171:4504-4511.
    • (2003) J Immunol , vol.171 , pp. 4504-4511
    • Anastasi, E.1    Campese, A.F.2    Bellavia, D.3
  • 9
    • 0141566334 scopus 로고    scopus 로고
    • Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes
    • Vigouroux S, Yvon E, Wagner HJ, et al. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol. 2003;77:10872-10880.
    • (2003) J Virol , vol.77 , pp. 10872-10880
    • Vigouroux, S.1    Yvon, E.2    Wagner, H.J.3
  • 10
    • 0242493801 scopus 로고    scopus 로고
    • Over-expression of the Notch ligand, Jagged-1. induces alloantigen-specific human regulatory Tcells
    • Yvon ES. Vigouroux S. Rousseau RF. et al. Over-expression of the Notch ligand, Jagged-1. induces alloantigen-specific human regulatory Tcells. Blood. 2003;102:3815-3821.
    • (2003) Blood , vol.102 , pp. 3815-3821
    • Yvon, E.S.1    Vigouroux, S.2    Rousseau, R.F.3
  • 11
    • 33846250032 scopus 로고    scopus 로고
    • Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
    • Kared H, Adle-Biassette H, Fois E, et al. Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity. 2006;25: 823-834.
    • (2006) Immunity , vol.25 , pp. 823-834
    • Kared, H.1    Adle-Biassette, H.2    Fois, E.3
  • 12
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T. Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 13
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive Tcells to CD4+CD25+ regulatory Tcells byTGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, etal. Conversion of peripheral CD4+CD25-naive Tcells to CD4+CD25+ regulatory Tcells byTGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 14
    • 4744356110 scopus 로고    scopus 로고
    • YoppAC, etal. TGF-beta induces Foxp3 + T-regulatory cells from CD4+ CD25-precursors
    • Fu S. Zhang N. YoppAC, etal. TGF-beta induces Foxp3 + T-regulatory cells from CD4+ CD25-precursors. Am JTransplant. 2004:4:1614-1627.
    • (2004) Am JTransplant , vol.4 , pp. 1614-1627
    • Fu, S.1    Zhang, N.2
  • 15
    • 12444279957 scopus 로고    scopus 로고
    • Differentiation and expansion of Tcells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}
    • Rao PE, PetroneAL, Ponath PD. Differentiation and expansion of Tcells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. J Immunol. 2005;174:1446-1455.
    • (2005) J Immunol , vol.174 , pp. 1446-1455
    • Rao, P.E.1    Petrone, A.L.2    Ponath, P.D.3
  • 16
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory Tcell-dependent and -independent mechanisms
    • Li MO. Sanjabi S, Flavell RA. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory Tcell-dependent and -independent mechanisms. Immunity. 2006;25:455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 17
    • 17144400393 scopus 로고    scopus 로고
    • TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory Tcells
    • Marie JC, Letterio JJ, Gavin M, RudenskyAY. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory Tcells. J Exp Med. 2005;201:1061-1067.
    • (2005) J Exp Med , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    RudenskyAY4
  • 18
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factorbeta 1 gene results in multifocal inflammatory disease
    • Shull MM, Ormsby I, KierAB, et al. Targeted disruption of the mouse transforming growth factorbeta 1 gene results in multifocal inflammatory disease. Nature. 1992;359:693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    KierAB3
  • 19
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory Tcells induces a scurfy-like disease
    • Lahl K, LoddenkemperC, Drouin C, et al. Selective depletion of Foxp3+ regulatory Tcells induces a scurfy-like disease. J Exp Med. 2007; 204:57-63.
    • (2007) J Exp Med , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3
  • 20
    • 34347364684 scopus 로고    scopus 로고
    • Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice
    • Sharma R, Jarjour WN, Zheng L Gaskin F, Fu SM. Ju ST. Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice. J Autoimmun. 2007;29:10-19.
    • (2007) J Autoimmun , vol.29 , pp. 10-19
    • Sharma, R.1    Jarjour, W.N.2    Zheng, L.3    Gaskin, F.4    Fu, S.M.5    Ju, S.T.6
  • 21
    • 0345166971 scopus 로고    scopus 로고
    • Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
    • Blokzijl A, Dahlqvist C, Reissmann E, et al. Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol. 2003;163:723-728.
    • (2003) J Cell Biol , vol.163 , pp. 723-728
    • Blokzijl, A.1    Dahlqvist, C.2    Reissmann, E.3
  • 22
    • 24044513994 scopus 로고    scopus 로고
    • Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling
    • Sun Y, Lowther W, Kato K, et al. Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. Oncogene. 2005;24: 5365-5374.
    • (2005) Oncogene , vol.24 , pp. 5365-5374
    • Sun, Y.1    Lowther, W.2    Kato, K.3
  • 23
    • 0035887655 scopus 로고    scopus 로고
    • VolginaV, etal. Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells
    • Cheng P, Zlobin A. VolginaV, etal. Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol. 2001;167:4458-4467.
