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Volumn 7, Issue 6, 1997, Pages 849-860

Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 4; MESSENGER RNA; TRANSCRIPTION FACTOR;

EID: 0031415048     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80403-3     Document Type: Article
Times cited : (152)

References (64)
  • 1
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A.K., Murphy, K.M., and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 2
    • 0030612781 scopus 로고    scopus 로고
    • Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice
    • Beebe, A.M., Mauze, S., Schork, N.J., and Coffman, R.L. (1997). Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity 6, 551-557.
    • (1997) Immunity , vol.6 , pp. 551-557
    • Beebe, A.M.1    Mauze, S.2    Schork, N.J.3    Coffman, R.L.4
  • 5
    • 0027159510 scopus 로고
    • Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency
    • Castigli, E., Pahwa, R., Good, R.A., Geha, R.S., and Chatila, T.A. (1993). Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency. Proc. Natl. Acad. Sci. USA 90, 4728-4732.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4728-4732
    • Castigli, E.1    Pahwa, R.2    Good, R.A.3    Geha, R.S.4    Chatila, T.A.5
  • 6
    • 0027714991 scopus 로고
    • Multiple closely-linked NFAT/ octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter
    • Chuvpilo, S., Schomberg, C., Gerwig, R., Heinfling, A., Reeves, R., Grummt, F., and Serfling, E. (1993). Multiple closely-linked NFAT/ octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21, 5694-5704.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5694-5704
    • Chuvpilo, S.1    Schomberg, C.2    Gerwig, R.3    Heinfling, A.4    Reeves, R.5    Grummt, F.6    Serfling, E.7
  • 8
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression and germinal center formation by BCL-6
    • Dent, A.L., Shaffer, A.L., Yu, X., Allman, D., and Staudt, L.M. (1997). Control of inflammation, cytokine expression and germinal center formation by BCL-6. Science 276, 589-592.
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 9
    • 0027492736 scopus 로고
    • Transcriptional and post-transcriptional regulation of the interleukin-4 and interleukin-3 genes in human T-cells
    • Dokter, W.H.A., Esselink, M.T., Sierdsema, S.J., Halie, M.R., and Vellenga, E. (1993). Transcriptional and post-transcriptional regulation of the interleukin-4 and interleukin-3 genes in human T-cells. Blood 81, 35-40.
    • (1993) Blood , vol.81 , pp. 35-40
    • Dokter, W.H.A.1    Esselink, M.T.2    Sierdsema, S.J.3    Halie, M.R.4    Vellenga, E.5
  • 11
    • 0029794222 scopus 로고    scopus 로고
    • Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings
    • Feske, S., Müller, J.M., Graf, D., Kroczek, R.A., Dräger, R., Niemeyer, C., Baeuerle, P.A., Peter, H.-H., and Schlesier, M. (1996). Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings. Eur. J. Immunol. 26, 2119-2126.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2119-2126
    • Feske, S.1    Müller, J.M.2    Graf, D.3    Kroczek, R.A.4    Dräger, R.5    Niemeyer, C.6    Baeuerle, P.A.7    Peter, H.-H.8    Schlesier, M.9
  • 12
    • 0028233726 scopus 로고
    • + T cells into IL-4-secreting cells
    • + T cells into IL-4-secreting cells. J. Immunol. 152, 5180-5188.
    • (1994) J. Immunol. , vol.152 , pp. 5180-5188
    • Gollob, K.J.1    Coffman, R.2
  • 15
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specifity
    • Hill, C.S., and Treisman, R. (1995). Transcriptional regulation by extracellular signals: mechanisms and specifity. Cell 80, 199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 16
    • 0030604714 scopus 로고    scopus 로고
    • The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
    • Ho, I.-C., Hodge, M.R., Rooney, J.W., and Glimcher, L. (1996). The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85, 973-983.
    • (1996) Cell , vol.85 , pp. 973-983
    • Ho, I.-C.1    Hodge, M.R.2    Rooney, J.W.3    Glimcher, L.4
  • 17
    • 0029125831 scopus 로고
    • NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA-binding specificity
    • Ho, S.N., Thomas, D.J., Timmerman, L.A., Li, X., Francke, U., and Crabtree, G.R. (1995). NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA-binding specificity. J. Biol. Chem. 270, 19898-19907.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19898-19907
    • Ho, S.N.1    Thomas, D.J.2    Timmerman, L.A.3    Li, X.4    Francke, U.5    Crabtree, G.R.6
  • 20
    • 0029053852 scopus 로고
    • Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
    • Hoey, T., Sun, Y.-L., Williamson, K., and Xu, X. (1995). Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2, 461-472.
