-
1
-
-
33750142276
-
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
-
Veldhoen, M., Hocking, R.J., Flavell, R.A., and Stockinger, B. 2006. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7:1151-1156.
-
(2006)
Nat. Immunol
, vol.7
, pp. 1151-1156
-
-
Veldhoen, M.1
Hocking, R.J.2
Flavell, R.A.3
Stockinger, B.4
-
2
-
-
33748448717
-
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
-
Li, M.O., Sanjabi, S., and Flavell, R.A. 2006. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity. 25:455-471.
-
(2006)
Immunity
, vol.25
, pp. 455-471
-
-
Li, M.O.1
Sanjabi, S.2
Flavell, R.A.3
-
3
-
-
0031456802
-
Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes
-
Wang, B., et al. 1997. Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. U. S. A. 94:13844-13849.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A
, vol.94
, pp. 13844-13849
-
-
Wang, B.1
-
4
-
-
0030444632
-
The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse
-
Nicoletti, F., et al. 1996. The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology. 137:5567-5575.
-
(1996)
Endocrinology
, vol.137
, pp. 5567-5575
-
-
Nicoletti, F.1
-
5
-
-
24144484765
-
Stat4-null non-obese diabetic mice: Protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread
-
Boyton, R.J., et al. 2005. Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread. Int. Immunol. 17:1157-1165.
-
(2005)
Int. Immunol
, vol.17
, pp. 1157-1165
-
-
Boyton, R.J.1
-
6
-
-
1642412663
-
Autoimmune diabetes is blocked in Stat4-deficient mice
-
Yang, Z., et al. 2004. Autoimmune diabetes is blocked in Stat4-deficient mice. J. Autoimmun. 22:191-200.
-
(2004)
J. Autoimmun
, vol.22
, pp. 191-200
-
-
Yang, Z.1
-
7
-
-
0028926524
-
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
-
Trembleau, S., et al. 1995. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:817-821.
-
(1995)
J. Exp. Med
, vol.181
, pp. 817-821
-
-
Trembleau, S.1
-
8
-
-
0029948898
-
Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
-
Hultgren, B., Huang, X., Dybdal, N., and Stewart, T.A. 1996. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes. 45:812-817.
-
(1996)
Diabetes
, vol.45
, pp. 812-817
-
-
Hultgren, B.1
Huang, X.2
Dybdal, N.3
Stewart, T.A.4
-
9
-
-
0033669375
-
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
-
Serreze, D.V., et al. 2000. Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes. 49:2007-2011.
-
(2000)
Diabetes
, vol.49
, pp. 2007-2011
-
-
Serreze, D.V.1
-
10
-
-
0034175965
-
Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci
-
Kanagawa, O., Xu, G., Tevaarwerk, A., and Vaupel, B.A. 2000. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci. J. Immunol. 164:3919-3923.
-
(2000)
J. Immunol
, vol.164
, pp. 3919-3923
-
-
Kanagawa, O.1
Xu, G.2
Tevaarwerk, A.3
Vaupel, B.A.4
-
11
-
-
0027378612
-
Following a diabetogenic T cell from genesis through pathogenesis
-
Katz, J.D., Wang, B., Haskins, K., Benoist, C., and Mathis, D. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 74:1089-1100.
-
(1993)
Cell
, vol.74
, pp. 1089-1100
-
-
Katz, J.D.1
Wang, B.2
Haskins, K.3
Benoist, C.4
Mathis, D.5
-
12
-
-
0030879734
-
Mechanism underlying counterregulation of autoimmune diabetes by IL-4
-
Mueller, R., Bradley, L.M., Krahl, T., and Sarvetnick, N. 1997. Mechanism underlying counterregulation of autoimmune diabetes by IL-4. Immunity. 7:411-418.
-
(1997)
Immunity
, vol.7
, pp. 411-418
-
-
Mueller, R.1
Bradley, L.M.2
Krahl, T.3
Sarvetnick, N.4
-
13
-
-
0035575760
-
Cutting edge: Interactions through the IL-10 receptor regulate autoimmune diabetes
-
Phillips, J.M., Parish, N.M., Drage, M., and Cooke, A. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J. Immunol. 167:6087-6091.
-
(2001)
J. Immunol
, vol.167
, pp. 6087-6091
-
-
Phillips, J.M.1
Parish, N.M.2
Drage, M.3
Cooke, A.4
-
14
-
-
34547204632
-
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
-
You, S., et al. 2007. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc. Natl. Acad. Sci. U. S. A. 104:6335-6340.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A
, vol.104
, pp. 6335-6340
-
-
You, S.1
-
15
-
-
38749111445
-
Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
-
Jain, R., et al. 2008. Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J. Exp. Med. 205:207-218.
-
(2008)
J. Exp. Med
, vol.205
, pp. 207-218
-
-
Jain, R.1
-
16
-
-
0025647147
-
Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages
-
Hutchings, P., et al. 1990. Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages. Nature. 348:639-642.
-
(1990)
Nature
, vol.348
, pp. 639-642
-
-
Hutchings, P.1
-
17
-
-
33746904348
-
Salmonella typhimurium infection in nonobese diabetic mice generates immunomodulatory dendritic cells able to prevent type 1 diabetes
-
Raine, T., Zaccone, P., Mastroeni, P., and Cooke, A. 2006. Salmonella typhimurium infection in nonobese diabetic mice generates immunomodulatory dendritic cells able to prevent type 1 diabetes. J. Immunol. 177:2224-2233.