    • (2001) J Immunol , vol.167 , pp. 4458-4467
    • Cheng, P.1    Zlobin, A.2
  • 24
    • 31044448265 scopus 로고    scopus 로고
    • Characterization of SIS3. a novel specific inhibitor of Smad3. and its effect on transforming growth factor-beta1-induced extracellular matrix expression
    • Jinnin M, Ihn H, Tamaki K. Characterization of SIS3. a novel specific inhibitor of Smad3. and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006;69:597-607.
    • (2006) Mol Pharmacol , vol.69 , pp. 597-607
    • Jinnin, M.1    Ihn, H.2    Tamaki, K.3
  • 25
    • 38349095578 scopus 로고    scopus 로고
    • Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    • Tone Y, Furuuchi K, Kojima Y, Tykocinski ML. Greene Ml, Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol. 2008;9:194-202.
    • (2008) Nat Immunol , vol.9 , pp. 194-202
    • Tone, Y.1    Furuuchi, K.2    Kojima, Y.3    Tykocinski, M.L.4    Ml, G.5    Tone, M.6
  • 26
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential forTGF-beta to convert naive CD4+CD25-cells to CD25 + Foxp3+ regulatory Tcells and for expansion of these cells
    • Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential forTGF-beta to convert naive CD4+CD25-cells to CD25 + Foxp3+ regulatory Tcells and for expansion of these cells. J Immunol. 2007;178:2018-2027.
    • (2007) J Immunol , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 27
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill JA, Feuerer M, Tash K, et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity. 2007;27:786-800.
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3
  • 28
    • 33748460087 scopus 로고    scopus 로고
    • Foxp3-dependent and -independent molecules specific for CD25 + CD4+ natural regulatory Tcells revealed by DNA microarray analysis
    • Sugimoto N, Oida T. Hirota K, et al. Foxp3-dependent and -independent molecules specific for CD25 + CD4+ natural regulatory Tcells revealed by DNA microarray analysis. Int Immunol. 2006;18:1197-1209.
    • (2006) Int Immunol , vol.18 , pp. 1197-1209
    • Sugimoto, N.1    Oida, T.2    Hirota, K.3
  • 29
    • 33644844341 scopus 로고    scopus 로고
    • Molecular mechanisms underlying FOXP3 induction in human Tcells
    • Mantel PY, Ouaked N. Ruckert B, et al. Molecular mechanisms underlying FOXP3 induction in human Tcells. J Immunol. 2006;176:3593-3602.
    • (2006) J Immunol , vol.176 , pp. 3593-3602
    • Mantel, P.Y.1    Ouaked, N.2    Ruckert, B.3
  • 30
    • 33846258832 scopus 로고    scopus 로고
    • Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
    • Schouwey K, Delmas V, Lame L, et al. Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev Dyn. 2007;236:282-289.
    • (2007) Dev Dyn , vol.236 , pp. 282-289
    • Schouwey, K.1    Delmas, V.2    Lame, L.3
  • 31
    • 33748296240 scopus 로고    scopus 로고
    • Human CD4+ CD25hi Foxp3+ regulatory Tcells are derived by rapid turnover of memory populations in vivo
    • Vukmanovic-Stejic M, Zhang Y, Cook JE, et al. Human CD4+ CD25hi Foxp3+ regulatory Tcells are derived by rapid turnover of memory populations in vivo. J Clin Invest. 2006;116:2423-2433.
    • (2006) J Clin Invest , vol.116 , pp. 2423-2433
    • Vukmanovic-Stejic, M.1    Zhang, Y.2    Cook, J.E.3
  • 32
    • 33847237223 scopus 로고    scopus 로고
    • The dynamic co-evolution of memory and regulatory CD4+ Tcells in the periphery
    • Akbar AN. Vukmanovic-Stejic M. Taams LS. Macallan DC. The dynamic co-evolution of memory and regulatory CD4+ Tcells in the periphery. Nat Rev Immunol. 2007;7:231-237.
    • (2007) Nat Rev Immunol , vol.7 , pp. 231-237
    • Akbar, A.N.1    Vukmanovic-Stejic, M.2    Taams, L.S.3    Macallan, D.C.4
  • 33
    • 4444246433 scopus 로고    scopus 로고
    • Coordinated activation of notch. Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis: Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity
    • Zamurovic N, Cappellen D, Rohner D, Susa M. Coordinated activation of notch. Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis: notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J Biol Chem. 2004;279:37704-37715.
    • (2004) J Biol Chem , vol.279 , pp. 37704-37715
    • Zamurovic, N.1    Cappellen, D.2    Rohner, D.3    Susa, M.4
  • 34
    • 33745099879 scopus 로고    scopus 로고
    • The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
    • Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T. The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol. 2006;294:458-470.
    • (2006) Dev Biol , vol.294 , pp. 458-470
    • Seo, S.1    Fujita, H.2    Nakano, A.3    Kang, M.4    Duarte, A.5    Kume, T.6
  • 36
    • 34848838902 scopus 로고    scopus 로고
    • A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    • Kitamura T, Kitamura Yl, Funahashi Y, et al. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest. 2007;117:2477-2485.
