Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development

Immunity

Volumn 9, Issue 5, 1998, Pages 627-635

  Ranger, Ann M ^a   Oukka, Mohamed ^a   Rengarajan, Jyothi ^a   Glimcher, Laurie H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 4; NUCLEAR FACTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLEPHARITIS; CONTROLLED STUDY; HOMEOSTASIS; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INTERSTITIAL PNEUMONIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

EID: 0032212631     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80660-3     Document Type: Article

References (51)

1. Beals, C.R., Clipstone, N.A., Ho, S.N., and Crabtree, G.R. (1997). Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 11, 824-834.
2. Boise, L.H., Petryniak, B., Mao, X., June, C.H., Wang, C.-Y., Lindsten, T., Bravo, R., Kovary, K., Leiden, J.M., and Thompson, C.B. (1993). The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol. Cell. Biol. 13, 1911-1919.
3. Choi, M.S.K., Brines, R.D., Holman, M.J., and Klaus, G.G.B. (1994). Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or DC40 ligand in conjunction with IL-4. Immunogenetics 1, 179-187.
4. Chuvpilo, S., Schomberg, C., Gerwig, R., Heinfling, A., Reeves, R., Grummt, F., and Serfling, E. (1993). Multiple closely-linked NFAT/ octamer and HMG I (Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21, 5694-5704.
5. Clipstone, N.A., and Crabtree, G.R. (1992). Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation. Nature 357, 695-697.
6. Cockerill, P.N., Bert, A.G., Jenkins, F., Ryan, G.R., Shannon, M.F., and Vadas, M.A. (1995). Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c. Mol. Cell. Biol. 15, 2071-2079.
7. Cohen, P.L., and Eisenberg, R.A. (1991). Lprand gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269.
8. Crabtree, G. (1989). Contingent genetic regulatory events in T lymphocyte activation. Science 249, 355-360.
9. Del Prete, G.F., De Carli, M., Mastromauro, C., Biagniotti, R., Macchia, D., Falagiani, P., Ricci, M., and Romagnani, S. (1991). Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J. Clin. Invest. 88, 346-350.
10. Emmel, E.A., Verweij, C.L., Durand, D.B., Higgins, K.M., Lacy, E., and Crabtree, G.R. (1989). Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246, 1617-1620.
11. Flanagan, W.M., Corthesy, B., Bram, R.J., and Crabtree, G.R. (1991). Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 352, 803-807.
12. Goldfeld, A.E., McCaffrey, P.G., Strominger, J.L., and Rao, A. (1993). Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter. J. Exp. Med. 178, 1365-1379.
13. Ho, I-C., Hodge, M.R., Rooney, J.W., and Glimcher, L.H. (1996). The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85, 973-983.
14. Ho, S.N., Thomas, D.J., Timmerman, L.A., Li, X., Francke, U., and Crabtree, G.R. (1995). NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J. Biol. Chem. 270, 19898-19907.
15. Hodge, M.R., Ranger, A.M., Charles de la Brousse, F., Hoey, T., Grusby, M.J., and Glimcher, L.H. (1996). Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 4, 1-20.
16. Hoey, T., Sun, Y-L., Williamson, K., and Xu, X. (1995). Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2, 461-472.
17. Jain, J., McCaffrey, P.G., Valge-Archer, V.E., and Rao, A. (1992). Nuclear factor of activated T cells contains Fos and Jun. Nature 356, 801-804.
18. Jain, J., McCaffrey, P.G., Miner, Z., Kerppola, T.K., Lambert, J.N., Verdine, G.L., Curran, T., and Rao, A. (1993). The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365, 352-355.
19. Kiani, A., Viola, J.P.B., Lichtman, A.H., and Rao, A. (1997). Downregulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 7, 849-860.
20. Kinoshita, S., Su, L., Amano, M., Timmerman, L.A., Kaneshima, H., and Nolan, G.P. (1997). The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immunity 6, 235-244.
21. Latinis, K.M., Carr, L.L., Peterson, E.J., Norian, L.A., Eliason, S.L., and Koretzky, G.A. (1997). Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J. Immunol. 158, 4602-4611.
22. Luis de la Pompa, J., Timmerman, L.A., Takimoto, H., Yoshida, H., Elia, A.J., Samper, E., Potter, J., Wakeham, A., Marengere, L., Langille, B.L., et al. (1998). Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392, 182-186.
23. Luo, C., Burgeon, E., and Rao, A. (1996). Mechanisms of transactivation by nuclear factor of activated T cells-1. J. Exp. Med. 184, 141-147.
24. Markowitz, J.S., Rogers, P.R., Grusby, M.J., Parker, D.C., and Glimcher, L.H. (1993). B lymphocyte development and activation independent of MHC class II expression. J. Immunol. 150, 1223-1233.
