메뉴 건너뛰기




Volumn 108, Issue 5, 2006, Pages 1595-1601

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 23; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR T BET;

EID: 33748174156     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-04-015016     Document Type: Article
Times cited : (127)

References (39)
  • 1
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
    • Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 2003;19:641-644.
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 2
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    • Parham C, Chirica M, Timans J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002;168:5699-5708.
    • (2002) J Immunol , vol.168 , pp. 5699-5708
    • Parham, C.1    Chirica, M.2    Timans, J.3
  • 3
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 4
    • 0036604062 scopus 로고    scopus 로고
    • IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
    • Belladonna ML, Renauld JC, Bianchi R, et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol. 2002;168:5448-5454.
    • (2002) J Immunol , vol.168 , pp. 5448-5454
    • Belladonna, M.L.1    Renauld, J.C.2    Bianchi, R.3
  • 5
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278:1910-1914.
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 6
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005;201:233-240.
    • (2005) J Exp Med , vol.201 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3
  • 7
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 8
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3
  • 9
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy CA, Langrish CL, Chen Y, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med. 2003;198:1951-1957.
    • (2003) J Exp Med , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3
  • 11
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002;295:338-342.
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 12
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto S, Neurath MF, Glickman JN, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002;295:336-338.
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3
  • 13
    • 0346034780 scopus 로고    scopus 로고
    • Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells
    • Bruns HA, Schindler U, Kaplan MH. Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J Immunol. 2003;170:3478-3487.
    • (2003) J Immunol , vol.170 , pp. 3478-3487
    • Bruns, H.A.1    Schindler, U.2    Kaplan, M.H.3
  • 14
    • 0035070944 scopus 로고    scopus 로고
    • Influence of multiplicity of infection and protein stability on retroviral vector-mediated gene expression in hematopoietic cells
    • Wahlers A, Schwieger M, Li Z, et al. Influence of multiplicity of infection and protein stability on retroviral vector-mediated gene expression in hematopoietic cells. Gene Ther. 2001;8:477-486.
    • (2001) Gene Ther , vol.8 , pp. 477-486
    • Wahlers, A.1    Schwieger, M.2    Li, Z.3
  • 15
    • 13544249617 scopus 로고    scopus 로고
    • RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells
    • Gu Y, Jasti AC, Jansen M, Siefring JE. RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells. Blood. 2005;105:1467-1475.
    • (2005) Blood , vol.105 , pp. 1467-1475
    • Gu, Y.1    Jasti, A.C.2    Jansen, M.3    Siefring, J.E.4
  • 16
    • 0028845730 scopus 로고
    • Cloning of a new cytokine that induces IFN-gamma production by T cells
    • Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995;378:88-91.
    • (1995) Nature , vol.378 , pp. 88-91
    • Okamura, H.1    Tsutsi, H.2    Komatsu, T.3
  • 17
    • 0035910037 scopus 로고    scopus 로고
    • T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
    • Lighvani AA, Frucht DM, Jankovic D, et al. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A. 2001;98:15137-15142.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15137-15142
    • Lighvani, A.A.1    Frucht, D.M.2    Jankovic, D.3
  • 18
    • 0035997908 scopus 로고    scopus 로고
    • T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
    • Afkarian M, Sedy JR, Yang J, et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol. 2002;3:549-557.
    • (2002) Nat Immunol , vol.3 , pp. 549-557
    • Afkarian, M.1    Sedy, J.R.2    Yang, J.3
  • 19
    • 15244344110 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
    • Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity. 2005;22:285-294.
    • (2005) Immunity , vol.22 , pp. 285-294
    • Stark, M.A.1    Huo, Y.2    Burcin, T.L.3    Morris, M.A.4    Olson, T.S.5    Ley, K.6
  • 20
    • 0033616607 scopus 로고    scopus 로고
    • The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
    • Ouyang W, Jacobson NG, Bhattacharya D, et al. The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. Proc Natl Acad Sci U S A. 1999;96:3888-3893.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3888-3893
    • Ouyang, W.1    Jacobson, N.G.2    Bhattacharya, D.3
  • 21
    • 0036301997 scopus 로고    scopus 로고
    • Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction
    • Mullen AC, Hutchins AS, High FA, et al. Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol. 2002;3:652-658.
