-
2
-
-
77954948735
-
Effector T cell plasticity: Flexibility in the face of changing circumstances
-
Murphy, K.M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11, 674-680 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 674-680
-
-
Murphy, K.M.1
Stockinger, B.2
-
4
-
-
33646122005
-
T helper cell effector fates-who, how and where?
-
Reinhardt, R.L., Kang, S.J., Liang, H.E. & Locksley, R.M. T helper cell effector fates-who, how and where? Curr. Opin. Immunol. 18, 271-277 (2006).
-
(2006)
Curr. Opin. Immunol.
, vol.18
, pp. 271-277
-
-
Reinhardt, R.L.1
Kang, S.J.2
Liang, H.E.3
Locksley, R.M.4
-
6
-
-
77952313777
-
Differentiation of effector CD4 T cell populations
-
Zhu, J., Yamane, H. & Paul, W.E. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 28, 445-489 (2010).
-
(2010)
Annu. Rev. Immunol.
, vol.28
, pp. 445-489
-
-
Zhu, J.1
Yamane, H.2
Paul, W.E.3
-
7
-
-
33745699554
-
The T-box transcription factor T-bet in immunity and autoimmunity
-
Peng, S.L. The T-box transcription factor T-bet in immunity and autoimmunity. Cell Mol. Immunol. 3, 87-95 (2006).
-
(2006)
Cell Mol. Immunol.
, vol.3
, pp. 87-95
-
-
Peng, S.L.1
-
9
-
-
33748588423
-
+ T helper cells
-
+ T helper cells. Cell 126, 1121-1133 (2006).
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
-
10
-
-
69249109601
-
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
-
Johnston, R.J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006-1010 (2009).
-
(2009)
Science
, vol.325
, pp. 1006-1010
-
-
Johnston, R.J.1
-
11
-
-
69249101229
-
Bcl6 mediates the development of T follicular helper cells
-
Nurieva, R.I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
-
(2009)
Science
, vol.325
, pp. 1001-1005
-
-
Nurieva, R.I.1
-
12
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655-669 (2000).
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
-
13
-
-
70049101558
-
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
-
Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457-468 (2009).
-
(2009)
Immunity
, vol.31
, pp. 457-468
-
-
Yu, D.1
-
14
-
-
0030810155
-
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
-
Zheng, W. & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
-
(1997)
Cell
, vol.89
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
15
-
-
33646805064
-
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects
-
Beima, K.M. et al. T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J. Biol. Chem. 281, 11992-12000 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 11992-12000
-
-
Beima, K.M.1
-
16
-
-
33846489173
-
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
-
Djuretic, I.M. et al. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat. Immunol. 8, 145-153 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 145-153
-
-
Djuretic, I.M.1
-
17
-
-
37549032110
-
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain
-
Lewis, M.D., Miller, S.A., Miazgowicz, M.M., Beima, K.M. & Weinmann, A.S. T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol. Cell. Biol. 27, 8510-8521 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8510-8521
-
-
Lewis, M.D.1
Miller, S.A.2
Miazgowicz, M.M.3
Beima, K.M.4
Weinmann, A.S.5
-
18
-
-
55749090506
-
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression
-
Miller, S.A., Huang, A.C., Miazgowicz, M.M., Brassil, M.M. & Weinmann, A.S. Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev. 22, 2980-2993 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 2980-2993
-
-
Miller, S.A.1
Huang, A.C.2
Miazgowicz, M.M.3
Brassil, M.M.4
Weinmann, A.S.5
-
19
-
-
78649263390
-
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression
-
Miller, S.A., Mohn, S.E. & Weinmann, A.S. Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol. Cell 40, 594-605 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 594-605
-
-
Miller, S.A.1
Mohn, S.E.2
Weinmann, A.S.3
-
20
-
-
0037059462
-
Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
-
Szabo, S.J. et al. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295, 338-342 (2002).
-
(2002)
Science
, vol.295
, pp. 338-342
-
-
Szabo, S.J.1
-
21
-
-
12344269852
-
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
-
Hwang, E.S., Szabo, S.J., Schwartzberg, P.L. & Glimcher, L.H. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307, 430-433 (2005).
-
(2005)
Science
, vol.307
, pp. 430-433
-
-
Hwang, E.S.1
Szabo, S.J.2
Schwartzberg, P.L.3
Glimcher, L.H.4
-
22
-
-
78650306567
-
T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt
-
Lazarevic, V. et al. T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat. Immunol. 12, 96-104 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 96-104
-
-
Lazarevic, V.1
-
23
-
-
13844319581
-
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
-
Mehta, D.S., Wurster, A.L., Weinmann, A.S. & Grusby, M.J. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc. Natl. Acad. Sci. USA 102, 2016-2021 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2016-2021
-
-
Mehta, D.S.1
Wurster, A.L.2
Weinmann, A.S.3
Grusby, M.J.4
-
24
-
-
79956201473
-
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
-
Oestreich, K.J., Huang, A.C. & Weinmann, A.S. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J. Exp. Med. 208, 1001-1013 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1001-1013
-
-
Oestreich, K.J.1
Huang, A.C.2
Weinmann, A.S.3
-
25
-
-
77955949060
-
BCL6: Master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis
-
Basso, K. & Dalla-Favera, R. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv. Immunol. 105, 193-210 (2010).
