Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages (DOI:10.1016/j.immuni.2008.05.009);Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

Immunity

Volumn 29, Issue 1, 2008, Pages 138-149

  Nurieva, Roza I ^a   Chung, Yeonseok ^a   Hwang, Daehee ^b   Yang, Xuexian O ^a   Kang, Hong Soon ^c   Ma, Li ^d   Wang, Yi hong ^a   Watowich, Stephanie S ^a   Jetten, Anton M ^c   Tian, Qiang ^d   Dong, Chen ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

INTERLEUKIN 21; NUCLEAR RECEPTOR NUR77; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CONTROLLED STUDY; GENE EXPRESSION; HELPER CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 46749151286     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.07.010     Document Type: Erratum

References (43)

1. Akiba H., Takeda K., Kojima Y., Usui Y., Harada N., Yamazaki T., Ma J., Tezuka K., Yagita H., and Okumura K. The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo. J. Immunol. 175 (2005) 2340-2348
2. Akimzhanov A.M., Yang X.O., and Dong C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282 (2007) 5969-5972
3. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
4. Bossaller L., Burger J., Draeger R., Grimbacher B., Knoth R., Plebani A., Durandy A., Baumann U., Schlesier M., Welcher A.A., et al. ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J. Immunol. 177 (2006) 4927-4932
5. Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., Lipp M., and Forster R. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192 (2000) 1545-1552
6. Bryant V.L., Ma C.S., Avery D.T., Li Y., Good K.L., Corcoran L.M., de Waal Malefyt R., and Tangye S.G. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol. 179 (2007) 8180-8190
7. Chtanova T., Tangye S.G., Newton R., Frank N., Hodge M.R., Rolph M.S., and Mackay C.R. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173 (2004) 68-78
8. Chung Y., Yang X., Chang S.H., Ma L., Tian Q., and Dong C. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 16 (2006) 902-907
9. Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8 (2008) 337-348
10. Dong C., and Flavell R.A. Cell fate decision: T-helper 1 and 2 subsets in immune responses. Arthritis Res. 2 (2000) 179-188
11. Dong C., and Nurieva R.I. Regulation of immune and autoimmune responses by ICOS. J. Autoimmun. 21 (2003) 255-260
12. Ebert L.M., Horn M.P., Lang A.B., and Moser B. B cells alter the phenotype and function of follicular-homing CXCR5+ T cells. Eur. J. Immunol. 34 (2004) 3562-3571
13. Haynes N.M., Allen C.D.C., Lesley R., Ansel K.M., Killeen N., and Cyster J.G. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 179 (2007) 5099-5108
14. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
15. Junt T., Fink K., Forster R., Senn B., Lipp M., Muramatsu M., Zinkernagel R.M., Ludewig B., and Hengartner H. CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. J. Immunol 175 (2005) 7109-7116
16. Kim C.H., Rott L.S., Clark-Lewis I., Campbell D.J., Wu L., and Butcher E.C. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J. Exp. Med. 193 (2001) 1373-1381
17. Kim C.H., Lim H.W., Kim J.R., Rott L., Hillsamer P., and Butcher E.C. Unique gene expression program of human germinal center T helper cells. Blood 104 (2004) 1952-1960
18. Kim H.-P., Korn L.L., Gamero A.M., and Leonard W.J. Calcium-dependent activation of interleukin-21 gene expression in T cells. J. Biol. Chem. 280 (2005) 25291-25297
19. Kopf M., Herren S., Wiles M.V., Pepys M.B., and Kosco-Vilbois M.H. Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J. Exp. Med. 188 (1998) 1895-1906
20. Korn T., Bettelli E., Gao W., Awasthi A., Jager A., Strom T.B., Oukka M., and Kuchroo V.K. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448 (2007) 484-487
21. Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., Blank R.B., Meylan F., Siegel R., Hennighausen L., et al. Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation. Immunity 26 (2007) 371-381
22. Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., Perez-Melgosa M., Sweetser M.T., Schlissel M.S., Nguyen S., et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15 (2001) 763-774
23. Mangan P.R., Harrington L.E., O'Quinn D.B., Helms W.S., Bullard D.C., Elson C.O., Hatton R.D., Wahl S.M., Schoeb T.R., and Weaver C.T. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441 (2006) 231-234
24. Nurieva R.I., Duong J., Kishikawa H., Dianzani U., Rojo J.M., Ho I., Flavell R.A., and Dong C. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity 18 (2003) 801-811
25. Nurieva R.I., Mai X.M., Forbush K., Bevan M.J., and Dong C. B7h is required for T cell activation, differentiation, and effector function. Proc. Natl. Acad. Sci. USA 100 (2003) 14163-14168
26. Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., Schluns K., Tian Q., Watowich S.S., Jetten A.M., and Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 (2007) 480-483
27. Nurieva R.I., Chuvpilo S., Wieder E.D., Elkon K.B., Locksley R., Serfling E., and Dong C. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J. Immunol. 179 (2007) 1096-1103
28. Rickert R.C., Rajewsky K., and Roes J. Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice. Nature 376 (1995) 352-355
29. Schaerli P., Willimann K., Lang A.B., Lipp M., Loetscher P., and Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192 (2000) 1553-1562
30. Spolski R., and Leonard W.J. Interleukin-21: Basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26 (2008) 57-79
31. Storey J.D., and Tibshirani R. Estimating the Positive False Discovery Rate Under Dependence, with Applications to DNA Microarrays, Volume 2001 (2001), Department of Statistics, Stanford University, Stanford, CA
32. Takeda K., Clausen B.E., Kaisho T., Tsujimura T., Terada N., Forster I., and Akira S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10 (1999) 39-49
33. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
34. Veldhoen M., Hocking R.J., Flavell R.A., and Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7 (2006) 1151-1156
35. Vinuesa C.G., Cook M.C., Angelucci C., Athanasopoulos V., Rui L., Hill K.M., Yu D., Domaschenz H., Whittle B., Lambe T., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435 (2005) 452-458
36. Vinuesa C.G., Tangye S.G., Moser B., and Mackay C.R. Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 5 (2005) 853-865
37. Wang D., Long J., Dai F., Liang M., Feng X.-H., and Lin X. BCL6 represses Smad signaling in transforming growth factor-B resistance. Cancer Res. 68 (2008) 783-789
38. Yang X.O., Panopoulos A.D., Nurieva R., Chang S.H., Wang D., Watowich S.S., and Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282 (2007) 9358-9363
39. Yang X.O., Chang S.H., Park H., Nurieva R., Shah B., Acero L., Wang Y.H., Schluns K.S., Broaddus R.R., Zhu Z., and Dong C. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205 (2008) 1063-1075
40. Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR[alpha] and ROR. Immunity 28 (2008) 29-39
41. Yu D., Tan A.H., Hu X., Athanasopoulos V., Simpson N., Silva D.G., Hutloff A., Giles K.M., Leedman P.J., Lam K.P., et al. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 450 (2007) 299-303
42. Wu Z., Irizarry R.A., Gentleman R., Martinez-Murillo F., and Spencer F. A model-based background adjustment for oligonucleotide expression arrays. J. Am. Stat. Assoc. 99 (2004) 909-917
43. Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., Levy D.E., Leonard W.J., and Littman D.R. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8 (2007) 967-974