Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression

Journal of Immunology

Volumn 175, Issue 9, 2005, Pages 5981-5985

  Martins, Gislâine A ^a   Hutchins, Anne S ^a   Reiner, Steven L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HOMEODOMAIN PROTEIN; INTERLEUKIN 4; PROTEIN HIX; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; CELL FATE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIGENETICS; GENE; GENE DISRUPTION; GENE INTERACTION; GENE SILENCING; GENE SWITCHING; HELPER CELL; IFNG GENE; INTERFERON PRODUCTION; MOLECULAR STABILITY; MOUSE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TH1 CELL; TH2 CELL; TRANSCRIPTION REGULATION;

EID: 27144526101     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.9.5981     Document Type: Article

References (32)

1. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2: 933-944.
2. Szabo, S. J., B. M. Sullivan, S. L. Peng, and L. H. Glimcher. 2003. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21: 713-758.
3. Ansel, K. M., D. U. Lee, and A. Rao. 2003. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4: 616-623.
4. Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
5. Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292: 1907-1910.
6. + T cells. Nat. Immunol. 3: 549-557.
7. H1 gene induction. Nat. Immunol. 3: 652-658.
8. Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295: 338-342.
9. Zheng, W., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
10. Ouyang, W., S. H. Ranganath, K. Weindel, D. Bhattacharya, T. L. Murphy, W. C. Sha, and K. M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9: 745-755.
11. Takemoto, N., Y. Kamogawa, H. Jun Lee, H. Kurata, K.-i. Arai, A. O'Garra, N. Arai, and S. Miyatake. 2000. Cutting edge: chromatin remodeling at the IL-4/1L-13 intergenic regulatory region for Th2-specific cytokine gene cluster. J. Immunol. 165: 6687-6691.
12. Pai, S. Y., M. L. Truitt, and I. C. Ho. 2004. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA 101: 1993-1998.
13. H2 responses. Nat. Immunol. 5: 1157-1165.
14. Sallusto, F., and S. L. Reiner. 2005. Sliding doors in the immune response. Nat. Immunol. 6: 10-12.
15. Reiner, S. L. 2005. Epigenetic control in the immune response. Hum. Mol. Genet. 14: R41-R46.
16. + T cell function by the transcription factor Eomesodermin. Science 302: 1041-1043.
17. Scott, P., P. Caspar, and A. Sher. 1990. Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes. J. Immunol. 144: 1075-1079.
18. Kim, J., and R. A. Feldman. 2002. Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1. Mol. Cell Biol. 22: 1903-1918.
19. Zheng, W. P., Q. Zhao, X. Zhao, B. Li, M. Hubank, D. G. Schatz, and R. A. Flavell. 2004. Up-regulation of Hlx in immature Th cells induces IFN-γ expression. J. Immunol. 172: 114-122.
20. Lando, D., D. J. Peet, I. Pongratz, and M. L. Whitelaw. 2002. Mammalian two-hybrid assay showing redox control of HIF-like factor. Methods Enzymol. 353: 3-10.
21. Stennard, F. A., M. W. Costa, D. A. Elliott, S. Rankin, S. J. Haast, D. Lai, L. P. McDonald, K. Niederreither, P. Dolle, B. G. Bruneau, et al. 2003. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev. Biol. 262: 206-224.
22. Hiroi, Y., S. Kudoh, K. Monzen, Y. Ikeda, Y. Yazaki, R. Nagai, and I. Komuro. 2001. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat. Genet. 28: 276-280.
23. Lamolet, B., A. M. Pulichino, T. Lamonerie, Y. Gauthier, T. Brue, A. Enjalbert, and J. Drouin. 2001. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104: 849-859.
24. Hentsch, B., I. Lyons, R. Li, L. Hartley, T. J. Lints, J. M. Adams, and R. P. Harvey. 1996. Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut. Genes Dev. 10: 70-79.
25. Han, K., and J. L. Manley. 1993. Functional domains of the Drosophila Engrailed protein. EMBO J. 12: 2723-2733.
26. Kessler, D. S. 1997. Siamois is required for formation of Spemann's organizer. Proc. Natl. Acad. Sci. USA 94: 13017-13022.
27. Grogan, J. L., M. Mohrs, B. Harraon, D. A. Lacy, J. W. Sedat, and R. M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14: 205-215.
28. Lee, D. U., S. Agarwal, and A. Rao. 2002. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16: 649-660.
29. Lee, H. J., N. Takemoto, H. Kurata, Y. Kamogawa, S. Miyatake, A. O'Garra, and N. Arai. 2000. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J. Exp. Med. 192: 105-115.
30. Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335: 563-564.
31. Memedula, S., and A. S. Belmont. 2003. Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16. Curr. Biol. 13: 241-246.
32. Ansel, K. M., R. J. Greenwald, S. Agarwal, C. H. Bassing, S. Monticelli, J. Interlandi, I. M. Djuretic, D. U. Lee, A. H. Sharpe, F. W. Alt, and A. Rao. 2004. Deletion of a conserved 114 silencer impairs T helper type 1-mediated immunity. Nat. Immunol. 5: 1251-1259.