-
(2010)
Adv. Immunol.
, vol.105
, pp. 193-210
-
-
Basso, K.1
Dalla-Favera, R.2
-
26
-
-
0037427528
-
Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers
-
Mascle, X., Albagli, O. & Lemercier, C. Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers. Biochem. Biophys. Res. Commun. 300, 391-396 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.300
, pp. 391-396
-
-
Mascle, X.1
Albagli, O.2
Lemercier, C.3
-
27
-
-
27744498868
-
Follicular B helper T cells in antibody responses and autoimmunity
-
Vinuesa, C.G., Tangye, S.G., Moser, B. & Mackay, C.R. Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 5, 853-865 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 853-865
-
-
Vinuesa, C.G.1
Tangye, S.G.2
Moser, B.3
Mackay, C.R.4
-
28
-
-
74549216531
-
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
-
Pipkin, M.E. et al. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32, 79-90 (2010).
-
(2010)
Immunity
, vol.32
, pp. 79-90
-
-
Pipkin, M.E.1
-
29
-
-
79959328032
-
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
-
Choi, Y.S. et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34, 932-946 (2011).
-
(2011)
Immunity
, vol.34
, pp. 932-946
-
-
Choi, Y.S.1
-
30
-
-
80053608499
-
IL-2 family cytokines: New insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
-
Liao, W., Lin, J.X. & Leonard, W.J. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr. Opin. Immunol. 23, 598-604 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 598-604
-
-
Liao, W.1
Lin, J.X.2
Leonard, W.J.3
-
31
-
-
77954417145
-
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
-
Merkenschlager, M. & von Boehmer, H. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J. Exp. Med. 207, 1347-1350 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1347-1350
-
-
Merkenschlager, M.1
Von Boehmer, H.2
-
32
-
-
77958149675
-
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes
-
Stittrich, A.B. et al. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat. Immunol. 11, 1057-1062 (2011).
-
(2011)
Nat. Immunol.
, vol.11
, pp. 1057-1062
-
-
Stittrich, A.B.1
-
33
-
-
81255154496
-
Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2
-
Mandal, M. et al. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat. Immunol. 12, 1212-1220 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1212-1220
-
-
Mandal, M.1
-
34
-
-
79951682333
-
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
-
Yang, X.P. et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12, 247-254 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 247-254
-
-
Yang, X.P.1
-
35
-
-
33846410668
-
+ central memory T cells
-
+ central memory T cells. J. Exp. Med. 204, 79-91 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 79-91
-
-
Riou, C.1
-
36
-
-
80055108071
-
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
-
Hurtz, C. et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J. Exp. Med. 208, 2163-2174 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 2163-2174
-
-
Hurtz, C.1
-
37
-
-
75649136214
-
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
-
Crotty, S., Johnston, R.J. & Schoenberger, S.P. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat. Immunol. 11, 114-120 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 114-120
-
-
Crotty, S.1
Johnston, R.J.2
Schoenberger, S.P.3
-
38
-
-
42649120075
-
Regulation and functions of Blimp-1 in T and B lymphocytes
-
Martins, G. & Calame, K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu. Rev. Immunol. 26, 133-169 (2008).
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 133-169
-
-
Martins, G.1
Calame, K.2
-
39
-
-
74549179138
-
+ cell subset with combined Th2 and Th1 cell functions
-
+ cell subset with combined Th2 and Th1 cell functions. Immunity 32, 116-128 (2010).
-
(2010)
Immunity
, vol.32
, pp. 116-128
-
-
Hegazy, A.N.1
-
40
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch, M.A. et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
-
41
-
-
80053130719
-
An essential role of the transcription factor GATA-3 for the function of regulatory T cells
-
Wang, Y., Su, M.A. & Wan, Y.Y. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35, 337-348 (2011).
-
(2011)
Immunity
, vol.35
, pp. 337-348
-
-
Wang, Y.1
Su, M.A.2
Wan, Y.Y.3
-
42
-
-
79956085895
-
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
-
Liao, W., Lin, J.X., Wang, L., Li, P. & Leonard, W.J. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat. Immunol. 12, 551-559 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 551-559
-
-
Liao, W.1
Lin, J.X.2
Wang, L.3
Li, P.4
Leonard, W.J.5
-
43
-
-
80755172184
-
Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
-
Pepper, M., Pagan, A.J., Igyarto, B.Z., Taylor, J.J. & Jenkins, M.K. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35, 583-595 (2011).
-
(2011)
Immunity
, vol.35
, pp. 583-595
-
-
Pepper, M.1
Pagan, A.J.2
Igyarto, B.Z.3
Taylor, J.J.4
Jenkins, M.K.5
-
44
-
-
58449124804
-
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
-
Bauquet, A.T. et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10, 167-175 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 167-175
-
-
Bauquet, A.T.1
-
45
-
-
79956081339
-
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
-
Ise, W. et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 12, 536-543 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 536-543
-
-
Ise, W.1
-
46
-
-
79960342424
-
B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
-
Lee, S.K. et al. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J. Exp. Med. 208, 1377-1388 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1377-1388
-
-
Lee, S.K.1
|