-
(2006)
J. Immunol
, vol.177
, pp. 2224-2233
-
-
Raine, T.1
Zaccone, P.2
Mastroeni, P.3
Cooke, A.4
-
18
-
-
41149094942
-
Rapid ex vivo isolation and long-term culture of human Th17 cells
-
Streeck, H., et al. 2008. Rapid ex vivo isolation and long-term culture of human Th17 cells. J. Immunol. Methods. 333:115-125.
-
(2008)
J. Immunol. Methods
, vol.333
, pp. 115-125
-
-
Streeck, H.1
-
19
-
-
33751243318
-
Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis
-
Uyttenhove, C., and Van Snick, J. 2006. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur. J. Immunol. 36:2868-2874.
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 2868-2874
-
-
Uyttenhove, C.1
Van Snick, J.2
-
20
-
-
33751242743
-
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis
-
Sonderegger, I., et al. 2006. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur. J. Immunol. 36:2849-2856.
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 2849-2856
-
-
Sonderegger, I.1
-
21
-
-
33751254750
-
Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
-
Rohn, T.A., et al. 2006. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur. J. Immunol. 36:2857-2867.
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 2857-2867
-
-
Rohn, T.A.1
-
22
-
-
0029010646
-
In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice
-
Healey, D., et al. 1995. In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95:2979-2985.
-
(1995)
J. Clin. Invest
, vol.95
, pp. 2979-2985
-
-
Healey, D.1
-
23
-
-
0029030964
-
T helper cell subsets in insulin-dependent diabetes
-
Katz, J.D., Benoist, C., and Mathis, D. 1995. T helper cell subsets in insulin-dependent diabetes. Science. 268:1185-1188.
-
(1995)
Science
, vol.268
, pp. 1185-1188
-
-
Katz, J.D.1
Benoist, C.2
Mathis, D.3
-
24
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park, H., et al. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6:1133-1141.
-
(2005)
Nat. Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
-
25
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
Mangan, P.R., et al. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 441:231-234.
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
-
26
-
-
18544392433
-
Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1
-
Moritani, M., et al. 1998. Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1. J. Clin. Invest. 102:499-506.
-
(1998)
J. Clin. Invest
, vol.102
, pp. 499-506
-
-
Moritani, M.1
-
27
-
-
0036700341
-
Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism
-
Grewal, I.S., et al. 2002. Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J. Autoimmun. 19:9-22.
-
(2002)
J. Autoimmun
, vol.19
, pp. 9-22
-
-
Grewal, I.S.1
-
28
-
-
33748174156
-
T-bet is a critical determinant in the instability of the IL-17-secreting Thelper phenotype
-
Mathur, A.N., et al. 2006. T-bet is a critical determinant in the instability of the IL-17-secreting Thelper phenotype. Blood. 108:1595-1601.
-
(2006)
Blood
, vol.108
, pp. 1595-1601
-
-
Mathur, A.N.1
-
29
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, I.I., et al. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 126:1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
-
30
-
-
42249084849
-
Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category
-
Luger, D., et al. 2008. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 205:799-810.
-
(2008)
J. Exp. Med
, vol.205
, pp. 799-810
-
-
Luger, D.1
-
31
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington, L.E., et al. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6:1123-1132.
-
(2005)
Nat. Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
-
32
-
-
34547734621
-
Phenotypic and functional features of human Th17 cells
-
Annunziato, F., et al. 2007. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204:1849-1861.
-
(2007)
J. Exp. Med
, vol.204
, pp. 1849-1861
-
-
Annunziato, F.1
-
33
-
-
38749121326
-
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
-
Lohning, M., et al. 2008. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J. Exp. Med. 205:53-61.
-
(2008)
J. Exp. Med
, vol.205
, pp. 53-61
-
-
Lohning, M.1
-
34
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli, E., et al. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
35
-
-
43449135305
-
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
-
Zhou, L., et al. 2008. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 453:236-240.
-
(2008)
Nature
, vol.453
, pp. 236-240
-
-
Zhou, L.1
-
36
-
-
46749138596
-
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
-
Yang, X.O., et al. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 29:44-56.
-
(2008)
Immunity
, vol.29
, pp. 44-56
-
-
Yang, X.O.1
-
37
-
-
58149216715
-
Th memory for interleukin-17 expression is stable in vivo
-
Lexberg, M.H., et al. 2008. Th memory for interleukin-17 expression is stable in vivo. Eur. J. Immunol. 38:2654-2664.
-
(2008)
Eur. J. Immunol
, vol.38
, pp. 2654-2664
-
-
Lexberg, M.H.1
-
38
-
-
56349154943
-
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen, M., et al. 2008. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9:1341-1346.
-
(2008)
Nat. Immunol
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
-
39
-
-
0036560003
-
Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains
-
Ymer, S.I., et al. 2002. Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains. Genes Immun. 3:151-157.
-
(2002)
Genes Immun
, vol.3
, pp. 151-157
-
-
Ymer, S.I.1
-
40
-
-
0141886225
-
Cuttine edge: Diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice
-
Simpson, P.B., et al. 2003. Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice. J. Immunol. 171:3333-3337.
-
(2003)
J. Immunol
, vol.171
, pp. 3333-3337
-
-
Simpson, P.B.1
-
41
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B., et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
-
42
-
-
0029965236
-
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
-
Murphy, E., et al. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183:901-913.
-
(1996)
J. Exp. Med
, vol.183
, pp. 901-913
-
-
Murphy, E.1
-
43
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., and Stockinger, B. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24:179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
|