    • (2002) Nat Immunol , vol.3 , pp. 652-658
    • Mullen, A.C.1    Hutchins, A.S.2    High, F.A.3
  • 22
    • 0029965236 scopus 로고    scopus 로고
    • Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
    • Murphy E, Shibuya K, Hosken N, et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp Med. 1996;183:901-913.
    • (1996) J Exp Med , vol.183 , pp. 901-913
    • Murphy, E.1    Shibuya, K.2    Hosken, N.3
  • 23
    • 27744461314 scopus 로고    scopus 로고
    • IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
    • Hwang ES, Hong JH, Glimcher LH. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med. 2005;202:1289-1300.
    • (2005) J Exp Med , vol.202 , pp. 1289-1300
    • Hwang, E.S.1    Hong, J.H.2    Glimcher, L.H.3
  • 24
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-433.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 25
    • 13844319581 scopus 로고    scopus 로고
    • NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
    • Mehta DS, Wurster AL, Weinmann AS, Grusby MJ. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A. 2005;102:2016-2021.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2016-2021
    • Mehta, D.S.1    Wurster, A.L.2    Weinmann, A.S.3    Grusby, M.J.4
  • 26
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24:179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 27
    • 0037867066 scopus 로고    scopus 로고
    • Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation
    • Chen CH, Seguin-Devaux C, Burke NA, et al. Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J Exp Med. 2003;197:1689-1699.
    • (2003) J Exp Med , vol.197 , pp. 1689-1699
    • Chen, C.H.1    Seguin-Devaux, C.2    Burke, N.A.3
  • 28
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    • Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med. 2002;195:1499-1505.
    • (2002) J Exp Med , vol.195 , pp. 1499-1505
    • Gorelik, L.1    Constant, S.2    Flavell, R.A.3
  • 29
    • 27144502396 scopus 로고    scopus 로고
    • TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1
    • Park IK, Shultz LD, Letterio JJ, Gorham JD. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol. 2005;175:5666-5674.
    • (2005) J Immunol , vol.175 , pp. 5666-5674
    • Park, I.K.1    Shultz, L.D.2    Letterio, J.J.3    Gorham, J.D.4
  • 30
    • 15844402155 scopus 로고    scopus 로고
    • T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    • Fossiez F, Djossou O, Chomarat P, et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med. 1996;183:2593-2603.
    • (1996) J Exp Med , vol.183 , pp. 2593-2603
    • Fossiez, F.1    Djossou, O.2    Chomarat, P.3
  • 31
    • 0032403506 scopus 로고    scopus 로고
    • IL-17 stimulates granulopoiesis in mice: Use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines
    • Schwarzenberger P, La Russa V, Miller A, et al. IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol. 1998;161:6383-6389.
    • (1998) J Immunol , vol.161 , pp. 6383-6389
    • Schwarzenberger, P.1    La Russa, V.2    Miller, A.3
  • 32
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye P, Rodriguez FH, Kanaly S, et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001;194:519-527.
    • (2001) J Exp Med , vol.194 , pp. 519-527
    • Ye, P.1    Rodriguez, F.H.2    Kanaly, S.3
  • 33
    • 0034326645 scopus 로고    scopus 로고
    • Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    • Luzza F, Parrello T, Monteleone G, et al. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J Immunol. 2000;165:5332-5337.
    • (2000) J Immunol , vol.165 , pp. 5332-5337
    • Luzza, F.1    Parrello, T.2    Monteleone, G.3
  • 34
    • 0037442115 scopus 로고    scopus 로고
    • CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
    • Chung DR, Kasper DL, Panzo RJ, et al. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol. 2003;170:1958-1963.
    • (2003) J Immunol , vol.170 , pp. 1958-1963
    • Chung, D.R.1    Kasper, D.L.2    Panzo, R.J.3
  • 35
    • 0036481263 scopus 로고    scopus 로고
    • Epitope spreading in immune-mediated diseases: Implications for immunotherapy
    • Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat Rev Immunol. 2002;2:85-95.
    • (2002) Nat Rev Immunol , vol.2 , pp. 85-95
    • Vanderlugt, C.L.1    Miller, S.D.2
  • 36
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421:744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 37
    • 3142724732 scopus 로고    scopus 로고
    • Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    • Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004;200:79-87.
    • (2004) J Exp Med , vol.200 , pp. 79-87
    • Bettelli, E.1    Sullivan, B.2    Szabo, S.J.3    Sobel, R.A.4    Glimcher, L.H.5    Kuchroo, V.K.6
  • 38
    • 27744571314 scopus 로고    scopus 로고
    • T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
    • Lord GM, Rao RM, Choe H, et al. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood. 2005;106:3432-3439.
    • (2005) Blood , vol.106 , pp. 3432-3439
    • Lord, G.M.1    Rao, R.M.2    Choe, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.