    • (1995) Immunity , vol.2 , pp. 461-472
    • Hoey, T.1    Sun, Y.-L.2    Williamson, K.3    Xu, X.4
  • 23
    • 0028906593 scopus 로고
    • T cell genetic background determines default T helper phenotype development in vitro
    • Hsieh, C.S., Macatonia, S.E., O'Garra, A., and Murphy, K.M. (1995). T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181, 713-721.
    • (1995) J. Exp. Med. , vol.181 , pp. 713-721
    • Hsieh, C.S.1    Macatonia, S.E.2    O'Garra, A.3    Murphy, K.M.4
  • 24
    • 0028838971 scopus 로고
    • Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
    • Hunter, T. (1995). Protein kinases and phosphatases: the Yin and Yang of protein phosphorylation and signaling. Cell 80, 225-236.
    • (1995) Cell , vol.80 , pp. 225-236
    • Hunter, T.1
  • 25
    • 0028943484 scopus 로고
    • Interleukin-12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signaltransducer and activator of transcription (Stat)3 and Stat4
    • Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E., Jr., and Murphy, K.M. (1995). Interleukin-12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signaltransducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181, 1755-1762.
    • (1995) J. Exp. Med. , vol.181 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell J.E., Jr.6    Murphy, K.M.7
  • 26
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • Kaplan, M.H., Schindler, U., Smiley, S.T., and Grusby, M.J. (1996a). Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4, 313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 27
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat-4-deficient mice
    • Kaplan, M.H., Sun, Y.-L., Hoey, T., and Grusby, M.J. (1996b). Impaired IL-12 responses and enhanced development of Th2 cells in Stat-4-deficient mice. Nature 382, 174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 29
    • 0024506159 scopus 로고
    • Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
    • Lindsten, T., June, C.H., Ledbetter, J., Stella, G., and Thompson, C.B. (1989). Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244, 339-343.
    • (1989) Science , vol.244 , pp. 339-343
    • Lindsten, T.1    June, C.H.2    Ledbetter, J.3    Stella, G.4    Thompson, C.B.5
  • 30
    • 0030012566 scopus 로고    scopus 로고
    • T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1
    • Loh, C., Carew, J., Kim, J., Hogan, P.G., and Rao, A. (1996a). T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1. Mol. Cell. Biol. 16, 3945-3954.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3945-3954
    • Loh, C.1    Carew, J.2    Kim, J.3    Hogan, P.G.4    Rao, A.5
  • 31
    • 15844416253 scopus 로고    scopus 로고
    • Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
    • Loh, C., Shaw, K.T.-Y., Carew, J., Viola, J.P.B., Luo, C., Perrino, B.A., and Rao, A. (1996b). Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271, 10884-10891.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10884-10891
    • Loh, C.1    Shaw, K.T.-Y.2    Carew, J.3    Viola, J.P.B.4    Luo, C.5    Perrino, B.A.6    Rao, A.7
  • 32
    • 0029940394 scopus 로고    scopus 로고
    • Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
    • Luo, C., Burgeon, E., Carew, J.A., McCaffrey, P.G., Badalian, T.M., Lane, W.S., Hogan, P.G., and Rao, A. (1996). Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol. Cell. Biol. 16, 3955-3966.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3955-3966
    • Luo, C.1    Burgeon, E.2    Carew, J.A.3    McCaffrey, P.G.4    Badalian, T.M.5    Lane, W.S.6    Hogan, P.G.7    Rao, A.8
  • 33
    • 0030949834 scopus 로고    scopus 로고
    • Expression of NFAT-family proteins in normal human T cells
    • Lyakh, L., Ghosh, P., and Rice, N.R. (1996). Expression of NFAT-family proteins in normal human T cells. Mol. Cell. Biol. 17, 2475-2484.
    • (1996) Mol. Cell. Biol. , vol.17 , pp. 2475-2484
    • Lyakh, L.1    Ghosh, P.2    Rice, N.R.3
  • 35
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T.R., and Coffman, R.L. (1989). Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 37
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul, W.E., and Seder, R.A. (1994). Lymphocyte responses and cytokines. Cell 76, 241-251.
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 38
    • 0025865570 scopus 로고
    • Signaling mechanisms in T cells
    • Rao, A. (1991). Signaling mechanisms in T cells. Crit. Rev. Immunol. 10, 495-519.