25. Masuda, E.S., Tokumitsu, H., Tsuboi, A., Shlomai, J., Hung, P., Arai, K-i., and Arai, N. (1993). The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT. Mol. Cell. Biol. 13, 7399-7407.
26. Masuda, E.S., Naito, Y., Tokumitsu, H., Campbell, D., Saito, F., Hannum, C., Arai, K-i., and Arai, N. (1995). NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol. Cell. Biol. 15, 2697-2706.
27. McCaffrey, P.G., Luo, C., Kerppola, T.K., Jain, J., Badalian, T.M., Ho, A.M., Burgeon, E., Lane, W.S., Lambert, J.N., Curran, T., et al. (1993). Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262, 750-754.
28. Miyatake, S., Shlomai, J., Arai, K., and Arai, N. (1991). Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes - those for GM-CSF, interleukin-4 (IL-4), and IL-5. Mol. Cell. Biol. 11, 5894-5901.
29. Northrop, J.P., Ho, S.N., Chen, L., Thomas, D.J., Timmerman, L.A., Nolan, G.P., Admon, A., and Crabtree, G.R. (1994). NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497-502.
30. Oukka, M., Ho, I-C., Charles de la Brousse, F., Hoey, T., Grusby, M.J., and Glimcher, L.H. (1998). The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity 9, 295-304.
31. Ranger, A.M., Grusby, M.J., Hodge, M.R., Gravallese, E.M., Charles de la Brousse, F., Hoey, T., Mickanin, C., Baldwin, H.S., and Glimcher, L.H. (1998a). The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392, 186-190.
32. Ranger, A.M., Hodge, M.R., Gravallese, E.M., Oukka, M., Davidson, L., Alt, F.W., de la Brousse, F.C., Hoey, T., Grusby, M., and Glimcher, L.H. (1998b). Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NFATc. Immunity 8, 125-134.
33. Rao, A., Luo, C., and Hogan, P.G. (1997). Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747.
34. Rooney, J., Sun, Y-L., Glimcher, L.H., and Hoey, T. (1995). Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15, 6299-6310.
35. Rooney, J.W., Hodge, M.R., McCaffrey, P.G., Rao, A., and Glimcher, L.H. (1994). A common factor regulates both Th1-and Th2-specific cytokine gene expression. EMBO J. 13, 625-633.
36. Rooney, J.W., Hoey, T., and Glimcher, L.H. (1995). Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2, 545-553.
37. Sadlack, B., Löhler, J., Schorle, H., Klebb, G., Haber, H., Sickel, E., Noelle, R.J., and Horak, I. (1995). Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur. J. Immunol. 25, 3053-3059.
38. Shaw, J., Utz, P., Durand, D., Toole, J., Emmel, E., and Crabtree, G. (1988). Identification of a putative regulator of early T cell activation genes. Science 241, 202-205.
39. Takahashi, T., Tanaka, M., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Suda, T., and Nagata, S. (1994). Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76, 969-976.
40. Tepper, R.I., Levinson, D.A., Stanger, B.Z., Campos-Torres, J., Abbas, A.K., and Leder, P. (1990). IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62, 457-467.
41. Timmerman, L.A., Healy, J.I., Ho, S.N., Chen, L., Goodnow, C.C., and Crabtree, G.R. (1997). Redundant expression but selective utilization of nuclear factor of activated T cells family members. J. Immunol. 159, 2735-2740.
42. Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A., and Sharpe, A.H. (1995). Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547.
43. Tsitsikov, E.N., Ramesh, N., and Geha, R.S. (1994). Structure of the murine CD40 ligand gene. Mol. Immunol. 31, 895-900.
44. Venkataraman, L., Francis, D.A., Wang, Z., Liu, J., Rothstein, T.L., and Sen, R. (1994). Cyclosporin-A sensitive induction of NF-AT in murine B cells. Immunity 1, 189-196.
45. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., and Nagata, S. (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
46. Waterhouse, P., Penninger, J.M., Timms, E., Wakeham, A., Shahinian, A., Lee, K.P., Thompson, C.B., Griesser, H., and Mak, T.W. (1995). Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988.
47. Willerford, D.M., Chen, J., Ferry, J.A., Davidson, L., Ma, A., and Alt, F.W. (1995). Interleukin-2 receptor a chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3, 521-530.
48. Wynn, T.A., and Cheever, A.W. (1995). Cytokine regulation of granuloma formation in schistosomiasis. Curr. Opin. Immunol. 7, 505-511.
49. Xanthoudakis, S., Viola, J.P.B., Shaw, K.T.Y., Luo, C., Wallace, J.D., Bozza, P.T., Luk, D.C., Curran, T., and Rao, A. (1996). An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272, 892-895.
50. Yoshida, H., Nishina, H., Takimoto, H., Marengère, L.E.M., Wakeham, A.C., Bouchard, D., Kong, Y-Y., Ohteki, T., Shahinian, A., Bachmann, M., et al. (1998). The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 8, 115-124.
51. Zheng, W-P., and Flavell, R.A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596.