    • (2007) J Clin Invest , vol.117 , pp. 2477-2485
    • Kitamura, T.1    Kitamura, Y.2    Funahashi, Y.3
  • 37
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. 2004;117:211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 39
    • 33645506145 scopus 로고    scopus 로고
    • Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta
    • Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A. Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. J Clin Invest. 2006;116:996-1004.
    • (2006) J Clin Invest , vol.116 , pp. 996-1004
    • Ostroukhova, M.1    Qi, Z.2    Oriss, T.B.3    Dixon-McCarthy, B.4    Ray, P.5    Ray, A.6
  • 40
    • 0034775446 scopus 로고    scopus 로고
    • Oswald F, Tauber B. DobnerT et al. p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol. 2001;21:7761-7774.
    • Oswald F, Tauber B. DobnerT et al. p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol. 2001;21:7761-7774.
  • 41
    • 0031773264 scopus 로고    scopus 로고
    • TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
    • Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP. Wang XF. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol Biol Cell. 1998; 9:3309-3319.
    • (1998) Mol Biol Cell , vol.9 , pp. 3309-3319
    • Shen, X.1    Hu, P.P.2    Liberati, N.T.3    Datto, M.B.4    Frederick, J.P.5    Wang, X.F.6
  • 42
    • 0141940255 scopus 로고    scopus 로고
    • Enhanced gene activation by Notch and BMP signaling cross-talk
    • Takizawa T, Ochiai W, Nakashima K, Taga T Enhanced gene activation by Notch and BMP signaling cross-talk. Nucleic Acids Res. 2003;31: 5723-5731.
    • (2003) Nucleic Acids Res , vol.31 , pp. 5723-5731
    • Takizawa, T.1    Ochiai, W.2    Nakashima, K.3    Taga, T.4
  • 43
    • 34249886282 scopus 로고    scopus 로고
    • Notch activation stimulates transient and selective binding of Su(H)/CSLto target enhancers
    • Krejcf A, Bray S. Notch activation stimulates transient and selective binding of Su(H)/CSLto target enhancers. Genes Dev. 2007;21:1322-1327.
    • (2007) Genes Dev , vol.21 , pp. 1322-1327
    • Krejcf, A.1    Bray, S.2
  • 44
    • 4544357207 scopus 로고    scopus 로고
    • TGF-beta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo
    • Schramm C, Huber S, Protschka M, et al. TGF-beta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. Int Immunol. 2004;16:1241-1249.
    • (2004) Int Immunol , vol.16 , pp. 1241-1249
    • Schramm, C.1    Huber, S.2    Protschka, M.3
  • 45
    • 0026043866 scopus 로고
    • Fatal lymphoreticular disease in the scurfy (sf) mouse requires Tcells that mature in a sf thymic environment: Potential model for thymic education
    • Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB. Fatal lymphoreticular disease in the scurfy (sf) mouse requires Tcells that mature in a sf thymic environment: potential model for thymic education. Proc Natl Acad Sci U S A. 1991;88:5528-5532.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 5528-5532
    • Godfrey, V.L.1    Wilkinson, J.E.2    Rinchik, E.M.3    Russell, L.B.4
  • 46
    • 3242713169 scopus 로고    scopus 로고
    • Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
    • Tournoy J, Bossuyt X, Snellinx A. et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Hum Mol Genet. 2004;13:1321-1331.
    • (2004) Hum Mol Genet , vol.13 , pp. 1321-1331
    • Tournoy, J.1    Bossuyt, X.2    Snellinx, A.3
  • 48
    • 6344288772 scopus 로고    scopus 로고
    • Serum level of transforming growth factor-beta1 (TGF-beta1) and the expression of TGF-beta receptor type II in peripheral blood mononuclear cells in patients with autoimmune hepatitis
    • Sakaguchi K, Kitano M, Nishimura M, et al. Serum level of transforming growth factor-beta1 (TGF-beta1) and the expression of TGF-beta receptor type II in peripheral blood mononuclear cells in patients with autoimmune hepatitis. Hepatogastroenterology. 2004;51:1780-1783.
    • (2004) Hepatogastroenterology , vol.51 , pp. 1780-1783
    • Sakaguchi, K.1    Kitano, M.2    Nishimura, M.3
  • 49
    • 0037370898 scopus 로고    scopus 로고
    • Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice
    • Schramm C, Protschka M, Kohler HH, et al. Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2003;284:G525-G535.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Schramm, C.1    Protschka, M.2    Kohler, H.H.3
  • 50
    • 33646052605 scopus 로고    scopus 로고
    • Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis
    • Longhi MS, Hussain MJ, Mitry RR, et al. Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis. J Immunol. 2006;176:4484-4491.
    • (2006) J Immunol , vol.176 , pp. 4484-4491
    • Longhi, M.S.1    Hussain, M.J.2    Mitry, R.R.3
  • 51
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature. 2007;445:766-770.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2


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