    • (1991) Crit. Rev. Immunol. , vol.10 , pp. 495-519
    • Rao, A.1
  • 39
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: Regulation and function
    • Rao, A., Luo, C., and Hogan, P.G. (1997). Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 40
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S.L., and Locksley, R.M. (1995). The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13, 151-177.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 41
    • 0031034051 scopus 로고    scopus 로고
    • - T helper 2 (Th2) cells but not in Th1 cells
    • - T helper 2 (Th2) cells but not in Th1 cells. Mol. Cell. Biol. 17, 1522-1534.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1522-1534
    • Rincón, M.1    Flavell, R.A.2
  • 44
    • 0031172781 scopus 로고    scopus 로고
    • The Th1/Th2 paradigm
    • Romagnani, S. (1997). The Th1/Th2 paradigm. Immunol. Today 18, 263-266.
    • (1997) Immunol. Today , vol.18 , pp. 263-266
    • Romagnani, S.1
  • 45
    • 0028157768 scopus 로고
    • A common factor regulates both Th1- and Th2-specific cytokine gene expression
    • Rooney, J.W., Hodge, M.R., McCaffrey, P.G., Rao, A., and Glimcher, L.H. (1994). A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J. 13, 625-633.
    • (1994) EMBO J. , vol.13 , pp. 625-633
    • Rooney, J.W.1    Hodge, M.R.2    McCaffrey, P.G.3    Rao, A.4    Glimcher, L.H.5
  • 46
    • 0029030775 scopus 로고
    • Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
    • Rooney, J.W., Hoey, T., and Glimcher, L.H. (1995). Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2, 473-483.
    • (1995) Immunity , vol.2 , pp. 473-483
    • Rooney, J.W.1    Hoey, T.2    Glimcher, L.H.3
  • 48
    • 0023886642 scopus 로고
    • Mechanisms regulating the level of IL-2 mRNA in T lymphocytes
    • Shaw, J., Meerovitch, K., Bleackley, R.C., and Paetkau, V. (1988). Mechanisms regulating the level of IL-2 mRNA in T lymphocytes. J. Immunol. 140, 2243-2248.
    • (1988) J. Immunol. , vol.140 , pp. 2243-2248
    • Shaw, J.1    Meerovitch, K.2    Bleackley, R.C.3    Paetkau, V.4
  • 49
    • 0029761681 scopus 로고    scopus 로고
    • Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
    • Shibasaki, F., Price, E.R., Milan, D., and McKeon, F. (1996). Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382, 370-373.
    • (1996) Nature , vol.382 , pp. 370-373
    • Shibasaki, F.1    Price, E.R.2    Milan, D.3    McKeon, F.4
  • 51
    • 0027305687 scopus 로고
    • Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
    • Szabo, S.J., Gold, J.S., Murphy, T.L., and Murphy, K.M. (1993). Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol. Cell. Biol. 13, 4793-4805.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4793-4805
    • Szabo, S.J.1    Gold, J.S.2    Murphy, T.L.3    Murphy, K.M.4
  • 52
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S.J., Dighe, A.S., Gubler, U., and Murphy, K.M. (1997). Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817-824.
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 54
    • 0024502120 scopus 로고
    • Murine interleukin-4 displays potent anti-tumor activity in vivo
    • Tepper, R.I., Pattengale, P.K., and Leder, P. (1989). Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 57, 503-512.
    • (1989) Cell , vol.57 , pp. 503-512
    • Tepper, R.I.1    Pattengale, P.K.2    Leder, P.3
  • 56
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 57
    • 0029003507 scopus 로고
    • Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: Both nuclear and cytoplasmic RNAs are regulated with complex kinetics
    • Umlauf, S.W., Beverly, B., Lantz, O., and Schwartz, R.H. (1995). Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell. Biol. 15, 3197-3205.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3197-3205
    • Umlauf, S.W.1    Beverly, B.2    Lantz, O.3    Schwartz, R.H.4
  • 60
    • 0030845413 scopus 로고    scopus 로고
    • Pathways leading to cell death in T cells
    • Wong, B., and Choi, Y. (1997). Pathways leading to cell death in T cells. Curr. Opin. Immunol. 9, 358-364.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 358-364
    • Wong, B.1    Choi, Y.2
  • 62
    • 0028177589 scopus 로고
    • pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285-1295.
    • (1994) J. Exp. Med. , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 63
    • 0030970526 scopus 로고    scopus 로고
    • Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis
    • Zhang, X., Brunner, T., Carter, L., Dutton, R.W., Rogers, P., Bradley, L., Sato, T., Reed, J.C., Green, D., and Swain, S.L. (1997). Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185, 1837-1849.
    • (1997) J. Exp. Med. , vol.185 , pp. 1837-1849
    • Zhang, X.1    Brunner, T.2    Carter, L.3    Dutton, R.W.4    Rogers, P.5    Bradley, L.6    Sato, T.7    Reed, J.C.8    Green, D.9    Swain, S.L.10
  • 64
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W.-p., and Flavell, R.A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.-P.1    Flavell, R.A.2


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